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    IND-enabling safety and efficacy of RPESC-RPE-4W, an adult RPE progenitor cell therapy for dry age-related macular degeneration
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  3. Mar 2026
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    Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer
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    Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial
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    Therapeutic stress triggers tumor STAT1 acetylation to disarm immunotherapy
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    Dual molecular therapy targeting tumor cell heterogeneity improves therapeutic efficacy in glioblastoma
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    Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis
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    Impact of the tumor immune contexture in microsatellite-stable metastatic colorectal cancer treated with avelumab, cetuximab, and irinotecan
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    Epigenomic regulation of stemness contributes to the low immunogenicity of the most mutated human cancer
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    Hypoxia-Induced Long Noncoding RNA HIF1A-AS2 Regulates Stability of MHC Class I Protein in Head and Neck Cancer
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    Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness
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    Genetic interactions reveal distinct biological and therapeutic implications in breast cancer
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    Multimodal immune phenotyping reveals microbial-T cell interactions that shape pancreatic cancer
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    Intratumoral NKp46+ natural killer cells are spatially distanced from T and MHC-I+ cells with prognostic implications in soft tissue sarcoma
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    Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment
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  31. Sep 2022
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    A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy
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  33. Aug 2022
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    Cancer genes disfavoring T cell immunity identified via integrated systems approach
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    Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors
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  37. Oct 2021
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    Multiplexed imaging reveals an IFN-γ-driven inflammatory state in nivolumab-associated gastritis
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  39. Aug 2021
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    Untitled document
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  41. Jul 2021
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    Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance
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  43. May 2021
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    Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas
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  45. Sep 2020
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    Virus-Mediated Suppression of the Antigen Presentation Molecule MR1
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  47. May 2020
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    Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes
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    1. nPOD_Curator 15 May 2020
      Immunohistochemistry was performed using a standard immunoperoxidase approach, as previously described [21]. To examine multiple antigens within the same FFPE section, samples were probed in a sequential manner with up to three different antibodies (ESM Tables 3, 4). The mean fluorescence intensity (MFI) of stained antigens was measured using ImageJ Version 1.50b Java 1.8.0_77; https://imagej.nih.gov/ij/download.html. Some slides were processed with isotype control antisera to confirm the specificity of labelling (ESM Fig. 1). Frozen sections were stained using a standard immunofluorescence approach [22].

      Immunohistochemistry

      (HLA, Ins, Glu, NLRC5, STAT1, B2M abs determined from supplementary)

      obiwan:Method PMID:27506584 RRID:AB_1269092 RRID:AB_10013624 RRID:AB_1658481 RRID:AB_11129988 RRID:AB_303057 RRID:AB_10933380 RRID:AB_2716551
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  49. Jan 2020
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    Pathogenesis of anti-PIT-1 antibody syndrome: PIT-1 presentation by HLA class I on anterior pituitary cells
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  51. Nov 2018
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    A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment
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  53. Nov 2017
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    Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
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    elifesciences.org/articles/25306
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    Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses
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    sciencedirect.com/science/article/pii/S0092867417304270