31 Matching Annotations
  1. Jun 2026
  2. www.sciencedirect.com www.sciencedirect.com
    Structures of the PI3Kα/KRas complex on lipid bilayers reveal molecular mechanisms of PI3Kα activation
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    sciencedirect.com/science/article/pii/S1097276526003813
  3. aacrjournals.org aacrjournals.org
    PI3Kα inhibitor and degrader inavolisib can co-opt FGFR2 to enhance responses in patients with PIK3CA-mutated solid tumors and in preclinical models
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    aacrjournals.org/clincancerres/article/32/1/56/771272/PI3K-Inhibitor-and-Degrader-Inavolisib-Can-Co-opt
  4. Apr 2026
  5. aacrjournals.org aacrjournals.org
    Targeting tumor microenvironment-derived NRG1-HER2/3 signaling with zenocutuzumab restores sensitivity to AR inhibition in PTEN wild-type prostate cancer
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    aacrjournals.org/mct/article/25/4/662/776472/Targeting-Tumor-Microenvironment-Derived-NRG1-HER2
  6. Jan 2026
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A combined strategy of EGFR-MET bispecific antibody and HER3 ADC to overcome osimertinib resistance in NSCLC
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847129/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sevabertinib, a Reversible HER2 Inhibitor with Activity in Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12793832/
  9. Nov 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Increased ErbB2 signaling is an early adaptation to androgen signaling inhibition and persists in castration resistant prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12580767/
  11. Jun 2025
  12. www.sciencedirect.com www.sciencedirect.com
    Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation
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    sciencedirect.com/science/article/pii/S2451945625001667
  13. May 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046322/
  15. Oct 2024
  16. aacrjournals.org aacrjournals.org
    Identification of Predictive ERBB Mutations by Leveraging Publicly Available Cell Line Databases
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    aacrjournals.org/mct/article/20/3/564/92877/Identification-of-Predictive-ERBB-Mutations-by
  17. Mar 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10621596/
  19. Aug 2023
  20. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
    2
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    52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
  21. Jun 2023
  22. www.sciencedirect.com www.sciencedirect.com
    Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
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    sciencedirect.com/science/article/pii/S1535610823001836
  23. Apr 2023
  24. www.nature.com www.nature.com
    Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer
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    nature.com/articles/s41416-023-02264-4
  25. Nov 2022
  26. www.sciencedirect.com www.sciencedirect.com
    Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling
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    sciencedirect.com/science/article/pii/S1534580722007638
  27. Jun 2022
  28. www.jneurosci.org www.jneurosci.org
    Disruption of endosomal sorting in Schwann cells leads to defective myelination and endosomal abnormalities observed in Charcot-Marie-Tooth disease
    1
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    jneurosci.org/content/42/25/5085
  29. May 2022
  30. aacrjournals.org aacrjournals.org
    Triple targeting of HER receptors overcomes heregulin-mediated resistance to EGFR blockade in colorectal cancer
    1
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    aacrjournals.org/mct/article/21/5/799/694777/Triple-Targeting-of-HER-Receptors-Overcomes
  31. Oct 2021
  32. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer
    1
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    clincancerres.aacrjournals.org/content/27/18/5096
  33. Sep 2021
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activity and mechanism of acquired resistance to tarloxotinib in HER2 mutant lung cancer: an in vitro study
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8435395/
  35. Aug 2021
  36. www.sciencedirect.com www.sciencedirect.com
    Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments
    1
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    sciencedirect.com/science/article/pii/S2666379121002275
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC5926201/
  38. www.sciencedirect.com www.sciencedirect.com
    ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma
    1
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    sciencedirect.com/science/article/pii/S221112472100872X
  39. Jul 2021
  40. www.embopress.org www.embopress.org
    CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling
    1
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    embopress.org/doi/10.15252/embr.201948058
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC5926201/
  42. Jun 2021
  43. www.sciencedirect.com www.sciencedirect.com
    Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity
    1
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    sciencedirect.com/science/article/pii/S1535610821002841
  44. Apr 2021
  45. www.sciencedirect.com www.sciencedirect.com
    Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S1550413120305519
  46. Sep 2020
  47. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer
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    pubmed.ncbi.nlm.nih.gov/32679108/
  48. Jan 2020
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC6606022/
  50. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S2211124718319247
  51. Nov 2018
  52. www.sciencedirect.com www.sciencedirect.com
    Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade
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    sciencedirect.com/science/article/pii/S1535610818301740
  53. Nov 2017
  54. elifesciences.org elifesciences.org
    Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors
    1
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    elifesciences.org/content/3/e04037