48 Matching Annotations
  1. Last 7 days
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    MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics
    1
    1. scibot 21 Dec 2024
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      DOI: 10.1016/j.celrep.2024.115104

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    sciencedirect.com/science/article/pii/S2211124724014554
  3. Dec 2024
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    Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis
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    1. scibot 14 Dec 2024
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      DOI: 10.1016/j.celrep.2024.115060

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    sciencedirect.com/science/article/pii/S2211124724014116
  5. Jun 2024
  6. www.sciencedirect.com www.sciencedirect.com
    IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility
    1
    1. scibot 04 Jun 2024
      RRID:AB_1523836

      DOI: 10.1016/j.celrep.2021.108891

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    sciencedirect.com/science/article/pii/S2211124721002059
  7. May 2024
  8. www.sciencedirect.com www.sciencedirect.com
    Development of nitroalkene-based inhibitors to target STING-dependent inflammation
    1
    1. scibot 23 May 2024
      RRID:AB_1523836

      DOI: 10.1016/j.redox.2024.103202

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    sciencedirect.com/science/article/pii/S2213231724001800
  9. Apr 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
    1
    1. scibot 30 Apr 2024
      RRID:AB_1523836

      DOI: 10.1016/j.xcrm.2024.101528

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    sciencedirect.com/science/article/pii/S2666379124001976
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SETD2 loss and ATR inhibition synergize to promote cGAS signaling and immunotherapy response in renal cell carcinoma
    1
    1. scibot 03 Apr 2024
      RRID:AB_1523836

      DOI: 10.1158/1078-0432.CCR-23-1003

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    ncbi.nlm.nih.gov/pmc/articles/PMC10592192/
  12. Feb 2024
  13. www.sciencedirect.com www.sciencedirect.com
    SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
    1
    1. scibot 02 Feb 2024
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      DOI: 10.1016/j.cell.2024.01.008

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    sciencedirect.com/science/article/pii/S0092867424000102
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutations in the non-catalytic polyproline motif destabilize TREX1 and amplify cGAS-STING signaling
    1
    1. scibot 01 Feb 2024
      RRID:AB_1523836

      DOI: 10.1101/2024.01.04.574136

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    ncbi.nlm.nih.gov/pmc/articles/PMC10802300/
  15. Jan 2024
  16. www.sciencedirect.com www.sciencedirect.com
    DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells
    1
    1. scibot 19 Jan 2024
      RRID:AB_1523836

      DOI: 10.1016/j.isci.2023.108760

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    sciencedirect.com/science/article/pii/S2589004223028377
  17. Nov 2023
  18. www.embopress.org www.embopress.org
    SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1
    1
    1. scibot 03 Nov 2023
      RRID:AB_1523836

      DOI: 10.15252/embr.202357500

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    embopress.org/doi/10.15252/embr.202357500
  19. Oct 2023
  20. www.sciencedirect.com www.sciencedirect.com
    SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing
    1
    1. scibot 28 Oct 2023
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      DOI: 10.1016/j.immuni.2023.10.001

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    sciencedirect.com/science/article/pii/S1074761323004417
  21. www.sciencedirect.com www.sciencedirect.com
    Regulation of STING activity in DNA sensing by ISG15 modification
    1
    1. scibot 27 Oct 2023
      RRID:AB_1523836

      DOI: 10.1016/j.celrep.2023.113277

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    sciencedirect.com/science/article/pii/S2211124723012895
  22. Jul 2023
  23. www.sciencedirect.com www.sciencedirect.com
    MEF2A suppresses stress responses that trigger DDX41-dependent IFN production
    1
    1. scibot 21 Jul 2023
      RRID:AB_1523836

      DOI: 10.1016/j.celrep.2023.112805

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    sciencedirect.com/science/article/pii/S2211124723008161
  24. Jun 2023
  25. www.sciencedirect.com www.sciencedirect.com
    Cancer cell-autonomous cGAS-STING response confers drug resistance
    1
    1. scibot 01 Jun 2023
      RRID:AB_1523836

      DOI: 10.1016/j.chembiol.2023.05.005

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    sciencedirect.com/science/article/pii/S2451945623001411
  26. Apr 2023
  27. www.sciencedirect.com www.sciencedirect.com
    Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses
    1
    1. scibot 29 Apr 2023
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      DOI: 10.1016/j.xcrm.2023.101024

