161 Matching Annotations
  1. Jun 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice
    1
    1. scibot 09 Jun 2024
      RRID:AB_1903938

      DOI: 10.1016/j.isci.2024.109991

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    ncbi.nlm.nih.gov/pmc/articles/PMC11154205/
  3. May 2024
  4. www.biorxiv.org www.biorxiv.org
    BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer
    1
    1. scibot 29 May 2024
      RRID:AB_1903938

      DOI: 10.1101/2024.03.09.584256

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    biorxiv.org/content/10.1101/2024.03.09.584256v1
  5. www.sciencedirect.com www.sciencedirect.com
    The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects
    1
    1. scibot 23 May 2024
      RRID:AB_1903938

      DOI: 10.1016/j.immuni.2024.04.026

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    sciencedirect.com/science/article/pii/S1074761324002310
  6. www.sciencedirect.com www.sciencedirect.com
    Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity
    1
    1. scibot 23 May 2024
      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2024.114261

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    sciencedirect.com/science/article/pii/S2211124724005898
  7. www.sciencedirect.com www.sciencedirect.com
    The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells
    1
    1. scibot 14 May 2024
      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2024.114222

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    sciencedirect.com/science/article/pii/S2211124724005503
  8. Apr 2024
  9. www.sciencedirect.com www.sciencedirect.com
    ER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection
    1
    1. scibot 30 Apr 2024
      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2024.114156

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    sciencedirect.com/science/article/pii/S2211124724004844
  10. www.sciencedirect.com www.sciencedirect.com
    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
    1
    1. scibot 11 Apr 2024
      RRID:AB_1903938

      DOI: 10.1016/j.ebiom.2024.105099

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    sciencedirect.com/science/article/pii/S2352396424001348
  11. www.sciencedirect.com www.sciencedirect.com
    Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs
    2
    1. scibot 09 Apr 2024
      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2024.114073

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    2. scibot 09 Apr 2024
      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2024.114073

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    sciencedirect.com/science/article/pii/S2211124724004017
  12. www.sciencedirect.com www.sciencedirect.com
    The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
    1
    1. scibot 04 Apr 2024
      RRID:AB_1903938

      DOI: 10.1016/j.devcel.2024.03.018

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    sciencedirect.com/science/article/pii/S1534580724001837
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma
    1
    1. scibot 03 Apr 2024
      AB_1903938

      DOI: 10.1016/j.xcrm.2024.101472

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    ncbi.nlm.nih.gov/pmc/articles/PMC10983107/
  14. Mar 2024
  15. www.sciencedirect.com www.sciencedirect.com
    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
    2
    1. scibot 29 Mar 2024
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      DOI: 10.1016/j.xcrm.2024.101468

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    2. scibot 29 Mar 2024
      RRID:AB_1903938

      DOI: 10.1016/j.xcrm.2024.101468

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    sciencedirect.com/science/article/pii/S2666379124001149
  16. www.sciencedirect.com www.sciencedirect.com
    A therapeutically targetable positive feedback loop between lnc-HLX-2-7, HLX, and MYC that promotes group 3 medulloblastoma
    1
    1. scibot 12 Mar 2024
      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2024.113938

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    sciencedirect.com/science/article/pii/S2211124724002663
  17. Feb 2024
  18. www.sciencedirect.com www.sciencedirect.com
    Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1
    1
    1. scibot 27 Feb 2024
      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2024.113837

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    sciencedirect.com/science/article/pii/S2211124724001657
  19. 52.53.155.43 52.53.155.43
    Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
    1
    1. scibot 22 Feb 2024
      RRID:AB_19

      DOI: 10.1101/2023.10.02.560521

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    52.53.155.43/4a182fdd92d1ce35b13f136f7657c6c9ec6a6224/2023.10.02.560521v1.full-html.html
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    G-quadruplex DNA structure is a positive regulator of MYC transcription
    1
    1. scibot 21 Feb 2024
      RRID:AB_1903938

      DOI: 10.1073/pnas.2320240121

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    ncbi.nlm.nih.gov/pmc/articles/PMC10873556/
  21. www.sciencedirect.com www.sciencedirect.com
    Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer
    1
    1. scibot 16 Feb 2024
      RRID:AB_1903938

      DOI: 10.1016/j.molmet.2024.101900

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    sciencedirect.com/science/article/pii/S2212877824000310
  22. www.sciencedirect.com www.sciencedirect.com
    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
    1
    1. scibot 09 Feb 2024
      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2024.113714

