185 Matching Annotations
  1. Nov 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan
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    pmc.ncbi.nlm.nih.gov/articles/PMC12626231/
  3. www.biorxiv.org www.biorxiv.org
    Thyrotropin-releasing hormone protects hippocampal neurons against glutamate toxicity via phosphatidylinositol 3-kinase/AKT pathway and new protein synthesis
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    biorxiv.org/content/10.1101/2025.11.11.687668v1
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Assessment of distinct effects of Parinari curatellifolia Planch.ex Benth Ethanolic leaf extract on glucose transport in different cell types
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    pmc.ncbi.nlm.nih.gov/articles/PMC12614100/
  5. Oct 2025
  6. www.sciencedirect.com www.sciencedirect.com
    Tuning insulin receptor signaling using de novo-designed agonists
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    sciencedirect.com/science/article/pii/S1097276525007804
  7. Sep 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BRAFV600E-Driven Lung Tumorigenesis Requires Ligand-Mediated Activation of ERBB Receptor Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12248061/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aurora kinase A promotes trained immunity via regulation of endogenous S-adenosylmethionine metabolism
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    pmc.ncbi.nlm.nih.gov/articles/PMC12416886/
  10. Aug 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kinome reprogramming of G2/M kinases and repression of MYCN contribute to superior efficacy of lorlatinib in ALK-driven neuroblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12322148/
  12. Jul 2025
  13. www.cell.com www.cell.com
    FGF-induced phospholipase Cγ signaling regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism
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    cell.com/cell-reports/abstract/S2211-1247(25)00817-4
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intracrine VEGF Signaling Is Required for Adult Hippocampal Neural Stem Cell Maintenance and Vascular Proximity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12289830/
  15. Mar 2025
  16. www.biorxiv.org www.biorxiv.org
    In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer
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    biorxiv.org/content/10.1101/2025.03.20.644389v1
  17. Feb 2025
  18. journals.biologists.com journals.biologists.com
    Akt is a mediator of artery specification during zebrafish development
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    journals.biologists.com/dev/article/151/17/dev202727/361847/Akt-is-a-mediator-of-artery-specification-during
  19. aacrjournals.org aacrjournals.org
    TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma
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    aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
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    Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma
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    biorxiv.org/content/10.1101/2025.01.28.635193v1
  21. Jan 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
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    pmc.ncbi.nlm.nih.gov/articles/PMC11750134/
  23. www.nature.com www.nature.com
    Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma
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    nature.com/articles/s41598-024-83912-4
  24. Nov 2024
  25. www.sciencedirect.com www.sciencedirect.com
    Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane
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    sciencedirect.com/science/article/pii/S0969212624004556
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High fat diet induced hepatic insulin resistance per se attenuates murine de novo lipogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11550620/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chelating drug-induced labile Zn2+ with nanoparticle-encapsulated TPEN at low dose enhances lung cancer chemotherapy through inhibiting ABCB1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11539588/
  28. www.jneurosci.org www.jneurosci.org
    Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development
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    jneurosci.org/content/44/42/e0072242024
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females
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    pmc.ncbi.nlm.nih.gov/articles/PMC11491842/
  30. Oct 2024
  31. aacrjournals.org aacrjournals.org
    Identification of Predictive ERBB Mutations by Leveraging Publicly Available Cell Line Databases
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    aacrjournals.org/mct/article/20/3/564/92877/Identification-of-Predictive-ERBB-Mutations-by
  32. Sep 2024
  33. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP286715
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    Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway
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  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/Stat3 attenuation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11401886/
  36. aacrjournals.org aacrjournals.org
    Activating mTOR mutations are detrimental in nutrient-poor conditions
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  37. Aug 2024
  38. www.sciencedirect.com www.sciencedirect.com
    Multiplex Spatial Omics Reveals Changes in Immune-Epithelial Crosstalk During Inflammation and Dysplasia Development in Chronic IBD Patients
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  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    Hepatic BMAL1 and HIF1α regulate a time-dependent hypoxic response and prevent hepatopulmonary-like syndrome
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    Exploring visceral and subcutaneous adipose tissue secretomes in human obesity: implications for metabolic disease
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  42. www.mdpi.com www.mdpi.com
    Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy
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  43. Jul 2024
  44. www.sciencedirect.com www.sciencedirect.com
    Cell-specific Nav1.6 knockdown reduced astrocyte-derived Aβ by reverse Na+-Ca2+ transporter-mediated autophagy in alzheimer-like mice
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    sciencedirect.com/science/article/pii/S2090123224003096
  45. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway
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    onlinelibrary.wiley.com/doi/10.1111/acel.14258
  46. www.science.org www.science.org
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    science.org/doi/10.1126/science.adk0775
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippocampal astrocytes induce sex-dimorphic effects on memory
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    Local vascular Klotho mediates diabetes-induced atherosclerosis via ERK1/2 and PI3-kinase-dependent signaling pathways.
