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    Oncolytic cytomegaloviruses expressing EGFR-retargeted fusogenic glycoprotein complex and drug-controllable interleukin 12
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    cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00645-1
  3. Dec 2024
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    Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells
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    Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity
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    Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1
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    IL-17A/CEBPβ/OPN/LYVE-1 axis inhibits anti-tumor immunity by promoting tumor-associated tissue-resident macrophages
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    Dynamic tracking of native precursors in adult mice
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    Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis
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    Nucleo-cytosolic acetyl-CoA drives tumor immune evasion by regulating PD-L1 in melanoma
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  11. Nov 2024
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    Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn’s disease
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  13. Oct 2024
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    MerTK+ macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation
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    Epitope prime editing shields hematopoietic cells from CD123 immunotherapy for acute myeloid leukemia
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  16. Sep 2024
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    Granulocyte colony stimulating factor promotes scarless tissue regeneration
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    Group X phospholipase A2 links colonic lipid homeostasis to systemic metabolism via host-microbiota interaction
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    Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy
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    mRNA-delivery of IDO1 suppresses T cell-mediated autoimmunity
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  21. Aug 2024
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    Stress-sensitive neural circuits change the gut microbiome via duodenal glands
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    Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis
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  24. Jul 2024
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    VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway
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    Constant surface area-to-volume ratio during cell growth as a design principle in mammalian cells
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    Metabolic reprogramming and dysregulated IL-17 production impairs CD4 T cell function post sepsis
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    Profiling Proteins and Phosphorylation Sites During T Cell Activation Using an Integrated Thermal Shift Assay
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    Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts
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    SWI/SNF chromatin remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cell migration
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    CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma
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  32. Jun 2024
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    Moderate-intensity aerobic exercise training improves CD8+ tumor-infiltrating lymphocytes effector function by reducing mitochondrial loss.
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    cell.com/iscience/abstract/S2589-0042(24)01346-4
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    FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity
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  35. May 2024
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    A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation
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    Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance
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  38. Apr 2024
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    Ultrasound-visible engineered bacteria for tumor chemo-immunotherapy
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    Determination of the FABP5 expression profile in skin lesions of an IMQ-induced psoriasis mouse model using flow cytometry
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    Tim4 enables large peritoneal macrophages to cross-present tumor antigens at early stages of tumorigenesis
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    Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages
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    IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
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    Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer
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    High affinity mAb infusion can enhance maximum affinity maturation during HIV Env immunisation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10973984/
  46. Mar 2024
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    Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer
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    SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions
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    Ly6C+ monocytes in the skin promote systemic alphavirus dissemination
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    Protocol to examine immune subpopulations in murine conjunctiva and lacrimal gland using flow cytometry
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    Protocol for quantifying SA-β-gal activity as a measure of senescence in islets of a mouse model of type 1 diabetes
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    The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression
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  53. Feb 2024
  54. www.sciencedirect.com www.sciencedirect.com
    Noninvasive neuromodulation protects against doxorubicin-induced cardiotoxicity and inhibits tumor growth
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  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mononuclear cell composition and activation in blood and mucosal tissue of eosinophilic esophagitis
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    A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection
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  57. Jan 2024
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    Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells
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    A time- and single-cell-resolved model of murine bone marrow hematopoiesis
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    An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains
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  61. Dec 2023
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    Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression
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    Direct assessment of nitrative stress in lipid environments: Applications of a designer lipid-based biosensor for peroxynitrite
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    FGFR3 alterations in bladder cancer stimulate serine synthesis to induce immune-inert macrophages that suppress T-cell recruitment and activation
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    CD62L expression marks a functionally distinct subset of memory B cells
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  67. Nov 2023
  68. www.sciencedirect.com www.sciencedirect.com
    The antitumor activities of anti-CD47 antibodies require Fc-FcγR interactions
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    Mice with FVB-derived sequence on chromosome 17 succumb to disseminated virus infection due to aberrant NK cell and T cell responses
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    IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development
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  71. Oct 2023
  72. www.science.org www.science.org
    Lymph node–resident dendritic cells drive TH2 cell development involving MARCH1
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  73. 52.53.155.43 52.53.155.43
    Antigen presentation by tumor-associated macrophages mediates progenitor to terminal exhaustion transition in GBM and other solid tumors
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  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
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    ApoE enhances mitochondrial metabolism via microRNA-142a/146a-regulated circuits that suppress hematopoiesis and inflammation in hyperlipidemia
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  76. Sep 2023
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for in vivo and in vitro activation of NLRP3 inflammasome in mice using monosodium urate
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  78. Aug 2023
  79. 52.53.155.43 52.53.155.43
    Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice
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    Original research: Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma
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  81. 52.53.155.43 52.53.155.43
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  82. Jul 2023
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    High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic γδ T cell IL-17 production
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  84. Jun 2023
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    Vectored immunoprophylaxis and treatment of SARS-CoV-2 infection in a preclinical model
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    Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells
