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Apr 2026
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Rational discovery of therapeutic PAK1 allosteric activators

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1. scibot 02 Apr 2026
  
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  DOI: 10.1016/j.cell.2026.03.008
  
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sciencedirect.com/science/article/pii/S0092867426002758
Mar 2026
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ALG6 orchestrates coronavirus replication via the endoplasmic reticulum stress-autophagy axis

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1. scibot 20 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117108
  
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sciencedirect.com/science/article/pii/S2211124726001865
Feb 2026
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Triglycerides induce endoplasmic reticulum lipid bilayer stress to activate PERK and enhance antifungal immunity

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1. scibot 13 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.116976
  
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sciencedirect.com/science/article/pii/S2211124726000549
Jan 2026
54.241.53.176 54.241.53.176

2026.01.07.697614v1.full-html.html

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1. scibot 13 Jan 2026
  
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Endometrial stromal cell-derived TMAO sustains decidualization to prevent recurrent spontaneous abortion

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.cmet.2025.11.014
  
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sciencedirect.com/science/article/pii/S1550413125005285
Dec 2025
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circATF6 triggers calcium overload to synergize with EGFR-TKI in non-small cell lung cancer via modulation of proteostasis

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1. scibot 09 Dec 2025
  
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sciencedirect.com:5037/science/article/pii/S2211124725014317
Nov 2025
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Inhibition of Histone Deacetylases Induces Cancer Cell Apoptosis Through the PERK Pathway of ER Stress Response

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1. scibot 01 Nov 2025
  
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  DOI: 10.1111/jcmm.70928
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12571189/
Sep 2025
52.53.155.43 52.53.155.43

2025.09.04.674332v2.full-html.html

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1. scibot 18 Sep 2025
  
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52.53.155.43/304402c0b5b5e8844bb324b2732dfcb1e481f20c/2025.09.04.674332v2.full-html.html
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Recombinant tissue plasminogen activator protects neurons after intracerebral hemorrhage through activating the PI3K/AKT/mTOR pathway

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1. scibot 07 Sep 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12407559/
Aug 2025
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2025.08.17.670564v1.full-html.html

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1. scibot 22 Aug 2025
  
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52.53.155.43/5faff91dc4a1d4c7cd6e1fe4e1a4aa5aa8538a5d/2025.08.17.670564v1.full-html.html
Jul 2025
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Uric Acid Causes Pancreatic β Cell Death and Dysfunction via Modulating CHOP-Mediated Endoplasmic Reticulum Stress Pathways

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1. scibot 30 Jul 2025
  
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  DOI: 10.3390/diseases13070213
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12293447/
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Ceftriaxone ameliorates tau phosphorylation and mislocalization in APP/PS1 AD mice by inhibiting endoplasmic reticulum stress

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.neuropharm.2025.110600
  
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sciencedirect.com/science/article/pii/S0028390825003089
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Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.cell.2025.06.027
  
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The DRD2 antagonist haloperidol mediates autophagy-induced ferroptosis to increase temozolomide sensitivity by promoting endoplasmic reticulum stress in glioblastoma

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1. scibot 08 Jul 2025
  
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  DOI: 10.1158/1078-0432.CCR-22-3971
  
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aacrjournals.org/clincancerres/article/29/16/3172/728242/The-DRD2-Antagonist-Haloperidol-Mediates-Autophagy
Jun 2025
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Resting Ca2+ fluxes protect cells from fast mitochondrial fragmentation, cell stress responses, and immediate transcriptional reprogramming

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1. scibot 17 Jun 2025
  
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  DOI: 10.1007/s00018-025-05745-2
  
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link.springer.com/article/10.1007/s00018-025-05745-2
May 2025
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Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress

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1. scibot 24 May 2025
  
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  DOI: 10.4103/NRR.NRR-D-24-00044
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12094565/
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Selective removal of astrocytic PERK protects against glymphatic impairment and decreases toxic aggregation of β-amyloid and tau

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.neuron.2025.04.027
  
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sciencedirect.com/science/article/pii/S0896627325003101
Mar 2025
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Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

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1. scibot 04 Mar 2025
  
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  DOI: 10.1002/advs.202414260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12021055/
Jan 2025
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Targeting the mevalonate pathway potentiates NUAK1 inhibition-induced immunogenic cell death and antitumor immunity

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1. scibot 17 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2024.101913
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866496/
Dec 2024
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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury: PERK as a potential target for intervention

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1. scibot 11 Dec 2024
  
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  DOI: 10.4103/NRR.NRR-D-23-00794
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11624856/
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DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.114984
  
