114 Matching Annotations
  1. Dec 2025
  2. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Macrophage PD-1 regulates energy expenditure and metabolic dysfunction under immune checkpoint blockade
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    sciencedirect.com:5037/science/article/pii/S1550413125004930
  3. Nov 2025
  4. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004225023211-main-html.html
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    54.241.53.176/47affe1a4d4a9b40800ebf858c65f50b8ac99aa9/1-s2.0-S2589004225023211-main-html.html
  5. Oct 2025
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    The E3 ligase RNF32 controls the IκB kinase complex and NF-κB signaling in intestinal stem cells
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    sciencedirect.com/science/article/pii/S1097276525008226
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    Limited activation interdependence and differing patterns of the in vivo effects of IKK1 and IKK2 downstream of NIK
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    sciencedirect.com/science/article/pii/S2211124725011751
  8. Sep 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12459955/
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    Sigma-1 receptor counteracts non-cell-autonomous poly-PR-induced astrocytic oxidative stress in C9orf72 ALS
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    sciencedirect.com/science/article/pii/S221323172500388X
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    Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S1074761325003334
  12. Aug 2025
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    Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
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    sciencedirect.com/science/article/pii/S1535610825003186
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    1-s2.0-S2589004225015664-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC12396248/
  15. Jul 2025
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate
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    pmc.ncbi.nlm.nih.gov/articles/PMC12208667/
  17. Jun 2025
  18. www.sciencedirect.com www.sciencedirect.com
    Piezo1 senses hyphae and initiates host defense against pathogenic fungi
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    sciencedirect.com/science/article/pii/S2211124725006102
  19. link.springer.com link.springer.com
    RNA polymerase II subunit 5-mediating protein limits TLR4-induced innate immune activation in macrophages by inhibiting IKKβ/NF-κB signaling during sepsis
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    link.springer.com/article/10.1186/s12964-025-02278-w
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Muscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147913/
  21. May 2025
  22. www.sciencedirect.com www.sciencedirect.com
    Microbiota-derived urocanic acid triggered bytyrosine kinase inhibitors potentiates cancer immunotherapy efficacy
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    sciencedirect.com/science/article/pii/S1931312825001556
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    NANS suppresses NF-κB signaling to promote ferroptosis by perturbing iron homeostasis
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    sciencedirect.com/science/article/pii/S2211124725004723
  24. Apr 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Co-targeting BMI1 and MYC to eliminate cancer stem cells in squamous cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147845/
  26. Mar 2025
  27. www.sciencedirect.com www.sciencedirect.com
    Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1
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    sciencedirect.com/science/article/pii/S2211124725001974
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    ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity
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    sciencedirect.com/science/article/pii/S2211124725001688
  29. Jan 2025
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Anandamide Inhibits Vascular Smooth Muscle Migration, Endothelial Adhesion Protein Expression and Monocyte Adhesion of Human Coronary Artery Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11727187/
  31. Dec 2024
  32. www.sciencedirect.com www.sciencedirect.com
    MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics
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    sciencedirect.com/science/article/pii/S2211124724014554
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    Increased CSN5 expression enhances the sensitivity to lenalidomide in multiple myeloma cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11647120/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CCDC134 controls TLR biogenesis through the ER chaperone Gp96
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    pmc.ncbi.nlm.nih.gov/articles/PMC11629888/
  35. Nov 2024
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kaempferol attenuates hyperuricemia combined with gouty arthritis via urate transporters and NLRP3/NF-κB pathway modulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11550584/
  37. Oct 2024
  38. www.sciencedirect.com www.sciencedirect.com
    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
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    sciencedirect.com/science/article/pii/S0092867424010729
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    Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon
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    sciencedirect.com/science/article/pii/S1550413124003668
  40. Aug 2024
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    Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence
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    sciencedirect.com/science/article/pii/S1097276524006609
  42. Jul 2024
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    pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism
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  44. Jun 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC11140209/
  46. May 2024
  47. www.sciencedirect.com www.sciencedirect.com
    A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death
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  48. Mar 2024
  49. link.springer.com link.springer.com
    Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway
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    link.springer.com/article/10.1007/s00210-024-03045-3
  50. Feb 2024
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mycobacterial Rv1804c binds to the PEST domain of IκBα and activates macrophage-mediated proinflammatory responses
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    ncbi.nlm.nih.gov/pmc/articles/PMC10879709/
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    The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection
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    sciencedirect.com/science/article/pii/S2211124724001232
  53. content.iospress.com content.iospress.com
    Inhibition of mGluR5/PI3K-AKT Pathway Alleviates Alzheimer’s Disease-Like Pathology Through the Activation of Autophagy in 5XFAD Mice
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    content.iospress.com/articles/journal-of-alzheimers-disease/jad221058
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
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    ncbi.nlm.nih.gov/pmc/articles/PMC10524254/
  55. Jan 2024
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10776897/
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    CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise
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    sciencedirect.com/science/article/pii/S2211124723016376
  58. Nov 2023
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC10675918/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins
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    ncbi.nlm.nih.gov/pmc/articles/PMC10629731/
