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Discovery and Preclinical Validation of a Clinically Optimized Mitochondrial Complex I Modulator for Alzheimer’s Disease

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1. scibot 24 Apr 2026
  
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  DOI: 10.64898/2026.04.10.717554
  
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biorxiv.org/content/10.64898/2026.04.10.717554v1
Apr 2026
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BPS Publications

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1. scibot 01 Apr 2026
  
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  DOI: 10.1111/bph.70412
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70412
Feb 2026
54.241.53.176 54.241.53.176

1-s2.0-S0014488626000488-main-html.html

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1. scibot 20 Feb 2026
  
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  DOI: 10.1016/j.expneurol.2026.115685
  
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54.241.53.176/4d63b547cc6ba6bbe69fdb3ed047f81fabe0a84b/1-s2.0-S0014488626000488-main-html.html
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Repressed mTORC1 signaling and transient dendritic pruning support axonal regeneration

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1. scibot 19 Feb 2026
  
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  DOI: 10.64898/2026.02.11.705324
  
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biorxiv.org/content/10.64898/2026.02.11.705324v1
Jan 2026
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Endometrial stromal cell-derived TMAO sustains decidualization to prevent recurrent spontaneous abortion

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  DOI: 10.1016/j.cmet.2025.11.014
  
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sciencedirect.com/science/article/pii/S1550413125005285
Dec 2025
54.241.53.176 54.241.53.176

1-s2.0-S2589004225026409-main-html.html

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1. scibot 11 Dec 2025
  
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54.241.53.176/d8bbd04c46ca910f251a61aef810030530a4983a/1-s2.0-S2589004225026409-main-html.html
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1-s2.0-S2589004225025532-main-html.html

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54.241.53.176/5d87d160757da073ce52ccfdd6f8180fdf9242bd/1-s2.0-S2589004225025532-main-html.html
Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Inhibition of GSK3 and TSC2 Mediates the Oncogenic Activity of AKT in Hepatocellular Carcinoma

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1. scibot 17 Oct 2025
  
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  DOI: 10.1158/0008-5472.CAN-25-1615
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12500318/
Sep 2025
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Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer's disease

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1. scibot 16 Sep 2025
  
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  DOI: 10.1016/j.ebiom.2025.105924
  
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sciencedirect.com/science/article/pii/S2352396425003688
Jun 2025
52.53.155.43 52.53.155.43

PDF-html.html

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1. scibot 18 Jun 2025
  
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  DOI: 10.1158/1535-7163.mct-25-0117
  
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  DOI: 10.1158/1535-7163.mct-25-0117
  
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52.53.155.43/4c4ba8e26a369e7baf8cacabd22776836e074b0d/PDF-html.html
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer’s disease

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1. scibot 13 Mar 2025
  
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  DOI: 10.1101/2025.02.12.637918
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11870434/
Feb 2025
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TGF-β1-mediated intercellular signaling fuels cooperative cellular invasion

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115315
  
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sciencedirect.com/science/article/pii/S2211124725000865
Jan 2025
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Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation

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1. scibot 16 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115204
  
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sciencedirect.com/science/article/pii/S2211124724015559
Sep 2024
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IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.cmet.2024.08.012
  
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sciencedirect.com/science/article/pii/S1550413124003644
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Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer

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1. scibot 25 Sep 2024
  
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  DOI: 10.1038/s41467-024-52523-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11410950/
Aug 2024
elifesciences.org elifesciences.org

Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

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1. scibot 02 Aug 2024
  
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  DOI: 10.7554/eLife.17047
  
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elifesciences.org/content/5/e17047
Jul 2023
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mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112868
  
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sciencedirect.com/science/article/pii/S2211124723008793
Apr 2023
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

Deletion of the tyrosine phosphatase Shp2 in cervical cancer cells promotes reprogramming of glutamine metabolism

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1. scibot 29 Apr 2023
  
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  DOI: 10.1096/fj.202202078RR
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202202078RR
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Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice

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1. scibot 26 Apr 2023
  
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  DOI: 10.1016/j.chom.2023.04.002
  
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sciencedirect.com/science/article/pii/S1931312823001464
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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

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1. scibot 21 Apr 2023
  
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  DOI: 10.1016/j.cmet.2023.03.021
  
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sciencedirect.com/science/article/pii/S1550413123001262
Jan 2023
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Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance

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1. scibot 27 Jan 2023
  
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  DOI: 10.1016/j.ccell.2023.01.001
  
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sciencedirect.com/science/article/pii/S1535610823000016
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CDK1 bridges NF-κB and β-catenin signaling in response to H. pylori infection in gastric tumorigenesis

