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Targeting the noncanonical function of metabolic enzyme PHGDH in driving PD-L1 expression and cancer immune evasion

1
1. scibot 31 Mar 2026
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.xcrm.2026.102704
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
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sciencedirect.com/science/article/pii/S2666379126001217
Sep 2025
rupress.org rupress.org

Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation

1
1. scibot 16 Sep 2025
  
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  RRID:AB_1855299
  
  DOI: 10.1084/jem.20250185
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
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rupress.org/jem/article/222/11/e20250185/278317/Autoimmune-disease-risk-gene-ANKRD55-promotes-TH17
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability

1
1. scibot 16 Jul 2025
  
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  RRID:AB_1855299
  
  DOI: 10.1158/0008-5472.CAN-24-2471
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11735329/
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Failure to repair damaged NAD(P)H blocks de novo serine synthesis in human cells

1
1. scibot 15 Jan 2025
  
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  RRID:AB_1855299
  
  DOI: 10.1186/s11658-024-00681-8
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11715087/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

MYC Drives mRNA Pseudouridylation to Mitigate Proliferation-Induced Cellular Stress during Cancer Development

1
1. scibot 12 Dec 2024
  
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  RRID:AB_1855299
  
  DOI: 10.1158/0008-5472.CAN-24-1102
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11609627/
Sep 2024
cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

2
1. scibot 25 Sep 2024
  
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  RRID:AB_1855299
  
  DOI: 10.1158/2159-8290.CD-19-1228
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_1855299
  
  Curator comments: Nuclear mitotic apparatus protein antibody Abcam Cat# ab97585
  
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  RRID:AB_1855299 RRID:AB_10680001 RRIDCUR:Incorrect
2. scibot 25 Sep 2024
  
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  RRID:AB_10680001
  
  DOI: 10.1158/2159-8290.CD-19-1228
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_1855299
  
  Curator comments: Anti-PHGDH antibody produced in rabbit Sigma-Aldrich Cat# HPA021241
  
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  RRID:AB_1855299 RRID:AB_10680001 RRIDCUR:Incorrect
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cancerdiscovery.aacrjournals.org/content/10/9/1352
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Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides

1
1. scibot 25 Sep 2024
  
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  RRID:AB_1855399
  
  DOI: 10.1016/j.cmet.2018.09.001
  
  Resource: (Sigma-Aldrich Cat# K1142, RRID:AB_1855399)
  
  Curator: @Jmenke
  
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  RRID:AB_1855399 RRID:AB_1855299 RRIDCUR:Incorrect
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sciencedirect.com/science/article/pii/S1550413118305667
Aug 2024
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Serine and glycine physiology reversibly modulate retinal and peripheral nerve function

1
1. scibot 27 Aug 2024
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.cmet.2024.07.021
  
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sciencedirect.com/science/article/pii/S1550413124003231
May 2024
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Central carbon metabolism exhibits unique characteristics during the handling of fungal patterns by monocyte-derived dendritic cells

2
1. scibot 14 May 2024
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.redox.2024.103187
  
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2. scibot 14 May 2024
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.redox.2024.103187
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2213231724001654
Mar 2024
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PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

1
1. scibot 01 Mar 2024
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.celrep.2024.113868
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
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sciencedirect.com/science/article/pii/S2211124724001967
Sep 2023
www.nature.com www.nature.com

Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

1
1. scibot 22 Sep 2023
  
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  RRID:AB_1855299
  
  DOI: 10.1038/s41422-023-00874-4
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @scibot
  
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nature.com/articles/s41422-023-00874-4
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses

1
1. scibot 08 Jul 2023
  
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  AB_1855299
  
  DOI: 10.1158/2643-3230.BCD-22-0029
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9816815/
May 2023
52.53.155.43 52.53.155.43

Spatially Resolved Proteomic Profiling Uncovers Structural and Functional Regulators of the Axon Initial Segment