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    sciencedirect.com/science/article/pii/S2211124724000421
  23. www.biorxiv.org www.biorxiv.org
    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
    1
    1. scibot 04 Feb 2024
      RRID:AB_1903938

      DOI: 10.1101/2023.09.28.560054

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    biorxiv.org/content/10.1101/2023.09.28.560054v1
  24. Jan 2024
  25. www.sciencedirect.com www.sciencedirect.com
    Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor
    1
    1. scibot 09 Jan 2024
      RRID:AB_1903938

      DOI: 10.1016/j.xcrm.2023.101354

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    sciencedirect.com/science/article/pii/S2666379123005712
  26. Dec 2023
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery
    1
    1. scibot 22 Dec 2023
      RRID:AB_1903938

      DOI: 10.1038/s41467-023-43614-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC10730884/
  28. www.sciencedirect.com www.sciencedirect.com
    ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors
    1
    1. scibot 20 Dec 2023
      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2023.113541

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    sciencedirect.com/science/article/pii/S221112472301553X
  29. www.sciencedirect.com www.sciencedirect.com
    Subtype-selective prenylated isoflavonoids disrupt regulatory drivers of MYCN-amplified cancers
    1
    1. scibot 20 Dec 2023
      RRID:AB_1903938

      DOI: 10.1016/j.chembiol.2023.11.007

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    sciencedirect.com/science/article/pii/S2451945623004221
  30. www.sciencedirect.com www.sciencedirect.com
    SON is an essential m6A target for hematopoietic stem cell fate
    1
    1. scibot 17 Dec 2023
      RRID:AB_1903938

      DOI: 10.1016/j.stem.2023.11.006

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    sciencedirect.com/science/article/pii/S1934590923003983
  31. www.sciencedirect.com www.sciencedirect.com
    An oncogenic phenoscape of colonic stem cell polarization
    2
    1. scibot 17 Dec 2023
      RRID:AB_1903938

      DOI: 10.1016/j.cell.2023.11.004

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    2. scibot 17 Dec 2023
      RRID:AB_1903938

      DOI: 10.1016/j.cell.2023.11.004

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    sciencedirect.com/science/article/pii/S0092867423012217
  32. Nov 2023
  33. www.sciencedirect.com www.sciencedirect.com
    mTORC1 promotes cell growth via m6A-dependent mRNA degradation
    1
    1. scibot 18 Nov 2023
      RRID:AB_1903938

      DOI: 10.1016/j.molcel.2021.03.010

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    sciencedirect.com/science/article/pii/S1097276521001787
  34. www.sciencedirect.com www.sciencedirect.com
    Detection of early prognostic biomarkers for metastasis of Ewing's sarcoma in pediatric patients
    1
    1. scibot 10 Nov 2023
      RRID:AB_1903938

      DOI: 10.1016/j.lfs.2023.122237

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    sciencedirect.com/science/article/pii/S002432052300872X
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
    2
    1. scibot 04 Nov 2023
      RRID:AB_1903938

      DOI: 10.1126/science.adh5021

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      RRID:AB_1903938

      DOI: 10.1126/science.adh5021

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    ncbi.nlm.nih.gov/pmc/articles/PMC10617673/
  36. link.springer.com link.springer.com
    MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice
    1
    1. scibot 03 Nov 2023
      RRID:AB_1903938

      DOI: 10.1186/s40478-023-01654-2

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    link.springer.com/article/10.1186/s40478-023-01654-2
  37. Oct 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
    1
    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113198

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    sciencedirect.com/science/article/pii/S221112472301210X
  39. www.science.org www.science.org
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
    1
    1. scibot 17 Oct 2023
      RRID:AB_1903938

      DOI: 10.1126/science.adh5021

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    science.org/doi/10.1126/science.adh5021
  40. www.sciencedirect.com www.sciencedirect.com
    High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription
    1
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      DOI: 10.1016/j.chom.2023.09.003

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    sciencedirect.com/science/article/pii/S1931312823003700
  41. www.sciencedirect.com www.sciencedirect.com
    TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2
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      DOI: 10.1016/j.celrep.2023.113231

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    sciencedirect.com/science/article/pii/S2211124723012433
  42. Sep 2023
  43. www.cell.com www.cell.com
    Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation
    1
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      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2023.113079

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    cell.com/cell-reports/fulltext/S2211-1247(23)01090-2
  44. Aug 2023
  45. www.science.org www.science.org
    A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
    1
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      RRID:AB_1903938

