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NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

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1. scibot 04 Sep 2025
  
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  DOI: 10.7554/eLife.103904
  
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elifesciences.org/articles/103904
Aug 2025
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Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress

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1. scibot 14 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.07.013
  
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sciencedirect.com/science/article/pii/S1097276525006148
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Combined MEK and PARP inhibition enhances radiation response in rectal cancer

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1. scibot 09 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102284
  
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sciencedirect.com/science/article/pii/S266637912500357X
Jul 2025
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CF10/LV overcomes acquired resistance to 5-FU/LV in colorectal cancer cells through downregulation of the c-Myc/ABCB5 axis

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1. scibot 31 Jul 2025
  
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  DOI: 10.20517/cdr.2025.76
  
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oaepublish.com/articles/cdr.2025.76
Jun 2025
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The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.06.002
  
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sciencedirect.com/science/article/pii/S1097276525005027
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CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance

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  DOI: 10.1016/j.molcel.2025.04.006
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12240685/
May 2025
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Trichosanthes kirilowii Maxim. and Bioactive Compound Cucurbitacin D Alleviate Cisplatin-Induced Peripheral Neuropathy In Vitro and In Vivo

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1. scibot 22 May 2025
  
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  DOI: 10.1177/15347354251339121
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12089711/
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Reducing Dietary Protein Enhances the Antitumor Effects of Chemotherapy through Immune-Mediated Mechanisms

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1. scibot 20 May 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0545
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617599/
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Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.cell.2025.04.012
  
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sciencedirect.com/science/article/pii/S0092867425004143
Apr 2025
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Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer

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1. scibot 16 Apr 2025
  
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  DOI: 10.1038/s41419-025-07624-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11992107/
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Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance

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1. scibot 11 Apr 2025
  
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  DOI: 10.1016/j.ccell.2025.03.031
  
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sciencedirect.com/science/article/pii/S1535610825001321
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Injured tubular epithelia-derived CCN1 promotes the mobilization of fibroblasts toward injury sites after kidney injury

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1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.isci.2025.112176
  
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sciencedirect.com/science/article/pii/S2589004225004377
Mar 2025
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PDF-html.html

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1. scibot 24 Mar 2025
  
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  DOI: 10.1158/1535-7163.mct-24-0545
  
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52.53.155.43/089c935c8b8375c73eca3bfe64a1d2170a0cdb88/PDF-html.html
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Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair

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1. scibot 14 Mar 2025
  
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  DOI: 10.1126/sciadv.adt1241
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11900879/
Feb 2025
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Linking LEDGF/p75 Overexpression With Microsatellite Instability and KRAS Mutations: A Small-Scale Study in Colorectal Cancer

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1. scibot 27 Feb 2025
  
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  DOI: 10.1177/10732748251313499
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11837075/
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KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition

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1. scibot 06 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115272
  
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sciencedirect.com/science/article/pii/S2211124725000439
Dec 2024
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DDX39A resolves replication fork-associated RNA-DNA hybrids to balance fork protection and cleavage for genomic stability maintenance

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.029
  
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Transcriptional and functional regulation of cell cycle and UV response by PPARβ in human skin epidermal cells

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1. scibot 06 Dec 2024
  
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  DOI: 10.1096/fj.202401950R
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11610672/
Nov 2024
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p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb

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1. scibot 21 Nov 2024
  
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  DOI: 10.1038/s44318-024-00246-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11574164/
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Profound synthetic lethality between SMARCAL1 and FANCM

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1. scibot 17 Nov 2024
  
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  DOI: 10.1016/j.molcel.2024.10.016
  
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sciencedirect.com/science/article/pii/S1097276524008566
Sep 2024
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In vivo DNA replication dynamics unveil aging-dependent replication stress

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.034
  
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sciencedirect.com/science/article/pii/S0092867424009632
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A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib

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1. scibot 04 Sep 2024
  
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  DOI: 10.1016/j.xcrm.2024.101703
  
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sciencedirect.com/science/article/pii/S2666379124004245
Aug 2024
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PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair

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1. scibot 13 Aug 2024
  
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  DOI: 10.1038/s44318-024-00043-2
  
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52.53.155.43/96a93e3423f1799636791061d7a89146b9cf3fe1/andronikou-et-al-2024-parg-deficient-tumor-cells-have-an-increased-dependence-on-exo1-fen1-mediated-dna-repair (1)-html.html
Jul 2024
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Identification of the main barriers to Ku accumulation in chromatin

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1. scibot 30 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114538
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11411529/
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Renal inflammation combined with renal function reserve reduction accelerate kidney aging via pentose phosphate pathway

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1. scibot 03 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110045
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11214290/
Jun 2024
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Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC

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1. scibot 30 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.110132
  
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cell.com/iscience/abstract/S2589-0042(24)01357-9
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Fully automated viability and toxicity screening—A reliable all‐in‐one attempt

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1. scibot 25 Jun 2024
  
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  DOI: 10.1002/cam4.7392
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11193055/
May 2024
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Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis

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1. scibot 24 May 2024
  
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  DOI: 10.1016/j.chom.2024.04.020
  
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sciencedirect.com/science/article/pii/S1931312824001409
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Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations

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  DOI: 10.1016/j.xcrm.2024.101578
  
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sciencedirect.com/science/article/pii/S2666379124002702
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SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis

