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L-asparaginase treatment induces a tumor metabolic plasticity and reveals a vulnerability to PARP1/2 inhibitor Olaparib, in B-cell lymphomas

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1. scibot 30 Oct 2025
  
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  DOI: 10.1101/2025.10.24.683536
  
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biorxiv.org/content/10.1101/2025.10.24.683536v1
Oct 2025
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The m6A reader IGF2BP2 promotes homologous recombination-mediated DNA repair by eliminating DNA-RNA hybrids

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  DOI: 10.1016/j.celrep.2025.116438
  
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sciencedirect.com/science/article/pii/S2211124725012094
Aug 2025
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Extrachromosomal DNA biogenesis is dependent on DNA looping and religation by YY1-Lig3-PARylation complex

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  DOI: 10.1016/j.molcel.2025.07.007
  
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sciencedirect.com/science/article/pii/S1097276525006082
Jul 2025
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Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102251
  
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sciencedirect.com/science/article/pii/S2666379125003246
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Cancer-associated fibroblast-derived fibulin-5 promotes radioresistance in non-small-cell lung cancer

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  DOI: 10.1016/j.celrep.2025.116018
  
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sciencedirect.com/science/article/pii/S2211124725007892
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Effective Treatment of Disseminated Prostate Cancer Using CD46-Targeted 225Ac Therapy

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1. scibot 17 Jul 2025
  
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  DOI: 10.1158/1078-0432.CCR-24-2850
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12260511/
May 2025
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Single-nucleus profiling of mouse inner ear aging uncovers cell type heterogeneity and hair cell subtype-specific age-related signatures

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115781
  
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sciencedirect.com/science/article/pii/S2211124725005522
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Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cells

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.jare.2025.04.033
  
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sciencedirect.com/science/article/pii/S2090123225002772
Feb 2025
dx.doi.org dx.doi.org

The role of prolactin in amniotic membrane regeneration: Therapeutic potential for premature rupture of membranes

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1. scibot 20 Feb 2025
  
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  DOI: 10.1210/endocr/bqae095
  
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dx.doi.org/10.1210/endocr/bqae095
Dec 2024
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Zinc finger protein 593 promotes breast cancer development by ensuring DNA damage repair and cell-cycle progression

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  DOI: 10.1016/j.isci.2024.111513
  
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sciencedirect.com/science/article/pii/S2589004224027408
Sep 2024
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m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.040
  
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sciencedirect.com/science/article/pii/S0092867424009693
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Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma

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1. scibot 05 Sep 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-3720
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11369621/
Jul 2024
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Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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1. scibot 17 Jul 2024
  
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  DOI: 10.4103/NRR.NRR-D-23-00928
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11246146/
Jun 2024
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LEUTX regulates porcine embryonic genome activation in somatic cell nuclear transfer embryos

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114372
  
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sciencedirect.com/science/article/pii/S2211124724007009
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Reversion from basal histone H4 hypoacetylation at the replication fork increases DNA damage in FANCA deficient cells

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1. scibot 05 Jun 2024
  
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  DOI: 10.1371/journal.pone.0298032
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11142588/
May 2024
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2024.02.25.581951v1.full-html.html

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1. scibot 16 May 2024
  
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  DOI: 10.1038/nature12362
  
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52.53.155.43/3cbbb6c4022cb0d94766603ef526c2fd13dcbc89/2024.02.25.581951v1.full-html.html
Apr 2024
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SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.113924
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11025316/
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Babaodan overcomes cisplatin resistance in cholangiocarcinoma via inhibiting YAP1

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1. scibot 10 Apr 2024
  
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  DOI: 10.1080/13880209.2024.2331060
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10997361/
Mar 2024
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SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

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  DOI: 10.1016/j.celrep.2024.113924
  
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  DOI: 10.1016/j.celrep.2024.113924
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11025316/
Feb 2024
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Glycolysis Induced by METTL14 Is Essential for Macrophage Phagocytosis and Phenotype in Cervical Cancer

