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Combining fruquintinib with TAS-102 as a promising strategy: antitumor activity in preclinical colorectal and gastric cancer xenograft models

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  DOI: 10.1186/s12885-026-16153-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13422279/
Jun 2026
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Mutational signatures of environmental carcinogens in human tissue organoids revealed by duplex sequencing

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  DOI: 10.1016/j.celrep.2026.117406
  
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sciencedirect.com/science/article/pii/S2211124726004845
May 2026
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Adaptive Regulation of dNTP Homeostasis Confers Osimertinib Resistance in EGFR-Mutant Non–Small Cell Lung Carcinoma

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1. scibot 27 May 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3237
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13198874/
Apr 2026
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MDC1 promotes nuclear localization of Beclin-1 and supports its role in ATM pathway in response to oxidative stress

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1. scibot 21 Apr 2026
  
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  DOI: 10.1016/j.ejcb.2026.151540
  
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sciencedirect.com/science/article/pii/S0171933526000117
Mar 2026
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PRMT5 is Frequently Upregulated and a Potential Therapeutic Target in MTAP-deficient Malignant Peripheral Nerve Sheath Tumors

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1. scibot 19 Mar 2026
  
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  DOI: 10.64898/2026.03.09.710638
  
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biorxiv.org/content/10.64898/2026.03.09.710638v1
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CF10 Displays Improved Synergy with Oxaliplatin in TP53-Null and Wild-Type CRC Cells from Increased Top1cc and Replication Stress

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1. scibot 17 Mar 2026
  
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  DOI: 10.3390/cancers18050882
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12984549/
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1-s2.0-S2589004226005778-main-html.html

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1. scibot 05 Mar 2026
  
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  AB_2080501
  
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54.241.53.176/ed8e1992a674080ffa080c602d1162809d86e16e/1-s2.0-S2589004226005778-main-html.html
Feb 2026
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Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition

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1. scibot 14 Feb 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12900515/
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Delactylation of the tumor suppressor ARHGDIB drives metastasis and chemoresistance in bladder cancer

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1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.116941
  
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sciencedirect.com/science/article/pii/S2211124726000197
Jan 2026
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FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion

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1. scibot 28 Jan 2026
  
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  DOI: 10.1083/jcb.202311082
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11770945/
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2026.01.09.698661v1.full-html.html

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1. scibot 13 Jan 2026
  
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  DOI: 10.64898/2026.01.09.698661
  
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54.241.53.176/229f150d292937106a4e15fcfbf1923f59503af0/2026.01.09.698661v1.full-html.html
Aug 2025
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PARP inhibitors potentiate proton therapy end-of-range effects by accelerating replication forks and promoting transcription conflict

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1. scibot 28 Aug 2025
  
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  DOI: 10.1016/j.ijrobp.2025.08.049
  
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sciencedirect.com/science/article/pii/S0360301625061978
Jun 2025
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Functional assessment of all ATM SNVs using prime editing and deep learning

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.05.046
  
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sciencedirect.com/science/article/pii/S0092867425006348
May 2025
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IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.isci.2025.112567
  
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sciencedirect.com/science/article/pii/S2589004225008284
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Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cells

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.jare.2025.04.033
  
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sciencedirect.com/science/article/pii/S2090123225002772
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Genomic context influences translesion synthesis DNA polymerase-dependent mechanisms of micronuclei induction by G-quadruplexes

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115706
  
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sciencedirect.com/science/article/pii/S2211124725004772
Apr 2025
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Halting hepatocellular carcinoma: Identifying intercellular crosstalk in HBV-driven disease

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1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115457
  
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sciencedirect.com/science/article/pii/S2211124725002281
Mar 2025
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Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair

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1. scibot 14 Mar 2025
  
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  DOI: 10.1126/sciadv.adt1241
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11900879/
Dec 2024
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Transcriptional and functional regulation of cell cycle and UV response by PPARβ in human skin epidermal cells

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1. scibot 06 Dec 2024
  
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  DOI: 10.1096/fj.202401950R
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11610672/
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The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.10.044
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11671030/
Nov 2024
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A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.xcrm.2024.101823
  
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sciencedirect.com/science/article/pii/S2666379124005949
Jul 2024
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Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication

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1. scibot 14 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110144
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11233922/
Jun 2024
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Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

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1. scibot 04 Jun 2024
  
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  DOI: 10.1016/j.devcel.2024.05.010
  
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sciencedirect.com/science/article/pii/S1534580724003277
May 2024
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NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors

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1. scibot 02 May 2024
  
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  DOI: 10.1016/j.xgen.2024.100550
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11099347/
Apr 2024
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DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response

