Hypothesis

16 Matching Annotations

Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Delivering Progranulin to Astrocytic Lysosomes Promotes Growth of Co‐Cultured Neurons

1
1. scibot 07 Nov 2025
  
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  RRID:AB_2114489
  
  DOI: 10.1111/jnc.70284
  
  Resource: (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2114489
  
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  RRID:AB_2114489
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pmc.ncbi.nlm.nih.gov/articles/PMC12580966/
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia

1
1. scibot 10 Aug 2025
  
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  RRID:AB_2114489
  
  DOI: 10.1016/j.nbd.2025.107024
  
  Resource: (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2114489
  
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  RRID:AB_2114489
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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC12320091/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia

1
1. scibot 08 Jul 2025
  
  in Public
  
  RRID:AB_2114489
  
  DOI: 10.1016/j.nbd.2025.107024
  
  Resource: (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2114489
  
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  RRID:AB_2114489
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RRID:AB_2114489

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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC12320091/
Apr 2025
www.sciencedirect.com www.sciencedirect.com

Excessive expression of progranulin leads to neurotoxicity rather than neuroprotection

1
1. scibot 03 Apr 2025
  
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  RRID:AB_2114489
  
  DOI: 10.1016/j.nbd.2025.106895
  
  Resource: (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2114489
  
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  RRID:AB_2114489
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sciencedirect.com/science/article/pii/S0969996125001111
Nov 2024
www.sciencedirect.com www.sciencedirect.com

Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency

1
1. scibot 24 Nov 2024
  
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  RRID:AB_2114489
  
  DOI: 10.1016/j.celrep.2024.114985
  
  Resource: (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2114489
  
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sciencedirect.com/science/article/pii/S2211124724013366
Feb 2024
jneuroinflammation.biomedcentral.com jneuroinflammation.biomedcentral.com

Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia

2
1. scibot 22 Feb 2024
  
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  RRID:AB_2114489
  
  DOI: 10.1186/s12974-024-03039-1
  
  Resource: (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2114489
  
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  RRID:AB_2114489
2. scibot 15 Feb 2024
  
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  RRID:AB_2114489
  
  DOI: 10.1186/s12974-024-03039-1
  
  Resource: (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2114489
  
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  RRID:AB_2114489
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jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-024-03039-1
Oct 2023
www.sciencedirect.com www.sciencedirect.com

SorCS2 binds progranulin to regulate motor neuron development

1
1. scibot 28 Oct 2023
  
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  RRID:AB_2114489
  
  DOI: 10.1016/j.celrep.2023.113333
  
  Resource: (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2114489
  
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  RRID:AB_2114489
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sciencedirect.com/science/article/pii/S2211124723013451
Jul 2023
www.sciencedirect.com www.sciencedirect.com

AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b-/-Grn-/- mice

1
1. scibot 15 Jul 2023
  
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  RRID:AB_2114489
  
  DOI: 10.1016/j.isci.2023.107247
  
  Resource: (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2114489
  
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  RRID:AB_2114489
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sciencedirect.com/science/article/pii/S258900422301324X
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

1
1. scibot 27 Aug 2021
  
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  RRID:AB_2114489
  
  DOI: 10.1016/j.cell.2021.08.002
  
  Resource: (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2114489
  
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  RRID:AB_2114489
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sciencedirect.com/science/article/pii/S0092867421009442
academic.oup.com academic.oup.com

Female-Specific Role of Progranulin to Suppress Bone Formation

1
1. scibot 01 Aug 2021
  
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  RRID:AB_2114489
  
  DOI: 10.1210/en.2018-00842
  
  Resource: (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2114489
  
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  RRIDCUR:Validated RRID:AB_2114489
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RRID:AB_2114489

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scibot

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academic.oup.com/endo/article/160/9/2024/5522004
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Delivering progranulin to neuronal lysosomes protects against excitotoxicity

2
1. scibot 24 Jul 2021
  
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  AF2420
  
  DOI: 10.1016/j.jbc.2021.100993
  
  Resource: (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2114489
  
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  RRID:AB_2114489 RRIDCUR:Missing
2. scibot 24 Jul 2021
  
  in Public
  
  AF2420
  
  DOI: 10.1016/j.jbc.2021.100993
  
  Resource: (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2114489
  
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  RRID:AB_2114489 RRIDCUR:Missing
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RRID:AB_2114489

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sciencedirect.com/science/article/pii/S002192582100795X
Oct 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

GRN, NOTCH3, FN1, and PINK1 expression in eutopic endometrium – potential biomarkers in the detection of endometriosis – a pilot study

1
1. scibot 13 Oct 2020
  
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  RRID:AB_2114489
  
  DOI: 10.1007/s10815-020-01905-4
  
  Resource: (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2114489
  
  What is this?
  
  RRID:AB_2114489 RRIDCUR:Validated
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RRID:AB_2114489

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pubmed.ncbi.nlm.nih.gov/33029756/
Jan 2020
www.sciencedirect.com www.sciencedirect.com

CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2114489
  
  DOI: 10.1016/j.neuron.2019.07.014
  
  Resource: (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2114489
  
  What is this?
  
  RRID:AB_2114489 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_2114489

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scibot

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sciencedirect.com/science/article/pii/S0896627319306403
Nov 2018
onlinelibrary.wiley.com onlinelibrary.wiley.com

The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_2114489
  
  Curator: @Jmenke
  
  Resource used:
  
  (R and D Systems Cat# AF2420, RRID:AB_2114489)
  
  SciCrunch record: RRID:AB_2114489
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_2114489
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RRID:AB_2114489

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scibot

URL

onlinelibrary.wiley.com/doi/full/10.1111/jnc.14110