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Subclinical cholestasis is a hallmark of gut dysbiosis causing resistance to cancer immunotherapy

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1. scibot 01 Aug 2026
  
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  DOI: 10.1016/j.ccell.2026.06.022
  
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sciencedirect.com/science/article/pii/S1535610826003090
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SCLC humanized mice identify T cell infiltration phenotypes in response to combination immune-radiation therapies

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1. scibot 27 Jul 2026
  
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  DOI: 10.1016/j.isci.2026.116864
  
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sciencedirect.com/science/article/pii/S258900422602242X
Jun 2026
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Non-genetically reprogrammed meta-neutrophils potentiate chemo-immunotherapy against lung metastatic triple-negative breast cancer

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1. scibot 13 Jun 2026
  
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  DOI: 10.1016/j.xcrm.2026.102868
  
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sciencedirect.com/science/article/pii/S2666379126002855
May 2026
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Ciclopirox reprograms effector responses and modulates Notch1 activation in activated human T cells

1
1. scibot 28 May 2026
  
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  DOI: 10.1016/j.isci.2026.116079
  
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sciencedirect.com/science/article/pii/S2589004226014549
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VPS33B regulates MHC class II antigen presentation in dendritic cells to drive CD4 T cell immunity

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1. scibot 27 May 2026
  
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  DOI: 10.1016/j.isci.2026.116052
  
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sciencedirect.com/science/article/pii/S2589004226014276
Apr 2026
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Engineering functionality-optimized fully human B7-H3 CAR T cells for enhanced solid tumor therapy

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1. scibot 30 Apr 2026
  
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  DOI: 10.1016/j.xcrm.2026.102782
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13198247/
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Dissecting the cellular architecture of breast cancer brain metastases reveals prognostically distinct immune landscapes

1
1. scibot 29 Apr 2026
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.ccell.2026.03.016
  
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sciencedirect.com/science/article/pii/S1535610826001704
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Combinatorial therapy regimens targeting preclinical models of melanoma resistant to immune checkpoint blockade

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1. scibot 24 Apr 2026
  
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  RRID:AB_2114575
  
  DOI: 10.1172/JCI185220
  
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jci.org/articles/view/185220
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Distinct tissue niches contribute to prostate tissue-resident memory CD8+ T cell differentiation and heterogeneity

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1. scibot 02 Apr 2026
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.immuni.2026.03.003
  
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sciencedirect.com/science/article/pii/S1074761326001147
Mar 2026
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A senescent tumor cell-derived nanovesicle directly primes splenic T cells to potentiate cancer radiotherapy

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1. scibot 31 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102709
  
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sciencedirect.com/science/article/pii/S2666379126001266
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Engineered MSCs enable bone marrow-targeted immunomodulation

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1. scibot 27 Mar 2026
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.stem.2026.03.003
  
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sciencedirect.com/science/article/pii/S193459092600113X
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Subversion of kynurenine-induced AHR activation in CD8 T cells by kynureninase-expressing antigen-presenting cells

1
1. scibot 24 Mar 2026
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.celrep.2026.117149
  
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sciencedirect.com/science/article/pii/S2211124726002275
Feb 2026
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Metabolic reinvigoration of NK cells by IL-21 enhances immunotherapy against MHC class I-deficient solid tumors

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1. scibot 27 Feb 2026
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.celrep.2026.117035
  
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sciencedirect.com/science/article/pii/S2211124726001130
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The transcriptional repressor Fli1 inhibits proteostasis during nutrient stress to limit NK cell persistence in solid tumors

1
1. scibot 19 Feb 2026
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.immuni.2026.01.017
  
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sciencedirect.com/science/article/pii/S107476132600035X
Jan 2026
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DF6215, an α-optimized IL-2-Fc fusion, expands immune effectors and drives robust preclinical anti-tumor activity

1
1. scibot 09 Jan 2026
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.xcrm.2025.102518
  
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sciencedirect.com/science/article/pii/S2666379125005919
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p57 increases immunotherapy efficacy by promoting cGAS-STING-mediated innate sensing in hepatocellular carcinoma

1
1. scibot 09 Jan 2026
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.celrep.2025.116769
  
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sciencedirect.com/science/article/pii/S2211124725015414
Dec 2025
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Sensitized mast cells for targeted drug delivery and augmented cancer immunotherapy

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1. scibot 10 Dec 2025
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.cell.2025.11.015
  
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sciencedirect.com:5037/science/article/pii/S009286742501311X
Aug 2025
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Long-range deployment of tumor-antigen-specific cytotoxic T lymphocytes inhibits lung metastasis of breast cancer

1
1. scibot 28 Aug 2025
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.devcel.2025.08.003
  
