96 Matching Annotations
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    An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells
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  3. Dec 2025
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    Recruitment of FBXO22 for targeted degradation of NSD2
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    Glutamine synthetase modulates YAP activation by stabilizing LATS under glutamine homeostasis
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  9. Sep 2025
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    Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4+ T Cells
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    TIM3+ breast cancer cells license immune evasion during micrometastasis outbreak
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    Vault RNAs aid RNA virus infection by facilitating cytoplasmic localization of hnRNP C and ELAVL1
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    CDK4/6 activity is required during G2 arrest to prevent stress induced endoreplication
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    Generation of a human embryonic stem cell line (WAe009-A-3B) carrying homozygous TNNT2 gene knockout by CRISPR/Cas9 editing
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    TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing factors
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    Isogenic comparison of Airn and Xist reveals core principles of Polycomb recruitment by lncRNAs
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    Translesion-synthesis-mediated bypass of DNA lesions occurs predominantly behind replication forks restarted by PrimPol
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    The integrated stress response regulates 18S nonfunctional rRNA decay in mammals
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    RIOK3 mediates the degradation of 40S ribosomes
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  28. Jan 2025
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    Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1
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    Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders
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    Increased nuclear factor I-mediated chromatin access drives transition to androgen receptor splice variant dependence in prostate cancer
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    METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma
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    Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis
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  38. Sep 2024
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  40. Aug 2024
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    Microgravity Induces Transient EMT in Human Keratinocytes by Early Down-Regulation of E-Cadherin and Cell-Adhesion Remodeling
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  42. Jul 2024
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    Identification of the main barriers to Ku accumulation in chromatin
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  53. May 2024
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  57. Apr 2024
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    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
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    Mutant FOXO1 controls an oncogenic network via enhancer accessibility
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  60. Mar 2024
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    Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression
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    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
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  65. Nov 2023
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    RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
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    Recruitment of FBXO22 for Targeted Degradation of NSD2
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  69. Oct 2023
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    Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria
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    ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct
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  74. Aug 2023
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    The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway
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  76. Jul 2023
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    Mapping Pregnancy-dependent Sulfhydrome Unfolds Diverse Functions of Protein Sulfhydration in Human Uterine Artery
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  79. Jun 2023
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    QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism
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    Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
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    Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition
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  83. May 2023
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  85. Apr 2023
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  87. Feb 2023
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    Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
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  89. Jan 2023
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    A Genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma
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  92. Dec 2022
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    Raptinal induces Gasdermin E-dependent pyroptosis in naive and therapy-resistant melanoma
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  94. Nov 2022
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    FOXR2 is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits
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  96. Oct 2022
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    Chromosome silencing in vitro reveals trisomy 21 causes cell-autonomous deficits in angiogenesis and early dysregulation in Notch signaling
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  101. Jul 2022
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  103. Mar 2022
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    TIGAR deficiency enhances skeletal muscle thermogenesis by increasing neuromuscular junction cholinergic signaling
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    Circulating MicroRNA Profiles as Potential Biomarkers for differentiated thyroid cancer recurrence
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    Full-length and split-NanoLuc reporters identify pathogenic COL4A5 nonsense mutations susceptible to premature termination codon readthrough
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  107. Feb 2022
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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  109. Nov 2021
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    AXL cooperates with EGFR to mediate neutrophil elastase-induced migration of prostate cancer cells
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  112. Oct 2021
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  114. Sep 2021
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    Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction
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    Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function
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  117. Aug 2021
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    Chemo-proteomics exploration of HDAC degradability by small molecule degraders
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  119. Jul 2021
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    Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis
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    Autophagy inhibition as a promising therapeutic target for laryngeal cancer
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    Differential Sensitivity to CDK2 Inhibition Discriminates the Molecular Mechanisms of CHK1 Inhibitors as Monotherapy or in Combination with the Topoisomerase I Inhibitor SN38
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    Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
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  124. Mar 2021
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    A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection
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  126. Feb 2021
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    Differential Sensitivity to CDK2 Inhibition Discriminates the Molecular Mechanisms of CHK1 Inhibitors as Monotherapy or in Combination with the Topoisomerase I Inhibitor SN38
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  128. Jan 2021
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  130. Nov 2020
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  132. Sep 2020
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    Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses
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    Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity
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  137. Jan 2020
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  141. Nov 2017
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    Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function
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