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    sciencedirect.com/science/article/pii/S0021915024010992
  49. May 2024
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Contrasting consequences of podocyte IGF1R inhibition
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    ncbi.nlm.nih.gov/pmc/articles/PMC11068853/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging
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  52. 52.53.155.43 52.53.155.43
    Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development
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    Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas
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    sciencedirect.com/science/article/pii/S1535610824001314
  54. Apr 2024
  55. www.sciencedirect.com www.sciencedirect.com
    Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity
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    sciencedirect.com/science/article/pii/S2211124724004224
  56. www.sciencedirect.com www.sciencedirect.com
    Mutant FOXO1 controls an oncogenic network via enhancer accessibility
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    sciencedirect.com/science/article/pii/S2666979X24000934
  57. Mar 2024
  58. www.sciencedirect.com www.sciencedirect.com
    Ankrd26 is a retinoic acid-responsive plasma membrane-binding and -shaping protein critical for proper cell differentiation
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    sciencedirect.com/science/article/pii/S2211124724002675
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10621596/
  60. Feb 2024
  61. 52.53.155.43 52.53.155.43
    RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation
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    52.53.155.43/19126de606c776a10e00c0c9a385ef3636eaaf16/2023.10.05.561021v2.full (1)-html.html
  62. www.biorxiv.org www.biorxiv.org
    Simulated Microgravity Enhances Adipocyte Maturation and Glucose Uptake via Increased Cortical Actin Remodeling
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    biorxiv.org/content/10.1101/2024.01.30.578049v1
  63. www.sciencedirect.com www.sciencedirect.com
    TMED2 promotes glioma tumorigenesis by being involved in EGFR recycling transport
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    sciencedirect.com/science/article/pii/S0141813024008584
  64. Jan 2024
  65. www.science.org www.science.org
    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    science.org/doi/10.1126/sciadv.ade1282
  66. www.sciencedirect.com www.sciencedirect.com
    Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death
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    sciencedirect.com/science/article/pii/S0092867423013478
  67. Dec 2023
  68. www.sciencedirect.com www.sciencedirect.com
    Epinephrine inhibits PI3Kα via the Hippo kinases
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    sciencedirect.com/science/article/pii/S2211124723015474
  69. Nov 2023
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    Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria
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    sciencedirect.com/science/article/pii/S2211124723014018
  71. Oct 2023
  72. www.sciencedirect.com www.sciencedirect.com
    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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    sciencedirect.com/science/article/pii/S221112472301210X
  73. Aug 2023
  74. www.sciencedirect.com www.sciencedirect.com
    Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties
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    sciencedirect.com/science/article/pii/S221112472300877X
  75. Jul 2023
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation of the N-terminus of Syntaxin-16 controls interaction with mVps45 and GLUT4 trafficking in adipocytes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10373645/
  77. Jun 2023
  78. www.sciencedirect.com www.sciencedirect.com
    Overcoming MET-mediated resistance in oncogene-driven NSCLC
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    sciencedirect.com/science/article/pii/S2589004223010830
  79. www.sciencedirect.com www.sciencedirect.com
    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypomorphism of a Novel Long ERα Isoform Causes Severe Reproductive Dysfunctions in Female Mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10233398/
  81. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus
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    onlinelibrary.wiley.com/doi/10.1111/jne.13187
  82. May 2023
  83. www.sciencedirect.com www.sciencedirect.com
    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    sciencedirect.com/science/article/pii/S2211124723005818
  84. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Prenatal overexpression of platelet-derived growth factor receptor A results in central nervous system hypomyelination