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    sciencedirect.com/science/article/pii/S2666379123001349
  28. www.sciencedirect.com www.sciencedirect.com
    The mechanism of STING autoinhibition and activation
    1
    1. scibot 22 Apr 2023
      RRID:AB_1523836

      DOI: 10.1016/j.molcel.2023.03.029

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    sciencedirect.com/science/article/pii/S1097276523002435
  29. Mar 2023
  30. europepmc.org europepmc.org
    UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS
    1
    1. scibot 23 Mar 2023
      RRID:AB_1523836

      DOI: 10.1016/j.celrep.2023.112272

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    europepmc.org/article/med/36943869
  31. Dec 2022
  32. www.embopress.org www.embopress.org
    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
    2
    1. scibot 31 Dec 2022
      RRID:AB_1523836

      DOI: 10.15252/embj.2022111961

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      RRID:AB_1523836

      DOI: 10.15252/embj.2022111961

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    embopress.org/doi/10.15252/embj.2022111961
  33. Nov 2022
  34. www.sciencedirect.com www.sciencedirect.com
    AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity
    1
    1. scibot 17 Nov 2022
      RRID:AB_1523836

      DOI: 10.1016/j.molcel.2022.10.026

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    sciencedirect.com/science/article/pii/S1097276522010541
  35. Oct 2022
  36. www.sciencedirect.com www.sciencedirect.com
    Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas
    1
    1. scibot 07 Oct 2022
      RRID:AB_1523836

      DOI: 10.1016/j.molcel.2022.09.007

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    sciencedirect.com/science/article/pii/S1097276522008966
  37. Apr 2022
  38. www.sciencedirect.com www.sciencedirect.com
    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
    1
    1. scibot 27 Apr 2022
      RRID:AB_1523836

      DOI: 10.1016/j.molcel.2022.03.034

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    sciencedirect.com/science/article/pii/S1097276522002908
  39. Mar 2022
  40. www.sciencedirect.com www.sciencedirect.com
    The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity
    1
    1. scibot 09 Mar 2022
      RRID:AB_1523836

      DOI: 10.1016/j.celrep.2022.110434

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    sciencedirect.com/science/article/pii/S2211124722001619
  41. Feb 2022
  42. www.sciencedirect.com www.sciencedirect.com
    FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expression
    1
    1. scibot 16 Feb 2022
      RRID:AB_1523836

      DOI: 10.1016/j.celrep.2022.110396

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    sciencedirect.com/science/article/pii/S2211124722001176
  43. Oct 2021
  44. www.cell.com www.cell.com
    Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains
    1
    1. scibot 13 Oct 2021
      RRID:AB_1523836

      DOI: 10.1016/j.immuni.2021.09.008

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    cell.com/immunity/fulltext/S1074-7613(21)00393-9
  45. Sep 2021
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STING nuclear partners contribute to innate immune signaling responses
    1
    1. scibot 22 Sep 2021
      RRID:AB_1523836

      DOI: 10.1016/j.isci.2021.103055

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    ncbi.nlm.nih.gov/pmc/articles/PMC8436130/
  47. Aug 2021
  48. www.sciencedirect.com www.sciencedirect.com
    Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity
    1
    1. scibot 28 Aug 2021
      RRID:AB_1523836

      DOI: 10.1016/j.molcel.2021.07.040

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    sciencedirect.com/science/article/pii/S1097276521006249
  49. www.sciencedirect.com www.sciencedirect.com
    Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death
    1
    1. scibot 07 Aug 2021
      RRID:AB_1523836

      DOI: 10.1016/j.cell.2021.07.026

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    sciencedirect.com/science/article/pii/S0092867421008850
  50. Jul 2021
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity
    1
    1. scibot 14 Jul 2021
      RRID:AB_1523836

      DOI: 10.1016/j.cell.2019.01.016

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    ncbi.nlm.nih.gov/pmc/articles/PMC8274936/
  52. May 2021
  53. www.sciencedirect.com www.sciencedirect.com
    Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion
    1
    1. scibot 20 May 2021
      RRID:AB_1523836

