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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition

1
1. scibot 06 Jun 2026
  
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  RRID:AB_1842235
  
  DOI: 10.1158/0008-5472.CAN-25-3625
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13237827/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas

1
1. scibot 05 Jun 2026
  
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  RRID:AB_1842235
  
  DOI: 10.1158/2159-8290.CD-25-0734
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13227558/
May 2026
www.sciencedirect.com www.sciencedirect.com

Disrupted molecular glue complex drives RAS inhibitor resistance

1
1. scibot 06 May 2026
  
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  RRID:AB_1842235
  
  DOI: 10.1016/j.cell.2026.03.031
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
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sciencedirect.com/science/article/pii/S0092867426003326
Apr 2026
www.sciencedirect.com www.sciencedirect.com

Anticancer activity of RAS-GTP inhibition in cholangiocarcinoma

1
1. scibot 24 Apr 2026
  
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  RRID:AB_1842235
  
  DOI: 10.1016/j.ccell.2026.03.020
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
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sciencedirect.com/science/article/pii/S1535610826001741
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Mutant and Wild-type RAS Crosstalk and Stoichiometric Deficiencies are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma

1
1. scibot 18 Apr 2026
  
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  RRID:AB_1842235
  
  DOI: 10.1158/0008-5472.CAN-25-0018
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13080315/
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells

1
1. scibot 30 Jan 2026
  
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  RRID:AB_1842235
  
  DOI: 10.1038/s41419-025-08362-w
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12847887/
www.sciencedirect.com www.sciencedirect.com

Protocols to evaluate mutant specificity of an oncogene-targeting siRNA using orthogonal in vitro and in vivo approaches

1
1. scibot 13 Jan 2026
  
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  RRID:AB_1842235
  
  DOI: 10.1016/j.xpro.2025.104323
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
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sciencedirect.com/science/article/pii/S2666166725007294
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer

1
1. scibot 15 Nov 2025
  
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  RRID:AB_1842235
  
  DOI: 10.1158/0008-5472.CAN-24-4501
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12614194/
Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Pancreatic Cells Are Resistant to KRASQ61L Expression due to Hyperactive ERK/MAPK Signaling and Apoptosis Induction

1
1. scibot 25 Oct 2025
  
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  RRID:AB_1842235
  
  DOI: 10.1158/2767-9764.CRC-25-0281
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12541299/
www.sciencedirect.com www.sciencedirect.com

P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity

1
1. scibot 16 Oct 2025
  
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  RRID:AB_1842235
  
  DOI: 10.1016/j.celrep.2025.116403
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
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sciencedirect.com/science/article/pii/S221112472501174X
www.science.org www.science.org

Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer

1
1. scibot 04 Oct 2025
  
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  RRID:AB_1842235
  
  DOI: 10.1126/scisignal.adu7145
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1842235
  
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science.org/doi/10.1126/scisignal.adu7145
Jun 2025
www.sciencedirect.com www.sciencedirect.com

A first-in-class EGFR-directed KRAS G12V selective inhibitor

1
1. scibot 21 Jun 2025
  
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  RRID:AB_1842235
  
  DOI: 10.1016/j.ccell.2025.05.016
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
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  SciCrunch record: RRID:AB_1842235
  
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sciencedirect.com/science/article/pii/S1535610825002259
Sep 2024
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

1
1. scibot 15 Sep 2024
  
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  RRID:AB_1842235
  
  DOI: 10.1002/1878-0261.13725
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1842235
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13725
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

1
1. scibot 21 Aug 2024
  
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  RRID:AB_1842235
  
  DOI: 10.1126/science.adk0775
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer

1
1. scibot 21 Aug 2024
  
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  RRID:AB_1842235
  
  DOI: 10.1126/science.adk0850
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11301400/
www.sciencedirect.com www.sciencedirect.com

The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes

1
1. scibot 19 Aug 2024
  
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  AB_1842235
  
  DOI: 10.1016/j.isci.2024.110499
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1842235
  
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sciencedirect.com/science/article/pii/S2589004224017243
Jul 2024
www.science.org www.science.org

Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

1
1. scibot 18 Jul 2024
  
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  RRID:AB_1842235
  
  DOI: 10.1126/science.adk0775
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1842235
  
