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The transcription factor BACH1 couples chromatin priming and repression to enable macrophage plasticity and adaptation

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1. scibot 20 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.022
  
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sciencedirect.com/science/article/pii/S1074761326002736
Jun 2026
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EZH1/2 inhibition improves immunotherapy response through MHC Class II de-repression and neutrophil reprogramming

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1. scibot 11 Jun 2026
  
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  DOI: 10.64898/2026.06.01.725956
  
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biorxiv.org/content/10.64898/2026.06.01.725956v1
Apr 2026
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MMP8 mediates CD115 cleavage-dependent elimination of large peritoneal macrophages in response to microbial exposure

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1. scibot 16 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117234
  
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sciencedirect.com/science/article/pii/S2211124726003128
Mar 2026
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Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer

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sciencedirect.com/science/article/pii/S1535610826001066
Feb 2026
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Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection

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1. scibot 26 Feb 2026
  
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Protocol for modeling innate immune training by repeated alum exposure in mice (adjuvant conditioning)

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1. scibot 24 Feb 2026
  
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Glutamine metabolism tunes myeloid responses to drive resolution of inflammation during skin repair

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1. scibot 19 Feb 2026
  
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Jan 2026
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Innate lymphoid cells activated by the cytokine TL1A link colitis to emergency granulopoiesis and the recruitment of tumor-promoting neutrophils

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In vivo detection of immune responses via cytokine activity labeling

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1. scibot 08 Jan 2026
  
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sciencedirect.com/science/article/pii/S0092867425014242
Dec 2025
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BFAR promotes neutrophil infiltration and immunosuppressive reprogramming through the PRP19-YBX1 axis to induce immune evasion in gastric cancer

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1. scibot 06 Dec 2025
  
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  DOI: 10.1158/2326-6066.CIR-24-1011
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12670071/
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Depleting IL1R2+ Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti–PD-1 Immunotherapy

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1. scibot 03 Dec 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-3095
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12666320/
Nov 2025
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Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity

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1. scibot 29 Nov 2025
  
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sciencedirect.com:5037/science/article/pii/S0092867425012474
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Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling

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1. scibot 15 Nov 2025
  
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  DOI: 10.1016/j.isci.2025.113862
  
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Developing a therapeutic elastase that stimulates anti-tumor immunity by selectively killing cancer cells

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1. scibot 13 Nov 2025
  
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  DOI: 10.1016/j.xcrm.2025.102446
  
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sciencedirect.com/science/article/pii/S2666379125005191
Oct 2025
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RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition

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1. scibot 28 Oct 2025
  
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  DOI: 10.1016/j.ccell.2025.09.014
  
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sciencedirect.com/science/article/pii/S1535610825004064
Aug 2025
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Biomimetic nanoimmunotherapy boosts spatiotemporal PANoptosis and reshapes desmoplastic tumor microenvironment

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102312
  
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sciencedirect.com/science/article/pii/S2666379125003854
Jul 2025
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Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102251
  
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sciencedirect.com/science/article/pii/S2666379125003246
Jun 2025
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Targeting the CD40 costimulatory receptor to improve virotherapy efficacy in diffuse midline gliomas

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102204
  
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Bile acids activate cancer-associated fibroblasts and induce an immunosuppressive microenvironment in cholangiocarcinoma

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.ccell.2025.05.017
  
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sciencedirect.com/science/article/pii/S1535610825002260
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The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

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1. scibot 18 Jun 2025
  
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sciencedirect.com/science/article/pii/S0092867425006166
May 2025
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Acyloxyacyl Hydrolase Prevents Colitis and Colitis-Associated Colorectal Cancer by Inactivating Stimulatory LPS in the Intestine

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1. scibot 19 May 2025
  
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  DOI: 10.1096/fj.202500310R
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202500310R
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Trajectories of macrophage ontogeny and reprogramming in cancer

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  DOI: 10.1016/j.isci.2025.112498
  
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Apr 2025
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Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.cell.2025.03.020
  
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Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance

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1. scibot 02 Apr 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11444901/
Feb 2025
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ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation

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β2 integrin regulates neutrophil trans endothelial migration following traumatic brain injury

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1. scibot 11 Feb 2025
  
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  DOI: 10.1186/s12964-025-02071-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11806581/
Sep 2024
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Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.celrep.2019.12.028
  
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sciencedirect.com/science/article/pii/S221112471931678X
Aug 2024
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Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells

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1. scibot 23 Aug 2024
  
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  DOI: 10.7554/eLife.76940
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11333044/
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A postnatal peak in microglial development in the mouse hippocampus is correlated with heightened sensitivity to seizure triggers

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  DOI: 10.1002/brb3.403
  
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onlinelibrary.wiley.com/doi/10.1002/brb3.403/full
Jun 2024
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STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

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  DOI: 10.1016/j.cell.2024.05.031
  
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May 2024
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An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination

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  DOI: 10.1016/j.immuni.2024.05.005
  
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Apr 2024
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Early-life vitamin A treatment rescues neonatal infection-induced durably impaired tolerogenic properties of celiac lymph nodes