      DOI: 10.1126/scisignal.ade6737

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    science.org/doi/10.1126/scisignal.ade6737
  46. www.sciencedirect.com www.sciencedirect.com
    Modelling Duchenne muscular dystrophy in vitro with newly generated, blood cell-derived induced pluripotent stem cell line ORIONi003-A
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    1. scibot 28 Aug 2023
      RRID:AB_1903938

      DOI: 10.1016/j.scr.2023.103187

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    sciencedirect.com/science/article/pii/S1873506123001733
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    Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy
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    1. scibot 23 Aug 2023
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      DOI: 10.1016/j.celrep.2023.113016

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    sciencedirect.com/science/article/pii/S2211124723010276
  48. 52.53.155.43 52.53.155.43
    A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis
    2
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      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2023.112961

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    2. scibot 10 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112961

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    Inhibition of heterogeneous nuclear ribonucleoproteins A1 and oxidative stress reduces glycolysis pyruvate kinase M2 in chronic thromboembolic pulmonary hypertension
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  60. Mar 2023
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  63. Feb 2023
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    Piperlongumine conjugates induce targeted protein degradation
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  67. Jan 2023
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    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
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    GOT1 regulates CD8+ effector and memory T cell generation
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    The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria
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  71. Nov 2022
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    Title: Generation and characterization of a human induced pluripotent stem cell (iPSC) line from a patient with congenital heart disease (CHD)
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  73. Oct 2022
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    Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors
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  75. Sep 2022
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    SerpinB3 drives cancer stem cell survival in glioblastoma
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  77. Aug 2022
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    Functional and biological heterogeneity of KRASQ61 mutations
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  79. Jul 2022
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    Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines
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    In vitro modeling of amyotrophic lateral sclerosis with induced pluripotent stem cell technology-derived cell line ORIONi002-A
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    Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate
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    Exploration of the niche effect on tumor satellite budding of head and neck cancer with biomimicking modeling
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    Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma
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    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
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    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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    Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers
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    PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
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    PBRM1 loss in kidney cancer unbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation
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    Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor
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  107. Aug 2021
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    LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice
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    TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer
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    Pathogenic <i>FAM83G</i> palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling.
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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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    A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases
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  124. Jun 2021
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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  130. May 2021
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    Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma
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  143. Mar 2021
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    Generation of ORIONi001-A induced pluripotent stem cell line for in vitro modeling of sporadic form of amyotrophic lateral sclerosis
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  149. Nov 2020
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    Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer
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    Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells
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    Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation
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    MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia
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  155. Sep 2020
  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation
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    Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains
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    MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate
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  159. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System
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      DOI: 10.1016/j.chembiol.2020.06.012

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  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
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  161. www.sciencedirect.com www.sciencedirect.com
    FBXW7 Confers Radiation Survival by Targeting p53 for Degradation
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      DOI: 10.1016/j.celrep.2019.12.032

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  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531
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  163. www.sciencedirect.com www.sciencedirect.com
    Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation
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  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy
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    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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  166. Aug 2020
  167. link.springer.com link.springer.com
    Rare osteosarcoma cell subpopulation protein array and profiling using imaging mass cytometry and bioinformatics analysis
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  168. Jan 2020
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    Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection
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      DOI: 10.1016/j.celrep.2019.10.129

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  170. elifesciences.org elifesciences.org
    FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy
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    Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA
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    The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability
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      DOI: 10.1016/j.ccell.2019.10.004

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    YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression
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    Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer
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    A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
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      RRID:AB_1903938

      DOI: 10.1016/j.ccell.2019.10.002

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    Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy
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      DOI: 10.1016/j.cell.2019.05.041

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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer
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      RRID:AB_1903938

      DOI: 10.1016/j.ebiom.2019.06.046

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  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment
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      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2019.07.032

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  179. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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      RRID:AB_1903938

      DOI: 10.1016/j.molcel.2018.11.006

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  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      RRID:AB_1903938

      DOI: 10.1016/j.cell.2019.03.005

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  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells
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      RRID:AB_1903938

      DOI: 10.1038/s41408-018-0165-5

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  183. elifesciences.org elifesciences.org
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      RRID:AB_1903938

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  184. Nov 2018
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    A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network
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    Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups
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    Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization
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      AB_1903938

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    The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
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  189. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas
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    Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients
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    Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element
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    B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells
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  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns
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    Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins.
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    MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
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  196. Nov 2017
  197. www.sciencedirect.com www.sciencedirect.com
    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
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      CSTCat#5605S

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    Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
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    Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation
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  200. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling
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