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An orally active dual CBP/p300 degrader targets core dependencies of multiple myeloma

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1. scibot 04 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117464
  
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sciencedirect.com/science/article/pii/S2211124726005425
Apr 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

p16 expression confers sensitivity to CDK2 inhibitors in cyclin E1–driven ovarian cancers

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1. scibot 21 Apr 2026
  
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  DOI: 10.1126/scisignal.adv0415
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13089646/
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Inhibition of USP7 destabilizes the noncanonical PRC1.1 complex and induces neuroblastoma differentiation

1
1. scibot 17 Apr 2026
  
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  DOI: 10.1158/1541-7786.MCR-25-1153
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13082235/
Aug 2025
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Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells

1
1. scibot 01 Aug 2025
  
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  DOI: 10.1016/j.immuni.2025.07.008
  
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sciencedirect.com/science/article/pii/S1074761325003176
May 2025
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KDM3A and KDM3B regulate alternative splicing in mouse pluripotent stem cells

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.isci.2025.112612
  
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sciencedirect.com/science/article/pii/S2589004225008739
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Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.ccell.2025.04.013
  
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sciencedirect.com/science/article/pii/S1535610825001722
Feb 2025
aacrjournals.org aacrjournals.org

CDK9 inhibition by dinaciclib is a therapeutic vulnerability in epithelioid hemangioendothelioma

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/1078-0432.CCR-24-1097
  
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aacrjournals.org/clincancerres/article/30/18/4179/747481/CDK9-Inhibition-by-Dinaciclib-Is-a-Therapeutic
Jan 2025
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A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells

1
1. scibot 28 Jan 2025
  
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  DOI: 10.1016/j.chembiol.2025.01.002
  
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sciencedirect.com/science/article/pii/S2451945625000029
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Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy

1
1. scibot 16 Jan 2025
  
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  RRID:AB_1642229
  
  DOI: 10.1016/j.celrep.2024.115205
  
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sciencedirect.com/science/article/pii/S2211124724015560
Dec 2024
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H4K20me3-Mediated Repression of Inflammatory Genes is a Characteristic and Targetable Vulnerability of Persister Cancer Cells

1
1. scibot 13 Dec 2024
  
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  RRID:AB_1642229
  
  DOI: 10.1158/0008-5472.CAN-24-0529
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617193/
Nov 2024
52.53.155.43 52.53.155.43

can-24-0529-html.html

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1. scibot 07 Nov 2024
  
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  DOI: 10.1158/0008-5472.can-24-0529
  
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52.53.155.43/4faeafb6ce934469a644c8bc705adf42bb41b860/can-24-0529-html.html
May 2024
52.53.155.43 52.53.155.43

2024.04.30.591961v1.full-html.html

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1. scibot 09 May 2024
  
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  DOI: 10.1101/2024.04.30.591961
  
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52.53.155.43/dbb28a477ba70dfb57cc390e0c058bd8beca74c4/2024.04.30.591961v1.full-html.html
Mar 2024
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MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance

1
1. scibot 06 Mar 2024
  
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  RRID:AB_1642229
  
  DOI: 10.1016/j.celrep.2024.113908
  
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sciencedirect.com/science/article/pii/S2211124724002365
Feb 2024
52.53.155.43 52.53.155.43

The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells

2
1. scibot 22 Feb 2024
  
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  RRID:AB_1642229
  
  DOI: 10.1152/ajpcell.00293.2023
  
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2. scibot 22 Feb 2024
  
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  DOI: 10.1152/ajpcell.00293.2023
  
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52.53.155.43/d532629e4f1cf755a6f5c302a21018f2c97350c4/reisbeck-et-al-2023-the-iron-chelator-and-oxphos-inhibitor-vlx600-induces-mitophagy-and-an-autophagy-dependent-type-of (1)-html.html
journals.physiology.org journals.physiology.org

The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells

1
1. scibot 16 Feb 2024
  
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  DOI: 10.1152/ajpcell.00293.2023
  
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journals.physiology.org/doi/10.1152/ajpcell.00293.2023
Dec 2023
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ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors

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1. scibot 20 Dec 2023
  
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  RRID:AB_1642229
  
  DOI: 10.1016/j.celrep.2023.113541
  
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sciencedirect.com/science/article/pii/S221112472301553X
Nov 2023
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Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies

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1. scibot 28 Nov 2023
  
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  RRID:AB_1642229
  
  DOI: 10.1016/j.ccell.2023.11.001
  
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sciencedirect.com/science/article/pii/S1535610823003665
Aug 2023
52.53.155.43 52.53.155.43

MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC

2
1. scibot 17 Aug 2023
  
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  RRID:AB_1642229
  
  DOI: 10.1016/j.celrep.2023.112939
  
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2. scibot 11 Aug 2023
  
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  RRID:AB_1642229
  
  DOI: 10.1016/j.celrep.2023.112939
  
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52.53.155.43/bd09065dee8428d4c17fca329effba1c6cc59b0c/PIIS2211124723009506-html.html
Jul 2023
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Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis

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1. scibot 22 Jul 2023
  
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  DOI: 10.1016/j.cmet.2023.06.013
  
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sciencedirect.com/science/article/pii/S1550413123002231
Jun 2023
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Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity

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1. scibot 02 Jun 2023
  
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  RRID:AB_1642229
  
  DOI: 10.1016/j.cell.2023.05.013
  
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sciencedirect.com/science/article/pii/S0092867423005329
May 2023
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Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.