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  DOI: 10.1016/j.devcel.2024.04.023
  
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sciencedirect.com/science/article/pii/S153458072400296X
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SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production

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1. scibot 21 May 2024
  
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  DOI: 10.1016/j.stem.2024.04.023
  
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sciencedirect.com/science/article/pii/S1934590924001760
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Viral mimicry and memory deficits upon microglial deletion of ATRX

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1. scibot 16 May 2024
  
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  DOI: 10.1101/2024.05.07.592875
  
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biorxiv.org/content/10.1101/2024.05.07.592875v1
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Neoadjuvant radiotherapy in ER+, HER2+, and triple-negative -specific breast cancer based humanized tumor mice enhances anti-PD-L1 treatment efficacy

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1. scibot 15 May 2024
  
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  DOI: 10.3389/fimmu.2024.1355130
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11089195/
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p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

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1. scibot 09 May 2024
  
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  DOI: 10.1126/sciadv.adl6082
  
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science.org/doi/10.1126/sciadv.adl6082
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The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex

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1. scibot 07 May 2024
  
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  DOI: 10.1016/j.molcel.2024.04.007
  
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p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

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PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response

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The chromatin remodeler CHD4 sustains Ewing Sarcoma cell survival by controlling global chromatin architecture

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PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair

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Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection

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PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma

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The importance of proinflammatory failed-repair tubular epithelia as a predictor of diabetic kidney disease progression

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Quantitative and qualitative mutational impact of ionizing radiation on normal cells

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Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells

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MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer

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Spatial metabolomics identifies distinct tumor-specific and stroma-specific subtypes in patients with lung squamous cell carcinoma

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Loss of EIF4G2 Mediates Aggressiveness in Distinct Human Endometrial Cancer Subpopulations with Poorer Survival Outcome in Patients

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Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis

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Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome

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A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma

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Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

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L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

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Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer

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DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype

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Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitors

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MEF2A suppresses stress responses that trigger DDX41-dependent IFN production

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Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer

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Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

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Human embryo live imaging reveals nuclear DNA shedding during blastocyst expansion and biopsy

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CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis

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Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination

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Integrator facilitates RNAPII removal to prevent transcription-replication collisions and genome instability

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Profiling the metabolome of uterine fluid for early detection of ovarian cancer

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Evolution of Resistance to Irinotecan in Cancer Cells Involves Generation of Topoisomerase-Guided Mutations in Non-Coding Genome That Reduce the Chances of DNA Breaks

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Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway

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Potential New Therapeutic Approaches for Cisplatin-Resistant Testicular Germ Cell Tumors

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Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase

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Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis

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Asparagine and Glutamine Deprivation Alters Ionizing Radiation Response, Migration and Adhesion of a p53null Colorectal Cancer Cell Line

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MDC1 maintains active elongation complexes of RNA polymerase II

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Loss of epigenetic information as a cause of mammalian aging

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The ADP-ribose hydrolase NUDT5 is important for DNA repair

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The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response

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NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step

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Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy

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A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

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Guiding ATR and PARP inhibitor combinationswith chemogenomic screens

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Establishment of Patient-derived Succinate Dehydrogenase-deficient Gastrointestinal Stromal Tumor Models for Predicting Therapeutic Response

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Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

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Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8+ T cell exhaustion

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Nde1 is required for heterochromatin compaction and stability in neocortical neurons

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WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC

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Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

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PTIP governs NAD+ metabolism by regulating CD38 expression to drive macrophage inflammation

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Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer

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CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer

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WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity

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ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization

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Antibody-drug conjugate efficacy in neuroblastoma - role of payload, resistance mechanisms, target density, and antibody internalization

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Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells

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Altered H3 histone acetylation impairs high-fidelity DNA repair to promote cerebellar degeneration in spinocerebellar ataxia type 7

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MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts

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Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair

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Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps

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Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells

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Viral targeting of glioblastoma stem cells with patient-specific genetic and post-translational p53 deregulations

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Cdc42 is required for male germline niche development in mice

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Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy

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A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

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Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

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MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer

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Epithelial DNA methyltransferase-1 regulates cell survival, growth and maturation in developing prostatic buds

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A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope

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Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

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NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir

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Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage

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High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity

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p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation

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Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters

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CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress

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Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury

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Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut

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Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss

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AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ

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The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells

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Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A

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RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3α Co-localization

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Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination

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Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage

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Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations

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Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection

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The integrated stress response induces R-loops and hinders replication fork progression

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Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma

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PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network

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Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres

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CoA Synthase (COASY) mediates radiation resistance via PI3K signaling in rectal cancer

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N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor

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PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

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Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics

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LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL

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Stress hormone-mediated acceleration of breast cancer metastasis is halted by inhibition of nitric oxide synthase

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SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance

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IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer

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ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma

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1. scibot 13 Jan 2020
  
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  DOI: 10.7554/eLife.39159
  
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  DOI: 10.1016/j.molcel.2019.02.025
  
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  DOI: 10.1016/j.cmet.2019.01.019
  
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Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells

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MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer

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Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements

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Modulation of DNA Repair Systems in Blind Cavefish during Evolution in Constant Darkness

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The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage

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The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures

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β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

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Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

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Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

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Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates

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The Polyploid State Plays a Tumor-Suppressive Role in the Liver

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ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks

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Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals

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DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis

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RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health

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