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  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
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      DOI: 10.1101/2024.11.29.626084

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    pmc.ncbi.nlm.nih.gov/articles/PMC11642745/
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    Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease
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    cell.com/cell-host-microbe/fulltext/S1931-3128(24)00443-8
  4. Dec 2024
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    A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
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    sciencedirect.com/science/article/pii/S0092867424013266
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    Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates
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    sciencedirect.com/science/article/pii/S2451945624004586
  7. Nov 2024
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    AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection
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    Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development
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      DOI: 10.1523/JNEUROSCI.0072-24.2024

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    jneurosci.org/content/44/42/e0072242024
  10. Sep 2024
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    An ILK/STAT3 pathway controls glioblastoma stem cell plasticity
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  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endothelial cell elongation and alignment in response to shear stress requires acetylation of microtubules
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      DOI: 10.3389/fphys.2024.1425620

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    ncbi.nlm.nih.gov/pmc/articles/PMC11420013/
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    Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer
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    1. scibot 25 Sep 2024
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    STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
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      Curator comments: ATM (D2E2) XP(Tm) Rabbit MAb Antibody Cell Signaling Technology Cat# 2873

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    Dynamic remodeling of Septin structures fine-tunes myogenic differentiation
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    New dual inducible cellular model to investigate temporal control of oncogenic cooperating genes
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    A conserved transcription factor regulatory program promotes tendon fate
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    GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant
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    sciencedirect.com/science/article/pii/S1535610824003052
  19. Jul 2024
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    Amphiregulin orchestrates the paracrine immune-suppressive function of amniotic-derived cells through its interplay with COX-2/PGE2/EP4 axis
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    sciencedirect.com/science/article/pii/S2589004224017334
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    PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection
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    sciencedirect.com/science/article/pii/S1097276524004799
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    Tandem LIM domain-containing proteins, LIMK1 and LMO1, directly bind to force-bearing keratin intermediate filaments
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    cell.com/cell-reports/abstract/S2211-1247(24)00809-X
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    Exercise training and cold exposure trigger distinct molecular adaptations to inguinal white adipose tissue
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    Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor
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    1. scibot 04 Jul 2024
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      DOI: 10.1101/2024.06.11.598518

