123 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    1. scibot 21 Dec 2024
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      DOI: 10.1101/2024.02.20.581056

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    pmc.ncbi.nlm.nih.gov/articles/PMC11601497/
  3. Dec 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters in collective cell migration of epithelial cells
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    sciencedirect.com/science/article/pii/S2211124724013378
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence
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    1. scibot 11 Dec 2024
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    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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    1. scibot 05 Dec 2024
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    sciencedirect.com/science/article/pii/S2211124724013779
  7. Nov 2024
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bilateral regulation of EGFR activity and local PI(4,5)P2 dynamics in mammalian cells observed with superresolution microscopy
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    1. scibot 15 Nov 2024
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      DOI: 10.7554/eLife.101652

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  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells
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    1. scibot 07 Nov 2024
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      DOI: 10.3389/fimmu.2024.1470620

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    pmc.ncbi.nlm.nih.gov/articles/PMC11487346/
  10. Oct 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis
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    1. scibot 05 Oct 2024
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      DOI: 10.1083/jcb.202401167

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    ncbi.nlm.nih.gov/pmc/articles/PMC11449124/
  12. aacrjournals.org aacrjournals.org
    YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma
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    1. scibot 02 Oct 2024
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    aacrjournals.org/cancerres/article/80/21/4741/645935/YAP-Mediated-Repression-of-HRK-Regulates-Tumor
  13. Sep 2024
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    Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer
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    1. scibot 25 Sep 2024
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  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
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    1. scibot 05 Sep 2024
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  16. Aug 2024
  17. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    1. scibot 22 Aug 2024
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    cell.com/cell/fulltext/S0092-8674(20)30163-X
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    Activation of limbal epithelial proliferation is partly controlled by the ACE2-LCN2 pathway
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    1. scibot 19 Aug 2024
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    sciencedirect.com/science/article/pii/S2589004224017590
  19. www.sciencedirect.com www.sciencedirect.com
    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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    1. scibot 18 Aug 2024
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    sciencedirect.com/science/article/pii/S266637912400377X
  20. Jul 2024
  21. www.cell.com www.cell.com
    Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK
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    1. scibot 30 Jul 2024
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    cell.com/cell-host-microbe/abstract/S1931-3128(24)00254-3
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    Harnessing the CD44-targeted delivery of self-assembled hyaluronan nanogel to reverse the antagonism between Cisplatin and Gefitinib in NSCLC cancer therapy
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    1. scibot 24 Jul 2024
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    sciencedirect.com/science/article/pii/S0144861724007471
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11293357/
  24. www.cell.com www.cell.com
    TSPAN4 influences glioblastoma progression through regulating EGFR stability
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    cell.com/iscience/fulltext/S2589-0042(24)01642-0
  25. Jun 2024
  26. www.sciencedirect.com www.sciencedirect.com
    Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform
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    sciencedirect.com/science/article/pii/S2211124724006417
  27. May 2024
  28. www.sciencedirect.com www.sciencedirect.com
    Targeted blocking of EGFR and GLUT1 by compound H reveals a new strategy for treatment of triple-negative breast cancer and nasopharyngeal carcinoma
    1
    1. scibot 07 May 2024
      3777

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    sciencedirect.com/science/article/pii/S0928098724001003
  29. Mar 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers
    1
    1. scibot 22 Mar 2024
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      DOI: 10.1038/s41467-024-46284-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10951324/
  31. www.sciencedirect.com www.sciencedirect.com
    An engineering strategy to target activated EGFR with CAR T cells
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    1. scibot 19 Mar 2024
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    sciencedirect.com/science/article/pii/S2667237524000511
  32. Feb 2024
  33. www.sciencedirect.com www.sciencedirect.com
    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    sciencedirect.com/science/article/pii/S2211124724000421
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    Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR
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    sciencedirect.com/science/article/pii/S1534580724000303
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831936/
  36. Dec 2023
  37. www.sciencedirect.com www.sciencedirect.com
    EGFR-activated myofibroblasts promote metastasis of pancreatic cancer
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    sciencedirect.com/science/article/pii/S1535610823004300
  38. Nov 2023
  39. www.sciencedirect.com www.sciencedirect.com
    EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma
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    1. scibot 28 Nov 2023
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    sciencedirect.com/science/article/abs/pii/S1097276523008626
  40. Oct 2023
  41. www.science.org www.science.org
    Piezo1 activates noncanonical EGFR endocytosis and signaling
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    1. scibot 17 Oct 2023
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      DOI: 10.1126/sciadv.adi1328

