146 Matching Annotations
  1. Oct 2025
  2. www.embopress.org www.embopress.org
    Phosphoproteomics of osimertinib-tolerant persister cells reveals targetable kinase-substrate signatures
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    embopress.org/doi/10.1038/s44320-025-00141-1
  3. 54.241.53.176 54.241.53.176
    hsu-et-al-2025-phosphoproteomics-of-osimertinib-tolerant-persister-cells-reveals-targetable-kinase-substrate-signatures-html.html
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    54.241.53.176/9c78a41645fcc9eb1ef3871f95e64fd70faf70c8/hsu-et-al-2025-phosphoproteomics-of-osimertinib-tolerant-persister-cells-reveals-targetable-kinase-substrate-signatures-html.html
  4. Sep 2025
  5. www.sciencedirect.com www.sciencedirect.com
    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    sciencedirect.com/science/article/pii/S2666379125004367
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12340909/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875910/
  8. Aug 2025
  9. www.sciencedirect.com www.sciencedirect.com
    Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis
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    sciencedirect.com/science/article/pii/S153458072500471X
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12262427/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential Efficacy of Bevacizumab and Erlotinib in Preclinical Models of Renal Medullary Carcinoma and Fumarate Hydratase–Deficient Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12323885/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12317733/
  13. Jul 2025
  14. www.biorxiv.org www.biorxiv.org
    High Throughput Screening Identifies Small Molecules that Synergize with MRTX1133 Against Acquired Resistant KRAS G12D Mutated CRC
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    biorxiv.org/content/10.1101/2025.06.27.662039v1
  15. www.biorxiv.org www.biorxiv.org
    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    biorxiv.org/content/10.1101/2025.06.18.660406v1
  16. Jun 2025
  17. www.sciencedirect.com www.sciencedirect.com
    A first-in-class EGFR-directed KRAS G12V selective inhibitor
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    sciencedirect.com/science/article/pii/S1535610825002259
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EGFR phosphorylates DNAJB1 to suppress α-synuclein aggregation in Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12145416/
  19. www.sciencedirect.com www.sciencedirect.com
    Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation
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    sciencedirect.com/science/article/pii/S2451945625001667
  20. link.springer.com link.springer.com
    PIN1 serves as a prognostic and therapeutic biomarker in lung adenocarcinoma
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    link.springer.com/article/10.1007/s10142-025-01629-7
  21. www.sciencedirect.com www.sciencedirect.com
    Amiloride synergizes with EGFR PROTACs and inhibitors to overcome therapeutic resistance in NSCLC
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    sciencedirect.com/science/article/pii/S0045206825005218
  22. May 2025
  23. www.sciencedirect.com www.sciencedirect.com
    Stress-induced pro-inflammatory glioblastoma stem cells secrete TNFAIP6 to enhance tumor growth and induce suppressive macrophages
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    sciencedirect.com/science/article/pii/S1534580725002874
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12052438/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046322/
  26. Mar 2025
  27. www.sciencedirect.com www.sciencedirect.com
    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S1097276525001947
  28. Jan 2025
  29. www.sciencedirect.com www.sciencedirect.com
    A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance
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    sciencedirect.com/science/article/pii/S1534580725000012
  30. www.sciencedirect.com www.sciencedirect.com
    ERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells
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    sciencedirect.com/science/article/pii/S2211124724015444
  31. Dec 2024
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11601497/
  33. www.sciencedirect.com www.sciencedirect.com
    Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters in collective cell migration of epithelial cells
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    sciencedirect.com/science/article/pii/S2211124724013378
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC11617384/
  35. www.sciencedirect.com www.sciencedirect.com
    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124724013779
  36. Nov 2024
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bilateral regulation of EGFR activity and local PI(4,5)P2 dynamics in mammalian cells observed with superresolution microscopy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11548882/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11487346/
  39. Oct 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11449124/
  41. aacrjournals.org aacrjournals.org
    YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma
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    aacrjournals.org/cancerres/article/80/21/4741/645935/YAP-Mediated-Repression-of-HRK-Regulates-Tumor
  42. Sep 2024
  43. www.sciencedirect.com www.sciencedirect.com
    Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S235239642400392X
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
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    ncbi.nlm.nih.gov/pmc/articles/PMC11370239/
  45. Aug 2024
  46. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    cell.com/cell/fulltext/S0092-8674(20)30163-X
  47. www.sciencedirect.com www.sciencedirect.com
    Activation of limbal epithelial proliferation is partly controlled by the ACE2-LCN2 pathway
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    sciencedirect.com/science/article/pii/S2589004224017590
  48. www.sciencedirect.com www.sciencedirect.com
    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S266637912400377X
  49. Jul 2024
  50. www.cell.com www.cell.com
    Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK
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    cell.com/cell-host-microbe/fulltext/S1931-3128(24)00254-3
  51. www.sciencedirect.com www.sciencedirect.com
    Harnessing the CD44-targeted delivery of self-assembled hyaluronan nanogel to reverse the antagonism between Cisplatin and Gefitinib in NSCLC cancer therapy
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    sciencedirect.com/science/article/pii/S0144861724007471
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11293357/
  53. www.cell.com www.cell.com
    TSPAN4 influences glioblastoma progression through regulating EGFR stability
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    cell.com/iscience/fulltext/S2589-0042(24)01642-0
  54. Jun 2024
  55. www.sciencedirect.com www.sciencedirect.com
    Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform
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    sciencedirect.com/science/article/pii/S2211124724006417
  56. May 2024
  57. www.sciencedirect.com www.sciencedirect.com
    Targeted blocking of EGFR and GLUT1 by compound H reveals a new strategy for treatment of triple-negative breast cancer and nasopharyngeal carcinoma
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    sciencedirect.com/science/article/pii/S0928098724001003
  58. Mar 2024
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers
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    ncbi.nlm.nih.gov/pmc/articles/PMC10951324/
  60. www.sciencedirect.com www.sciencedirect.com
    An engineering strategy to target activated EGFR with CAR T cells
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    sciencedirect.com/science/article/pii/S2667237524000511
  61. Feb 2024
  62. www.sciencedirect.com www.sciencedirect.com
    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    sciencedirect.com/science/article/pii/S2211124724000421
  63. www.sciencedirect.com www.sciencedirect.com
    Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR
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    sciencedirect.com/science/article/pii/S1534580724000303
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831936/
  65. Dec 2023
  66. www.sciencedirect.com www.sciencedirect.com
    EGFR-activated myofibroblasts promote metastasis of pancreatic cancer
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    sciencedirect.com/science/article/pii/S1535610823004300
  67. Nov 2023
  68. www.sciencedirect.com www.sciencedirect.com
    EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma
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    sciencedirect.com/science/article/abs/pii/S1097276523008626
  69. Oct 2023
  70. www.science.org www.science.org
    Piezo1 activates noncanonical EGFR endocytosis and signaling
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    science.org/doi/10.1126/sciadv.adi1328
  71. 52.53.155.43 52.53.155.43
    The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers
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    52.53.155.43/e45e39aa6be90d4518c1365e2458466145a6420b/2023.06.16.545259v2.full-html.html
  72. www.sciencedirect.com www.sciencedirect.com
    Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor
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    sciencedirect.com/science/article/abs/pii/S245194562300332X
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Piezo1 activates noncanonical EGFR endocytosis and signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10530101/
  74. Sep 2023
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Promoting the activity of a receptor tyrosine phosphatase with a novel pH‐responsive transmembrane agonist inhibits cancer‐associated phenotypes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10461461/
  76. Aug 2023
  77. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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    sciencedirect.com/science/article/pii/S1535610823002453
  78. Jun 2023
  79. www.sciencedirect.com www.sciencedirect.com
    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    sciencedirect.com/science/article/pii/S030438352300215X
  80. www.science.org www.science.org
    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    science.org/doi/10.1126/sciadv.ade1155
  81. dx.doi.org dx.doi.org
    LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL
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    dx.doi.org/10.1158/2159-8290.CD-22-0376
  82. May 2023
  83. academic.oup.com academic.oup.com
    Mechanisms of estradiol-induced EGF-like factor expression and oocyte maturation via G protein-coupled estrogen receptor