1
1. scibot 25 May 2023
  
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  HPA021241
  
  DOI: 10.1101/2023.03.06.531334
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @anisehay
  
  SciCrunch record: RRID:AB_1855299
  
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52.53.155.43/1b0cedf04512903e90b9ef1858ffefd94df1235f/2023.03.06.531334v1.full-html.html
Feb 2023
www.sciencedirect.com www.sciencedirect.com

PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy

1
1. scibot 23 Feb 2023
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.cmet.2023.01.010
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1550413123000104
Nov 2022
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Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells

1
1. scibot 03 Nov 2022
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.molcel.2022.10.005
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1097276522009625
May 2022
www.nature.com www.nature.com

Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis

1
1. scibot 17 May 2022
  
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  RRID:AB_1855299
  
  DOI: 10.1038/s41467-022-30363-y
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @scibot
  
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nature.com/articles/s41467-022-30363-y
aacrjournals.org aacrjournals.org

Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis

1
1. scibot 13 May 2022
  
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  RRID:AB_1855299
  
  DOI: 10.1158/2159-8290.CD-21-1006
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1855299
  
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aacrjournals.org/cancerdiscovery/article/12/5/1314/694563/Melanoma-Secreted-Amyloid-Beta-Suppresses
Jan 2022
www.sciencedirect.com www.sciencedirect.com

Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors

1
1. scibot 19 Jan 2022
  
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  AB_1855299
  
  DOI: 10.1016/j.celrep.2021.110278
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2211124721017939
Sep 2021
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ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction

1
1. scibot 22 Sep 2021
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.celrep.2021.109706
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
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sciencedirect.com/science/article/pii/S2211124721011530
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells

1
1. scibot 15 Aug 2021
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.cmet.2021.07.015
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
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sciencedirect.com/science/article/pii/S1550413121003314
Apr 2021
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Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

1
1. scibot 24 Apr 2021
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.cell.2020.10.016
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S0092867420313222
Feb 2021
www.nature.com www.nature.com

Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities

1
1. scibot 25 Feb 2021
  
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  RRID:AB_1855299
  
  DOI: 10.1038/s41467-020-17139-y
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
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nature.com/articles/s41467-020-17139-y
www.cell.com www.cell.com

In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

1
1. scibot 25 Feb 2021
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.molcel.2020.11.027
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_1855299
  
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  RRIDCUR:Validated RRID:AB_1855299
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cell.com/molecular-cell/fulltext/S1097-2765(20)30827-3
www.cell.com www.cell.com

Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation

1
1. scibot 24 Feb 2021
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.celrep.2020.01.011
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @scibot
  
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cell.com/cell-reports/abstract/S2211-1247(20)30020-6
Jan 2021
www.sciencedirect.com www.sciencedirect.com

Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma

1
1. scibot 28 Jan 2021
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.celrep.2020.108678
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_1855299
  
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  RRID:AB_1855299 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720316673
Sep 2020
www.cell.com www.cell.com

Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation

1
1. scibot 17 Sep 2020
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.celrep.2020.01.011
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_1855299
  
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  RRIDCUR:Validated RRID:AB_1855299
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cell.com/cell-reports/abstract/S2211-1247(20)30020-6
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer

1
1. scibot 13 Jan 2020
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.ccell.2019.01.018
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_1855299
  
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  RRID:AB_1855299 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610819300522
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 13 Jan 2020
  
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  RRID:AB_1855299
  
  DOI: 10.1016/j.cmet.2019.02.015
  
  Resource: (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_1855299
  
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  RRID:AB_1855299 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1550413119301251
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells

1
1. scibot 05 Nov 2018
  
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  RRID:AB_1855299
  
  Resource used:
  
  (Sigma-Aldrich Cat# HPA021241, RRID:AB_1855299)
  
  SciCrunch record: RRID:AB_1855299
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_1855299
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sciencedirect.com/science/article/pii/S1550413118303917