741 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12900515/
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    Cellular Mg2+ decrease causes a distinctive NF-κB-dependent form of cell death
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    sciencedirect.com/science/article/pii/S2211124726000422
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    Pharmacokinetic-pharmacodynamic-efficacy modeling of the MDM2 inhibitor brigimadlin in glioblastoma patient-derived xenografts
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    pmc.ncbi.nlm.nih.gov/articles/PMC12883205/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting and dissociating HIF2α from the molecular chaperone Hsp70 triggers apoptosis in kidney cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12881505/
  6. Feb 2026
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Microbial Bile Acid Metabolite 3-oxo-LCA Inhibits Colorectal Cancer Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12871761/
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    Luteolin mitigates inflammatory organ injury by targeting XIAP to block PANoptosis and mitochondrial dysfunction
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    sciencedirect.com/science/article/pii/S1567576926001141
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    Targeting ATR signaling in sarcoma with homologous recombination deficiency
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    sciencedirect.com/science/article/pii/S0304383526000637
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    Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer’s disease risk factors
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    sciencedirect.com/science/article/pii/S1074761326000361
  11. Jan 2026
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Thimerosal Inhibits Tumor Malignant Progression through Direct Action and Enhancing the Efficacy of PD-1-Based Immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12848756/
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    Pyroptosis modulates multiple immune cell populations in targeted therapy–treated melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12851756/
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    SNAP23 deficiency triggers Trim21 mitochondrial translocation to suppress TFAM-mediated oxidative metabolism and drive chemoresistance in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12811313/
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    Impaired PARP1-dependent DNA repair in MORC2 mutations drives axonal degeneration in Charcot-Marie-Tooth disease subtype 2Z and spinal muscular atrophy-like neuromotor disorders
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    sciencedirect.com/science/article/pii/S1043661826000186
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    KDM7B-mediated demethylation of RNF113A regulates small cell lung cancer sensitivity to alkylation damage
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    biorxiv.org/content/10.64898/2026.01.03.697470v1
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    The combination of BCL-xL PROTAC and mTOR inhibitor sensitizes pancreatic ductal adenocarcinoma to KRASG12D inhibitor treatment by enhancing apoptosis induction
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    biorxiv.org/content/10.64898/2026.01.05.697773v1
  18. 54.241.53.176 54.241.53.176
    2026.01.09.698661v1.full-html.html
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    FGFR1 and FGFR4 are essential regulators of muscle stem cell quiescence
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    link.springer.com/article/10.1186/s12964-025-02533-0
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LncRNA DANCR Activates p38/mTOR‐Mediated Autophagy via ANXA2 to Exacerbate Oxygen‐Induced Retinal Neovascularization in Mice
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    Gut-derived succinic acid potentiates high-altitude-related spermatogenesis dysfunction
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    sciencedirect.com/science/article/pii/S1931312825005244
  23. Dec 2025
  24. 54.241.53.176 54.241.53.176
    A K27-linked Ubiquitin Checkpoint Controls NOTCH Homeostasis
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    Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through apoptosis in the neonatal lung
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    Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12700530/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Anti-Cancer Effects of the Ethyl Acetate Fraction From Opuntia humifusa on Human Triple-Negative Breast Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12705953/
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    Myeloid Irf5 Deficiency Enhances the Therapeutic Efficacy of IMD-0354 in a TDP-25-Induced Neurodegeneration Model
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    link.springer.com/article/10.1007/s12035-025-05606-w
  29. www.biorxiv.org www.biorxiv.org
    Longitudinal analysis of matched patient biospecimens reveals Neural Reprogramming of Cancer-Associated Fibroblasts Following Chemotherapy in Pancreatic Ductal Adenocarcinoma
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    biorxiv.org/content/10.64898/2025.12.01.691614v1
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    Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche
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    Microglial Prrc2a regulates microglia-neuron interaction in cerebellum and motor functions in mice
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    In vivo proteomic labeling reveals diverse proteomes for therapeutic targets
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    FAME-CRISPR improves CRISPR-Cas9 genome editing via HDAC inhibition and engineered virus-like particle delivery
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    A tabletop blast device for the study of the long-term consequences of traumatic brain injury on brain organoids
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  35. Nov 2025
  36. www.sciencedirect.com www.sciencedirect.com
    Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
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    Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity
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    Hierarchical regulation of cerebellar neurogenesis by Sin3A-mediated gene repression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12632768/
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    UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression
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    Transcription factor Zfx regulates tumor’s evasion to T cell killing in immunotherapy
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    Chromatin remodeler Chd7 regulates reactive astrogliosis after ischemic stroke
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    An immunometabolic prodrug strategy overcomes DHODH inhibitor resistance in refractory melanoma
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    link.springer.com/article/10.1186/s13046-025-03566-6
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    Bicyclol improves cognition deficits and inhibits oxidative stress-induced neuronal cell apoptosis in alzheimer’s disease via Nrf2/HO-1 pathway
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    link.springer.com/article/10.1007/s11011-025-01738-z
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    YAP/TAZ transcriptional co-activators create therapeutic vulnerability to verteporfin in EGFR mutant glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC8440125/
