189 Matching Annotations
  1. Last 7 days
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    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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    sciencedirect.com/science/article/pii/S2211124724014529
  3. Dec 2024
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    A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
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    sciencedirect.com/science/article/pii/S0092867424013266
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    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124724013779
  6. Sep 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anabolic deficits and divergent unfolded protein response underlie skeletal and cardiac muscle growth impairments in the Yoshida hepatoma tumor model of cancer cachexia
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    ncbi.nlm.nih.gov/pmc/articles/PMC11410559/
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    A TBK1-independent primordial function of STING in lysosomal biogenesis
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    sciencedirect.com/science/article/pii/S1097276524007032
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice
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      DOI: 10.1210/endocr/bqad133

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    ncbi.nlm.nih.gov/pmc/articles/PMC10502789/
  10. Aug 2024
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    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
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    sciencedirect.com/science/article/pii/S2211124724010143
  12. www.cell.com www.cell.com
    RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
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      4E-BP1

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    cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
  13. Jul 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging
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    ncbi.nlm.nih.gov/pmc/articles/PMC11262205/
  15. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004224017851-main-html.html
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  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dystrophin S3059 phosphorylation partially attenuates denervation atrophy in mouse tibialis anterior muscles
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    1. scibot 17 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11245571/
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    Multi-step regulation of microRNA expression and secretion into small extracellular vesicles by insulin
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    sciencedirect.com/science/article/pii/S2211124724008209
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    Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11199525/
  19. Jun 2024
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    Electron transport chain inhibition increases cellular dependence on purine transport and salvage
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    sciencedirect.com/science/article/pii/S1550413124001906
  21. May 2024
  22. www.sciencedirect.com www.sciencedirect.com
    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
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    sciencedirect.com/science/article/pii/S1097276524003939
  23. 52.53.155.43 52.53.155.43
    Everolimus exerts anticancer effects through inhibiting the interaction of matrix metalloproteinase-7 with syndecan-2 in colon cancer cells
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    52.53.155.43/76598b44d554c4165a9f84a25bc34c671709ff41/lee-et-al-2024-everolimus-exerts-anticancer-effects-through-inhibiting-the-interaction-of-matrix-metalloproteinase-7-html.html
  24. www.biorxiv.org www.biorxiv.org
    Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells
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      DOI: 10.1101/2024.05.13.593567

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    biorxiv.org/content/10.1101/2024.05.13.593567v1
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    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
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    sciencedirect.com/science/article/pii/S1550413124001359
  26. Apr 2024
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    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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      DOI: 10.1016/j.celrep.2024.114149

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    sciencedirect.com/science/article/pii/S2211124724004777
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    The MYCN 5′ UTR as a therapeutic target in neuroblastoma
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  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
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      DOI: 10.1038/s41598-024-58716-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10998866/
  30. Mar 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
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    ncbi.nlm.nih.gov/pmc/articles/PMC10920058/
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    MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors
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    sciencedirect.com/science/article/pii/S2589004224004097
  33. Feb 2024
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831937/
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    β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
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    sciencedirect.com/science/article/pii/S0753332224000982
  36. Jan 2024
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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      DOI: 10.1016/j.jbc.2023.105619

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    pmc.ncbi.nlm.nih.gov/articles/PMC10839450/
  38. Dec 2023
  39. www.sciencedirect.com www.sciencedirect.com
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
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    sciencedirect.com/science/article/pii/S1097276523009681
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    Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner
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      DOI: 10.1152/japplphysiol.00247.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC9678410/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LP07 and LLC pre-clinical models of lung cancer induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting
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      DOI: 10.1152/japplphysiol.00246.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC9678411/
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    Nutrient-regulated control of lysosome function by signaling lipid conversion
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      DOI: 10.1016/j.cell.2023.09.027

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    sciencedirect.com/science/article/pii/S0092867423010814
  43. Nov 2023
  44. www.sciencedirect.com www.sciencedirect.com
    The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency
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    sciencedirect.com/science/article/abs/pii/S1550413123003856
  45. www.embopress.org www.embopress.org
    Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism
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      DOI: 10.15252/embr.202357339

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    embopress.org/doi/full/10.15252/embr.202357339
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    CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions
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      DOI: 10.1016/j.celrep.2023.113306

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    sciencedirect.com/science/article/pii/S2211124723013189
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    CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
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      DOI: 10.1016/j.celrep.2023.113269

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    sciencedirect.com/science/article/pii/S2211124723012810
  48. Oct 2023
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain Development
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      DOI: 10.1523/ENEURO.0159-23.2023

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    ncbi.nlm.nih.gov/pmc/articles/PMC10566546/
  50. 52.53.155.43 52.53.155.43
    s41586-023-06657-6_reference-html.html
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    52.53.155.43/0f3eb7b8d15ef36be47b7c18ecdf1d19ad34ca1a/s41586-023-06657-6_reference-html.html
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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  52. Sep 2023
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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    PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway
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  110. Jun 2022
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    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
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  130. Jan 2022
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  142. Aug 2021
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    Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
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  151. Jul 2021
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    mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
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    New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis
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    An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
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  155. Jun 2021
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    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
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    MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages
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  158. May 2021
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    Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility
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    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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    NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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    AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis
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    HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
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    Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth
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  166. Apr 2021
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    4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors
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    Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer
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    The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
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  172. Mar 2021
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    Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis
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    Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer
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      Anti-4EBP1 rabbit monoclonal

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  175. Feb 2021
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    Metabolic conditioning of CD8 + effector T cells for adoptive cell therapy
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  177. www.cell.com www.cell.com
    Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
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    Comprehensive pharmacogenomic characterization of gastric cancer
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  179. Dec 2020
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    Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2
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  181. Nov 2020
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    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
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  183. Oct 2020
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    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
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  185. Sep 2020
  186. elifesciences.org elifesciences.org
    The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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      RRID:AB_2097841

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    UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
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    Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module
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    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
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    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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    Kinetic Heterogeneity of Cancer Cell Fractional Killing
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  193. www.embopress.org www.embopress.org
    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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      4E‐BP1

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    Vcp Overexpression and Leucine Supplementation Increase Protein Synthesis and Improve Fear Memory and Social Interaction of Nf1 Mutant Mice
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  195. Jan 2020
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    Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming
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    Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α
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    Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in the dsRNA Response
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    Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters
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      RRID:AB_2097841

      DOI: 10.1016/j.chembiol.2019.05.009

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    p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
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    Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures
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      RRID:AB_2097841

      DOI: 10.1210/en.2019-00410

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    academic.oup.com/endo/article/160/11/2600/5535649
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    NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression
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    Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy
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    mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
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      RRID:AB_2097841

      DOI: 10.1016/j.molcel.2019.07.021

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    TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress
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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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      DOI: 10.1016/j.ccell.2019.01.006

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    Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer
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    Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
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  219. Nov 2018
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    Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides
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    Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool
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    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
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    Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance
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    Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells
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  227. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma
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  229. Nov 2017
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    A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
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    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
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    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
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    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
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    Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator
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    L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
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    Genetic Removal of Matrix Metalloproteinase 9 Rescues the Symptoms of Fragile X Syndrome in a Mouse Model
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