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TM6SF2 acts at ER membrane contact sites to enable RAB7-dependent endolysosomal VLDL secretion and maintain Golgi structure

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  DOI: 10.1016/j.celrep.2026.118116
  
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Oct 2026
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Structural Mechanisms of DNAJC13 Dimeric Assembly and InsP6 binding in Recycling Endosome Regulation

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Jul 2026
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Planar cell polarity complex internalization is dependent on Celsr1 cis-dimerization

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Jun 2026
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Ischemia-Induced Post-Translational Modifications of GLT-1 Mediate Aberrant Trafficking and Impaired Glutamate Uptake

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RAB5c orchestrates LC3-associated phagocytosis to promote microbicidal function of macrophages

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pmc.ncbi.nlm.nih.gov/articles/PMC13155314/
Apr 2026
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2026.04.09.717238.full-html.html

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Mar 2026
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Control of lysosome function by the GTPase-activating protein TBC1D9B and its binding partner TMEM55B

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Enucleated cells with Nectin-1 overexpression capture HSV-1 and promote viral elimination for herpes simplex encephalitis therapy

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Tanycytic degeneration impairs tau clearance and contributes to Alzheimer’s disease pathology

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Jan 2026
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Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder

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Dec 2025
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Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons

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PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment

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  DOI: 10.7554/eLife.103817
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12685304/
Oct 2025
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Splicing of HPV16 E6 promotes aggressive invasion in oropharyngeal cancer via endocytosis of E-cadherin

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  DOI: 10.1101/2025.10.16.682706
  
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Aug 2025
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1-s2.0-S2589004225017213-main-html.html

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dhar-et-al-programmed-cell-revival-from-imminent-cell-death-enhances-tissue-repair-and-regeneration-html.html

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52.53.155.43/6e1a51ae3d978e6c74ed455dd826dbf65caf9c68/dhar-et-al-programmed-cell-revival-from-imminent-cell-death-enhances-tissue-repair-and-regeneration-html.html
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A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression

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pmc.ncbi.nlm.nih.gov/articles/PMC12317733/
Jul 2025
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Direct interaction of HMGB1 with SARS-CoV-2 facilitates its infection via RAGE-dependent endocytosis

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EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration

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MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction

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sciencedirect.com/science/article/pii/S1097276525005052
May 2025
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Heterogeneity of late endosome/lysosomes shown by multiplexed DNA-PAINT imaging

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RNF13 variants L311S and L312P associated with developmental epileptic encephalopathy alter dendritic organization in hippocampal neurons

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Apr 2025
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RabGAP1L modulates Rab7A and Rab10 to orchestrate cell-autonomous immunity

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SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment

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1-s2.0-S2589004225005346-main-html.html

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RAF1 kinase contributes to autophagic lysosome reformation

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Mar 2025
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PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD

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IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex

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  DOI: 10.1002/advs.202501593
  
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Feb 2025
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Loss of the proton-activated chloride channel in neurons impairs AMPA receptor endocytosis and LTD via endosomal hyper-acidification

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pmc.ncbi.nlm.nih.gov/articles/PMC11938102/
Dec 2024
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Modelling quiescence exit of neural stem cells reveals a FOXG1-FOXO6 axis

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pmc.ncbi.nlm.nih.gov/articles/PMC11625887/
Oct 2024
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Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis

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ncbi.nlm.nih.gov/pmc/articles/PMC11449124/
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Design of a Cytotoxic Neuroblastoma-Targeting Agent Using an Enzyme Acting on Polysialic Acid Fused to a Toxin

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  DOI: 10.1158/1535-7163.MCT-20-1031
  
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aacrjournals.org/mct/article/20/10/1996/665734/Design-of-a-Cytotoxic-Neuroblastoma-Targeting
Aug 2024
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Therapeutic application of extracellular vesicular EGFR isoform D as a co-drug to target squamous cell cancers with tyrosine kinase inhibitors

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Jun 2024
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Identifying FUS amyotrophic lateral sclerosis disease signatures in patient dermal fibroblasts

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May 2024
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Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists

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ncbi.nlm.nih.gov/pmc/articles/PMC11042255/
Apr 2024
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Tim4 enables large peritoneal macrophages to cross-present tumor antigens at early stages of tumorigenesis

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  DOI: 10.1016/j.celrep.2024.114096
  
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A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism

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Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment

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Neutralizing monoclonal antibodies protect against human adenovirus type 55 infection in transgenic mice and tree shrews

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Loss of α-1,2-mannosidase MAN1C1 promotes tumorigenesis of intrahepatic cholangiocarcinoma through enhancing CD133-FIP200 interaction

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Five Inhibitory Receptors Display Distinct Vesicular Distributions in Murine T Cells

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Transgenic mouse models support a protective role of type I IFN response in SARS-CoV-2 infection-related lung immunopathology and neuroinvasion

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TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation

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S-acylation of the Wnt receptor Frizzled-5 by zDHHC5 controls its cellular localization and synaptogenic activity in the rodent hippocampus

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Five inhibitory receptors display distinct vesicular distributions in T cells

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Picolinic acid is a broad-spectrum inhibitor of enveloped virus entry that restricts SARS-CoV-2 and influenza A virus in vivo

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Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1

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Homotypic SCOTIN assemblies form ER-endosome membrane contacts and regulate endosome dynamics

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Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity

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The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein

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Lysosomal trafficking of the glucose transporter GLUT1 requires sequential regulation by TXNIP and ubiquitin

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A glycine-serine-alanine-rich peptide ameliorates Alzheimer-type neurodegeneration

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GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis

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The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

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Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix

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Inhibition of SIRT2 promotes APP acetylation and ameliorates cognitive impairment in APP/PS1 transgenic mice

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C910 chemical compound inhibits the traffiking of several bacterial AB toxins with cross-protection against influenza virus

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Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis

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Bimodal endocytic probe for three-dimensional correlative light and electron microscopy

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A TLR4-independent critical role for CD14 in intracellular LPS sensing

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Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate retriever-mediated recycling on endosomes

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E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression

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EGFR transactivates RON to drive oncogenic crosstalk

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O-GlcNAcylation Inhibits Endocytosis of Amyloid Precursor Protein by Decreasing Its Localization in Lipid Raft Microdomains

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Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis

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RNF13 Dileucine Motif Variants L311S and L312P Interfere with Endosomal Localization and AP-3 Complex Association

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De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist

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Protein Kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons

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Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation

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Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes

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Interaction and Subcellular Association of PRRT1/SynDIG4 With AMPA Receptors

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Regulation of the endosomal SNX27-retromer by OTULIN

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Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

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CREG1 promotes lysosomal biogenesis and function

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HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses

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Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

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PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding

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Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans

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Distribution and localization of phosphatidylinositol 5‐phosphate, 4‐kinase alpha and beta in the brain

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Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis

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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

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Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics

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Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption

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The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

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RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis

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Quantitative immunoblotting analyses reveal that the abundance of actin, tubulin, synaptophysin and EEA1 proteins is altered in the brains of aged mice

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Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2

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Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model

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iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

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Biallelic loss‐of‐function variants in TBC1D2B cause a neurodevelopmental disorder with seizures and gingival overgrowth

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Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

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Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

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The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis

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ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells

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Nov 2017
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Small Molecules for Early Endosome-Specific Patch Clamping

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  AB_2096811
  
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Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17

1
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  AB_2096811
  
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GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors

1
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  AB_2096811
  
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