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  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission
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    1. scibot 21 Dec 2024
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      DOI: 10.1126/sciadv.adp7423

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    pmc.ncbi.nlm.nih.gov/articles/PMC11567002/
  3. www.science.org www.science.org
    Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission
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    science.org/doi/10.1126/sciadv.adp7423
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    Acute MeCP2 loss in adult mice reveals transcriptional and chromatin changes that precede neurological dysfunction and inform pathogenesis
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    sciencedirect.com/science/article/pii/S0896627324008067
  5. Dec 2024
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    lncRNAs maintain the functional phase state of nucleolar prion-like protein to facilitate rRNA processing
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    sciencedirect.com/science/article/pii/S1097276524008761
  7. Nov 2024
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    ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss
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    sciencedirect.com/science/article/pii/S1097276524008608
  9. Sep 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ESR1 Fusions Invoke Breast Cancer Subtype-Dependent Enrichment of Ligand-Independent Oncogenic Signatures and Phenotypes
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      DOI: 10.1210/endocr/bqae111

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    ncbi.nlm.nih.gov/pmc/articles/PMC11384147/
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    Key roles of C2/GAP domains in SYNGAP1-related pathophysiology
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    1. scibot 13 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010842
  12. Aug 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The tyrosine phosphatases LAR and PTPRδ act as receptors of the nidogen-tetanus toxin complex
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    ncbi.nlm.nih.gov/pmc/articles/PMC11329502/
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    Sigma-1 receptor recruits LC3 mRNA to ER-associated omegasomes to promote localized LC3 translation enabling functional autophagy
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    sciencedirect.com/science/article/pii/S2211124724009690
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    A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain
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    1. scibot 19 Aug 2024
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    sciencedirect.com/science/article/pii/S153458072400443X
  16. link.springer.com link.springer.com
    Exclusive Characteristics of the p.E555K Dominant-Negative Variant in Autosomal Dominant E47 Deficiency
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    1. scibot 01 Aug 2024
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    link.springer.com/article/10.1007/s10875-024-01758-x
  17. Jul 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
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    1. scibot 31 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11285331/
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    Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response
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    sciencedirect.com/science/article/pii/S2211124724008611
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    Assembly mechanism of Integrator’s RNA cleavage module
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    1. scibot 25 Jul 2024
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    sciencedirect.com/science/article/pii/S1097276524005392
  21. www.cell.com www.cell.com
    m6A modification inhibits miRNAs’ intracellular function, favoring their extracellular export for intercellular communication
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    cell.com/cell-reports/abstract/S2211-1247(24)00697-1
  22. www.embopress.org www.embopress.org
    The tyrosine phosphatases LAR and PTPRδ act as receptors of the nidogen-tetanus toxin complex
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    embopress.org/doi/10.1038/s44318-024-00164-8
  23. May 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC11108982/
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    Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation
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    sciencedirect.com/science/article/pii/S1934590924001425
  26. Apr 2024
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    O-GlcNAcylation of RBM14 contributes to elevated cellular O-GlcNAc through regulation of OGA protein stability
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    sciencedirect.com/science/article/pii/S2211124724004911
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
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    1. scibot 24 Apr 2024
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      DOI: 10.1093/narcan/zcae018

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    ncbi.nlm.nih.gov/pmc/articles/PMC11034028/
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    The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
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    sciencedirect.com/science/article/pii/S1534580724001837
  30. Mar 2024
  31. www.sciencedirect.com www.sciencedirect.com
    Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes
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    sciencedirect.com/science/article/pii/S2211124724003000
  32. Feb 2024
  33. www.sciencedirect.com www.sciencedirect.com
    Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
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    sciencedirect.com/science/article/pii/S2211124724001736
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    N6-methyladenosine modification of the mRNA for a key gene in purine nucleotide metabolism regulates virus proliferation in an insect vector
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    sciencedirect.com/science/article/pii/S2211124724001499
  35. www.biorxiv.org www.biorxiv.org
    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
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    biorxiv.org/content/10.1101/2023.12.05.570182v1
  36. Dec 2023
  37. www.sciencedirect.com www.sciencedirect.com
    YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration
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    sciencedirect.com/science/article/pii/S2211124723015097
  38. Nov 2023
  39. 52.53.155.43 52.53.155.43
    Guanylate Binding Protein 1 (GBP1) modulates proteasomal machinery in ovarian cancer
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    52.53.155.43/53c790045212682105233198a95a2325be657a67/1-s2.0-S2589004223023696-main-html.html
  40. www.biorxiv.org www.biorxiv.org
    ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers
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    biorxiv.org/content/10.1101/2023.10.24.563645v1
  41. Sep 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Variation in the CENP-A sequence association landscape across diverse inbred mouse strains
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    sciencedirect.com/science/article/pii/S2211124723011907
  43. Aug 2023
  44. 52.53.155.43 52.53.155.43
    PIIS221112472300952X-html.html
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  45. Jul 2023
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    FOXA2 controls the anti-oxidant response in FH-deficient cells
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    sciencedirect.com/science/article/pii/S2211124723007623
  47. Jun 2023
  48. www.sciencedirect.com www.sciencedirect.com
    Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation
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      DOI: 10.1016/j.neuron.2023.05.033

