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Jun 2026
www.nature.com www.nature.com

DNA replication stress and translational repression converge to drive CDK1- and caspase-dependent apoptosis in Ewing sarcoma

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1. scibot 16 Jun 2026
  
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  DOI: 10.1038/s41388-026-03845-2
  
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nature.com/articles/s41388-026-03845-2
Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Sappanchalcone Suppresses NSCLC by Oxidative Stress-Driven DNA Damage and ER Stress Activation through PIEZO1 Modulation

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1. scibot 19 Dec 2025
  
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  DOI: 10.1016/j.isci.2025.114057
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12702247/
Oct 2025
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Coiled-coil interactions drive the ectopic condensation of overexpressed MAD1 to promote mitotic slippage in cancer cells

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1. scibot 15 Oct 2025
  
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  DOI: 10.1016/j.isci.2025.113638
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12547712/
www.embopress.org www.embopress.org

Phosphoproteomics of osimertinib-tolerant persister cells reveals targetable kinase-substrate signatures

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1. scibot 07 Oct 2025
  
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  DOI: 10.1038/s44320-025-00141-1
  
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embopress.org/doi/10.1038/s44320-025-00141-1
54.241.53.176 54.241.53.176

hsu-et-al-2025-phosphoproteomics-of-osimertinib-tolerant-persister-cells-reveals-targetable-kinase-substrate-signatures-html.html

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  DOI: 10.1038/s44320-025-00141-1
  
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54.241.53.176/9c78a41645fcc9eb1ef3871f95e64fd70faf70c8/hsu-et-al-2025-phosphoproteomics-of-osimertinib-tolerant-persister-cells-reveals-targetable-kinase-substrate-signatures-html.html
Aug 2025
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A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.07.023
  
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sciencedirect.com/science/article/pii/S109727652500646X
Jul 2025
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The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation

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1. scibot 24 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116019
  
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sciencedirect.com/science/article/pii/S2211124725007909
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer

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  DOI: 10.1016/j.xcrm.2025.102211
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12281435/
May 2025
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Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development

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  DOI: 10.1016/j.cell.2025.04.025
  
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sciencedirect.com/science/article/pii/S0092867425004581
Mar 2025
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death

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1. scibot 06 Mar 2025
  
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  DOI: 10.1111/bph.17464
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17464
Jan 2025
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ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs

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1. scibot 25 Jan 2025
  
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  DOI: 10.1158/0008-5472.CAN-23-2115
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11250573/
Dec 2024
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Dual inhibition of BET and EP300 has antitumor activity in undifferentiated pleomorphic sarcomas and synergizes with ferroptosis induction

1
1. scibot 17 Dec 2024
  
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  RRID:AB_2
  
  DOI: 10.1016/j.tranon.2024.102236
  
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sciencedirect.com/science/article/pii/S1936523324003620
Jul 2024
52.53.155.43 52.53.155.43

paul-chowdhuri-das-2024-tdp1-phosphorylation-by-cdk1-in-mitosis-promotes-mus81-dependent-repair-of-trapped-top1-dna-html.html

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1. scibot 23 Jul 2024
  
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  DOI: 10.1038/s44318-024-00169-3
  
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52.53.155.43/697f670316e6408b23a0d9d6a185a0597054fbec/paul-chowdhuri-das-2024-tdp1-phosphorylation-by-cdk1-in-mitosis-promotes-mus81-dependent-repair-of-trapped-top1-dna-html.html
www.embopress.org www.embopress.org

TDP1 phosphorylation by CDK1 in mitosis promotes MUS81-dependent repair of trapped Top1-DNA covalent complexes

1
1. scibot 23 Jul 2024
  
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  DOI: 10.1038/s44318-024-00169-3
  
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embopress.org/doi/10.1038/s44318-024-00169-3
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Bisbiguanide analogs induce mitochondrial stress to inhibit lung cancer cell invasion

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1. scibot 20 Apr 2024
  
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  DOI: 10.1016/j.isci.2024.109591
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11022046/
Dec 2023
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Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives

1
1. scibot 29 Dec 2023
  
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  RRID:AB_2074795
  
  DOI: 10.1016/j.isci.2023.108659
  
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sciencedirect.com/science/article/pii/S2589004223027360
Nov 2023
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers

