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Recycling endosomes in mature epithelia restrain tumorigenic signaling

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Aug 2025
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NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas

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Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures

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Jul 2025
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In vivo prime editing rescues alternating hemiplegia of childhood in mice

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cell.com/cell/fulltext/S0092-8674(25)00740-8
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1-s2.0-S0016508525057324-main-html.html

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52.53.155.43/a363e4ae90be5a0c17cae72bbc9ca19379f34011/1-s2.0-S0016508525057324-main-html.html
Jun 2025
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HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury

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cell.com/cell-stem-cell/abstract/S1934-5909(25)00177-8
May 2025
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A lncRNA-mediated metabolic rewiring of cell senescence

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Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

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Apr 2025
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Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics

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Mar 2025
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Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders

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sciencedirect.com/science/article/pii/S2405471225000377
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VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation

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Feb 2025
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Genomic mediators of acquired resistance to immunotherapy in metastatic melanoma

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cell.com/cancer-cell/abstract/S1535-6108(25)00027-3
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PARP7 Inhibitors and AHR Agonists Act Synergistically Across a Wide-Range of Cancer Models

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  DOI: 10.1158/1535-7163.MCT-24-0211
  
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aacrjournals.org/mct/article/24/1/56/750662/PARP7-Inhibitors-and-AHR-Agonists-Act
Dec 2024
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snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification

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Nov 2024
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The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC11539583/
Oct 2024
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Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition

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Aug 2024
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GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels

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sciencedirect.com/science/article/pii/S1534580724004556
Jul 2024
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The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells

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Endothelial cell signature in muscle stem cells validated by VEGFA-FLT1-AKT1 axis promoting survival of muscle stem cell

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ncbi.nlm.nih.gov/pmc/articles/PMC11216748/
Jun 2024
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A spatiotemporal map of co-receptor signaling networks underlying B cell activation

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Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancer

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sciencedirect.com/science/article/pii/S0304383524004051
May 2024
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Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancer

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Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer

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Apr 2024
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Protocol for efficient CRISPR-Cas9-mediated fluorescent tag knockin in hard-to-transfect erythroid cell lines

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sciencedirect.com/science/article/pii/S2666166724001813
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Extracellular signal‐regulated kinases 2 (Erk2) and Erk5 in the central nervous system differentially contribute to central sensitization in male mice

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Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma

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Mar 2024
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Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma

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Feb 2024
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Loss of TIM4-Dependent Efferocytosis in Kupffer Cells Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

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  DOI: 10.1101/2024.01.30.578023
  
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biorxiv.org/content/10.1101/2024.01.30.578023v1
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Sulfatase 2 Inhibition Sensitizes Triple-Negative Breast Cancer Cells to Chemotherapy Through Augmentation of Extracellular ATP

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biorxiv.org/content/10.1101/2023.09.15.557965v1
Nov 2023
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Virus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape

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  DOI: 10.1016/j.celrep.2023.113262
  
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sciencedirect.com/science/article/pii/S2211124723012743
Oct 2023
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Spatial-temporal proliferation of hepatocytes during pregnancy revealed by genetic lineage tracing

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  DOI: 10.1016/j.stem.2023.09.002
  
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sciencedirect.com/science/article/pii/S1934590923003235
Sep 2023
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Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis

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  DOI: 10.1016/j.chom.2023.08.003
  
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sciencedirect.com/science/article/pii/S1931312823003281
Jul 2023
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Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma

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  DOI: 10.1038/s41467-023-39717-6
  
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nature.com/articles/s41467-023-39717-6
Jun 2023
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Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression

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  DOI: 10.1080/2162402X.2023.2219164
  
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CCN2/CTGF tip the balance of growth factors towards TGF-β2 in primary open-angle glaucoma

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A Spatiotemporal Map of Co-Receptor Signaling Networks Underlying B Cell Activation

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Engineered cardiac tissue model of restrictive cardiomyopathy for drug discovery

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The Interactions of the 70 kDa Fragment of Cell Adhesion Molecule L1 with Topoisomerase 1, Peroxisome Proliferator-Activated Receptor γ and NADH Dehydrogenase (Ubiquinone) Flavoprotein 2 Are Involved in Gene Expression and Neuronal L1-Dependent Functions

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STK25 inhibits PKA signaling by phosphorylating PRKAR1A

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Circ-CCNB1 modulates trophoblast proliferation and invasion in spontaneous abortion by regulating miR-223/SIAH1 axis

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Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1

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CCN2/CTGF—A Modulator of the Optic Nerve Head Astrocyte

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CXCL12 May Drive Inflammatory Potential in the Ovine Corpus Luteum During Implantation

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NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells

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Selective activation of PFKL suppresses the phagocytic oxidative burst

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Differential Actions of Estrogen Receptor α and β via Non-Genomic Signaling in Human Prostate Stem and Progenitor Cells

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Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity

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Development of potent dimeric inhibitors of GAS41 YEATS domain

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Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

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Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation

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LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

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Biochemical characterization of proliferative and differentiated SH-SY5Y cell line as a model for Parkinson’s disease.

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Extracellular signal‐regulated kinases 2 (Erk2) and Erk5 in the central nervous system differentially contribute to central sensitization in male mice

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Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis

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CXCR4 signaling at the fetal-maternal interface may drive inflammation and syncytia formation during ovine pregnancy †

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CRISPR/Cas9-edited PKP2 knock-out (JMUi001-A-2) and DSG2 knock-out (JMUi001-A-3) iPSC lines as an isogenic human model system for arrhythmogenic cardiomyopathy (ACM)

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Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

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CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance

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Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

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Recycling endosomes in mature epithelia restrain tumorigenic signaling

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Generation of two patient-derived iPSC lines from siblings (LIBUCi001-A and LIBUCi002-A) and a genetically modified iPSC line (JMUi001-A-1) to mimic dilated cardiomyopathy with ataxia (DCMA) caused by a homozygous DNAJC19 mutation

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Next-generation sequencing identified novel Desmoplakin frame-shift variant in patients with Arrhythmogenic cardiomyopathy

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Experimentally Induced Sepsis Causes Extensive Hypomyelination in the Prefrontal Cortex and Hippocampus in Neonatal Rats

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link.springer.com/article/10.1007/s12017-020-08602-6
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Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes

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  DOI: 10.1016/j.chembiol.2019.09.004
  
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STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production

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  DOI: 10.1016/j.celrep.2019.09.069
  
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Complement C3a induces axonal hypomyelination in the periventricular white matter through activation of WNT/β‐catenin signal pathway in septic neonatal rats experimentally induced by lipopolysaccharide

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Modulation of RNA Condensation by the DEAD-Box Protein eIF4A

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  DOI: 10.1016/j.cell.2019.12.031
  
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Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity

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academic.oup.com/endo/article/159/8/3007/5040342
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Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

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  AB_1642205
  
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Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS

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  AB 1642205
  
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YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

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  AB_1642205
  
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