145 Matching Annotations
  1. Last 7 days
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    DDX39A resolves replication fork-associated RNA-DNA hybrids to balance fork protection and cleavage for genomic stability maintenance
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    sciencedirect.com/science/article/pii/S1097276524009547
  3. Dec 2024
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcriptional and functional regulation of cell cycle and UV response by PPARβ in human skin epidermal cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11610672/
  5. Nov 2024
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb
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    Profound synthetic lethality between SMARCAL1 and FANCM
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    sciencedirect.com/science/article/pii/S1097276524008566
  8. Sep 2024
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    In vivo DNA replication dynamics unveil aging-dependent replication stress
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    sciencedirect.com/science/article/pii/S0092867424009632
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    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
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    sciencedirect.com/science/article/pii/S2666379124004245
  11. Aug 2024
  12. 52.53.155.43 52.53.155.43
    PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair
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    52.53.155.43/96a93e3423f1799636791061d7a89146b9cf3fe1/andronikou-et-al-2024-parg-deficient-tumor-cells-have-an-increased-dependence-on-exo1-fen1-mediated-dna-repair (1)-html.html
  13. Jul 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of the main barriers to Ku accumulation in chromatin
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    ncbi.nlm.nih.gov/pmc/articles/PMC11411529/
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    Renal inflammation combined with renal function reserve reduction accelerate kidney aging via pentose phosphate pathway
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  16. Jun 2024
  17. www.cell.com www.cell.com
    Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC
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    cell.com/iscience/abstract/S2589-0042(24)01357-9
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fully automated viability and toxicity screening—A reliable all‐in‐one attempt
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  19. May 2024
  20. www.sciencedirect.com www.sciencedirect.com
    Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis
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    sciencedirect.com/science/article/pii/S1931312824001409
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    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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    SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis
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    SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production
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  24. www.biorxiv.org www.biorxiv.org
    Viral mimicry and memory deficits upon microglial deletion of ATRX
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    biorxiv.org/content/10.1101/2024.05.07.592875v1
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neoadjuvant radiotherapy in ER+, HER2+, and triple-negative -specific breast cancer based humanized tumor mice enhances anti-PD-L1 treatment efficacy
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  26. www.science.org www.science.org
    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
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    1. scibot 09 May 2024
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      DOI: 10.1126/sciadv.adl6082

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    The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex
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  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11068011/
  29. Apr 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response
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    ncbi.nlm.nih.gov/pmc/articles/PMC11052917/
  31. aacrjournals.org aacrjournals.org
    The chromatin remodeler CHD4 sustains Ewing Sarcoma cell survival by controlling global chromatin architecture
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      DOI: 10.1158/0008-5472.CAN-22-3950

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    aacrjournals.org/cancerres/article/84/2/241/733111/The-Chromatin-Remodeler-CHD4-Sustains-Ewing
  32. 52.53.155.43 52.53.155.43
    PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair
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    52.53.155.43/96a93e3423f1799636791061d7a89146b9cf3fe1/andronikou-et-al-2024-parg-deficient-tumor-cells-have-an-increased-dependence-on-exo1-fen1-mediated-dna-repair (1)-html.html
  33. Feb 2024
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    Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
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    sciencedirect.com/science/article/pii/S2211124724001736
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10873513/
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    The importance of proinflammatory failed-repair tubular epithelia as a predictor of diabetic kidney disease progression
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      DOI: 10.1016/j.isci.2024.109020

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    ncbi.nlm.nih.gov/pmc/articles/PMC10865398/
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    Quantitative and qualitative mutational impact of ionizing radiation on normal cells
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      DOI: 10.1016/j.xgen.2024.100499

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    sciencedirect.com/science/article/pii/S2666979X24000260
  39. Jan 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10105475/
  41. Nov 2023
  42. aacrjournals.org aacrjournals.org
    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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      DOI: 10.1158/2159-8290.CD-23-0669

