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Pharmacologically targeting CDK12 induces BRCAness and synergizes with merestinib to exacerbate DNA damage in high-risk neuroblastoma

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1. scibot 15 Oct 2026
  
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  RRID:AB_1547934
  
  DOI: 10.1016/j.celrep.2026.117997
  
  Resource: (Bethyl Cat# A301-939A, RRID:AB_1547934)
  
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sciencedirect.com/science/article/pii/S2211124726010752
Sep 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism

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1. scibot 10 Sep 2026
  
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  RRID:AB_1547934
  
  DOI: 10.1038/s41392-026-02932-w
  
  Resource: (Bethyl Cat# A301-939A, RRID:AB_1547934)
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13538385/
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

PAF1C-mediated activation of CDK12/13 kinase activity is critical for CTD phosphorylation and transcript elongation

1
1. scibot 03 Dec 2025
  
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  RRID:AB_1547934
  
  DOI: 10.1016/j.molcel.2025.04.012
  
  Resource: (Bethyl Cat# A301-939A, RRID:AB_1547934)
  
  Curator: @scibot
  
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sciencedirect.com:5037/science/article/pii/S1097276525003156
May 2025
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PAF1C-mediated activation of CDK12/13 kinase activity is critical for CTD phosphorylation and transcript elongation

1
1. scibot 18 May 2025
  
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  RRID:AB_1547934
  
  DOI: 10.1016/j.molcel.2025.04.012
  
  Resource: (Bethyl Cat# A301-939A, RRID:AB_1547934)
  
  Curator: @scibot
  
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sciencedirect.com:5037/science/article/pii/S1097276525003156
Nov 2024
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Degradome analysis to identify direct protein substrates of small-molecule degraders

1
1. scibot 14 Nov 2024
  
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  RRID:AB_1547934
  
  DOI: 10.1016/j.chembiol.2024.10.007
  
  Resource: (Bethyl Cat# A301-939A, RRID:AB_1547934)
  
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sciencedirect.com/science/article/pii/S2451945624004422
Oct 2024
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Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition

1
1. scibot 02 Oct 2024
  
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  AB_1547934
  
  DOI: 10.1016/j.xcrm.2024.101752
  
  Resource: (Bethyl Cat# A301-939A, RRID:AB_1547934)
  
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sciencedirect.com/science/article/pii/S2666379124004828
Mar 2022
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The PAF1 complex promotes 3′ processing of pervasive transcripts

1
1. scibot 16 Mar 2022
  
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  RRID:AB_1547934
  
  DOI: 10.1016/j.celrep.2022.110519
  
  Resource: (Bethyl Cat# A301-939A, RRID:AB_1547934)
  
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sciencedirect.com/science/article/pii/S2211124722002558
Jan 2020
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CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

1
1. scibot 13 Jan 2020
  
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  RRID:AB_1547934
  
  DOI: 10.1016/j.ccell.2019.11.003
  
  Resource: (Bethyl Cat# A301-939A, RRID:AB_1547934)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_1547934
  
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  RRID:AB_1547934 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610819305239
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_1547934
  
  DOI: 10.1016/j.chembiol.2019.02.015
  
  Resource: (Bethyl Cat# A301-939A, RRID:AB_1547934)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_1547934
  
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  RRID:AB_1547934 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2451945619300704
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_1547934
  
  DOI: 10.1016/j.chembiol.2019.02.012
  
  Resource: (Bethyl Cat# A301-939A, RRID:AB_1547934)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_1547934
  
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  RRID:AB_1547934 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2451945619300674
Nov 2018
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 05 Nov 2018
  
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  RRID:AB_1547934
  
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  (Bethyl Cat# A301-939A, RRID:AB_1547934)
  
  SciCrunch record: RRID:AB_1547934
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6039718/
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Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2

1
1. scibot 05 Nov 2018
  
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  RRID:AB_1547934
  
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  (Bethyl Cat# A301-939A, RRID:AB_1547934)
  
  SciCrunch record: RRID:AB_1547934
  
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  RRID:AB_1547934
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sciencedirect.com/science/article/pii/S1097276518303927
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A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response

1
1. scibot 05 Nov 2018
  
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  RRID:AB_1547934
  
  Curator: @Jmenke
  
  Resource used:
  
  (Bethyl Cat# A301-939A, RRID:AB_1547934)
  
  SciCrunch record: RRID:AB_1547934
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_1547934 RRIDCUR:Validated
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RRID:AB_1547934

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sciencedirect.com/science/article/pii/S0092867418301090