  61. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
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    pubmed.ncbi.nlm.nih.gov/37279095/
  62. Oct 2023
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric α-synuclein through NF-κB pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10590863/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-Psychoactive Phytocannabinoids Inhibit Inflammation-Related Changes of Human Coronary Artery Smooth Muscle and Endothelial Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10571842/
  65. www.biorxiv.org www.biorxiv.org
    Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival
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    biorxiv.org/content/10.1101/2023.10.06.560832v1
  66. 52.53.155.43 52.53.155.43
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  67. www.cell.com www.cell.com
    15-keto-PGE2 Alleviates Nonalcoholic Steatohepatitis through its Covalent Modification of NF-κB Factors
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    cell.com/iscience/abstract/S2589-0042(23)02074-6
  68. Sep 2023
  69. www.sciencedirect.com www.sciencedirect.com
    Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling
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    sciencedirect.com/science/article/pii/S109727652300641X
  70. Aug 2023
  71. www.embopress.org www.embopress.org
    Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome
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    embopress.org/doi/10.15252/embr.202357233
  72. 52.53.155.43 52.53.155.43
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IRP1 Mediated Ferroptosis Reverses Temozolomide Resistance in Glioblastoma via Affecting LCN2/FPN1 Signaling Axis Depended on NFKB2
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    ncbi.nlm.nih.gov/pmc/articles/PMC10374607/
  74. Jul 2023
  75. 52.53.155.43 52.53.155.43
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  76. Jun 2023
  77. www.sciencedirect.com www.sciencedirect.com
    Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design
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    sciencedirect.com/science/article/pii/S1074761323002315
  78. www.sciencedirect.com www.sciencedirect.com
    Sublethal necroptosis signaling promotes inflammation and liver cancer
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    sciencedirect.com/science/article/pii/S1074761323002340
  79. May 2023
  80. www.sciencedirect.com www.sciencedirect.com
    VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection
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    sciencedirect.com/science/article/pii/S2211124723005004
  81. Apr 2023
  82. link.springer.com link.springer.com
    N,N-Dimethyl-3β-hydroxycholenamide attenuates neuronal death and retinal inflammation in retinal ischemia/reperfusion injury by inhibiting Ninjurin 1
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    link.springer.com/article/10.1186/s12974-023-02754-5
  83. www.sciencedirect.com www.sciencedirect.com
    PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1
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    sciencedirect.com/science/article/pii/S2211124723003510
  84. Feb 2023
  85. www.sciencedirect.com www.sciencedirect.com
    Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise
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    sciencedirect.com/science/article/pii/S1550413123000116
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC10040382/
  87. Jan 2023
  88. www.sciencedirect.com www.sciencedirect.com
    SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD
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    sciencedirect.com/science/article/pii/S2211124722018654
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC9804112/
  90. Oct 2022
  91. www.sciencedirect.com www.sciencedirect.com
    The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling
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    sciencedirect.com/science/article/pii/S2589004222013384
  92. Sep 2022
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Na/K-ATPase Suppresses LPS-Induced Pro-Inflammatory Signaling Through Lyn
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    ncbi.nlm.nih.gov/pmc/articles/PMC9442361/
  94. Apr 2022
  95. www.sciencedirect.com www.sciencedirect.com
    Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB
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  96. Mar 2022
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    Indirubin-3’-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma
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    sciencedirect.com/science/article/pii/S2352396422001347
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    SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis
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    ncbi.nlm.nih.gov/pmc/articles/PMC8927994/
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    Urolithin A alleviates blood-brain barrier disruption and... : Neural Regeneration Research
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    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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  101. Jan 2022
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    Self-developed NF-κB inhibitor 270 protects against LPS-induced acute kidney injury and lung injury through improving inflammation
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    Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses
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  104. Dec 2021
  105. www.nature.com www.nature.com
    A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis
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    nature.com/articles/s41467-021-27452-9
  106. Oct 2021
  107. www.embopress.org www.embopress.org
    Promyelocytic leukemia protein targets MK2 to promote cytotoxicity
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    embopress.org/doi/full/10.15252/embr.202052254
  108. Aug 2021
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
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    ncbi.nlm.nih.gov/pmc/articles/PMC8369003/
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase
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    ncbi.nlm.nih.gov/pmc/articles/PMC4160779/
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    ncbi.nlm.nih.gov/pmc/articles/PMC5711380/
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    Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response
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    sciencedirect.com/science/article/pii/S0092867418311838
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    TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging
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    sciencedirect.com/science/article/pii/S0092867418309693
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    Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn’s disease
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    O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity
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    ncbi.nlm.nih.gov/pmc/articles/PMC5484619/
  117. Jul 2021
  118. www.sciencedirect.com www.sciencedirect.com
    Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death
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    sciencedirect.com/science/article/pii/S2211124719314858
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF‐κB signaling pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC6344303/
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    Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response
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  121. www.jneurosci.org www.jneurosci.org
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    A constitutively-active IKK-complex at the axon initial segment
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