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    aacrjournals.org/cancerdiscovery/article/13/11/2412/729848/MRTX1719-Is-an-MTA-Cooperative-PRMT5-Inhibitor
  43. www.nature.com www.nature.com
    Spatial metabolomics identifies distinct tumor-specific and stroma-specific subtypes in patients with lung squamous cell carcinoma
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      DOI: 10.1038/s41698-023-00434-4

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    nature.com/articles/s41698-023-00434-4
  44. Oct 2023
  45. www.biorxiv.org www.biorxiv.org
    Loss of EIF4G2 Mediates Aggressiveness in Distinct Human Endometrial Cancer Subpopulations with Poorer Survival Outcome in Patients
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      DOI: 10.1101/2023.09.14.557672

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    biorxiv.org/content/10.1101/2023.09.14.557672v1
  46. Sep 2023
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis
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      DOI: 10.7554/eLife.84710

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    ncbi.nlm.nih.gov/pmc/articles/PMC10519710/
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    Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome
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    sciencedirect.com/science/article/pii/S0002944023003152
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma
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      DOI: 10.1158/1078-0432.CCR-22-3897

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    ncbi.nlm.nih.gov/pmc/articles/PMC10472104/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor
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      DOI: 10.1158/2767-9764.CRC-23-0304

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    ncbi.nlm.nih.gov/pmc/articles/PMC10473160/
  51. Aug 2023
  52. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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      DOI: 10.1016/j.xcrm.2023.101142

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      DOI: 10.1016/j.xcrm.2023.101142

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    52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
  53. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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    Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer
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    Evolution of Resistance to Irinotecan in Cancer Cells Involves Generation of Topoisomerase-Guided Mutations in Non-Coding Genome That Reduce the Chances of DNA Breaks
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    Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase
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    Asparagine and Glutamine Deprivation Alters Ionizing Radiation Response, Migration and Adhesion of a p53null Colorectal Cancer Cell Line
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  74. Jan 2023
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    MDC1 maintains active elongation complexes of RNA polymerase II
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    The ADP-ribose hydrolase NUDT5 is important for DNA repair
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    The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response
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    NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step
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    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
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    CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer
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    Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells
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    Altered H3 histone acetylation impairs high-fidelity DNA repair to promote cerebellar degeneration in spinocerebellar ataxia type 7
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    MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts
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  109. Oct 2021
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    Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair
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  111. Sep 2021
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    Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
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    Viral targeting of glioblastoma stem cells with patient-specific genetic and post-translational p53 deregulations
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  115. Aug 2021
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    Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy
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    A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53
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    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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  120. Jul 2021
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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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    Epithelial DNA methyltransferase-1 regulates cell survival, growth and maturation in developing prostatic buds
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    A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope
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  129. Jun 2021
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    NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
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    Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage
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    High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
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  133. May 2021
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    p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation
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    Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters
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    CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress
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  137. Apr 2021
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    Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury
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    Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut
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  140. Feb 2021
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    Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
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    AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ
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    The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells
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  144. Jan 2021
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    Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A
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    RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3α Co-localization
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    Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
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  148. Dec 2020
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    Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage
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  150. Sep 2020
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    Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma
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    PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network
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    Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres
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  157. Aug 2020
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    CoA Synthase (COASY) mediates radiation resistance via PI3K signaling in rectal cancer
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  159. Jan 2020
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    N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor
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    PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD
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    Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics
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    LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL
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    Stress hormone-mediated acceleration of breast cancer metastasis is halted by inhibition of nitric oxide synthase
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    SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance
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    IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer
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    ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma
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    Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells
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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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    Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements
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  175. Nov 2018
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    Modulation of DNA Repair Systems in Blind Cavefish during Evolution in Constant Darkness
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    The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage
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    The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures
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    β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4
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  181. www.ncbi.nlm.nih.govhttp: www.ncbi.nlm.nih.govhttp:
    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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    Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality
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    Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates
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    The Polyploid State Plays a Tumor-Suppressive Role in the Liver
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  185. Nov 2017
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    ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks
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    Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals
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    DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis
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    RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health
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