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Cholangiocytes’ Primary Cilia Regulate DNA Damage Response and Repair

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Aug 2025
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5-HT6R-ATR-primary cilia network supports morphine-related memory extinction in the medial prefrontal cortex

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2025.08.06.668899v1.full-html.html

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Jun 2025
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Merlin controls limb development and thumb formation by regulating primary cilium-hedgehog signaling

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May 2025
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Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity

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Apr 2025
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The Chlamydia effector Dre1 binds dynactin to reposition host organelles during infection

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Mar 2025
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Forebrain Eml1 depletion reveals early centrosomal dysfunction causing subcortical heterotopia

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Rediscovering the rete ovarii, a secreting auxiliary structure to the ovary

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Feb 2025
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Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone

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Macrophage-derived CTSS drives the age-dependent disruption of the blood-CSF barrier

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Targeting SHCBP1 Inhibits Tumor Progression by Restoring Ciliogenesis in Ductal Carcinoma

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aacrjournals.org/cancerres/article/84/24/4156/750417/Targeting-SHCBP1-Inhibits-Tumor-Progression-by
Sep 2024
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A cell-autonomous role for primary cilium-mediated signaling in long-range commissural axon guidance

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Jul 2024
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1-s2.0-S258900422401825X-main-html.html

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1. scibot 30 Jul 2024
  
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Selective targeting of mu opioid receptors to primary cilia

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  DOI: 10.1016/j.celrep.2024.114164
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11257377/
Jun 2024
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Astrocyte-Specific Inhibition of the Primary Cilium Suppresses C3 Expression in Reactive Astrocyte

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  DOI: 10.1007/s10571-024-01482-5
  
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link.springer.com/article/10.1007/s10571-024-01482-5
May 2024
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Generation of FOXJ1-EGFP knock-in reporter human embryonic stem cell line, WAe001-A-2D, using CRISPR/Cas9-based gene targeting

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Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary

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52.53.155.43/d464a1c8cbadac762260d7e95892d01d1077dc1a/2023.11.08.566085v2.full-html.html
Apr 2024
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A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function

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Numb positively regulates Hedgehog signaling at the ciliary pocket

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  DOI: 10.1038/s41467-024-47244-1
  
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Characterization of the disease-causing mechanism of KIF3B mutations from ciliopathy patients

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  DOI: 10.3389/fmolb.2024.1327963
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11043552/
Mar 2024
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Primary cilia as a tumor marker in pituitary neuroendocrine tumors

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In vivo CRISPR screening directly targeting testicular cells

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A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened

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Feb 2024
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ESCRT-I protein UBAP1 controls ventricular expansion and cortical neurogenesis via modulating adherens junctions of radial glial cells

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KIF3A tail domain phosphorylation is not required for ciliogenesis in mouse embryonic fibroblasts

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DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling

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Jan 2024
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Cytoneme signaling provides essential contributions to mammalian tissue patterning

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Dec 2023
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Bi-allelic variants in CEP295 cause Seckel-like syndrome presenting with primary microcephaly, developmental delay, intellectual disability, short stature, craniofacial and digital abnormalities

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Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD

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Oct 2023
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MiniBAR/GARRE1 is a dual Rac and Rab effector required for ciliogenesis

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1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.devcel.2023.09.010
  
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Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method

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  DOI: 10.1016/j.devcel.2023.09.008
  
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Primary cilia control oligodendrocyte precursor cell proliferation in white matter injury via Hedgehog-independent CREB signaling

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  DOI: 10.1016/j.celrep.2023.113272
  
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PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model

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Beta cell primary cilia mediate somatostatin responsiveness via SSTR3

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Mutational burden of XPNPEP3 leads to defects in mitochondrial complex I and cilia in NPHPL1

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Calcium dynamics at the neural cell primary cilium regulate Hedgehog signaling–dependent neurogenesis in the embryonic neural tube

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Table 3 Antibodies

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Calcineurin associates with centrosomes and regulates cilia length maintenance

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Polycomb Ezh1 maintains murine muscle stem cell quiescence through non-canonical regulation of Notch signaling

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Evaluation of Epithelial–Mesenchymal Transition Markers in Autoimmune Thyroid Diseases

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The developmental basis of fingerprint pattern formation and variation

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Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis

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GRAMD1/ASTER-mediated cholesterol transport promotes Smoothened cholesterylation at the endoplasmic reticulum

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IFT-A structure reveals carriages for membrane protein transport into cilia

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Analysis of Primary Cilium Expression and Hedgehog Pathway Activation in Mesothelioma Throws Back Its Complex Biology

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Disease-associated mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2

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CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors

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A high-throughput electron tomography workflow reveals over-elongated centrioles in relapsed/refractory multiple myeloma

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Metabolomic fingerprinting of renal disease progression in Bardet-Biedl syndrome reveals mitochondrial dysfunction in kidney tubular cells

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Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

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The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling

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Distribution of prototypical primary cilia markers in subtypes of retinal ganglion cells

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Evolutionary conservation of centriole rotational asymmetry in the human centrosome

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TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling

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ExSTED microscopy reveals contrasting functions of dopamine and somatostatin CSF-c neurons along the lamprey central canal

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C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane

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Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity

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Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis

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Exocyst complex mediates recycling of internal cilia

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Cilium induction triggers differentiation of glioma stem cells

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Human brain organoids assemble functionally integrated bilateral optic vesicles

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Untitled document

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FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue

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Centrosome-derived microtubule radial array, PCM-1 protein, and primary cilia formation

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A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice

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Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia

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TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity

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Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis

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Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms

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Rab34 is necessary for early stages of intracellular ciliogenesis

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Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway

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Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex

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Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains

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Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia

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Transient Primary Cilia Mediate Robust Hedgehog Pathway-Dependent Cell Cycle Control

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Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis

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Gpr37l1/prosaposin receptor regulates Ptch1 trafficking, Shh production, and cell proliferation in cerebellar primary astrocytes

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Live imaging of hair bundle polarity acquisition demonstrates a critical timeline for transcription factor Emx2

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The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis

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Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution

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Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

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ARL13B regulates Sonic hedgehog signaling from outside primary cilia

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Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse

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Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex

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A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling

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Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

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Untitled document

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EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation

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Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination

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Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7

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Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways

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Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis

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The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base

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Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria

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Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids

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Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision

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