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1. scibot 03 Nov 2023
  
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  DOI: 10.1158/1078-0432.CCR-23-0103
  
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pubmed.ncbi.nlm.nih.gov/37279095/
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m6A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1α activation

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1. scibot 02 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113273
  
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sciencedirect.com/science/article/pii/S2211124723012858
Oct 2023
52.53.155.43 52.53.155.43

ccr-23-0103-html.html

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  DOI: 10.1158/1078-0432.ccr-23-0103
  
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52.53.155.43/05abf3a0903b8473a428373dc7a2f791e1da90bb/ccr-23-0103-html.html
Aug 2023
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FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth

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  DOI: 10.1016/j.celrep.2023.112886
  
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sciencedirect.com/science/article/pii/S2211124723008975
Jul 2023
52.53.155.43 52.53.155.43

ccr-23-0103-html.html

1
1. scibot 08 Jul 2023
  
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  RRID: AB_2074795
  
  DOI: 10.1158/1078-0432.ccr-23-0103
  
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52.53.155.43/05abf3a0903b8473a428373dc7a2f791e1da90bb/ccr-23-0103-html.html
Apr 2023
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Identification and characterization of the CDK1-BMAL1-UHRF1 pathway driving tumor progression

1
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  DOI: 10.1016/j.isci.2023.106544
  
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sciencedirect.com/science/article/pii/S2589004223006211
Jan 2023
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CDK1 bridges NF-κB and β-catenin signaling in response to H. pylori infection in gastric tumorigenesis

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  DOI: 10.1016/j.celrep.2023.112005
  
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sciencedirect.com/science/article/pii/S2211124723000165
Oct 2022
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A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1

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1. scibot 12 Oct 2022
  
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  RRID:AB_2074795
  
  DOI: 10.1016/j.celrep.2022.111475
  
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sciencedirect.com/science/article/pii/S2211124722013250
Dec 2021
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Low-intensity pulsed ultrasound-generated singlet oxygen induces telomere damage leading to glioma stem cell awakening from quiescence

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1. scibot 18 Dec 2021
  
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  RRID:AB_2074795
  
  DOI: 10.1016/j.isci.2021.103558
  
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sciencedirect.com/science/article/pii/S2589004221015285
Nov 2021
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Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle

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1. scibot 10 Nov 2021
  
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  RRID:AB_2074795
  
  DOI: 10.1016/j.celrep.2021.109987
  
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sciencedirect.com/science/article/pii/S2211124721014662
Sep 2021
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CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models

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1. scibot 25 Sep 2021
  
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  DOI: 10.1016/j.xcrm.2021.100394
  
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pmc.ncbi.nlm.nih.gov/articles/PMC8484689/
Aug 2021
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The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway

1
1. scibot 17 Aug 2021
  
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  9116
  
  DOI: 10.1016/j.apsb.2021.08.015
  
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sciencedirect.com/science/article/pii/S2211383521003051
Jul 2021
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Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target

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  9116
  
  DOI: 10.1016/j.biocel.2021.106028
  
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sciencedirect.com/science/article/pii/S1357272521001060
Oct 2020
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The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest

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  DOI: 10.1016/j.celrep.2020.108230
  
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sciencedirect.com/science/article/pii/S2211124720312195
Jan 2020
academic.oup.com academic.oup.com

Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures

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1. scibot 13 Jan 2020
  
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  RRID:AB_2074795
  
  DOI: 10.1210/en.2019-00410
  
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academic.oup.com/endo/article/160/11/2600/5535649
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SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-κB Activation

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1. scibot 13 Jan 2020
  
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  RRID:AB_2074795
  
  DOI: 10.1016/j.celrep.2019.06.027
  
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sciencedirect.com/science/article/pii/S2211124719307934
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Untitled document

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  DOI: 10.1016/j.celrep.2019.01.111
  
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sciencedirect.com/science/article/pii/S2211124719301482
Nov 2018
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Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding

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1. scibot 05 Nov 2018
  
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  RRID:AB_2074795
  
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sciencedirect.com/science/article/pii/S1097276517308419
Nov 2017
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The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior

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1. scibot 08 Nov 2017
  
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  AB_2074795
  
  Curator: @chewbeccax
  
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  (Cell Signaling Technology Cat# 9116, RRID:AB_2074795)
  
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sciencedirect.com/science/article/pii/S2352396417301585