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1. scibot 25 Apr 2024
  
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  DOI: 10.1083/jcb.202303141
  
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  DOI: 10.1083/jcb.202303141
  
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rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
Mar 2024
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Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors

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1. scibot 16 Mar 2024
  
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  DOI: 10.1038/s44319-024-00089-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10933359/
Feb 2024
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Temozolomide sensitizes ARID1A-mutated cancers to PARP inhibitors

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1. scibot 16 Feb 2024
  
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  DOI: 10.1158/0008-5472.CAN-22-3646
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10527942/
Jan 2024
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Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells

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1. scibot 19 Jan 2024
  
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  DOI: 10.1016/j.xcrm.2023.101376
  
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sciencedirect.com/science/article/pii/S2666379123006055
Sep 2023
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can-22-3646-html.html

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  DOI: 10.1158/0008-5472.can-22-3646
  
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52.53.155.43/7c5c0394bd7eaeefd5e70a237f23894cb3f7190b/can-22-3646-html.html
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The interplay of TARG1 and PARG protects against genomic instability

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1. scibot 12 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113113
  
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sciencedirect.com/science/article/pii/S2211124723011245
Aug 2023
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The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway

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1. scibot 05 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107449
  
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sciencedirect.com/science/article/pii/S2589004223015262
Jul 2023
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Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

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1. scibot 14 Jul 2023
  
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  DOI: 10.1016/j.ccell.2023.06.007
  
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sciencedirect.com/science/article/pii/S1535610823002179
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Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma

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1. scibot 08 Jul 2023
  
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  DOI: 10.1038/s41420-023-01526-7
  
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nature.com/articles/s41420-023-01526-7
Apr 2023
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A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer

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1. scibot 19 Apr 2023
  
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  DOI: 10.1016/j.xcrm.2023.101015
  
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sciencedirect.com/science/article/pii/S2666379123001258
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SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology

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1. scibot 06 Apr 2023
  
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  DOI: 10.1016/j.molcel.2023.02.004
  
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Nov 2022
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Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway

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  DOI: 10.1016/j.isci.2022.105342
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9633742/
Apr 2022
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A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress

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  DOI: 10.1038/s41598-022-09308-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8971416/
Mar 2022
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Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome

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  DOI: 10.1016/j.devcel.2022.02.013
  
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Jan 2022
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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

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  DOI: 10.1016/j.ccell.2019.04.011
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8717880/
Dec 2021
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Inhibition of ATM induces hypersensitivity to proton irradiation by upregulating toxic end joining

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1. scibot 17 Dec 2021
  
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  DOI: 10.1158/0008-5472.CAN-20-2960
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8260463/
Sep 2021
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GAGE mediates radio resistance in cervical cancers via the regulation of chromatin accessibility

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  DOI: 10.1016/j.celrep.2021.109621
  
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Jun 2021
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MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway

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  DOI: 10.1016/j.ebiom.2021.103441
  
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A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways

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1. scibot 16 Jun 2021
  
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  DOI: 10.3390/cancers13112840
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8201054/
May 2021
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Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging

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1. scibot 07 May 2021
  
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  DOI: 10.1016/j.molcel.2020.06.027
  
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Apr 2021
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Functional interrogation of DNA damage response variants with base editing screens

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  DOI: 10.1016/j.cell.2021.01.041
  
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Mar 2021
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DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1

1
1. scibot 17 Mar 2021
  
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  DOI: 10.1016/j.celrep.2021.108840
  
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Feb 2021
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FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

1
1. scibot 27 Feb 2021
  
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  DOI: 10.1016/j.cell.2020.11.042
  
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The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

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  DOI: 10.7554/eLife.61797
  
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elifesciences.org/articles/61797
Oct 2020
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Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell Cycle Arrest

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Sep 2020
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Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer

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1. scibot 26 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107745
  
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FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function

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Jan 2020
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The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics

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1. scibot 13 Jan 2020
  
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Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.07.070
  
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ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response

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  DOI: 10.1016/j.celrep.2019.09.008
  
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Untitled document

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  DOI: 10.1016/j.molcel.2019.04.024
  
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sciencedirect.com/science/article/pii/S1097276519303168
Nov 2018
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The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression

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sciencedirect.com/science/article/pii/S1097276518300406
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Systematic Functional Annotation of Somatic Mutations in Cancer

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sciencedirect.com/science/article/pii/S1535610818300217
Nov 2017
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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1. scibot 08 Nov 2017
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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sciencedirect.com/science/article/pii/S2405471216304082

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