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1. scibot 14 May 2023
  
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  RRID:AB_1642229
  
  DOI: 10.1016/j.isci.2023.106743
  
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sciencedirect.com/science/article/pii/S2589004223008209
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer

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1. scibot 16 Mar 2023
  
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  RRID:AB_1642229
  
  DOI: 10.1158/1078-0432.CCR-21-3603
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9481728/
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Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes

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1. scibot 10 Mar 2023
  
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  RRID:AB_1642229
  
  DOI: 10.1016/j.isci.2023.106161
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9988578/
Dec 2022
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Mechanisms of IRF2BPL-related disorders and identification of a potential therapeutic strategy

1
1. scibot 08 Dec 2022
  
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  RRID:AB_1642229
  
  DOI: 10.1016/j.celrep.2022.111751
  
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sciencedirect.com/science/article/pii/S2211124722016345
aacrjournals.org aacrjournals.org

BAF complex maintains glioma stem cells in pediatric H3K27M-glioma

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1. scibot 03 Dec 2022
  
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  RRID:AB_1642229
  
  DOI: 10.1158/2159-8290.CD-21-1491
  
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aacrjournals.org/cancerdiscovery/article/12/12/2880/711164/BAF-Complex-Maintains-Glioma-Stem-Cells-in
Nov 2022
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Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation

1
1. scibot 24 Nov 2022
  
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  RRID:AB_1642229
  
  DOI: 10.1016/j.molcel.2022.11.002
  
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sciencedirect.com/science/article/abs/pii/S1097276522010644
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Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins

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1. scibot 24 Nov 2022
  
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  DOI: 10.1016/j.celrep.2022.111688
  
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sciencedirect.com/science/article/pii/S2211124722015625
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Cytoplasmic pool of U1 spliceosome protein SNRNP70 shapes the axonal transcriptome and regulates motor connectivity

1
1. scibot 17 Nov 2022
  
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  DOI: 10.1016/j.cub.2022.10.048
  
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sciencedirect.com/science/article/pii/S0960982222016967
Aug 2022
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CHAMP1 binds to REV7/FANCV and promotes homologous recombination repair

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1. scibot 31 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111297
  
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sciencedirect.com/science/article/pii/S2211124722011172
52.53.155.43 52.53.155.43

ccr-21-3603-html.html

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1. scibot 27 Aug 2022
  
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  AB_1642229
  
  DOI: 10.1158/1078-0432.CCR-21-3603
  
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52.53.155.43/de81104a0064110ab6f8eb2e443412de8e9dbc9e/ccr-21-3603-html.html
Mar 2022
academic.oup.com academic.oup.com

Mst1/2 is necessary for satellite cell differentiation to promote muscle regeneration

1
1. scibot 02 Mar 2022
  
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  RRID:AB_1642229
  
  DOI: 10.1093/stmcls/sxab010
  
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academic.oup.com/stmcls/advance-article/doi/10.1093/stmcls/sxab010/6511691
Jan 2022
onlinelibrary.wiley.com onlinelibrary.wiley.com

SKI-G-801, an AXL kinase inhibitor, blocks metastasis through inducing anti-tumor immune responses and potentiates anti-PD-1 therapy in mouse cancer models

1
1. scibot 05 Jan 2022
  
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  3638
  
  DOI: 10.1002/cti2.1364
  
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onlinelibrary.wiley.com/doi/10.1002/cti2.1364
Aug 2021
www.nature.com www.nature.com

Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer

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1. scibot 15 Aug 2021
  
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  RRID:AB_1642229
  
  DOI: 10.1038/s41467-021-24687-4
  
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nature.com/articles/s41467-021-24687-4
Jul 2021
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  DOI: 10.1111/jnc.14144
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14144
May 2021
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Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis

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  DOI: 10.1016/j.cmet.2021.03.003
  
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sciencedirect.com/science/article/pii/S1550413121001108
Apr 2021
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Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor

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  DOI: 10.1016/j.chembiol.2021.04.004
  
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Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

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  DOI: 10.1016/j.ccell.2020.07.008
  
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sciencedirect.com/science/article/pii/S153561082030369X
Feb 2021
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Myeloid-derived Growth Factor Promotes Intestinal Glucagon-like Peptide-1 Production in Male Mice with Type 2 Diabetes

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  DOI: 10.1210/endocr/bqaa003
  
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academic.oup.com/endo/article/161/2/bqaa003/5698328
Dec 2020
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Translation in amino-acid-poor environments is limited by tRNAGln charging

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  DOI: 10.7554/eLife.62307
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7744096/
Nov 2020
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G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program

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  DOI: 10.1016/j.celrep.2020.108341
  
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An epilepsy‐associated ACTL6B variant captures neuronal hyperexcitability in a human induced pluripotent stem cell model

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onlinelibrary.wiley.com/doi/10.1002/jnr.24747
Sep 2020
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Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2

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Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis

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ncbi.nlm.nih.gov/pmc/articles/PMC7321798/
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Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

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sciencedirect.com/science/article/pii/S0092867420303457
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PRC1 Catalytic Activity Is Central to Polycomb System Function

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advances.sciencemag.org advances.sciencemag.org

Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity

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An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling

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Untitled document

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Untitled document

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MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis

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  DOI: 10.1016/j.molcel.2018.09.031
  
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sciencedirect.com/science/article/pii/S1097276518308025
Nov 2018
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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

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EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation

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sciencedirect.com/science/article/pii/S1535610818302290
Nov 2017
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Inhibition of histone deacetylase 1 or 2 reduces induced cytokine expression in microglia through a protein synthesis independent mechanism

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onlinelibrary.wiley.com/doi/10.1111/jnc.14144/full