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114 Matching Annotations

Jan 2026
www.thelancet.com www.thelancet.com

The rs713586 risk variant dysregulates ADCY3 rather than DNAJC27, leading to obesity through ZFP42-TET1-mediated DNA methylation

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1. scibot 16 Jan 2026
  
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  DOI: 10.1016/j.ebiom.2025.106112
  
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  DOI: 10.1016/j.ebiom.2025.106112
  
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thelancet.com/journals/ebiom/article/PIIS2352-3964(25)00562-6/abstract
Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CU Cilia – an application for image analysis by machine learning – reveals significance of cysteine cathepsin K activity for primary cilia of human thyroid epithelial cells

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1. scibot 19 Dec 2025
  
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  DOI: 10.3389/fendo.2025.1588394
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12695601/
54.241.53.176 54.241.53.176

1-s2.0-S2589004225025519-main-html.html

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1. scibot 14 Dec 2025
  
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  DOI: 10.1016/j.isci.2025.114290
  
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54.241.53.176/8c76358cffbdca3590659296903fbb7ba84db3c2/1-s2.0-S2589004225025519-main-html.html
Nov 2025
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A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology

1
1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.devcel.2025.10.015
  
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sciencedirect.com/science/article/pii/S1534580725006665
Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function

1
1. scibot 23 Oct 2025
  
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  DOI: 10.1016/j.cub.2024.08.058
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11496028/
www.biorxiv.org www.biorxiv.org

Dishevelled drives Wnt-stimulated disassembly of primary cilia through a unique PDZ-mediated binding mode with Daple and Girdin

1
1. scibot 07 Oct 2025
  
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  DOI: 10.1101/2025.09.26.678488
  
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biorxiv.org/content/10.1101/2025.09.26.678488v1
Sep 2025
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Intrinsic heterogeneity of primary cilia revealed through spatial proteomics

1
1. scibot 27 Sep 2025
  
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  DOI: 10.1016/j.cell.2025.08.039
  
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sciencedirect.com/science/article/pii/S0092867425010293
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Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence

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1. scibot 25 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116339
  
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sciencedirect.com/science/article/pii/S2211124725011106
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Adducins regulate morphology and fate of neural progenitors during neocortical neurogenesis

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1. scibot 13 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116276
  
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sciencedirect.com/science/article/pii/S2211124725010472
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KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia

1
1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.cub.2025.08.022
  
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sciencedirect.com/science/article/pii/S0960982225010887
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cholangiocytes’ Primary Cilia Regulate DNA Damage Response and Repair

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1. scibot 07 Sep 2025
  
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  DOI: 10.1152/ajpgi.00055.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12409734/
Aug 2025
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5-HT6R-ATR-primary cilia network supports morphine-related memory extinction in the medial prefrontal cortex

1
1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.isci.2025.113208
  
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sciencedirect.com/science/article/pii/S2589004225014695
52.53.155.43 52.53.155.43

2025.08.06.668899v1.full-html.html

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1. scibot 14 Aug 2025
  
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  DOI: 10.1101/2025.08.06.668899
  
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52.53.155.43/54427366624e4701e0e08ab46e106362d151106f/2025.08.06.668899v1.full-html.html
Jun 2025
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Merlin controls limb development and thumb formation by regulating primary cilium-hedgehog signaling

1
1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115849
  
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sciencedirect.com/science/article/pii/S2211124725006205
May 2025
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Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity

1
1. scibot 31 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115766
  
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sciencedirect.com/science/article/pii/S2211124725005376
Apr 2025
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The Chlamydia effector Dre1 binds dynactin to reposition host organelles during infection

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115509
  
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sciencedirect.com/science/article/pii/S2211124725002803
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Forebrain Eml1 depletion reveals early centrosomal dysfunction causing subcortical heterotopia

1
1. scibot 28 Mar 2025
  
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  DOI: 10.1083/jcb.202310157
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11450323/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Rediscovering the rete ovarii, a secreting auxiliary structure to the ovary

1
1. scibot 21 Mar 2025
  
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  DOI: 10.7554/eLife.96662
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11922502/
Feb 2025
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Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone

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1. scibot 28 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115264
  
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sciencedirect.com/science/article/pii/S221112472500035X
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Macrophage-derived CTSS drives the age-dependent disruption of the blood-CSF barrier

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1. scibot 27 Feb 2025
  
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  DOI: 10.1016/j.neuron.2025.01.023
  
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sciencedirect.com/science/article/pii/S0896627325000492
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Targeting SHCBP1 Inhibits Tumor Progression by Restoring Ciliogenesis in Ductal Carcinoma

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-1095
  
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aacrjournals.org/cancerres/article/84/24/4156/750417/Targeting-SHCBP1-Inhibits-Tumor-Progression-by
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A cell-autonomous role for primary cilium-mediated signaling in long-range commissural axon guidance

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1. scibot 27 Sep 2024
  
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  DOI: 10.1242/dev.202788
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11423920/
Jul 2024
52.53.155.43 52.53.155.43

1-s2.0-S258900422401825X-main-html.html

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1. scibot 30 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110600
  
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52.53.155.43/7b2053fa2b6f1dae1cb07986f7ba7cee9e5d1284/1-s2.0-S258900422401825X-main-html.html
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Selective targeting of mu opioid receptors to primary cilia

1
1. scibot 20 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114164
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11257377/
Jun 2024
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Astrocyte-Specific Inhibition of the Primary Cilium Suppresses C3 Expression in Reactive Astrocyte

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1. scibot 04 Jun 2024
  
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  DOI: 10.1007/s10571-024-01482-5
  