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    onlinelibrary.wiley.com/doi/full/10.1002/brb3.2332
  85. aacrjournals.org aacrjournals.org
    RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition
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    aacrjournals.org/clincancerres/article/28/14/3091/706867/RASGRF1-Fusions-Activate-Oncogenic-RAS-Signaling
  86. Apr 2023
  87. www.sciencedirect.com www.sciencedirect.com
    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
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    sciencedirect.com/science/article/pii/S2211124723004473
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    ncbi.nlm.nih.gov/pmc/articles/PMC10115456/
  89. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition
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    sciencedirect.com/science/article/pii/S0896627323002635
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    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
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    sciencedirect.com/science/article/pii/S1550413123001262
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    AKT activity orchestrates marginal zone B cell development in mice and humans
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    sciencedirect.com/science/article/pii/S2211124723003893
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    N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer
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    sciencedirect.com/science/article/pii/S266637912300112X
  93. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Oncogene-mediated nuclear accumulation of lactate promotes epigenetic alterations to induce cancer cell proliferation
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    onlinelibrary.wiley.com/doi/10.1002/jcb.30381
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    Site-1 protease inhibits mitochondrial respiration by controlling the TGF-β target gene Mss51
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    sciencedirect.com/science/article/pii/S2211124723003479
  95. Mar 2023
  96. www.ijbs.com www.ijbs.com
    IFNγ blockade in capillary leak site improves tumour chemotherapy by inhibiting lactate-induced endocytosis of vascular endothelial-cadherins
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    ijbs.com/v19p1490.htm
  97. Feb 2023
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC9912829/
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of DNA damage response by trimeric G-proteins
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    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity
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    ncbi.nlm.nih.gov/pmc/articles/PMC9883198/
  102. Jan 2023
  103. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system
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    pmc.ncbi.nlm.nih.gov/articles/PMC9888514/
  104. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Restricted physical activity after volumetric muscle loss alters whole-body and local muscle metabolism
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP283959
  105. Dec 2022
  106. www.mdpi.com www.mdpi.com
    Dysregulation of ErbB4 Signaling Pathway in the Dorsal Hippocampus after Neonatal Hypoxia-Ischemia and Late Deficits in PV+ Interneurons, Synaptic Plasticity and Working Memory
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    mdpi.com/1422-0067/24/1/508
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes
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    ncbi.nlm.nih.gov/pmc/articles/PMC9716095/
  108. Nov 2022
  109. www.sciencedirect.com www.sciencedirect.com
    Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling
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    sciencedirect.com/science/article/pii/S1534580722007638
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical characterization and phase I clinical trial of CT053PTSA targets MET, AXL, and VEGFR2 in patients with advanced solid tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC9632963/
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NetrinG1+ cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic cancer cells under nutritional stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC9608356/
  112. Sep 2022
  113. www.sciencedirect.com www.sciencedirect.com
    Hepatic ER stress suppresses adipose browning through ATF4-CIRP-ANGPTL3 cascade
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    sciencedirect.com/science/article/pii/S2211124722012633
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Na/K-ATPase Suppresses LPS-Induced Pro-Inflammatory Signaling Through Lyn
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