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    CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability
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  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kynurenic Acid Protects Against Myocardial Ischemia/Reperfusion Injury by Activating GPR35 Receptors and Preserving Mitochondrial Structure and Function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12562769/
  49. Oct 2025
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    The distinct roles of TGF-β signaling in retinal development
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    Pancreatic Cells Are Resistant to KRASQ61L Expression due to Hyperactive ERK/MAPK Signaling and Apoptosis Induction
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    pmc.ncbi.nlm.nih.gov/articles/PMC12541299/
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    CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success
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  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PARL stabilizes mitochondrial BCL-2 via Nur77-mediated scaffolding as a therapeutic strategy for Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12501375/
  54. link.springer.com link.springer.com
    Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke
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    link.springer.com/article/10.1186/s40478-025-02125-6
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    CD169+ macrophages identify and eliminate tumor cells in colorectal cancer through CD169/CD43 interaction and FasL-driven apoptosis
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    sciencedirect.com/science/article/pii/S2211124725011222
  56. Sep 2025
  57. www.sciencedirect.com www.sciencedirect.com
    Pharmacological and toxicological profiling of JAMC-4/108: targeted induction of apoptosis in human colorectal cancer cells
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    sciencedirect.com/science/article/pii/S0022356525402407
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    FLT3L-based drug conjugate effectively targets chemoresistant leukemia stem cells in acute myeloid leukemia
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  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
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    pmc.ncbi.nlm.nih.gov/articles/PMC12434395/
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    Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures
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  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CF10 Displayed Improved Activity Relative to 5-FU in a Mouse CRLM Model Under Conditions of Physiological Folate
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  62. 52.53.155.43 52.53.155.43
    Cardiac mural cells are rate-limiting for coronary vascularization after heart injury
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  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Peach Gum Polysaccharide Prevents Chemotherapy-Induced Intestinal Injury and Degenerative Behavior
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    pmc.ncbi.nlm.nih.gov/articles/PMC12375157/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sympathetic Neurons Promote Small Cell Lung Cancer Through the Beta-2 Adrenergic Receptor
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875942/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pre-clinical Modeling of Navtemadlin Pharmacokinetics, Pharmacodynamics, and Efficacy in IDH-wildtype Glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12402800/
  67. Aug 2025
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer
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    Peach Gum Polysaccharide Prevents Chemotherapy-Induced Intestinal Injury and Degenerative Behavior
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    journals.sagepub.com/doi/full/10.1177/15347354251368410
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    TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation
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    sciencedirect.com/science/article/pii/S221112472500957X
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    MAVS phosphorylation acts as a cellular stress sensor that modulates antiviral immunity
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    Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis
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  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated real-time imaging of executioner caspase dynamics, apoptosis-induced proliferation, and immunogenic cell death using a stable fluorescent reporter platform
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    Integrator promotes the association of TFIID and RNA polymerase II to maintain pluripotency during development
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A RAS(ON) Multi-Selective Inhibitor Combination Therapy Triggers Long-term Tumor Control through Senescence-Associated Tumor-Immune Equilibrium in Pancreatic Ductal Adenocarcinoma
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  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Azenosertib Is a Potent and Selective WEE1 Kinase Inhibitor with Broad Antitumor Activity Across a Range of Solid Tumors
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  79. Jul 2025
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting the WSB2–NOXA axis in cancer cells for enhanced sensitivity to BCL-2 family protein inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12286604/
  81. www.biorxiv.org www.biorxiv.org
    Multilayered molecular and cellular mechanisms underlying intestinal epithelial regeneration
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    biorxiv.org/content/10.1101/2025.07.20.665802v1
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    Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer
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    Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners
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  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Potent Inhibitor of Caspase-8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases
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    Unlocking the therapeutic potential of rigosertib as a selective therapy for ovarian cancer
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    Formyl peptide receptor 2 (FPR2) mediates cisplatin-induced cochlear inflammation and hair cell apoptosis
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  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer
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  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sensitivity and activation of endoplasmic reticulum stress response and apoptosis in the perinatal sheep heart
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    Conserved signals control self-organization and symmetry breaking of murine bilayered epithelia during development and regeneration
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  91. Jun 2025
  92. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    An optimised Bcl-3 inhibitor for melanoma treatment
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  191. Jul 2024
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  204. Jun 2024
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  212. May 2024
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