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    ZEB2 drives intra-tumor heterogeneity and skin squamous cell carcinoma formation with distinct EMP transition states.
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  3. Dec 2024
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    Transcriptional memory drives accelerated re-activation of several biosynthetic gene clusters in Aspergillus nidulans.
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    Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain
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  6. Nov 2024
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    Dual inhibition of aminoacyl-tRNA synthetase interacting multifunctional protein-2 and α-synuclein by steroid derivative is neuroprotective in Parkinson’s model
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    FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma
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  9. Oct 2024
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    Transgenic sensors reveal compartment-specific effects of aggregation-prone proteins on subcellular proteostasis during aging
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  11. Sep 2024
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    Paneth cell TNF signaling induces gut bacterial translocation and sepsis
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  13. Aug 2024
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    Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis
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  15. Jul 2024
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    Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance
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    Regulation of the DLC3 tumor suppressor by a novel phosphoswitch
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  18. Jun 2024
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    RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia
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    FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity
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  21. May 2024
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    Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation
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    Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling
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    Membrane-Targeted palGFP Predominantly Localizes to the Plasma Membrane but not to Neurosecretory Vesicle Membranes in Rat Oxytocin Neurons
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  25. Apr 2024
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    Trafficking of Connexin36 (Cx36) in the early secretory pathway
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  27. Mar 2024
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    Pneumococcal sialidase promotes bacterial survival by fine-tuning of pneumolysin-mediated membrane disruption
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    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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    FH variant pathogenicity promotes purine salvage pathway dependence in kidney cancer
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  32. Feb 2024
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    Neuronal reprogramming of mouse and human fibroblasts using transcription factors involved in suprachiasmatic nucleus development
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs
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    Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor
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  37. Jan 2024
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    RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling
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  39. Dec 2023
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    B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling
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    Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair
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    ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
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  43. Nov 2023
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    Protocol for simultaneous detection of dual subcellular localized dengue virus protease by co-transfection
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    Differential Ire1 determines loser cell fate in tumor-suppressive cell competition
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  46. Sep 2023
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    Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping
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    SARS-CoV-2 Nsp15 suppresses type I interferon production by inhibiting IRF3 phosphorylation and nuclear translocation
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    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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  50. Aug 2023
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    Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression
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    Hedgehog receptors exert immune-surveillance roles in the epidermis across species
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    Cannabinoid receptor type 1 (CB1R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3
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  54. Jul 2023
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    Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism
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  56. Jun 2023
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    Differential localization of dengue virus protease affects cell homeostasis and triggers to thrombocytopenia
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    Faulty Metabolism: A Potential Instigator of an Aggressive Phenotype in Cdk5-dependent Medullary Thyroid Carcinoma
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  59. May 2023
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    p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS
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    The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
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    Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity
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  63. Apr 2023
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    Transcriptional kinetic synergy: A complex landscape revealed by integrating modeling and synthetic biology
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    Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
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    Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns
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  67. Mar 2023
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    CARD-only proteins regulate in vivo inflammasome responses and ameliorate gout
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  69. Feb 2023
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    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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    Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
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  72. Jan 2023
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    Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues
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    HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease
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    Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging
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  76. Dec 2022
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    Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension
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    Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer
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  79. Nov 2022
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    NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step
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  81. rupress.org rupress.org
    V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans
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    NetrinG1+ cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic cancer cells under nutritional stress
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  83. Sep 2022
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    Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury
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    Early-life vitamin B12 orchestrates lipid peroxidation to ensure reproductive success via SBP-1/SREBP1 in Caenorhabditis elegans
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    A biochemical reconstitution approach to identify autophagy receptors for aggrephagy in mammalian cells
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    CANCER-ASSOCIATED SF3B1 MUTATIONS CONFER A BRCA-LIKE CELLULAR PHENOTYPE AND SYNTHETIC LETHALITY TO PARP INHIBITORS
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  88. Aug 2022
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    CHAMP1 binds to REV7/FANCV and promotes homologous recombination repair
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    ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain
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    Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma
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    Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia
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    Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer
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    Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status
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  95. Jul 2022
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    AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation
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    Filter trapping protocol to detect aggregated proteins in human cell lines
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  98. Jun 2022
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    Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
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  100. Apr 2022
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    CCT2 is an aggrephagy receptor for clearance of solid protein aggregates
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  102. Feb 2022
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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  104. Nov 2021
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    Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response
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    Tumor-derived extracellular vesicles regulate tumor-infiltrating regulatory T cells via the inhibitory immunoreceptor CD300a
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  107. Oct 2021
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mechanistic Insights into COVID-19 by Global Analysis of the SARS-CoV-2 3CLpro Substrate Degradome
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    Tyrosine Phosphorylation of DEPTOR Functions as a Molecular Switch to Activate mTOR Signaling
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    Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages
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  112. Aug 2021
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    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer
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    Compartmentalization-Aided Interaction Screening Reveals Extensive High-Order Complexes within the SARS-CoV-2 Proteome
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    The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection
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    Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes
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    hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids
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    The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3
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    USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication
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    Translation stress and collided ribosomes are co-activators of cGAS
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    SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts
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    Actin Polymerization and ESCRT Trigger Recruitment of the Fusogens Syntaxin-2 and EFF-1 to Promote Membrane Repair in C. elegans
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    PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression
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    GPR120 regulates pancreatic polypeptide secretion from male mouse islets via PLC-mediated calcium mobilization
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    Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1
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    Histone deacetylase 6 promotes growth of glioblastoma through the MKK7/JNK/c‐Jun signaling pathway
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    In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8–16-mer Oligomer Species
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    Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
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    HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry
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    The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3
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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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    hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids
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    NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus
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    The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment
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    The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
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    Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
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    Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1
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    The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma
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    AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity
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    CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis
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    Different Doublecortin (DCX) Patient Alleles Show Distinct Phenotypes in Cultured Neurons EVIDENCE FOR DIVERGENT LOSS-OF-FUNCTION AND “OFF-PATHWAY” CELLULAR MECHANISMS
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