137 Matching Annotations
  1. Last 7 days
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Renal inflammation combined with renal function reserve reduction accelerate kidney aging via pentose phosphate pathway
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    1. scibot 03 Jul 2024
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      DOI: 10.1016/j.isci.2024.110045

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    ncbi.nlm.nih.gov/pmc/articles/PMC11214290/
  3. www.cell.com www.cell.com
    Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC
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    1. scibot 30 Jun 2024
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    cell.com/iscience/abstract/S2589-0042(24)01357-9
  4. Jun 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fully automated viability and toxicity screening—A reliable all‐in‐one attempt
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    1. scibot 25 Jun 2024
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      DOI: 10.1002/cam4.7392

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    ncbi.nlm.nih.gov/pmc/articles/PMC11193055/
  6. May 2024
  7. www.sciencedirect.com www.sciencedirect.com
    Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis
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    sciencedirect.com/science/article/pii/S1931312824001409
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    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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    sciencedirect.com/science/article/pii/S2666379124002702
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    SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis
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    1. scibot 23 May 2024
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    sciencedirect.com/science/article/pii/S153458072400296X
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    SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production
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    1. scibot 21 May 2024
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    sciencedirect.com/science/article/pii/S1934590924001760
  11. www.biorxiv.org www.biorxiv.org
    Viral mimicry and memory deficits upon microglial deletion of ATRX
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      DOI: 10.1101/2024.05.07.592875

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    biorxiv.org/content/10.1101/2024.05.07.592875v1
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neoadjuvant radiotherapy in ER+, HER2+, and triple-negative -specific breast cancer based humanized tumor mice enhances anti-PD-L1 treatment efficacy
    1
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      DOI: 10.3389/fimmu.2024.1355130

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    ncbi.nlm.nih.gov/pmc/articles/PMC11089195/
  13. www.science.org www.science.org
    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
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    1. scibot 09 May 2024
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      DOI: 10.1126/sciadv.adl6082

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    science.org/doi/10.1126/sciadv.adl6082
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    The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex
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    sciencedirect.com/science/article/pii/S1097276524002855
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
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    1. scibot 05 May 2024
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      DOI: 10.1126/sciadv.adl6082

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    ncbi.nlm.nih.gov/pmc/articles/PMC11068011/
  16. Apr 2024
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response
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    1. scibot 20 Apr 2024
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      DOI: 10.1016/j.ebiom.2024.105129

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    ncbi.nlm.nih.gov/pmc/articles/PMC11052917/
  18. aacrjournals.org aacrjournals.org
    The chromatin remodeler CHD4 sustains Ewing Sarcoma cell survival by controlling global chromatin architecture
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    1. scibot 19 Apr 2024
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      DOI: 10.1158/0008-5472.CAN-22-3950

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    aacrjournals.org/cancerres/article/84/2/241/733111/The-Chromatin-Remodeler-CHD4-Sustains-Ewing
  19. www.embopress.org www.embopress.org
    PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair
    1
    1. scibot 18 Apr 2024
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    embopress.org/doi/full/10.1038/s44318-024-00043-2
  20. Feb 2024
  21. 52.53.155.43 52.53.155.43
    241-html.html
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    52.53.155.43/ef1c2343cba3a29438101d6931686796493196a8/241-html.html
  22. www.sciencedirect.com www.sciencedirect.com
    Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
    1
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    sciencedirect.com/science/article/pii/S2211124724001736
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
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      DOI: 10.1038/s41467-024-45760-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC10873513/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The importance of proinflammatory failed-repair tubular epithelia as a predictor of diabetic kidney disease progression
    1
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      DOI: 10.1016/j.isci.2024.109020

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    ncbi.nlm.nih.gov/pmc/articles/PMC10865398/
  25. www.sciencedirect.com www.sciencedirect.com
    Quantitative and qualitative mutational impact of ionizing radiation on normal cells
    1
    1. scibot 15 Feb 2024
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      DOI: 10.1016/j.xgen.2024.100499

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    sciencedirect.com/science/article/pii/S2666979X24000260
  26. Jan 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells
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    1. scibot 26 Jan 2024
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      DOI: 10.1186/s13148-023-01477-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10105475/
  28. Nov 2023
  29. aacrjournals.org aacrjournals.org
    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
    1
    1. scibot 03 Nov 2023
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      DOI: 10.1158/2159-8290.CD-23-0669

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    aacrjournals.org/cancerdiscovery/article/13/11/2412/729848/MRTX1719-Is-an-MTA-Cooperative-PRMT5-Inhibitor
  30. www.nature.com www.nature.com
    Spatial metabolomics identifies distinct tumor-specific and stroma-specific subtypes in patients with lung squamous cell carcinoma
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    1. scibot 03 Nov 2023
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      DOI: 10.1038/s41698-023-00434-4