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sciencedirect.com/science/article/pii/S1534580725005039
Jul 2025
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BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma

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1. scibot 31 Jul 2025
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.xcrm.2025.102258
  
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1-s2.0-S2589004225014087-main-html.html

1
1. scibot 22 Jul 2025
  
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  AB_2114575
  
  DOI: 10.1016/j.isci.2025.113147
  
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52.53.155.43/3e67ae4731f75e6f120a4c7a7c507c84a3acae93/1-s2.0-S2589004225014087-main-html.html
Jun 2025
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Prolonged but finite antigen presentation promotes reversible defects of “helpless” memory CD8+ T cells

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.immuni.2025.05.025
  
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sciencedirect.com/science/article/pii/S1074761325002468
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Trametinib potentiates anti-PD-1 efficacy in tumors established from chemotherapy-primed pancreatic cancer cells

1
1. scibot 11 Jun 2025
  
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  DOI: 10.1158/1535-7163.MCT-23-0833
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11614707/
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Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells

1
1. scibot 11 Jun 2025
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.molcel.2025.05.019
  
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sciencedirect.com/science/article/pii/S1097276525004587
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Glutamate transporter SLC1A6 promotes resistance to immunotherapy in cancer

1
1. scibot 11 Jun 2025
  
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  RRID:AB_2114575
  
  DOI: 10.1007/s00262-025-04074-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12145344/
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KMT2D coordinates antiviral CD4+ T cell responses through opposing effects on T follicular helper and cytotoxic gene expression

1
1. scibot 03 Jun 2025
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.celrep.2025.115775
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12302258/
May 2025
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Cancer vaccine from intracellularly gelated tumor cells functionalized with CD47 blockage and damage-associated molecular pattern exposure

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1. scibot 19 May 2025
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.xcrm.2025.102092
  
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Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.027
  
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sciencedirect.com/science/article/pii/S1074761325001906
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Selective requirement of glycosphingolipid synthesis for natural killer and cytotoxic T cells

1
1. scibot 16 May 2025
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.cell.2025.04.007
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12204804/
Mar 2025
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23ME-01473, an Fc Effector–Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell–Mediated Antitumor Immunity through NKG2D and FcγRIIIa Activation

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1. scibot 27 Mar 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0478
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11927390/
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PDF-html.html

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1. scibot 23 Mar 2025
  
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  DOI: 10.1101/2025.03.19.643961
  
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52.53.155.43/6ffb1e8f8e61cda81dc9b10ac8db2b4f9e212959/PDF-html.html
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Interferon-γ-stimulated antigen-presenting cancer-associated fibroblasts hinder neoadjuvant chemoimmunotherapy efficacy in lung cancer

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.xcrm.2025.102017
  
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sciencedirect.com/science/article/pii/S2666379125000904
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IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis

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1. scibot 05 Mar 2025
  
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  DOI: 10.1016/j.immuni.2025.02.005
  
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cell.com/immunity/fulltext/S1074-7613(25)00073-1
Feb 2025
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Repetitive antigen stimulation in the periphery dictates the composition and recall responses of brain-resident memory CD8+ T cells

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1. scibot 04 Feb 2025
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.celrep.2025.115247
  
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sciencedirect.com/science/article/pii/S221112472500018X
Jan 2025
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Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy

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1. scibot 30 Jan 2025
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.cmet.2024.12.007
  
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sciencedirect.com/science/article/pii/S1550413124004893
Dec 2024
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Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3

1
1. scibot 24 Dec 2024
  
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  RRID:AB_2114575
  
  DOI: 10.1016/j.immuni.2024.11.020
  
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sciencedirect.com/science/article/pii/S1074761324005351
Nov 2024
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cir-24-0324-html.html

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  DOI: 10.1158/2326-6066.cir-24-0324
  
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52.53.155.43/d81834c4f435bac92597aa4fc554551b530ce2ba/cir-24-0324-html.html
Aug 2024
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LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

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  DOI: 10.1016/j.cell.2024.07.016
  
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52.53.155.43 52.53.155.43

41467_2021_22885_MOESM1_ESM (1)-html.html

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  DOI: 10.1038/s41467-021-22885-8
  
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Jul 2024
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Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity

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  DOI: 10.1016/j.xcrm.2024.101640
  
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Jun 2024
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Intergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis

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May 2024
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ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity

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IL-7-primed bystander CD8 tumor-infiltrating lymphocytes optimize the antitumor efficacy of T cell engager immunotherapy

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  DOI: 10.1016/j.xcrm.2024.101567
  
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The Gut Microbiome Controls Liver Tumors via the Vagus Nerve

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  DOI: 10.1101/2024.01.23.576951
  
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Mar 2024
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Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis

