112 Matching Annotations
  1. Last 7 days
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    The E3 ligase RNF32 controls the IκB kinase complex and NF-κB signaling in intestinal stem cells
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    sciencedirect.com/science/article/pii/S1097276525008226
  3. Oct 2025
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    Limited activation interdependence and differing patterns of the in vivo effects of IKK1 and IKK2 downstream of NIK
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    sciencedirect.com/science/article/pii/S2211124725011751
  5. Sep 2025
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    Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12459955/
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    Sigma-1 receptor counteracts non-cell-autonomous poly-PR-induced astrocytic oxidative stress in C9orf72 ALS
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    sciencedirect.com/science/article/pii/S221323172500388X
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    Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease
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  9. Aug 2025
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    Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
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    sciencedirect.com/science/article/pii/S1535610825003186
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    1-s2.0-S2589004225015664-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC12396248/
  12. Jul 2025
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    Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate
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    pmc.ncbi.nlm.nih.gov/articles/PMC12208667/
  14. Jun 2025
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    Piezo1 senses hyphae and initiates host defense against pathogenic fungi
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    RNA polymerase II subunit 5-mediating protein limits TLR4-induced innate immune activation in macrophages by inhibiting IKKβ/NF-κB signaling during sepsis
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    link.springer.com/article/10.1186/s12964-025-02278-w
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    Muscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147913/
  18. May 2025
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    Microbiota-derived urocanic acid triggered bytyrosine kinase inhibitors potentiates cancer immunotherapy efficacy
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    NANS suppresses NF-κB signaling to promote ferroptosis by perturbing iron homeostasis
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  21. Apr 2025
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    Co-targeting BMI1 and MYC to eliminate cancer stem cells in squamous cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147845/
  23. Mar 2025
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    Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1
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    ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity
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  26. Jan 2025
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    Anandamide Inhibits Vascular Smooth Muscle Migration, Endothelial Adhesion Protein Expression and Monocyte Adhesion of Human Coronary Artery Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11727187/
  28. Dec 2024
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    MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics
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    Increased CSN5 expression enhances the sensitivity to lenalidomide in multiple myeloma cells
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    CCDC134 controls TLR biogenesis through the ER chaperone Gp96
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  32. Nov 2024
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    Kaempferol attenuates hyperuricemia combined with gouty arthritis via urate transporters and NLRP3/NF-κB pathway modulation
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  34. Oct 2024
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    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
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    Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon
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  37. Aug 2024
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    Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence
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  39. Jul 2024
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    pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism
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  41. Jun 2024
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    Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
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  43. May 2024
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    A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death
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  45. Mar 2024
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    Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway
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  47. Feb 2024
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    Mycobacterial Rv1804c binds to the PEST domain of IκBα and activates macrophage-mediated proinflammatory responses
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    The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection
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    Inhibition of mGluR5/PI3K-AKT Pathway Alleviates Alzheimer’s Disease-Like Pathology Through the Activation of Autophagy in 5XFAD Mice
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    Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
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  52. Jan 2024
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    SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation
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    CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise
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  55. Nov 2023
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    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins
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    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
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  59. Oct 2023
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    LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric α-synuclein through NF-κB pathway
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    Non-Psychoactive Phytocannabinoids Inhibit Inflammation-Related Changes of Human Coronary Artery Smooth Muscle and Endothelial Cells
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    Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival
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    15-keto-PGE2 Alleviates Nonalcoholic Steatohepatitis through its Covalent Modification of NF-κB Factors
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    cell.com/iscience/abstract/S2589-0042(23)02074-6
  65. Sep 2023
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    Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling
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  67. Aug 2023
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    Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome
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    IRP1 Mediated Ferroptosis Reverses Temozolomide Resistance in Glioblastoma via Affecting LCN2/FPN1 Signaling Axis Depended on NFKB2
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  71. Jul 2023
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  73. Jun 2023
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    Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design
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    Sublethal necroptosis signaling promotes inflammation and liver cancer
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  76. May 2023
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    VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection
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  78. Apr 2023
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    N,N-Dimethyl-3β-hydroxycholenamide attenuates neuronal death and retinal inflammation in retinal ischemia/reperfusion injury by inhibiting Ninjurin 1
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    PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1
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  81. Feb 2023
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    Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise
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    Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease
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  84. Jan 2023
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    SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD
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    Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice
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  87. Oct 2022
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    The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling
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  89. Sep 2022
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    Na/K-ATPase Suppresses LPS-Induced Pro-Inflammatory Signaling Through Lyn
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  91. Apr 2022
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    Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB
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  93. Mar 2022
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    Indirubin-3’-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma
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    SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis
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    Urolithin A alleviates blood-brain barrier disruption and... : Neural Regeneration Research
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    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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  98. Jan 2022
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    Self-developed NF-κB inhibitor 270 protects against LPS-induced acute kidney injury and lung injury through improving inflammation
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    Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses
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  101. Dec 2021
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    A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis
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  103. Oct 2021
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    Promyelocytic leukemia protein targets MK2 to promote cytotoxicity
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  105. Aug 2021
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
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    Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase
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    ncbi.nlm.nih.gov/pmc/articles/PMC4160779/
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    Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response
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    TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging
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    Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn’s disease
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    O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity
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  114. Jul 2021
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    Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death
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  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF‐κB signaling pathway
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    Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response
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    A constitutively-active IKK-complex at the axon initial segment
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    Palmitate‐induced C/EBP homologous protein activation leads to NF‐κB‐mediated increase in BACE1 activity and amyloid beta genesis
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14292/full
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    Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
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  122. Jun 2021
  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid
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