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science.org/doi/10.1126/science.adk0775
www.science.org www.science.org

Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer

1
1. scibot 18 Jul 2024
  
  in Public
  
  RRID:AB_1842235
  
  DOI: 10.1126/science.adk0850
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1842235
  
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  RRID:AB_1842235
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science.org/doi/10.1126/science.adk0850
Feb 2024
52.53.155.43 52.53.155.43

RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation

1
1. scibot 22 Feb 2024
  
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  RRID:AB_1842235
  
  DOI: 10.1101/2023.10.05.561021
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @scibot
  
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52.53.155.43/19126de606c776a10e00c0c9a385ef3636eaaf16/2023.10.05.561021v2.full (1)-html.html
Oct 2023
www.cell.com www.cell.com

Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer

1
1. scibot 06 Oct 2023
  
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  RRID:AB_1842235
  
  DOI: 10.1016/j.celrep.2023.113003
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1842235
  
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  RRID:AB_1842235
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cell.com/cell-reports/abstract/S2211-1247(23)01014-8
Sep 2023
www.sciencedirect.com www.sciencedirect.com

Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion

1
1. scibot 01 Sep 2023
  
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  RRID:AB_1842235
  
  DOI: 10.1016/j.celrep.2023.113042
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1842235
  
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  RRID:AB_1842235
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sciencedirect.com/science/article/pii/S2211124723010537
Jul 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Aberrant expression and subcellular localization of ECT2 drives colorectal cancer progression and growth

1
1. scibot 06 Jul 2022
  
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  RRID:AB_1842235
  
  DOI: 10.1158/0008-5472.CAN-20-4218
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9056178/
May 2022
elifesciences.org elifesciences.org

Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

1
1. scibot 11 May 2022
  
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  RRID:AB_1842235
  
  DOI: 10.7554/eLife.76495
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1842235
  
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  RRID:AB_1842235
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elifesciences.org/articles/76495
Dec 2021
www.sciencedirect.com www.sciencedirect.com

Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach

1
1. scibot 15 Dec 2021
  
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  WH0003845M1
  
  DOI: 10.1016/j.celrep.2021.110096
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_1842235
  
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  RRIDCUR:Missing RRID:AB_1842235
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sciencedirect.com/science/article/pii/S2211124721015904
www.sciencedirect.com www.sciencedirect.com

CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment

1
1. scibot 01 Dec 2021
  
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  RRID:AB_1842235
  
  DOI: 10.1016/j.celrep.2021.110060
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1842235
  
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sciencedirect.com/science/article/pii/S2211124721015461
Jun 2021
www.sciencedirect.com www.sciencedirect.com

Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

1
1. scibot 30 Jun 2021
  
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  RRID:AB_1842235
  
  DOI: 10.1016/j.celrep.2021.109291
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2211124721006628
Sep 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System

1
1. scibot 11 Sep 2020
  
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  RRID:AB_1842235
  
  DOI: 10.1016/j.chembiol.2020.06.012
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_1842235
  
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  RRIDCUR:Validated RRID:AB_1842235
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RRIDCUR:Validated

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pubmed.ncbi.nlm.nih.gov/32668202/
www.mdpi.com www.mdpi.com

Statin Drugs Plus Th1 Cytokines Potentiate Apoptosis and Ras Delocalization in Human Breast Cancer Lines and Combine with Dendritic Cell-Based Immunotherapy to Suppress Tumor Growth in a Mouse Model of HER-2pos Disease

1
1. scibot 04 Sep 2020
  
  in Public
  
  K-Ras
  
  DOI: 10.3390/vaccines8010072
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_1842235
  
  Curator comments: Monoclonal Anti-KRAS antibody produced in mouse Sigma-Aldrich Cat# WH0003845M1
  
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  RRID:AB_1842235 RRIDCUR:Missing
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mdpi.com/2076-393X/8/1/72
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

1
1. scibot 13 Jan 2020
  
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  RRID:AB_1842235
  
  DOI: 10.1016/j.molcel.2019.09.004
  
  Resource: (Sigma-Aldrich Cat# WH0003845M1, RRID:AB_1842235)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_1842235
  
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  RRID:AB_1842235 RRIDCUR:Validated
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RRIDCUR:Validated

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sciencedirect.com/science/article/pii/S1097276519306896