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    sciencedirect.com/science/article/pii/S0896627323004348
  49. www.sciencedirect.com www.sciencedirect.com
    QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism
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      DOI: 10.1016/j.cell.2023.05.047

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    sciencedirect.com/science/article/pii/S0092867423005986
  50. aacrjournals.org aacrjournals.org
    (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers
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    aacrjournals.org/cancerdiscovery/article/13/6/1478/726967/R-2-Hydroxyglutarate-Inhibits-KDM5-Histone-Lysine
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    (A) Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10227426/
  52. Apr 2023
  53. www.sciencedirect.com www.sciencedirect.com
    Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function
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    sciencedirect.com/science/article/pii/S2211124723004308
  54. www.sciencedirect.com www.sciencedirect.com
    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
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      DOI: 10.1016/j.xcrm.2023.101007

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    SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology
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  56. Mar 2023
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    Protocol for the identification and expression analysis of a cytoplasmic membrane-localized protein STING
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    Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma
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    CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2
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    MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function
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  61. Feb 2023
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    E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure
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    Role of FGF10/FGFR2b Signaling in Homeostasis and Regeneration of Adult Lacrimal Gland and Corneal Epithelium Proliferation
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  64. Jan 2023
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    EKLF/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release
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    Loss of epigenetic information as a cause of mammalian aging
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    Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin
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  68. Nov 2022
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    Allosteric potentiation of GABAA receptor single-channel conductance by netrin-1 during neuronal-excitation-induced inhibitory synaptic homeostasis
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  70. Oct 2022
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    Off-the-shelf proximity biotinylation using ProtA-TurboID
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  72. Sep 2022
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    Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
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    Histone H1 regulates non-coding RNA turnover on chromatin in a m6A-dependent manner
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    PRG-1 prevents neonatal stimuli-induced persistent hyperalgesia and memory dysfunction via NSF/Glu/GluR2 signaling
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  76. Aug 2022
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    The BASP1 transcriptional corepressor modifies chromatin through lipid-dependent and lipid-independent mechanisms
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    NMDA receptor-targeted enrichment of CaMKIIα improves fear memory
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    Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1
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    Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function
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    Histone chaperone FACT complex coordinates with HIF to mediate an expeditious transcription program to adapt to poorly oxygenated cancers
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  85. Jan 2022
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    Vitamin D receptor, STAT3, and TET2 cooperate to establish tolerogenesis
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    ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization
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  88. Dec 2021
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    NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis
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    The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics
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  91. Oct 2021
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    Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma
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    Synaptotagmin-11 inhibits spontaneous neurotransmission through vti1a
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    Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription
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  95. Sep 2021
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    Manipulation of TAD reorganization by chemical-dependent genome linking
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    Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice
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  98. Aug 2021
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    Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation
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    FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner
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    A Translational Repression Complex in Developing Mammalian Neural Stem Cells that Regulates Neuronal Specification
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  103. Jul 2021
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    Novel Endogenous, Insulin-Stimulated Akt2 Protein Interaction Partners in L6 Myoblasts
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    Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression
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  108. europepmc.org europepmc.org
    The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline.
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  109. Jun 2021
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    Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation
    1
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    H3K27 demethylases are dispensable for activation of Polycomb-regulated injury response genes in peripheral nerve.
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  112. May 2021
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    Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions
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    Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
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    Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging
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    Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas
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    m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development
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  118. Feb 2021
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    Control of the anterior pituitary cell lineage regulator POU1F1 by the stem cell determinant Musashi
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      DOI: 10.1210/endocr/bqaa245

