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RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition

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1. scibot 28 Oct 2025
  
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  DOI: 10.1016/j.ccell.2025.09.014
  
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sciencedirect.com/science/article/pii/S1535610825004064
Aug 2025
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Biomimetic nanoimmunotherapy boosts spatiotemporal PANoptosis and reshapes desmoplastic tumor microenvironment

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102312
  
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sciencedirect.com/science/article/pii/S2666379125003854
Jul 2025
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Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102251
  
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sciencedirect.com/science/article/pii/S2666379125003246
Jun 2025
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Targeting the CD40 costimulatory receptor to improve virotherapy efficacy in diffuse midline gliomas

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1. scibot 28 Jun 2025
  
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sciencedirect.com/science/article/pii/S2666379125002770
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Bile acids activate cancer-associated fibroblasts and induce an immunosuppressive microenvironment in cholangiocarcinoma

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sciencedirect.com/science/article/pii/S1535610825002260
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The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

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1. scibot 18 Jun 2025
  
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sciencedirect.com/science/article/pii/S0092867425006166
May 2025
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Acyloxyacyl Hydrolase Prevents Colitis and Colitis-Associated Colorectal Cancer by Inactivating Stimulatory LPS in the Intestine

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1. scibot 19 May 2025
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202500310R
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Trajectories of macrophage ontogeny and reprogramming in cancer

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1. scibot 18 May 2025
  
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sciencedirect.com/science/article/pii/S258900422500759X
Apr 2025
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Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens

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1. scibot 05 Apr 2025
  
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Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance

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1. scibot 02 Apr 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11444901/
Feb 2025
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ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation

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1. scibot 13 Feb 2025
  
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β2 integrin regulates neutrophil trans endothelial migration following traumatic brain injury

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1. scibot 11 Feb 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11806581/
Sep 2024
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Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.celrep.2019.12.028
  
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sciencedirect.com/science/article/pii/S221112471931678X
Aug 2024
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Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells

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1. scibot 23 Aug 2024
  
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  DOI: 10.7554/eLife.76940
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11333044/
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A postnatal peak in microglial development in the mouse hippocampus is correlated with heightened sensitivity to seizure triggers

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1. scibot 02 Aug 2024
  
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  DOI: 10.1002/brb3.403
  
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onlinelibrary.wiley.com/doi/10.1002/brb3.403/full
Jun 2024
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STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.cell.2024.05.031
  
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May 2024
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An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination

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1. scibot 31 May 2024
  
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  DOI: 10.1016/j.immuni.2024.05.005
  
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sciencedirect.com/science/article/pii/S1074761324002589
Apr 2024
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Early-life vitamin A treatment rescues neonatal infection-induced durably impaired tolerogenic properties of celiac lymph nodes

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114153
  
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A LTB4/CD11b self-amplifying loop drives pyogranuloma formation in chronic granulomatous disease

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1. scibot 18 Apr 2024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11016758/
Mar 2024
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Stress-free single-cell transcriptomic profiling and functional genomics of murine eosinophils

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1. scibot 26 Mar 2024
  
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  DOI: 10.1038/s41596-024-00967-3
  
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nature.com/articles/s41596-024-00967-3
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Ly6C+ monocytes in the skin promote systemic alphavirus dissemination

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1. scibot 06 Mar 2024
  
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sciencedirect.com/science/article/pii/S2211124724002043
Jan 2024
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Characterization of immune populations in the tumor microenvironment of diffuse midline glioma orthotopic mouse models by flow cytometry

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1. scibot 07 Jan 2024
  
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  DOI: 10.1016/j.xpro.2023.102803
  
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Dec 2023
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Evaluation of murine renal phagocyte-fungal interactions using intravital confocal microscopy and flow cytometry

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1. scibot 23 Dec 2023
  
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Oct 2023
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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

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1. scibot 13 Oct 2023
  
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Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection

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1. scibot 13 Oct 2023
  
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  DOI: 10.1016/j.cmet.2023.09.001
  
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sciencedirect.com/science/article/pii/S1550413123003327
Aug 2023
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An agonistic anti-signal regulatory protein α antibody for chronic inflammatory diseases

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1. scibot 26 Aug 2023
  
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  DOI: 10.1016/j.xcrm.2023.101130
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10439247/
Jul 2023
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Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis

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1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112763
  
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May 2023
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The enteric nervous system relays psychological stress to intestinal inflammation

