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23 Matching Annotations

Nov 2025
elifesciences.org elifesciences.org

A GCN1-independent activator of the kinase GCN2

1
1. scibot 11 Nov 2025
  
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  AB_75836
  
  DOI: 10.7554/eLife.108590.1
  
  Resource: None
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:AB_1310260
  
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  RRID:AB_1310260 RRIDCUR:Unresolved
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elifesciences.org/reviewed-preprints/108590
Oct 2025
www.biorxiv.org www.biorxiv.org

Cryo-EM reveals how ASX-173 inhibits human asparagine synthetase to activate the integrated stress response

1
1. scibot 23 Oct 2025
  
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  RRID:AB_1310260
  
  DOI: 10.1101/2025.10.16.682859
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
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biorxiv.org/content/10.1101/2025.10.16.682859v2
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AMPKα2 signals amino acid insufficiency to inhibit protein synthesis

1
1. scibot 08 Oct 2025
  
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  RRID:AB_1310260
  
  DOI: 10.1016/j.cmet.2025.09.004
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1550413125003894
Sep 2025
52.53.155.43 52.53.155.43

2025.09.04.674332v2.full-html.html

1
1. scibot 18 Sep 2025
  
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  AB_1310260
  
  DOI: 10.1101/2025.09.04.674332
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
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52.53.155.43/304402c0b5b5e8844bb324b2732dfcb1e481f20c/2025.09.04.674332v2.full-html.html
Jul 2025
www.science.org www.science.org

The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21

1
1. scibot 25 Jul 2025
  
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  RRID:AB_1310260
  
  DOI: 10.1126/sciadv.adt3142
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
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science.org/doi/10.1126/sciadv.adt3142
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma

1
1. scibot 20 May 2025
  
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  RRID:AB_1310260
  
  DOI: 10.1158/0008-5472.CAN-24-1393
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1310260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12079101/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21

1
1. scibot 28 Mar 2025
  
  in Public
  
  RRID:AB_1310260
  
  DOI: 10.1126/sciadv.adt3142
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1310260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11939056/
Feb 2025
www.sciencedirect.com www.sciencedirect.com

A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation

1
1. scibot 04 Feb 2025
  
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  RRID:AB_1310260
  
  DOI: 10.1016/j.molcel.2025.01.003
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1310260
  
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sciencedirect.com/science/article/pii/S1097276525000036
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

MYC Drives mRNA Pseudouridylation to Mitigate Proliferation-Induced Cellular Stress during Cancer Development

1
1. scibot 12 Dec 2024
  
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  RRID:AB_1310260
  
  DOI: 10.1158/0008-5472.CAN-24-1102
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1310260
  
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  RRID:AB_1310260
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pmc.ncbi.nlm.nih.gov/articles/PMC11609627/
www.science.org www.science.org

Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer

1
1. scibot 03 Dec 2024
  
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  RRID:AB_1310260
  
  DOI: 10.1126/scisignal.adp1375
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1310260
  
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science.org/doi/10.1126/scisignal.adp1375
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer

1
1. scibot 25 Sep 2024
  
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  RRID:AB_1310260
  
  DOI: 10.1016/j.celrep.2024.114606
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1310260
  
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  RRID:AB_1310260
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ncbi.nlm.nih.gov/pmc/articles/PMC11407228/
Jan 2024
www.sciencedirect.com www.sciencedirect.com

Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes

1
1. scibot 11 Jan 2024
  
  in Public
  
  AB_1310260
  
  DOI: 10.1016/j.celrep.2023.113658
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1310260
  
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  RRID:AB_1310260
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sciencedirect.com/science/article/pii/S2211124723016698
Jul 2023
www.sciencedirect.com www.sciencedirect.com

Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome

1
1. scibot 21 Jul 2023
  
  in Public
  
  RRID:AB_1310260
  
  DOI: 10.1016/j.neuron.2023.06.017
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1310260
  
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  RRID:AB_1310260
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sciencedirect.com/science/article/abs/pii/S0896627323004762
Apr 2023
www.sciencedirect.com www.sciencedirect.com

VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms

1
1. scibot 20 Apr 2023
  
  in Public
  
  RRID:AB_1310260
  
  DOI: 10.1016/j.celrep.2023.112209
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1310260
  
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  RRID:AB_1310260
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sciencedirect.com/science/article/pii/S2211124723002206
Oct 2022
elifesciences.org elifesciences.org

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

1
1. scibot 19 Oct 2022
  
  in Public
  
  RRID:AB_1310260
  
  DOI: 10.7554/eLife.81083
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1310260
  
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  RRID:AB_1310260
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elifesciences.org/articles/81083
Jul 2022
www.sciencedirect.com www.sciencedirect.com

GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment

1
1. scibot 15 Jul 2022
  
  in Public
  
  RRID:AB_1310260
  
  DOI: 10.1016/j.cmet.2022.06.010
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1310260
  
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  RRID:AB_1310260
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sciencedirect.com/science/article/pii/S1550413122002303
Apr 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MIRO2 regulates prostate cancer cell growth via GCN1-dependent stress signaling

1
1. scibot 08 Apr 2022
  
  in Public
  
  RRID:AB_1310260
  
  DOI: 10.1158/1541-7786.MCR-21-0374
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1310260
  
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  RRID:AB_1310260
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ncbi.nlm.nih.gov/pmc/articles/PMC8983529/
Mar 2022
www.sciencedirect.com www.sciencedirect.com

Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication

1
1. scibot 26 Mar 2022
  
  in Public
  
  RRID:AB_1310260
  
  DOI: 10.1016/j.molcel.2022.02.031
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1310260
  
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  RRID:AB_1310260
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sciencedirect.com/science/article/pii/S1097276522002052
www.sciencedirect.com www.sciencedirect.com

Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling

1
1. scibot 04 Mar 2022
  
  in Public
  
  RRID:AB_1310260
  
  DOI: 10.1016/j.molcel.2022.02.007
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1310260
  
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  RRID:AB_1310260
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sciencedirect.com/science/article/pii/S1097276522001125
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Translation in amino-acid-poor environments is limited by tRNAGln charging

1
1. scibot 27 Feb 2021
  
  in Public
  
  RRID:AB_1310260
  
  DOI: 10.7554/eLife.62307
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1310260
  
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  RRID:AB_1310260
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ncbi.nlm.nih.gov/pmc/articles/PMC7744096/
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_1310260
  
  DOI: 10.1016/j.cmet.2019.09.009
  
  Resource: (Abcam Cat# ab75836, RRID:AB_1310260)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_1310260
  
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  RRID:AB_1310260 RRIDCUR:Validated
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RRIDCUR:Validated

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sciencedirect.com/science/article/pii/S1550413119305121
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1

1
1. scibot 05 Nov 2018
  
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  RRID:AB_1310260
  
  Resource used:
  
  (Abcam Cat# ab75836, RRID:AB_1310260)
  
  SciCrunch record: RRID:AB_1310260
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_1310260
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sciencedirect.com/science/article/pii/S1931312818302038
www.sciencedirect.com www.sciencedirect.com

Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_1310260
  
  Resource used:
  
  (Abcam Cat# ab75836, RRID:AB_1310260)
  
  SciCrunch record: RRID:AB_1310260
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_1310260
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RRID:AB_1310260

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sciencedirect.com/science/article/pii/S1550413118301207