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link.springer.com/article/10.1007/s10571-024-01482-5
May 2024
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Generation of FOXJ1-EGFP knock-in reporter human embryonic stem cell line, WAe001-A-2D, using CRISPR/Cas9-based gene targeting

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1. scibot 30 May 2024
  
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  DOI: 10.1016/j.scr.2024.103445
  
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sciencedirect.com/science/article/pii/S1873506124001430
52.53.155.43 52.53.155.43

Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary

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1. scibot 02 May 2024
  
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  DOI: 10.1101/2023.11.08.566085
  
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52.53.155.43/d464a1c8cbadac762260d7e95892d01d1077dc1a/2023.11.08.566085v2.full-html.html
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function

1
1. scibot 30 Apr 2024
  
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  DOI: 10.1101/2024.04.02.587836
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11014585/
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Numb positively regulates Hedgehog signaling at the ciliary pocket

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1. scibot 29 Apr 2024
  
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  DOI: 10.1038/s41467-024-47244-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11045789/
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Characterization of the disease-causing mechanism of KIF3B mutations from ciliopathy patients

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1. scibot 28 Apr 2024
  
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  DOI: 10.3389/fmolb.2024.1327963
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11043552/
Mar 2024
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Primary cilia as a tumor marker in pituitary neuroendocrine tumors

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1. scibot 21 Mar 2024
  
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  DOI: 10.1016/j.modpat.2024.100475
  
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  DOI: 10.1016/j.modpat.2024.100475
  
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sciencedirect.com/science/article/pii/S0893395224000553
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In vivo CRISPR screening directly targeting testicular cells

1
1. scibot 06 Mar 2024
  
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  DOI: 10.1016/j.xgen.2024.100510
  
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sciencedirect.com/science/article/pii/S2666979X24000375
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A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened

3
1. scibot 05 Mar 2024
  
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  DOI: 10.1016/j.chembiol.2024.02.002
  
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2. scibot 05 Mar 2024
  
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  DOI: 10.1016/j.chembiol.2024.02.002
  
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ESCRT-I protein UBAP1 controls ventricular expansion and cortical neurogenesis via modulating adherens junctions of radial glial cells

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KIF3A tail domain phosphorylation is not required for ciliogenesis in mouse embryonic fibroblasts

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DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling

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Cytoneme signaling provides essential contributions to mammalian tissue patterning

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Bi-allelic variants in CEP295 cause Seckel-like syndrome presenting with primary microcephaly, developmental delay, intellectual disability, short stature, craniofacial and digital abnormalities

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Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD

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MiniBAR/GARRE1 is a dual Rac and Rab effector required for ciliogenesis

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Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method

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Primary cilia control oligodendrocyte precursor cell proliferation in white matter injury via Hedgehog-independent CREB signaling

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PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model

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Beta cell primary cilia mediate somatostatin responsiveness via SSTR3

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Mutational burden of XPNPEP3 leads to defects in mitochondrial complex I and cilia in NPHPL1

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Calcium dynamics at the neural cell primary cilium regulate Hedgehog signaling–dependent neurogenesis in the embryonic neural tube

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May 2023
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Table 3 Antibodies

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Calcineurin associates with centrosomes and regulates cilia length maintenance

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Polycomb Ezh1 maintains murine muscle stem cell quiescence through non-canonical regulation of Notch signaling

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Evaluation of Epithelial–Mesenchymal Transition Markers in Autoimmune Thyroid Diseases

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The developmental basis of fingerprint pattern formation and variation

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Jan 2023
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Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis

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GRAMD1/ASTER-mediated cholesterol transport promotes Smoothened cholesterylation at the endoplasmic reticulum

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IFT-A structure reveals carriages for membrane protein transport into cilia

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Analysis of Primary Cilium Expression and Hedgehog Pathway Activation in Mesothelioma Throws Back Its Complex Biology

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Disease-associated mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2

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CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors

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A high-throughput electron tomography workflow reveals over-elongated centrioles in relapsed/refractory multiple myeloma

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Metabolomic fingerprinting of renal disease progression in Bardet-Biedl syndrome reveals mitochondrial dysfunction in kidney tubular cells

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Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

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The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling

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Distribution of prototypical primary cilia markers in subtypes of retinal ganglion cells

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Evolutionary conservation of centriole rotational asymmetry in the human centrosome

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Feb 2022
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TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling

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ExSTED microscopy reveals contrasting functions of dopamine and somatostatin CSF-c neurons along the lamprey central canal

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Jan 2022
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C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane

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Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity

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Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis

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Exocyst complex mediates recycling of internal cilia

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Cilium induction triggers differentiation of glioma stem cells

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Human brain organoids assemble functionally integrated bilateral optic vesicles

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FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue

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Centrosome-derived microtubule radial array, PCM-1 protein, and primary cilia formation

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A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice

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Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia

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TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity

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Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis

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Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms

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Rab34 is necessary for early stages of intracellular ciliogenesis

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Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway

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Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex

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Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains

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Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia

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Transient Primary Cilia Mediate Robust Hedgehog Pathway-Dependent Cell Cycle Control

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Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis

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Gpr37l1/prosaposin receptor regulates Ptch1 trafficking, Shh production, and cell proliferation in cerebellar primary astrocytes

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Live imaging of hair bundle polarity acquisition demonstrates a critical timeline for transcription factor Emx2

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The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis

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Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution

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Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

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ARL13B regulates Sonic hedgehog signaling from outside primary cilia

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Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse

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Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex

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A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling

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Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

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EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation

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Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination

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Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7

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Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways

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Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis

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The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base

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Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria

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Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids

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Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision

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