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sciencedirect.com/science/article/pii/S2211124724013354
Sep 2024
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Pharmacologic activation of activating transcription factor 6 contributes to neuronal survival after spinal cord injury in mice

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1. scibot 27 Sep 2024
  
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  DOI: 10.1111/jnc.16092
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16092
Jun 2024
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Islet cell stress induced by insulin-degrading enzyme deficiency promotes regeneration and protection from autoimmune diabetes

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1. scibot 08 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.109929
  
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BPS Publications

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  DOI: 10.1111/bph.16436
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.16436
May 2024
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Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression

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  DOI: 10.1016/j.cmet.2024.04.014
  
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Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma

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1. scibot 07 May 2024
  
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sciencedirect.com/science/article/pii/S1074761324002115
Apr 2024
dx.doi.org dx.doi.org

Acute Exercise Increases GDF15 and Unfolded Protein Response/Integrated Stress Response in Muscle in Type 2 diabetes

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1. scibot 04 Apr 2024
  
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  DOI: 10.1210/clinem/dgae032
  
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dx.doi.org/10.1210/clinem/dgae032
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Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells

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  DOI: 10.1016/j.cell.2024.03.011
  
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sciencedirect.com/science/article/pii/S0092867424003039
Mar 2024
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A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease

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1. scibot 27 Mar 2024
  
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  DOI: 10.4103/1673-5374.389356
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10960274/
Feb 2024
52.53.155.43 52.53.155.43

Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway

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  DOI: 10.1101/2023.10.02.560521
  
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52.53.155.43/4a182fdd92d1ce35b13f136f7657c6c9ec6a6224/2023.10.02.560521v1.full-html.html
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FGF9 is required for Purkinje cell development and function in the cerebellum

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  DOI: 10.1016/j.isci.2024.109039
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10863307/
Oct 2023
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EDEM1 regulates the insulin mRNA level by inhibiting the endoplasmic reticulum stress-induced IRE1/JNK/c-Jun pathway

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1. scibot 14 Oct 2023
  
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  DOI: 10.1016/j.isci.2023.107956
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10562789/
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Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice

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1. scibot 13 Oct 2023
  
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  DOI: 10.1016/j.isci.2023.108082
  
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cell.com/iscience/abstract/S2589-0042(23)02159-4
Sep 2023
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Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity

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1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.xcrm.2023.101206
  
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British J Pharmacology - 2023 - Dai-html.html

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1. scibot 16 Sep 2023
  
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Jul 2023
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Exogenous hydrogen sulfide alleviates hepatic endoplasmic reticulum stress via SIRT1/FoxO1/PCSK9 pathway in NAFLD

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VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms

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Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response

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Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex

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TREM2 improves neurological dysfunction and attenuates neuroinflammation, TLR signaling and neuronal apoptosis in the acute phase of intracerebral hemorrhage

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Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses

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Lack of COL6/collagen VI causes megakaryocyte dysfunction by impairing autophagy and inducing apoptosis

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Gut microbe-derived metabolite trimethylamine N-oxide activates PERK to drive fibrogenic mesenchymal differentiation

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FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity

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TIMP2 mediates endoplasmic reticulum stress contributing to sepsis-induced acute kidney injury

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PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen

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BPS Publications

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Differential ER Stress as a Driver of Cell Fate following Ricin Toxin Exposure

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ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue

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Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction

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Co-opting regulation bypass repair as a gene correction strategy for monogenic diseases

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Untitled document

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Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

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ncbi.nlm.nih.gov/pmc/articles/PMC8315795/
Jun 2021
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Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells

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nature.com/articles/s41467-021-23593-z
May 2021
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Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling

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A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation

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Neddylation is required for presynaptic clustering of mGlu7 and maturation of presynaptic terminals

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Sep 2020
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ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress

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TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

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Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain

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The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

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Jan 2020
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Cartilage ablation of Sirt1 causes inhibition of growth plate chondrogenesis by hyperactivation of mTORC1 signaling

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Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

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BPS Publications

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Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells

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Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration

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Mast Cells Induce Blood Brain Barrier Damage in SCD by Causing Endoplasmic Reticulum Stress in the Endothelium

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  DOI: 10.3389/fncel.2019.00056
  
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Betulinic acid alleviates endoplasmic reticulum stress‐mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice

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Untitled document

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  DOI: 10.1016/j.cell.2019.04.010
  
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Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness

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Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate

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Vitamin D Switches BAF Complexes to Protect β Cells

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Chemical hypoxia‐induced integrated stress response activation in oligodendrocytes is mediated by the transcription factor nuclear factor (erythroid‐derived 2)‐like 2 (NRF2)

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The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling

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