168 Matching Annotations
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    EZH2 Inhibitors Sensitize Breast Cancer to HER2 Kinase Inhibitors through Cooperative Effects on YAP and Pro-apoptotic Regulators
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    aacrjournals.org/cancerres/article/86/6/1467/775076/EZH2-Inhibitors-Sensitize-Breast-Cancer-to-HER2
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    Amphiregulin-mediated EGFR activation drives both intrinsic and acquired resistance to KRAS G12C inhibitors in KRAS G12C–mutant non-small cell lung cancer
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    nature.com/articles/s41388-026-03877-8
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    BCAA metabolism promotes lung cancer tumorigenesis by enhancing cholesterol biosynthesis
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    sciencedirect.com/science/article/pii/S2211124726007199
  5. Jul 2026
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    Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis
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    sciencedirect.com/science/article/pii/S1934590926002286
  7. Jun 2026
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    Distinct ERK and PI3K dependencies mediate a heterogeneous response to RAS(ON) inhibition in KRAS-mutant colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124726006376
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    Targeting TROP2 in drug-tolerant persister cells delays EGFR tyrosine kinase inhibitor resistance in non-small-cell lung cancer
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    sciencedirect.com/science/article/pii/S1535610826002655
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    Hypoxia-activated PROTAC for dual inhibition of FAK and EGFR enables synergistic mechano-chemical cancer therapy
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    sciencedirect.com/science/article/pii/S1476558626000588
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-throughput screening identifies NT-1 that synergizes with MRTX1133 against acquired resistant KRASG12D colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13249833/
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    PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition
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  13. May 2026
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    PrPC-facilitated cell signaling activates phospholipase Cɣ1 and triggers an Arc/Arg3.1 response in mouse and iPSC-derived human neurons
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    sciencedirect.com/science/article/pii/S2213671126001359
  15. Apr 2026
  16. 54.241.53.176 54.241.53.176
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    A hotspot phosphorylation site on SHP2 drives oncoprotein activation and drug resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC13066003/
  18. aacrjournals.org aacrjournals.org
    Identification of Small-Molecule Inhibitors that Block the GTP-Binding Pocket of K-Ras and Other Members of the Ras Superfamily of Small GTPases
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    aacrjournals.org/mct/article/25/1/84/771280/Identification-of-Small-Molecule-Inhibitors-that
  19. Mar 2026
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Immunological effects of amivantamab in EGFR or MET-expressing non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13013883/
  21. Feb 2026
  22. dx.doi.org dx.doi.org
    PTEN status on gonadotropin-releasing hormone (GnRH) metabolite, GnRH-(1-5), effects in endometrial cancer cell lines migration, & transcriptomic analysis of basal cell line and tumor gene expressions
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    BCL-xL as a therapeutic target in cetuximab-refractory colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12876907/
  24. Jan 2026
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A combined strategy of EGFR-MET bispecific antibody and HER3 ADC to overcome osimertinib resistance in NSCLC
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847129/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genomic and Single-Cell Analyses Characterize Patient-Derived Tumor Organoids to Enable Personalized Therapy for Head and Neck Squamous Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12263324/
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    Aging | Sodium cantharidate targets STAT3 and abrogates EGFR inhibitor resistance in osteosarcoma - Full Text
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    PDZRN4 suppresses lung adenocarcinoma progression via inhibiting ubiquitin-mediated HIF-1A degradation
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  29. Dec 2025
  30. www.nature.com www.nature.com
    Deprivation of EGFR signal causes senolysis in PDAC with CDK4/6 inhibition
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  31. Oct 2025
  32. www.embopress.org www.embopress.org
    Phosphoproteomics of osimertinib-tolerant persister cells reveals targetable kinase-substrate signatures
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    embopress.org/doi/10.1038/s44320-025-00141-1
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  34. Sep 2025
  35. www.sciencedirect.com www.sciencedirect.com
    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance
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  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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  38. Aug 2025
  39. www.sciencedirect.com www.sciencedirect.com
    Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis
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    A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance
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  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential Efficacy of Bevacizumab and Erlotinib in Preclinical Models of Renal Medullary Carcinoma and Fumarate Hydratase–Deficient Renal Cell Carcinoma
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  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
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  43. Jul 2025
  44. www.biorxiv.org www.biorxiv.org
    High Throughput Screening Identifies Small Molecules that Synergize with MRTX1133 Against Acquired Resistant KRAS G12D Mutated CRC
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    biorxiv.org/content/10.1101/2025.06.27.662039v1
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    biorxiv.org/content/10.1101/2025.06.18.660406v1
  46. Jun 2025
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    A first-in-class EGFR-directed KRAS G12V selective inhibitor
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    EGFR phosphorylates DNAJB1 to suppress α-synuclein aggregation in Parkinson’s disease
