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HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis

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1. scibot 11 Oct 2025
  
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  RRID:AB_2091723
  
  DOI: 10.1016/j.celrep.2025.116382
  
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sciencedirect.com/science/article/pii/S2211124725011532
Sep 2025
www.biorxiv.org www.biorxiv.org

Mitochondrial ACSS1 Links Acetate Metabolism to Pyrimidine Biosynthesis in Nutrient-Stressed B-Cell Lymphomas

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1. scibot 09 Sep 2025
  
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  AB_2091723
  
  DOI: 10.1101/2025.08.29.673065
  
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biorxiv.org/content/10.1101/2025.08.29.673065v1
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SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer

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1. scibot 03 Sep 2025
  
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  RRID:AB_2091723
  
  DOI: 10.1016/j.celrep.2025.116139
  
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sciencedirect.com/science/article/pii/S2211124725009106
Jul 2025
www.biorxiv.org www.biorxiv.org

Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

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1. scibot 30 Jul 2025
  
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  RRID:AB_2091723
  
  DOI: 10.1101/2025.07.23.666448
  
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biorxiv.org/content/10.1101/2025.07.23.666448v1
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

1-s2.0-S2589004225006248-main-html.html

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1. scibot 10 Apr 2025
  
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  RRID:AB_2091723
  
  DOI: 10.1016/j.isci.2025.112363
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12053632/
Aug 2024
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Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration

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1. scibot 22 Aug 2024
  
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  AB_2091723
  
  DOI: 10.1016/j.neuron.2024.07.020
  
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sciencedirect.com/science/article/pii/S0896627324005427
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OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response

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1. scibot 21 Aug 2024
  
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  AB_2091723
  
  DOI: 10.1016/j.molcel.2024.07.020
  
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sciencedirect.com/science/article/pii/S109727652400618X
May 2024
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Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers

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1. scibot 17 May 2024
  
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  RRID:AB_2091723
  
  DOI: 10.1016/j.molcel.2024.04.009
  
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sciencedirect.com/science/article/pii/S1097276524003241
Dec 2023
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SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation

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1. scibot 01 Dec 2023
  
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  RRID:AB_2091723
  
  DOI: 10.1016/j.molcel.2023.10.042
  
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sciencedirect.com/science/article/pii/S1097276523009139
Nov 2022
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Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma

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1. scibot 11 Nov 2022
  
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  RRID:AB_2091723
  
  DOI: 10.1016/j.ccell.2022.10.009
  
  Resource: (Proteintech Cat# 14877-1-AP, RRID:AB_2091723)
  
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sciencedirect.com/science/article/pii/S1535610822005001
Aug 2022
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A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

1
1. scibot 22 Aug 2022
  
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  RRID:AB_2091723
  
  DOI: 10.1016/j.ccell.2022.07.012
  
  Resource: (Proteintech Cat# 14877-1-AP, RRID:AB_2091723)
  
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sciencedirect.com/science/article/pii/S1535610822003257
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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

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1. scibot 22 Aug 2022
  
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  RRID:AB_2091723
  
  DOI: 10.1016/j.ccell.2022.07.011
  
  Resource: (Proteintech Cat# 14877-1-AP, RRID:AB_2091723)
  
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sciencedirect.com/science/article/pii/S1535610822003245
Jul 2021
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Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

1
1. scibot 31 Jul 2021
  
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  RRID:AB_2091723
  
  DOI: 10.1016/j.cmet.2018.10.014
  
  Resource: (Proteintech Cat# 14877-1-AP, RRID:AB_2091723)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2091723
  
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sciencedirect.com/science/article/pii/S1550413118306466
Jan 2020
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_2091723
  
  DOI: 10.1016/j.cmet.2019.02.001
  
  Resource: (Proteintech Cat# 14877-1-AP, RRID:AB_2091723)
  
  Curator: @ethanbadger
  
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  RRID:AB_2091723 RRIDCUR:Validated
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RRID:AB_2091723

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sciencedirect.com/science/article/pii/S1550413119300658