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  120. Sep 2020
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    Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer
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  122. www.cell.com www.cell.com
    PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin
    2
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    Neutrophil Swarming in Damaged Tissue Is Orchestrated by Connexins and Cooperative Calcium Alarm Signals
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    LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice
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    Acetylation of UHRF1 Regulates Hemi-methylated DNA Binding and Maintenance of Genome-wide DNA Methylation
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  126. www.jneurosci.org www.jneurosci.org
    Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity
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      DOI: 10.1523/JNEUROSCI.1076-19.2019

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    Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer
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    Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation
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      DOI: 10.1016/j.scr.2020.101944

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    Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion
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      RRID:AB_145841

      DOI: 10.1016/j.celrep.2020.107879

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  130. www.eneuro.org www.eneuro.org
    Differential stability of miR-9-5p and miR-9-3p in the brain is determined by their unique cis- and trans-acting elements
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      RRID:AB_145841

      DOI: 10.1523/ENEURO.0094-20.2020

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  131. Jan 2020
  132. www.sciencedirect.com www.sciencedirect.com
    A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production
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      DOI: 10.1016/j.celrep.2019.10.113

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    Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation
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      DOI: 10.1016/j.celrep.2019.11.039

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    Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs
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      DOI: 10.1016/j.cub.2019.09.006

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    Histone Recycling by FACT and Spt6 during Transcription Prevents the Scrambling of Histone Modifications
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      DOI: 10.1016/j.celrep.2019.06.097

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    sciencedirect.com/science/article/pii/S2211124719308836
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    Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf
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      DOI: 10.1016/j.celrep.2019.09.064

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    A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling
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      DOI: 10.1016/j.stem.2019.06.008

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    sciencedirect.com/science/article/pii/S1934590919302723
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    Reconstruction of the Global Neural Crest Gene Regulatory Network In Vivo
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      RRID:AB_145841

      DOI: 10.1016/j.devcel.2019.10.003

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    sciencedirect.com/science/article/pii/S1534580719308123
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    sciencedirect.com/science/article/pii/S1534580718309274
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    sciencedirect.com/science/article/pii/S2211124719304632
  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.7554/eLife.41913

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    sciencedirect.com/science/article/pii/S1074761319301311
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  144. Nov 2018
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    CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation
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    Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome
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    PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification
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    Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis
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  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch
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  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch
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  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Method for the Acute and Rapid Degradation of Endogenous Proteins
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  153. academic.oup.com academic.oup.com
    Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells
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  154. Nov 2017
  155. www.sciencedirect.com www.sciencedirect.com
    The Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting
    1
    1. scibot 08 Nov 2017
      RRID:AB_145841

      Curator: @Jmenke

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      (Millipore Cat# 12-370, RRID:AB_145841)

      SciCrunch record: RRID:AB_145841

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      RRID:AB_145841 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276517306238
  156. www.sciencedirect.com www.sciencedirect.com
    Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation
    1
    1. scibot 08 Nov 2017
      AB_145841

      Curator: @gabimpine

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      (Millipore Cat# 12-370, RRID:AB_145841)

      SciCrunch record: RRID:AB_145841

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      RRID:AB_145841 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1534580717302083
  157. www.sciencedirect.com www.sciencedirect.com
    Transcriptional Elongation of HSV Immediate Early Genes by the Super Elongation Complex Drives Lytic Infection and Reactivation from Latency
    1
    1. scibot 08 Nov 2017
      AB_145841

      Curator: @gabimpine

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      (Millipore Cat# 12-370, RRID:AB_145841)

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      RRID:AB_145841 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1931312817301178
  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Satb2 determines miRNA expression and long-term memory in the adult central nervous system
    1
    1. scibot 08 Nov 2017
      AB_145841

      Curator: @chewbeccax

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      (Millipore Cat# 12-370, RRID:AB_145841)

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    ncbi.nlm.nih.gov/pmc/articles/PMC5207769/
  159. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression
    1
    1. scibot 08 Nov 2017
      AB_145841

      Resource used:

      (Millipore Cat# 12-370, RRID:AB_145841)

      SciCrunch record: RRID:AB_145841

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      RRID:AB_145841
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    ncbi.nlm.nih.gov/pmc/articles/PMC5179193/