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    Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation
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    PIN1 serves as a prognostic and therapeutic biomarker in lung adenocarcinoma
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    link.springer.com/article/10.1007/s10142-025-01629-7
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    Amiloride synergizes with EGFR PROTACs and inhibitors to overcome therapeutic resistance in NSCLC
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  52. May 2025
  53. www.sciencedirect.com www.sciencedirect.com
    Stress-induced pro-inflammatory glioblastoma stem cells secrete TNFAIP6 to enhance tumor growth and induce suppressive macrophages
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  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells
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  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
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  56. Mar 2025
  57. www.sciencedirect.com www.sciencedirect.com
    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
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  58. Jan 2025
  59. www.sciencedirect.com www.sciencedirect.com
    A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance
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    ERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells
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  61. Dec 2024
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters in collective cell migration of epithelial cells
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  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence
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    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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  66. Nov 2024
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bilateral regulation of EGFR activity and local PI(4,5)P2 dynamics in mammalian cells observed with superresolution microscopy
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    Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells
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  69. Oct 2024
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis
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    YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma
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  72. Sep 2024
  73. www.sciencedirect.com www.sciencedirect.com
    Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer
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    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
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  75. Aug 2024
  76. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    Activation of limbal epithelial proliferation is partly controlled by the ACE2-LCN2 pathway
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    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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  79. Jul 2024
  80. www.cell.com www.cell.com
    Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK
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    cell.com/cell-host-microbe/fulltext/S1931-3128(24)00254-3
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    Harnessing the CD44-targeted delivery of self-assembled hyaluronan nanogel to reverse the antagonism between Cisplatin and Gefitinib in NSCLC cancer therapy
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    Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway
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    TSPAN4 influences glioblastoma progression through regulating EGFR stability
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  84. Jun 2024
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    Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform
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  86. May 2024
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    Targeted blocking of EGFR and GLUT1 by compound H reveals a new strategy for treatment of triple-negative breast cancer and nasopharyngeal carcinoma
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  88. Mar 2024
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers
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    An engineering strategy to target activated EGFR with CAR T cells
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  91. Feb 2024
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR
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    Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831936/
  95. Dec 2023
  96. www.sciencedirect.com www.sciencedirect.com
    EGFR-activated myofibroblasts promote metastasis of pancreatic cancer
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  97. Nov 2023
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    EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma
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    sciencedirect.com/science/article/abs/pii/S1097276523008626
  99. Oct 2023
  100. www.science.org www.science.org
    Piezo1 activates noncanonical EGFR endocytosis and signaling
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    science.org/doi/10.1126/sciadv.adi1328
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    The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers
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    Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Piezo1 activates noncanonical EGFR endocytosis and signaling
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  104. Sep 2023
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Promoting the activity of a receptor tyrosine phosphatase with a novel pH‐responsive transmembrane agonist inhibits cancer‐associated phenotypes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10461461/
  106. Aug 2023
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    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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  108. Jun 2023
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    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL
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    dx.doi.org/10.1158/2159-8290.CD-22-0376
  112. May 2023
  113. academic.oup.com academic.oup.com
    Mechanisms of estradiol-induced EGF-like factor expression and oocyte maturation via G protein-coupled estrogen receptor
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    academic.oup.com/endo/article/161/12/bqaa190/5929646
  114. Apr 2023
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    IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma
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    Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer
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