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1. scibot 02 Feb 2024
  
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  DOI: 10.4049/jimmunol.2300339
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10828180/
Jan 2024
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TDP-43 chronic deficiency leads to dysregulation of transposable elements and gene expression by affecting R-loop and 5hmC crosstalk

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  DOI: 10.1016/j.celrep.2023.113662
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10857847/
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Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD

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1. scibot 06 Jan 2024
  
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  DOI: 10.1016/j.cmet.2023.12.013
  
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sciencedirect.com/science/article/pii/S1550413123004643
Oct 2023
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Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer

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1. scibot 27 Oct 2023
  
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  DOI: 10.1016/j.celrep.2023.113270
  
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sciencedirect.com/science/article/pii/S2211124723012822
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Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice

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  DOI: 10.1016/j.isci.2023.108082
  
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cell.com/iscience/abstract/S2589-0042(23)02159-4
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The biological effects of terahertz wave radiation-induced injury on neural stem cells

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1. scibot 06 Oct 2023
  
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  DOI: 10.1016/j.isci.2023.107418
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10523010/
Aug 2023
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The ATR inhibitor VE-821 increases the sensitivity of gastric cancer cells to cisplatin

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1. scibot 10 Aug 2023
  
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  DOI: 10.1016/j.tranon.2023.101743
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10400920/
Jul 2023
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Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112830
  
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sciencedirect.com/science/article/pii/S2211124723008410
May 2023
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

Integrative transcriptomics and cell systems analyses reveal protective pathways controlled by Igfbp-3 in anthracycline-induced cardiotoxicity

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1. scibot 24 May 2023
  
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  DOI: 10.1096/fj.202201885RR
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202201885RR
Feb 2023
www.embopress.org www.embopress.org

Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma

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  DOI: 10.15252/emmm.202216863
  
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embopress.org/doi/10.15252/emmm.202216863
www.mdpi.com www.mdpi.com

Asparagine and Glutamine Deprivation Alters Ionizing Radiation Response, Migration and Adhesion of a p53null Colorectal Cancer Cell Line

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1. scibot 08 Feb 2023
  
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  DOI: 10.3390/ijms24032983
  
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mdpi.com/1422-0067/24/3/2983
Dec 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cystatin B deficiency results in sustained histone H3 tail cleavage in postnatal mouse brain mediated by increased chromatin-associated cathepsin L activity

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1. scibot 16 Dec 2022
  
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  DOI: 10.3389/fnmol.2022.1069122
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9749902/
Oct 2022
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Selenium modulates cancer cell response to pharmacologic ascorbate

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1. scibot 27 Oct 2022
  
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  DOI: 10.1158/0008-5472.CAN-22-0408
  
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aacrjournals.org/cancerres/article/82/19/3486/709413/Selenium-Modulates-Cancer-Cell-Response-to
Aug 2022
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SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis

1
1. scibot 17 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111233
  
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sciencedirect.com/science/article/pii/S2211124722010506
Jul 2022
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HMCES modulates the transcriptional regulation of nodal/activin and BMP signaling in mESCs

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1. scibot 13 Jul 2022
  
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  DOI: 10.1016/j.celrep.2022.111038
  
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sciencedirect.com/science/article/pii/S2211124722008324
Dec 2021
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IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer

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1. scibot 22 Dec 2021
  
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Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males

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An Integrated Analysis of the Response of Colorectal Adenocarcinoma Caco-2 Cells to X-Ray Exposure

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Cas9 deactivation with photocleavable guide RNAs

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Translation of GGC repeat expansions into a toxic polyglycine protein in NIID defines a novel class of human genetic disorders: the polyG diseases

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A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia

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Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site

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The Mitochondrial Protein MAVS Stabilizes p53 to Suppress Tumorigenesis

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Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response

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Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice

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Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment

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Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

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Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability

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