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    science.org/doi/10.1126/sciadv.adi1328
  42. 52.53.155.43 52.53.155.43
    The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers
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    52.53.155.43/e45e39aa6be90d4518c1365e2458466145a6420b/2023.06.16.545259v2.full-html.html
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    Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor
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      DOI: 10.1016/j.chembiol.2023.09.013

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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Piezo1 activates noncanonical EGFR endocytosis and signaling
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      DOI: 10.1126/sciadv.adi1328

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    ncbi.nlm.nih.gov/pmc/articles/PMC10530101/
  45. Sep 2023
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Promoting the activity of a receptor tyrosine phosphatase with a novel pH‐responsive transmembrane agonist inhibits cancer‐associated phenotypes
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      DOI: 10.1002/pro.4742

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    ncbi.nlm.nih.gov/pmc/articles/PMC10461461/
  47. Aug 2023
  48. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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    sciencedirect.com/science/article/pii/S1535610823002453
  49. Jun 2023
  50. www.sciencedirect.com www.sciencedirect.com
    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    sciencedirect.com/science/article/pii/S030438352300215X
  51. www.science.org www.science.org
    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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      DOI: 10.1126/sciadv.ade1155

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    science.org/doi/10.1126/sciadv.ade1155
  52. dx.doi.org dx.doi.org
    LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL
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      DOI: 10.1158/2159-8290.CD-22-0376

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    dx.doi.org/10.1158/2159-8290.CD-22-0376
  53. May 2023
  54. academic.oup.com academic.oup.com
    Mechanisms of estradiol-induced EGF-like factor expression and oocyte maturation via G protein-coupled estrogen receptor
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      DOI: 10.1210/endocr/bqaa190

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    academic.oup.com/endo/article/161/12/bqaa190/5929646
  55. Apr 2023
  56. www.sciencedirect.com www.sciencedirect.com
    IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma
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    sciencedirect.com/science/article/pii/S2589004223007162
  57. www.nature.com www.nature.com
    Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer
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      DOI: 10.1038/s41416-023-02264-4

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    nature.com/articles/s41416-023-02264-4
  58. Feb 2023
  59. 52.53.155.43 52.53.155.43
    cd-22-0376-html.html
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    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
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    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
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    EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer
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    Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling
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    Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains
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    europepmc.org/articles/PMC5663478/
  161. www.sciencedirect.com www.sciencedirect.com
    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
    1
    1. scibot 05 Nov 2018
      RRID:AB_2096270

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      (Cell Signaling Technology Cat# 3777, RRID:AB_2096270)

      SciCrunch record: RRID:AB_2096270

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      RRID:AB_2096270
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    sciencedirect.com/science/article/pii/S1097276517307025
  162. Nov 2017
  163. www.sciencedirect.com www.sciencedirect.com
    Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer
    1
    1. scibot 08 Nov 2017
      3777

      Curator: @Jmenke

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      (Cell Signaling Technology Cat# 3777, RRID:AB_2096270)

      SciCrunch record: RRID:AB_2096270

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      RRID:AB_2096270 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S0092867417310474
  164. www.sciencedirect.com www.sciencedirect.com
    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
    1
    1. scibot 08 Nov 2017
      AB_2096270

      Curator: @chewbeccax

      Resource used:

      (Cell Signaling Technology Cat# 3777, RRID:AB_2096270)

      SciCrunch record: RRID:AB_2096270

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_2096270 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276517303945
  165. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TACE/ADAM17 Is Essential for Oligodendrocyte Development and CNS Myelination
    1
    1. scibot 08 Nov 2017
      AB_2096270

      Curator: @jcabotaj

      Curator note: author didn't write "RRID"

      Resource used:

      (Cell Signaling Technology Cat# 3777, RRID:AB_2096270)

      SciCrunch record: RRID:AB_2096270

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      RRID:AB_2096270
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    ncbi.nlm.nih.gov/pmc/articles/PMC4152601/