      DOI: 10.1016/j.molcel.2021.05.002

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    sciencedirect.com/science/article/pii/S1097276521003592
  54. www.sciencedirect.com www.sciencedirect.com
    TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology
    1
    1. scibot 07 May 2021
      RRID:AB_1523836

      DOI: 10.1016/j.molcel.2020.10.018

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    sciencedirect.com/science/article/pii/S1097276520307255
  55. Apr 2021
  56. www.sciencedirect.com www.sciencedirect.com
    cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing
    1
    1. scibot 12 Apr 2021
      RRID:AB_1523836

      DOI: 10.1016/j.molcel.2021.01.024

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    sciencedirect.com/science/article/pii/S1097276521000447
  57. Mar 2021
  58. www.sciencedirect.com www.sciencedirect.com
    IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility
    1
    1. scibot 24 Mar 2021
      RRID:AB_1523836

      DOI: 10.1016/j.celrep.2021.108891

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    sciencedirect.com/science/article/pii/S2211124721002059
  59. www.sciencedirect.com www.sciencedirect.com
    ER-directed TREX1 limits cGAS activation at micronuclei
    1
    1. scibot 01 Mar 2021
      RRID:AB_152383

      DOI: 10.1016/j.molcel.2020.12.037

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      RRIDCUR:Incorrect RRIDCUR:Unresolved RRID:AB_1523836
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    sciencedirect.com/science/article/pii/S1097276520309588
  60. Jan 2021
  61. www.sciencedirect.com www.sciencedirect.com
    MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells
    1
    1. scibot 22 Jan 2021
      RRID:AB_1523836

      DOI: 10.1016/j.celrep.2020.108628

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      RRID:AB_1523836 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S221112472031617X
  62. www.sciencedirect.com www.sciencedirect.com
    A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA
    1
    1. scibot 08 Jan 2021
      RRID:AB_1523836

      DOI: 10.1016/j.celrep.2020.108586

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      RRIDCUR:Validated RRID:AB_1523836
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    sciencedirect.com/science/article/pii/S2211124720315758
  63. Sep 2020
  64. www.sciencedirect.com www.sciencedirect.com
    The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice
    1
    1. scibot 23 Sep 2020
      RRID:AB_1523836

      DOI: 10.1016/j.neuron.2020.03.005

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      Curator: @ethanbadger

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      RRIDCUR:Validated RRID:AB_1523836
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    sciencedirect.com/science/article/pii/S0896627320301914
  65. www.sciencedirect.com www.sciencedirect.com
    ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway
    1
    1. scibot 15 Sep 2020
      RRID:AB_1523836

      DOI: 10.1016/j.celrep.2020.107564

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      Curator: @ethanbadger

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      RRID:AB_1523836 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124720305131
  66. www.sciencedirect.com www.sciencedirect.com
    mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
    1
    1. scibot 09 Sep 2020
      RRID:AB_1523836

      DOI: 10.1016/j.immuni.2020.02.002

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      Curator: @ethanbadger

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      RRIDCUR:Validated RRID:AB_1523836
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    sciencedirect.com/science/article/pii/S107476132030073X
  67. Jan 2020
  68. www.sciencedirect.com www.sciencedirect.com
    The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
    1
    1. scibot 13 Jan 2020
      RRID:AB_1523836

      DOI: 10.1016/j.cell.2019.05.035

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    MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.celrep.2019.07.085

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    sciencedirect.com/science/article/pii/S2211124719310010
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    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_1523836

      DOI: 10.1016/j.cell.2019.01.016

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    sciencedirect.com/science/article/pii/S0092867419300492
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    Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING
    1
    1. scibot 12 Jan 2020
      RRID:AB_1523836

      DOI: 10.1016/j.molcel.2019.02.038

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  72. Nov 2018
  73. www.sciencedirect.com www.sciencedirect.com
    IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages
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    1. scibot 05 Nov 2018
      RRID:AB_1523836

      Curator: @evieth

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    sciencedirect.com/science/article/pii/S2211124718314177
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    Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation
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    sciencedirect.com/science/article/pii/S1931312817304389
  75. Nov 2017
  76. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing
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    1. scibot 08 Nov 2017
      AB_1523836

      Curator: @gabimpine

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      AB_1523836

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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0292-z
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    Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses
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    1. scibot 08 Nov 2017
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      Curator: @chewbeccax

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