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Aug 2026
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Glycolytic reprogramming and the EMT drive cervical cancer progression via the NQO1/HIF1α-SIX1 axis

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Jul 2026
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HPD is a copper-binding protein that interacts with DLAT to promote colorectal cancer cuproptosis under copper stress

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May 2026
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Phospho-JNK agonists show promising effects for the treatment of hepatocellular carcinoma

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Mar 2026
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5-hydroxytryptamine 2B Receptor Antagonism Restores ATP and Reduces Tubulointerstitial Fibrosis in the Renal Cortices of Aged Mice

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Scap stabilizes PKM2 to promote glycolysis and enhance anti-fungal immunity in macrophages

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Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation

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Feb 2026
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2026.01.31.703051.full-html.html

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Jan 2026
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Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors

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Jul 2025
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Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL

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Jun 2025
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Pyruvate kinase M2 (PKM2) tetramerization protects against hepatic stellate cell activation and liver fibrosis

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Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney disease

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May 2025
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Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming

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AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

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Apr 2025
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Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction

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Mar 2025
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Hypoxia inducible factor-1α drives cancer resistance to cuproptosis

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Feb 2025
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Interferon-a potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment

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Jan 2025
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Metabolic reprogramming of macrophages by PKM2 promotes IL-10 production via adenosine

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Dec 2024
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Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease

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Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease

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Nov 2024
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Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence-Associated Pathologies

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Sep 2024
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Function of a complex of p-Y42 RhoA GTPase and pyruvate kinase M2 in EGF signaling pathway in glioma cells

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PDIA3 orchestrates effector T cell program by serving as a chaperone to facilitate the non-canonical nuclear import of STAT1 and PKM2

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Aug 2024
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SIRT1 improves lactate homeostasis in the brain to alleviate parkinsonism via deacetylation and inhibition of PKM2

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Supplemental_Materials (1)-html.html

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Jun 2024
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Intrathecal Fumagillin Alleviates Chronic Neuropathy-Induced Nociceptive Sensitization and Modulates Spinal Astrocyte-Neuronal Glycolytic and Angiogenic Proteins

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May 2024
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An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions

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Retinal metabolism displays evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycle

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Local glycolysis fuels actomyosin contraction during axonal retraction

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Apr 2024
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JNEUROSCI.1563-23.2024.full (1)-html.html

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Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia

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Bisbiguanide analogs induce mitochondrial stress to inhibit lung cancer cell invasion

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Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia

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Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signaling

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Bacterial muropeptides promote OXPHOS and suppress mitochondrial stress in mammals

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Feb 2024
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Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer

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Inosine induces stemness features in CAR-T cells and enhances potency

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Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity

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Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer

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Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease

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Characterization of an in vitro steatosis model simulating activated de novo lipogenesis in MAFLD patients

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NEAT1_2/RRAD/EHF positive feedback loop facilitates aerobic glycolysis in papillary thyroid cancer cells

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Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity

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Inhibition of heterogeneous nuclear ribonucleoproteins A1 and oxidative stress reduces glycolysis pyruvate kinase M2 in chronic thromboembolic pulmonary hypertension

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Optimal HSF1 activation in response to acute cold stress in BAT requires nuclear TXNIP

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Phosphoenolpyruvate regulates the Th17 transcriptional program and inhibits autoimmunity

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Pyruvate Kinase 2, an Energy Metabolism Related Enzyme, May Have a Neuroprotective Function in Retinal Degeneration

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IDH2 stabilizes HIF-1α-induced metabolic reprogramming and promotes chemoresistance in urothelial cancer

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Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

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Pyruvate Kinase M2 Promotes Hair Regeneration by Connecting Metabolic and Wnt/β-Catenin Signaling

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Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation

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A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice

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cd-21-1022-html.html

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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

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Identification of metabolic pathways underlying FGF1 and CHIR99021-mediated cardioprotection

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Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

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Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist

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Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch

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Targeting Pyruvate Kinase M2 phosphorylation reverses aggressive cancer phenotypes

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Extracellular Vesicles Induce an Aggressive Phenotype in Luminal Breast Cancer Cells Via PKM2 Phosphorylation

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Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells

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Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency

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Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy

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Extracellular PKM2 facilitates organ-tissue fibrosis progression

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Metabolic plasticity drives development during mammalian embryogenesis

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Untitled document

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Untitled document

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Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment

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LncRNA-Malat1 is involved in lipotoxicity-induced β-cell dysfunction and the therapeutic effect of exendin-4 via Ptbp1

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Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab

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PKM2 Determines Myofiber Hypertrophy In Vitro and Increases in Response to Resistance Exercise in Human Skeletal Muscle

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Renal protective effects of empagliflozin via inhibition of EMT and aberrant glycolysis in proximal tubules

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Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis

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Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway

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Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

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Pyruvate Kinase M2 Promotes the Activation of Dendritic Cells by Enhancing IL-12p35 Expression

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Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer

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BPS Publications

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Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration

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Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab

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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

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Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

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Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA

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Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

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UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses

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α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development

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Untitled document

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Genetic Modulation of RNA Splicing with a CRISPR-Guided Cytidine Deaminase

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Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis

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Distinct Activities of Glycolytic Enzymes Identify Chronic Lymphocytic Leukemia Patients with a more Aggressive Course and Resistance to Chemo-Immunotherapy

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Transcriptional Regulation of the Warburg Effect in Cancer by SIX1

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Hexokinase 2‐dependent Hyperglycolysis Driving Microglial Activation Contributes to Ischemic Brain Injury

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MYC Controls Human Pluripotent Stem Cell Fate Decisions through Regulation of Metabolic Flux

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The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity

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