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1. scibot 26 May 2023
  
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  DOI: 10.1016/j.cell.2023.05.001
  
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C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection

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1. scibot 24 May 2023
  
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  DOI: 10.1016/j.cell.2023.04.031
  
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sciencedirect.com/science/article/pii/S0092867423004658
Apr 2023
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NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection

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1. scibot 20 Apr 2023
  
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  DOI: 10.1016/j.celrep.2023.112410
  
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sciencedirect.com/science/article/pii/S2211124723004217
Jan 2023
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Impact of mouse model tumor implantation site on acquired resistance to anti-PD-1 immune checkpoint therapy

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1. scibot 27 Jan 2023
  
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  DOI: 10.3389/fimmu.2022.1011943
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9872099/
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SARS-CoV-2 variants induce distinct disease and impact in the bone marrow and thymus of mice

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1. scibot 27 Jan 2023
  
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  DOI: 10.1016/j.isci.2023.105972
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9838028/
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Capsaicin shapes gut microbiota and pre-metastatic niche to facilitate cancer metastasis to liver

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1. scibot 04 Jan 2023
  
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  DOI: 10.1016/j.phrs.2022.106643
  
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sciencedirect.com/science/article/pii/S1043661822005898
Nov 2022
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The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity

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1. scibot 15 Nov 2022
  
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  DOI: 10.1016/j.immuni.2022.10.020
  
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sciencedirect.com/science/article/pii/S1074761322005611
Sep 2022
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MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

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1. scibot 24 Sep 2022
  
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  DOI: 10.1016/j.ccell.2022.08.015
  
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sciencedirect.com/science/article/pii/S1535610822003798
Jun 2022
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Intestinal inflammation alters the antigen-specific immune response to a skin commensal

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1. scibot 03 Jun 2022
  
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  DOI: 10.1016/j.celrep.2022.110891
  
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PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms

1
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Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection

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Heterogeneity of tyrosine-based melanin anabolism regulates pulmonary and cerebral organotropic colonization microenvironment of melanoma cells

1
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Feb 2022
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Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation

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An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity

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Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord

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Macrophage calcium reporter mice reveal immune cell communication in vitro and in vivo

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CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection

1
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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

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Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis

1
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Modulating tumor infiltrating myeloid cells to enhance bispecific antibody-driven T cell infiltration and anti-tumor response

1
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Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope

1
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Untitled document

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Untitled document

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Untitled document

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A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection

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Apr 2021
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Pseudomonas aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation

1
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TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma

1
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Ultra-low Dose Aerosol Infection of Mice with Mycobacterium tuberculosis More Closely Models Human Tuberculosis

1
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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

1
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Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis

1
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Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

1
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Sep 2020
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Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition

1
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Targeting Lymph Node Niches Enhances Type 1 Immune Responses to Immunization

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Characterization of Resident Corneal Plasmacytoid Dendritic Cells and Their Pivotal Role in Herpes Simplex Keratitis

1
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Innate immune response in neuronopathic forms of Gaucher disease confers resistance against viral-induced encephalitis

1
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  DOI: 10.1186/s40478-020-01020-6
  
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Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System

1
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Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

1
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  DOI: 10.7554/eLife.53627
  
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Altered Immunity of Laboratory Mice in the Natural Environment Is Associated with Fungal Colonization

1
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Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis

1
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Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages

1
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Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria

1
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Absence of infiltrating peripheral myeloid cells in the brains of mouse models of lysosomal storage disorders

1
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  DOI: 10.1111/jnc.14483
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14483
Nov 2018
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An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis

1
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sciencedirect.com/science/article/pii/S0092867418310298
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Alveolar Macrophages Provide an Early Mycobacterium tuberculosis Niche and Initiate Dissemination

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1931312818304104
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Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1550413118300500
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The Cytokine TGF-β Promotes the Development and Homeostasis of Alveolar Macrophages

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1074761317304612
Nov 2017
onlinelibrary.wiley.com onlinelibrary.wiley.com

A postnatal peak in microglial development in the mouse hippocampus is correlated with heightened sensitivity to seizure triggers

2
1. scibot 08 Nov 2017
  
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2. scibot 08 Nov 2017
  
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  AB_1877271
  
  Curator: @jcabotaj
  
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  (BioLegend Cat# 127616, RRID:AB_1877271)
  
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  RRID:AB_1877271 RRIDCUR:Validated
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onlinelibrary.wiley.com/doi/10.1002/brb3.403/full

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