22 Matching Annotations
  1. Aug 2026
  2. 54.241.53.176 54.241.53.176
    Screening of a kinase library in human Huntington disease iPSC derived striatal precursor neurons reveals a neuroprotective effect of PKC alpha and PKC beta1 inhibition
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    54.241.53.176/33da50ece47d3ae2fab40cd411d44128656ba982/2025.09.18.677178.full-html.html
  3. Jun 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Increased Activity‐Dependent Bulk Endocytosis in Huntington's Disease Results From Huntingtin Haploinsufficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC12181757/
  5. Apr 2025
  6. www.nature.com www.nature.com
    Opposing roles for GSK3β and ERK1-dependent phosphorylation of huntingtin during neuronal dysfunction and cell death in Huntington’s disease
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    nature.com/articles/s41419-025-07524-0
  7. Nov 2024
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modulation of SNARE-dependent exocytosis in astrocytes improves neuropathology in Huntington's disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11583919/
  9. May 2024
  10. www.science.org www.science.org
    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
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    science.org/doi/10.1126/sciadv.adl6082
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
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    ncbi.nlm.nih.gov/pmc/articles/PMC11068011/
  12. Feb 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gene-dosage- and sex-dependent differences in the prodromal-Like phase of the F344tgHD rat model for Huntington disease
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10879377/
  14. Sep 2023
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10012955/
  16. May 2023
  17. www.nature.com www.nature.com
    Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
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    nature.com/articles/s41467-022-31905-0
  18. Apr 2023
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Semi-automated workflows to quantify AAV transduction in various brain areas and predict gene editing outcome for neurological disorders
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10120313/
  20. Aug 2022
  21. www.sciencedirect.com www.sciencedirect.com
    Huntingtin coordinates dendritic spine morphology and function through cofilin-mediated control of the actin cytoskeleton
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    sciencedirect.com/science/article/pii/S2211124722010798
  22. Sep 2021
  23. academic.oup.com academic.oup.com
    Immortalized striatal precursor neurons from Huntington’s disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics
    1
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    academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddab200/6325571
  24. Jul 2021
  25. europepmc.org europepmc.org
    Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models.
    2
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    europepmc.org/articles/PMC5717400/
  26. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1550413119301329
  27. May 2021
  28. www.sciencedirect.com www.sciencedirect.com
    The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain
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    sciencedirect.com/science/article/pii/S0969212620302112
  29. Jan 2021
  30. link.springer.com link.springer.com
    Inhibition of p38 Mitogen–Activated Protein Kinase Ameliorates HAP40 Depletion–Induced Toxicity and Proteasomal Defect in Huntington’s Disease Model
    1
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    link.springer.com/article/10.1007/s12035-020-02280-y
  31. Jan 2020
  32. www.nature.com www.nature.com
    Assessing average somatic CAG repeat instability at the protein level
    1
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    nature.com/articles/s41598-019-55202-x
  33. Nov 2018
  34. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Activation of caspase‐6 and cleavage of caspase‐6 substrates is an early event in NMDA receptor–mediated excitotoxicity
    1
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    onlinelibrary.wiley.com/doi/10.1002/jnr.24153/full
  35. Nov 2017
  36. www.jneurosci.org www.jneurosci.org
    Mutant huntingtin is secreted via a late endosomal/lysosomal unconventional secretory pathway
    1
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    jneurosci.org/content/37/37/9000
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Huntingtin Is Required for Normal Excitatory Synapse Development in Cortical and Striatal Circuits
    2
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    ncbi.nlm.nih.gov/pmc/articles/PMC4087216/