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  DOI: 10.1016/j.celrep.2024.113934
  
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Feb 2024
52.53.155.43 52.53.155.43

Combined blockade of VEGF, Angiopoietin-2, and PD1 reprograms glioblastoma endothelial cells into quasi-antigen-presenting cells

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Nov 2023
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GITR activation ex vivo impairs CD8 T cell function in people with HIV on antiretroviral therapy

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Prostate cancer cell-derived exosomal IL-8 fosters immune evasion by disturbing glucolipid metabolism of CD8+ T cell

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  DOI: 10.1016/j.celrep.2023.113424
  
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Mice with FVB-derived sequence on chromosome 17 succumb to disseminated virus infection due to aberrant NK cell and T cell responses

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  DOI: 10.1016/j.isci.2023.108348
  
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A robust pipeline for high-content, high-throughput immunophenotyping reveals age- and genetics-dependent changes in blood leukocytes

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  DOI: 10.1016/j.crmeth.2023.100619
  
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Oct 2023
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Cytotoxic T lymphocytes require transcription for infiltration but not target cell lysis

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  DOI: 10.15252/embr.202357653
  
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  DOI: 10.15252/embr.202357653
  
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Aug 2023
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Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin

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SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine

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Jul 2023
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Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation

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Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors

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Apr 2023
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Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance

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Mar 2023
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The ion channel CALHM6 controls bacterial infection-induced cellular cross-talk at the immunological synapse

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  DOI: 10.15252/embj.2022111450
  
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Jan 2023
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The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer

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  DOI: 10.1016/j.celrep.2022.111878
  
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Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes

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  DOI: 10.1016/j.immuni.2022.12.007
  
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Nov 2022
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The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity

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Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation

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  DOI: 10.1136/jitc-2022-004874
  
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Oct 2022
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Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

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Sep 2022
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Metronomic cyclophosphamide is more effective than a single dose in resistant tumours Cyclophosphamide depletes tumour infiltrating T regulatory cells and combined with anti-PD-1 therapy improves survival in murine neuroblastoma

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Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma

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  DOI: 10.1158/2159-8290.CD-21-1077
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8904298/
Jul 2022
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Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

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  DOI: 10.1016/j.cmet.2022.06.008
  
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cell.com/cell-metabolism/fulltext/S1550-4131(22)00228-5
Jun 2022
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The SETDB1–TRIM28 complex suppresses antitumor immunity

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  DOI: 10.1158/2326-6066.CIR-21-0754
  
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May 2022
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Post-acute COVID-19 is characterized by gut viral antigen persistence in inflammatory bowel diseases

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  DOI: 10.1053/j.gastro.2022.04.037
  
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Apr 2022
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Single-Cell Transcriptional Profiling Reveals Signatures of Helper, Effector, and Regulatory MAIT Cells during Homeostasis and Activation

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  DOI: 10.4049/jimmunol.2100522
  
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Tumor-derived Jagged1 promotes cancer progression through immune evasion

1
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Activating Mucosal-Associated Invariant T cells Induces a Broad Antitumor Response

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Tofacitinib Suppresses Natural Killer Cells In Vitro and In Vivo: Implications for Amyotrophic Lateral Sclerosis

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SARS-CoV-2 variant B.1.1.7 caused HLA-A2+ CD8+ T cell epitope mutations for impaired cellular immune response

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Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity

1
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Optimization of antigen specific CD8+ T cell activation conditions for infectious diseases including COVID-19

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Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

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NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines

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Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression

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Protocol to establish a lung adenocarcinoma immunotherapy allograft mouse model with FACS and immunofluorescence-based analysis of tumor response

1
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Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

1
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Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia

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Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function

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Measuring the effect of drug treatments on primary human CD8+ T cell activation and cytolytic potential

1
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Bach2 attenuates IL-2R signaling to control Treg homeostasis and Tfr development

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DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells

1
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Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation

1
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In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma

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An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

1
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UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability

1
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MAIT cell activation is associated with disease severity markers in acute hantavirus infection

1
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Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells

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CD103+CD8+ TRM Cells Accumulate in Tumors of Anti-PD-1-Responder Lung Cancer Patients and Are Tumor-Reactive Lymphocytes Enriched with Tc17

1
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Coordinated Viral Control by Cytotoxic Lymphocytes Ensures Optimal Adaptive NK Cell Responses

1
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Robust T cell response towards spike, membrane, and nucleocapsid SARS-CoV-2 proteins is not associated with recovery in critical COVID-19 patients

1
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Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity

1
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STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth

1
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  DOI: 10.1016/j.cmet.2019.10.013
  
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Untitled document

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Nov 2018
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Untitled document

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Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages

1
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LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

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Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response

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Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism

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Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection.

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