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  DOI: 10.1016/j.celrep.2024.114153
  
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A LTB4/CD11b self-amplifying loop drives pyogranuloma formation in chronic granulomatous disease

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1. scibot 18 Apr 2024
  
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  DOI: 10.1016/j.isci.2024.109589
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11016758/
Mar 2024
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Stress-free single-cell transcriptomic profiling and functional genomics of murine eosinophils

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1. scibot 26 Mar 2024
  
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  DOI: 10.1038/s41596-024-00967-3
  
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nature.com/articles/s41596-024-00967-3
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Ly6C+ monocytes in the skin promote systemic alphavirus dissemination

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  DOI: 10.1016/j.celrep.2024.113876
  
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Jan 2024
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Characterization of immune populations in the tumor microenvironment of diffuse midline glioma orthotopic mouse models by flow cytometry

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Evaluation of murine renal phagocyte-fungal interactions using intravital confocal microscopy and flow cytometry

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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

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Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection

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An agonistic anti-signal regulatory protein α antibody for chronic inflammatory diseases

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Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis

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The enteric nervous system relays psychological stress to intestinal inflammation

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C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection

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NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection

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Impact of mouse model tumor implantation site on acquired resistance to anti-PD-1 immune checkpoint therapy

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SARS-CoV-2 variants induce distinct disease and impact in the bone marrow and thymus of mice

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Capsaicin shapes gut microbiota and pre-metastatic niche to facilitate cancer metastasis to liver

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The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity

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MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

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Intestinal inflammation alters the antigen-specific immune response to a skin commensal

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PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms

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Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection

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Heterogeneity of tyrosine-based melanin anabolism regulates pulmonary and cerebral organotropic colonization microenvironment of melanoma cells

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Feb 2022
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Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation

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An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity

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Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord

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Macrophage calcium reporter mice reveal immune cell communication in vitro and in vivo

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CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection

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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

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Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis

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Modulating tumor infiltrating myeloid cells to enhance bispecific antibody-driven T cell infiltration and anti-tumor response

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Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope

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Untitled document

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Untitled document

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A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection

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Pseudomonas aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation

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TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma

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Ultra-low Dose Aerosol Infection of Mice with Mycobacterium tuberculosis More Closely Models Human Tuberculosis

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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

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Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis

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1. scibot 12 Apr 2021
  
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  DOI: 10.1016/j.cell.2021.01.051
  
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sciencedirect.com/science/article/pii/S0092867421000945
Dec 2020
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Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

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1. scibot 10 Dec 2020
  
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  DOI: 10.1016/j.cell.2020.11.025
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7674074/
Sep 2020
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Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition

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1. scibot 16 Sep 2020
  
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  DOI: 10.1016/j.chom.2020.03.001
  
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cell.com/cell-host-microbe/fulltext/S1931-3128(20)30124-4
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Targeting Lymph Node Niches Enhances Type 1 Immune Responses to Immunization

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1. scibot 11 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107679
  
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Characterization of Resident Corneal Plasmacytoid Dendritic Cells and Their Pivotal Role in Herpes Simplex Keratitis

1
1. scibot 09 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.108099
  
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Innate immune response in neuronopathic forms of Gaucher disease confers resistance against viral-induced encephalitis

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1. scibot 05 Sep 2020
  
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  DOI: 10.1186/s40478-020-01020-6
  
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Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System

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1. scibot 04 Sep 2020
  
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  anti-Ly6G (1A8
  
  DOI: 10.1016/j.celrep.2020.02.109
  
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Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

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1. scibot 04 Sep 2020
  
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  DOI: 10.7554/eLife.53627
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7062472/
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Altered Immunity of Laboratory Mice in the Natural Environment Is Associated with Fungal Colonization

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1. scibot 03 Sep 2020
  
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  DOI: 10.1016/j.chom.2020.02.015
  
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sciencedirect.com/science/article/pii/S1931312820301232
Jan 2020
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Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cmet.2019.10.014
  
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Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.immuni.2019.06.014
  
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Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.chom.2019.10.007
  
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Absence of infiltrating peripheral myeloid cells in the brains of mouse models of lysosomal storage disorders

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1. scibot 13 Jan 2020
  
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  DOI: 10.1111/jnc.14483
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14483
Nov 2018
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An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis

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1. scibot 05 Nov 2018
  
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Alveolar Macrophages Provide an Early Mycobacterium tuberculosis Niche and Initiate Dissemination

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1. scibot 05 Nov 2018
  
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Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis

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1. scibot 05 Nov 2018
  
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The Cytokine TGF-β Promotes the Development and Homeostasis of Alveolar Macrophages

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1074761317304612
Nov 2017
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A postnatal peak in microglial development in the mouse hippocampus is correlated with heightened sensitivity to seizure triggers

2
1. scibot 08 Nov 2017
  
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2. scibot 08 Nov 2017
  
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  AB_1877271
  
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onlinelibrary.wiley.com/doi/10.1002/brb3.403/full

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