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1. scibot 24 Jan 2023
  
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  DOI: 10.1016/j.celrep.2023.112005
  
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sciencedirect.com/science/article/pii/S2211124723000165
Jun 2022
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Icariin ameliorates memory deficits through regulating... : Neural Regeneration Research

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1. scibot 24 Jun 2022
  
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  DOI: 10.4103/1673-5374.344840
  
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journals.lww.com/nrronline/Fulltext/2023/01000/Icariin_ameliorates_memory_deficits_through.39.aspx
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Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer

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1. scibot 07 Jun 2022
  
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  DOI: 10.1158/2159-8290.CD-21-0209
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7612573/
May 2022
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c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity

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1. scibot 19 May 2022
  
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  DOI: 10.1016/j.isci.2022.104325
  
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sciencedirect.com/science/article/pii/S258900422200596X
Aug 2021
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An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver

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1. scibot 25 Aug 2021
  
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  DOI: 10.1016/j.celrep.2021.109569
  
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sciencedirect.com/science/article/pii/S2211124721010032
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Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines

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1. scibot 15 Aug 2021
  
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  DOI: 10.1016/j.isci.2021.102807
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8313754/
www.physiology.org www.physiology.org

Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner

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1. scibot 14 Aug 2021
  
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  DOI: 10.1152/ajpendo.00496.2018
  
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physiology.org/doi/abs/10.1152/ajpendo.00496.2018
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Untitled document

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1. scibot 12 Aug 2021
  
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  DOI: 10.1111/jnc.14081
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14081
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Untitled document

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  DOI: 10.1111/jnc.14537
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14537
Jul 2021
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Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

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1. scibot 30 Jul 2021
  
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  Phospho-GSK3β (Ser9) (5B3) Rabbit mAb
  
  DOI: 10.1016/j.ccell.2019.03.007
  
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sciencedirect.com/science/article/pii/S1535610819301527
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BPS Publications

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1. scibot 29 Jul 2021
  
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  DOI: 10.1111/bph.14802
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14802
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PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling

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1. scibot 29 Jul 2021
  
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  DOI: 10.7554/eLife.32021
  
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2. scibot 29 Jul 2021
  
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  RRID:AB_2115201
  
  DOI: 10.7554/eLife.32021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5839742/
Jan 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Schistosoma mansoni eggs induce Wnt/β-catenin signaling and activate the protooncogene c-Jun in human and hamster colon

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1. scibot 05 Jan 2021
  
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  DOI: 10.1038/s41598-020-79450-4
  
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Effect of Hyperbaric Oxygen Therapy on Acute Liver Injury and Survival in a Rat Cecal Slurry Peritonitis Model

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The potential use of tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells

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  phosphorylated GSK-3β
  
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Tideglusib attenuates growth of neuroblastoma cancer stem/progenitor cells in vitro and in vivo by specifically targeting GSK-3β

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BPS Publications

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A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3β(Ser9)-mediated Nrf2 activation

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Gut hormone GIP induces inflammation and insulin resistance in the hypothalamus

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Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination

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Chronic light cycle-disruption alters central insulin and leptin signalling as well as metabolic markers in male mice

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  DOI: 10.1210/en.2018-00935
  
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N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor

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Activation of GSK3β induced by recall of cocaine reward memories is dependent on GluN2A/B NMDA receptor signaling

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Untitled document

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Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non‐small cell lung cancer cells via Nrf2 inhibition

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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14652
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Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling

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In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver

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Maternal separation stress reduced prenatal-ethanol-induced increase in exploratory behaviour and extracellular signal-regulated kinase activity

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Untitled document

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Maternal exercise modifies body composition and energy substrates handling in high‐fat/high‐sucrose diet fed male offspring

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onlinelibrary.wiley.com/doi/10.1113/JP274739/full
Nov 2017
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Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor‐2 signaling impairment in the aged neurogenic niche

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Persistent Expression of VCAM1 in Radial Glial Cells Is Required for the Embryonic Origin of Postnatal Neural Stem Cells

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Early ethanol exposure and vinpocetine treatment alter learning‐ and memory‐related proteins in the rat hippocampus and prefrontal cortex

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Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

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Mice lacking circadian clock components display different mood-related behaviors and do not respond uniformly to chronic lithium treatment: Chronobiology International: Vol 32, No 8

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  Anti-phosphoGSK3β (Ser9)(5b3) 1:1000 (Cell Signaling Technology Cat# 9323P)
  
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