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    nature.com/articles/s41698-023-00434-4
  31. Oct 2023
  32. www.biorxiv.org www.biorxiv.org
    Loss of EIF4G2 Mediates Aggressiveness in Distinct Human Endometrial Cancer Subpopulations with Poorer Survival Outcome in Patients
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    1. scibot 28 Oct 2023
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      DOI: 10.1101/2023.09.14.557672

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    biorxiv.org/content/10.1101/2023.09.14.557672v1
  33. Sep 2023
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis
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    1. scibot 30 Sep 2023
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      DOI: 10.7554/eLife.84710

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    ncbi.nlm.nih.gov/pmc/articles/PMC10519710/
  35. www.sciencedirect.com www.sciencedirect.com
    Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome
    1
    1. scibot 08 Sep 2023
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      DOI: 10.1016/j.ajpath.2023.08.008

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    sciencedirect.com/science/article/pii/S0002944023003152
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma
    1
    1. scibot 07 Sep 2023
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      DOI: 10.1158/1078-0432.CCR-22-3897

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    ncbi.nlm.nih.gov/pmc/articles/PMC10472104/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor
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    1. scibot 06 Sep 2023
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      DOI: 10.1158/2767-9764.CRC-23-0304

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    ncbi.nlm.nih.gov/pmc/articles/PMC10473160/
  38. Aug 2023
  39. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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      DOI: 10.1016/j.xcrm.2023.101142

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      DOI: 10.1016/j.xcrm.2023.101142

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    52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
  40. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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    sciencedirect.com/science/article/pii/S1535610823002453
  41. www.sciencedirect.com www.sciencedirect.com
    DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype
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      DOI: 10.1016/j.celrep.2023.112927

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    sciencedirect.com/science/article/pii/S2211124723009385
  42. Jul 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitors
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      DOI: 10.1016/j.isci.2023.107302

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    sciencedirect.com/science/article/pii/S2589004223013792
  44. www.sciencedirect.com www.sciencedirect.com
    MEF2A suppresses stress responses that trigger DDX41-dependent IFN production
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      DOI: 10.1016/j.celrep.2023.112805

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    sciencedirect.com/science/article/pii/S2211124723008161
  45. www.sciencedirect.com www.sciencedirect.com
    Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer
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      DOI: 10.1016/j.ccell.2023.06.010

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    sciencedirect.com/science/article/pii/S1535610823002350
  46. www.sciencedirect.com www.sciencedirect.com
    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
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      DOI: 10.1016/j.molcel.2023.06.025

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    sciencedirect.com/science/article/pii/S1097276523004720
  47. www.cell.com www.cell.com
    Human embryo live imaging reveals nuclear DNA shedding during blastocyst expansion and biopsy
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      DOI: 10.1016/j.cell.2023.06.003

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    cell.com/cell/fulltext/S0092-8674(23)00643-8
  48. Jun 2023
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis
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      DOI: 10.1016/j.molcel.2022.12.004

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    ncbi.nlm.nih.gov/pmc/articles/PMC7614657/
  50. www.sciencedirect.com www.sciencedirect.com
    Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination
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      DOI: 10.1016/j.molcel.2023.05.026

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    sciencedirect.com/science/article/pii/S1097276523003829
  51. www.sciencedirect.com www.sciencedirect.com
    Integrator facilitates RNAPII removal to prevent transcription-replication collisions and genome instability
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      DOI: 10.1016/j.molcel.2023.05.015

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    Evolution of Resistance to Irinotecan in Cancer Cells Involves Generation of Topoisomerase-Guided Mutations in Non-Coding Genome That Reduce the Chances of DNA Breaks
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    Asparagine and Glutamine Deprivation Alters Ionizing Radiation Response, Migration and Adhesion of a p53null Colorectal Cancer Cell Line
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    The ADP-ribose hydrolase NUDT5 is important for DNA repair
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    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
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    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
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    Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair
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    Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
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    Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy
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    A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53
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    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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    Epithelial DNA methyltransferase-1 regulates cell survival, growth and maturation in developing prostatic buds
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    A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope
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  116. Jun 2021
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    High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
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  120. May 2021
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    Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury
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  127. Feb 2021
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  131. Jan 2021
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    RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3α Co-localization
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    Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
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  137. Sep 2020
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    IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer
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    ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma
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    Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells
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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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    Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements
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      DOI: 10.1016/j.molcel.2018.12.021

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  162. Nov 2018
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    Modulation of DNA Repair Systems in Blind Cavefish during Evolution in Constant Darkness
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    The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage
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    The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures
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    β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4
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    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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    Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality
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    Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates
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  172. Nov 2017
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    ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks
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    RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health
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