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  87. May 2023
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    Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103intCD11b+ dendritic cell population
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    Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
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    Vaccination with a bacterial peptide conjugated to SARS-CoV-2 receptor-binding domain accelerates immunity and protects against COVID-19
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  91. Apr 2023
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-Producing Dendritic Cells
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    Protocol for immunofluorescence staining of murine helminth-infected intestinal and lung tissues
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    Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis
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    NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection
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    An optimized IL-12-Fc expands its therapeutic window, achieving strong activity against mouse tumors at tolerable drug doses
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  97. Mar 2023
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell RNA sequencing identifies hippocampal microglial dysregulation in diet-induced obesity
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    CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor
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    Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes
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    Diurnal Expression of PD-1 on Tumor-Associated Macrophages Underlies the Dosing Time-Dependent Antitumor Effects of the PD-1/PD-L1 Inhibitor BMS-1 in B16/BL6 Melanoma-Bearing Mice
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  114. Nov 2022
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    Transcriptional Profiling of Phagocytic Leukocytes and Microglia Reveals a Critical Role for Reactive Oxygen Species in Biofilm Containment during Staphylococcus aureus Craniotomy Infection
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  117. Oct 2022
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    A neutrophil–B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4
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  120. Sep 2022
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    Protocol to isolate and culture primary mouse feto-placental endothelial cells
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    BCGΔBCG1419c increased memory CD8+ T cell-associated immunogenicity and mitigated pulmonary inflammation compared with BCG in a model of chronic tuberculosis
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  123. Aug 2022
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    Dysbiosis in imiquimod-induced psoriasis alters gut immunity and exacerbates colitis development
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    D-tryptophan suppresses enteric pathogens and pathobionts and prevents colitis by modulating microbial tryptophan metabolism
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    Optimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity
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    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
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    Tofacitinib Suppresses Natural Killer Cells In Vitro and In Vivo: Implications for Amyotrophic Lateral Sclerosis
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  142. Feb 2022
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    Immune translational control by CPEB4 regulates intestinal inflammation resolution and colorectal cancer development
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    An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity
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  146. Jan 2022
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    ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology
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    Correlation between circulating innate lymphoid cell precursors and thymic function
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    Isolation and characterization of the immune cell fraction from murine brain tumor microenvironment
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    The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth
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    Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction
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  164. Aug 2021
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    Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis
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    Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection
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    The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin
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    CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment
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  180. Jul 2021
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    Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection
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    A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection
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  190. May 2021
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    Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist
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    Repression of endogenous retroviruses prevents antiviral immune response and is required for mammary gland development
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    Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression
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    Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens
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    Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production
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  196. Apr 2021
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    Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis
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    MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism
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    UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability
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    Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes
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  203. Mar 2021
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    Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity
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    Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation
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    Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging
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  209. Feb 2021
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    RON Expression Mediates Lipopolysaccharide-Mediated Dendritic Cell Maturation via March-I
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    Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy
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  212. Dec 2020
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    Cuprizone‐induced demyelination triggers a CD8‐pronounced T cell recruitment
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    JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome
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    In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells
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    Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance
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    TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice
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    Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response
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  222. Sep 2020
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    Tumor-Promoting Ly-6G+ SiglecFhigh Cells Are Mature and Long-Lived Neutrophils
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    Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration
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    Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture
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    Targeting Lymph Node Niches Enhances Type 1 Immune Responses to Immunization
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    Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment
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    Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo
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    SYLARAS: A Platform for the Statistical Analysis and Visual Display of Systemic Immunoprofiling Data and Its Application to Glioblastoma
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    Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT
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    Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System
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    Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells
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    CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response
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  234. Jan 2020
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    Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21
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    TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease
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    Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis
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    Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation
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