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    biorxiv.org/content/10.1101/2024.06.11.598518v2
  25. Jun 2024
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    Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1
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  27. Apr 2024
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function
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    Collagen IV assembly is influenced by fluid flow in kidney cell-derived matrices
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    The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges
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    Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs
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    sciencedirect.com/science/article/pii/S2211124724004017
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Conditional dependency of LP-184 on prostaglandin reductase 1 is synthetic lethal in pancreatic cancers with DNA damage repair deficiencies.
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    ncbi.nlm.nih.gov/pmc/articles/PMC10592171/
  33. Mar 2024
  34. www.thelancet.com www.thelancet.com
    Female mice display sex-specific differences in cerebrovascular function and subarachnoid haemorrhage-induced injury
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    thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00093-8/abstract
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    Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin
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    52.53.155.43/87ec0518c5224f0fd07557d79aa684b0e2f086c0/s11427-023-2444-5 (1)-html.html
  36. Feb 2024
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    Mea6/cTAGE5 cooperates with TRAPPC12 to regulate PTN secretion and white matter development
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    sciencedirect.com/science/article/pii/S2589004224004012
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    Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production
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    sciencedirect.com/science/article/pii/S1074761324000773
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    Inhibition of mGluR5/PI3K-AKT Pathway Alleviates Alzheimer’s Disease-Like Pathology Through the Activation of Autophagy in 5XFAD Mice
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    content.iospress.com/articles/journal-of-alzheimers-disease/jad221058
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    Proline restores mitochondrial function and reverses aging hallmarks in senescent cells
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    sciencedirect.com/science/article/pii/S2211124724000664
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    Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation
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    sciencedirect.com/science/article/pii/S2211124724000743
  42. Jan 2024
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    Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma
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    sciencedirect.com/science/article/pii/S1097276523010298
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    Cytoneme signaling provides essential contributions to mammalian tissue patterning
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  45. Dec 2023
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    Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth
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    sciencedirect.com/science/article/pii/S245194562300421X
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    ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors
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    The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S1074761323004831
  49. Nov 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
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    Endonucleosis mediates internalization of cytoplasm into the nucleus in senescent cells
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    The calcium channel TRPC6 promotes chemotherapy-induced persistence by regulating integrin α6 mRNA splicing
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  53. Sep 2023
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    TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
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    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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  56. Aug 2023
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    TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development
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    Enzymatic assay for UDP-GlcNAc and its application in the parallel assessment of substrate availability and protein O-GlcNAcylation
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  60. Jun 2023
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    Fancm has dual roles in the limiting of meiotic crossovers and germ cell maintenance in mammals
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    Single-cell RNA-seq uncovers novel metabolic functions of Schwann cells beyond myelination
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    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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    MAP4K4 is involved in the neuronal development of retinal photoreceptors
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    Targeted deprivation of methionine with engineered Salmonella leads to oncolysis and suppression of metastasis in broad types of animal tumor models
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  66. May 2023
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    HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
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    Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity
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  69. Apr 2023
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    A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer
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    Boosting BDNF in muscle rescues impaired in vivo axonal transport in a mouse model of DI-CMTC peripheral neuropathy
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    VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis
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    PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation
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  74. Mar 2023
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    Restricting genomic actions of innate immune mediators on fetal hematopoietic progenitor cells
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    Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
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    Combinatory EHMT and PARP inhibition induces an interferon response and a CD8 T cell-dependent tumor regression in PARP inhibitor-resistant models
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  78. Feb 2023
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    Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis
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    CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2
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    Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification
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  82. Jan 2023
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    Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence
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  84. Dec 2022
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    Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling
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    Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors
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  87. Nov 2022
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    Parkinson’s disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila
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    B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer
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  91. Oct 2022
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    Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2-dependent glutaminolysis pathway
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    PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
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    Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2–dependent glutaminolysis pathway
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    En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH
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  96. Sep 2022
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding
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  98. Aug 2022
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    DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting
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    Neuroinflammatory disease disrupts the blood-CNS barrier via crosstalk between proinflammatory and endothelial-to-mesenchymal-transition signaling
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    CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder
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  102. Jul 2022
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    Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging
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    A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions
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  119. Jan 2022
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    The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2
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    MAP3K7 loss drives enhanced androgen signaling and independently confers risk of recurrence in prostate cancer with joint loss of CHD1
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  123. Dec 2021
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  125. Oct 2021
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    MEC17 Induced α-tubulin Acetylation Restores Mitochondrial Transport Function and Alleviates Axonal Injury after Intracerebral Hemorrhage in Mice
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  127. Sep 2021
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    A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes
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    Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis
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  148. Jun 2021
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    TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin.
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  151. May 2021
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    Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability
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    The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure
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    Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer
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    Cell Lineage-Based Stratification for Glioblastoma
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    Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling
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  162. Feb 2021
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  164. Nov 2020
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    Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG
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  170. Sep 2020
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    Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss
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    Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma
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  175. Jan 2020
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    Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters
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    The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity
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    ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer
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    β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4
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    Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions
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  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader
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  206. www.sciencedirect.com www.sciencedirect.com
    Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer
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  207. europepmc.org europepmc.org
    MELK is not necessary for the proliferation of basal-like breast cancer cells.
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      Curator: @evieth

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  208. wellcomeopenresearch.org wellcomeopenresearch.org
    Perturbation of PALB2 function by the T413S mutation found in small cell lung cancer
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    1. scibot 05 Nov 2018
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      Curator: @patriciaelyse_

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  209. Nov 2017
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    GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia
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    1. scibot 08 Nov 2017
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      Curator: @patriciaelyse_

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    Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C
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      Curator: @Jmenke

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  212. elifesciences.org elifesciences.org
    Untitled document
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      Curator: @chewbeccax

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    elifesciences.org/articles/20353
  213. www.sciencedirect.com www.sciencedirect.com
    Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance
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      3873

      Curator: @bandrow

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    Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation
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    sciencedirect.com/science/article/pii/S0167488916302774
  215. www.sciencedirect.com www.sciencedirect.com
    ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation
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    1. scibot 08 Nov 2017
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      Curator: @Zeljana_Babic

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