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    academic.oup.com/endo/article/161/12/bqaa190/5929646
  84. Apr 2023
  85. www.sciencedirect.com www.sciencedirect.com
    IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma
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    sciencedirect.com/science/article/pii/S2589004223007162
  86. www.nature.com www.nature.com
    Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer
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    nature.com/articles/s41416-023-02264-4
  87. Feb 2023
  88. 52.53.155.43 52.53.155.43
    cd-22-0376-html.html
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  89. www.sciencedirect.com www.sciencedirect.com
    CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
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    sciencedirect.com/science/article/pii/S1535610823000077
  90. www.sciencedirect.com www.sciencedirect.com
    Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation
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    sciencedirect.com/science/article/pii/S2451945623000302
  91. www.cell.com www.cell.com
    The developmental basis of fingerprint pattern formation and variation
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    cell.com/cell/fulltext/S0092-8674(23)00045-4
  92. Jan 2023
  93. www.sciencedirect.com www.sciencedirect.com
    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
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    sciencedirect.com/science/article/pii/S2211124723000426
  94. Dec 2022
  95. www.sciencedirect.com www.sciencedirect.com
    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
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    sciencedirect.com/science/article/pii/S1534580722008152
  96. www.sciencedirect.com www.sciencedirect.com
    EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer
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    sciencedirect.com/science/article/pii/S2211124722017193
  97. www.sciencedirect.com www.sciencedirect.com
    Immunological profiles of human oligodendrogliomas define two distinct molecular subtypes
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    sciencedirect.com/science/article/pii/S2352396422005928
  98. www.sciencedirect.com www.sciencedirect.com
    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
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    sciencedirect.com/science/article/pii/S1535610822005621
  99. Nov 2022
  100. www.sciencedirect.com www.sciencedirect.com
    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
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    sciencedirect.com/science/article/pii/S2589004222014560
  101. www.sciencedirect.com www.sciencedirect.com
    Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling
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    sciencedirect.com/science/article/pii/S2211124722014462
  102. Jun 2022
  103. www.sciencedirect.com www.sciencedirect.com
    Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma
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    sciencedirect.com/science/article/pii/S221112472200777X
  104. May 2022
  105. www.sciencedirect.com www.sciencedirect.com
    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    sciencedirect.com/science/article/pii/S1097276522004348
  106. aacrjournals.org aacrjournals.org
    Triple targeting of HER receptors overcomes heregulin-mediated resistance to EGFR blockade in colorectal cancer
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    aacrjournals.org/mct/article/21/5/799/694777/Triple-Targeting-of-HER-Receptors-Overcomes
  107. aacrjournals.org aacrjournals.org
    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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    aacrjournals.org/cancerdiscovery/article/12/5/1378/694560/EGFR-Inhibition-Potentiates-FGFR-Inhibitor-Therapy
  108. Apr 2022
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epidermal growth factor deficiency predisposes to progressive renal disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC9185668/
  110. www.sciencedirect.com www.sciencedirect.com
    Tissue remodeling by an opportunistic pathogen triggers allergic inflammation
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    sciencedirect.com/science/article/pii/S1074761322001728
  111. Feb 2022
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased efficacy of gefitinib on cisplatin-resistant wild-type epidermal growth factor receptor non-small cell lung cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8798197/
  113. Jan 2022
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC8717880/
  115. Dec 2021
  116. www.cell.com www.cell.com
    SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes
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    cell.com/cell-reports/fulltext/S2211-1247(21)01651-X
  117. www.sciencedirect.com www.sciencedirect.com
    Substratum stiffness regulates Erk signaling dynamics through receptor-level control
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    sciencedirect.com/science/article/pii/S2211124721016818
  118. link.springer.com link.springer.com
    Synergy of epidermal growth factor (EGFR) and angiotensin II (AT1R) receptor determines composition and temporal pattern of transcriptome variation
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    link.springer.com/article/10.1007/s00018-021-04065-5
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