78 Matching Annotations
  1. Sep 2024
  2. www.sciencedirect.com www.sciencedirect.com
    CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway
    1
    1. scibot 26 Sep 2024
      AB_2128522

      DOI: 10.1016/j.xgen.2024.100659

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    sciencedirect.com/science/article/pii/S2666979X24002702
  3. www.sciencedirect.com www.sciencedirect.com
    Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function
    1
    1. scibot 25 Sep 2024
      AB_10691469

      DOI: 10.1016/j.immuni.2020.07.006

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      Curator comments: Jak2 (D2E12) XP Rabbit mAb antibody Cell Signaling Technology Cat# 3230

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    sciencedirect.com/science/article/pii/S1074761320303137
  4. www.sciencedirect.com www.sciencedirect.com
    H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response
    1
    1. scibot 04 Sep 2024
      AB_2128522

      DOI: 10.1016/j.celrep.2024.114686

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    sciencedirect.com/science/article/pii/S2211124724010374
  5. Aug 2024
  6. www.sciencedirect.com www.sciencedirect.com
    Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression
    1
    1. scibot 28 Aug 2024
      AB_2128522

      DOI: 10.1016/j.devcel.2024.08.003

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    sciencedirect.com/science/article/pii/S1534580724004866
  7. jbiomedsci.biomedcentral.com jbiomedsci.biomedcentral.com
    Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells
    1
    1. scibot 02 Aug 2024
      3230

      DOI: 10.1186/s12929-021-00769-9

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    jbiomedsci.biomedcentral.com/articles/10.1186/s12929-021-00769-9
  8. Jul 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity
    1
    1. scibot 24 Jul 2024
      AB_2128522

      DOI: 10.1016/j.immuni.2024.05.025

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    sciencedirect.com/science/article/pii/S1074761324002796
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Influenza A virus infection activates STAT3 to enhance SREBP2 expression, cholesterol biosynthesis, and virus replication
    1
    1. scibot 19 Jul 2024
      AB_2128522

      DOI: 10.1016/j.isci.2024.110424

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    ncbi.nlm.nih.gov/pmc/articles/PMC11301072/
  11. May 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PABPC1L induces IDO1 to promote tryptophan metabolism and immune suppression in renal cell carcinoma
    1
    1. scibot 17 May 2024
      RRID:AB_2128522

      DOI: 10.1158/0008-5472.CAN-23-2521

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    ncbi.nlm.nih.gov/pmc/articles/PMC11094425/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ruxolitinib improves the inflammatory microenvironment, restores glutamate homeostasis, and promotes functional recovery after spinal cord injury
    1
    1. scibot 15 May 2024
      RRID:AB_2128522

      DOI: 10.4103/NRR.NRR-D-23-01863

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    ncbi.nlm.nih.gov/pmc/articles/PMC11090442/
  14. www.sciencedirect.com www.sciencedirect.com
    Active substances and molecular mechanisms of Astragali Radix and Angelicae Sinensis Radix against idiopathic pulmonary fibrosis effects by network pharmacology and in vitro experiments
    1
    1. scibot 14 May 2024
      3230S

      DOI: 10.1016/j.cjac.2024.100397

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    sciencedirect.com/science/article/pii/S1872204024000422
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
    1
    1. scibot 14 May 2024
      RRID:AB_2128522

      DOI: 10.1016/j.celrep.2024.114202

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    pmc.ncbi.nlm.nih.gov/articles/PMC11194014/
  16. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
    1
    1. scibot 02 May 2024
      RRID:AB_2128522

      DOI: 10.1111/bph.16393

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16393
  17. Apr 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anorexia-Induced Hypoleptinemia Drives Adaptations in the JAK2/STAT3 Pathway in the Ventral and Dorsal Hippocampus of Female Rats
    1
    1. scibot 30 Apr 2024
      RRID:AB_2128522

      DOI: 10.3390/nu16081171

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    ncbi.nlm.nih.gov/pmc/articles/PMC11054075/
  19. www.sciencedirect.com www.sciencedirect.com
    Oncostatin M signaling drives cancer-associated skeletal muscle wasting
    1
    1. scibot 05 Apr 2024
      RRID:AB_2128522

      DOI: 10.1016/j.xcrm.2024.101498

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    sciencedirect.com/science/article/pii/S2666379124001666
  20. Mar 2024
  21. www.sciencedirect.com www.sciencedirect.com
    Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon
    2
    1. scibot 06 Mar 2024
      RRID:AB_2128522

      DOI: 10.1016/j.devcel.2024.02.005

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    2. scibot 06 Mar 2024
      RRID:AB_2128522

      DOI: 10.1016/j.devcel.2024.02.005

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    sciencedirect.com/science/article/pii/S1534580724000765
  22. Feb 2024
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Schisandrin B promotes hepatic differentiation from human umbilical cord mesenchymal stem cells
    1
    1. scibot 08 Feb 2024
      RRID:AB_2128522

      DOI: 10.1016/j.isci.2024.108912

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    ncbi.nlm.nih.gov/pmc/articles/PMC10844828/
  24. Nov 2023
  25. www.sciencedirect.com www.sciencedirect.com
    Exosomes derived from platelet-rich plasma promote diabetic wound healing via the JAK2/STAT3 pathway
    1
    1. scibot 04 Nov 2023
      RRID:AB_2128522

      DOI: 10.1016/j.isci.2023.108236

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    sciencedirect.com/science/article/pii/S2589004223023131
  26. Oct 2023
  27. www.sciencedirect.com www.sciencedirect.com
    Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria
    1
    1. scibot 28 Oct 2023
      RRID:AB_2128522

      DOI: 10.1016/j.cell.2023.09.024

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    sciencedirect.com/science/article/pii/S0092867423010784
  28. www.sciencedirect.com www.sciencedirect.com
    High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
    1
    1. scibot 14 Oct 2023
      RRID:AB_2128522

      DOI: 10.1016/j.xcrm.2023.101214

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    sciencedirect.com/science/article/pii/S2666379123003816
  29. Sep 2023
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms
    1
    1. scibot 07 Sep 2023
      RRID:AB_2128522

      DOI: 10.1158/1078-0432.CCR-22-1763

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    ncbi.nlm.nih.gov/pmc/articles/PMC9992133/
  31. Aug 2023
  32. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2023 - Han-html.html
    1
    1. scibot 16 Aug 2023
      AB_2128522

      DOI: 10.1111/bph.16208

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    52.53.155.43/5e554e9cedd6e38ae632f7a8eb735fb3080af333/British J Pharmacology - 2023 - Han-html.html
  33. 52.53.155.43 52.53.155.43
    BPS Publications
    1
    1. scibot 01 Aug 2023
      RRID:AB_2128522

      DOI: 10.1111/bph.16202

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    52.53.155.43/d8c850c315bd1ef9a1794152cac296a4123affe5/British J Pharmacology - 2023 - Wang - Sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of STAT3-html.html
  34. Jul 2023
  35. www.sciencedirect.com www.sciencedirect.com
    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
    1
    1. scibot 27 Jul 2023
      RRID:AB_2128522

      DOI: 10.1016/j.celrep.2023.112868

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    sciencedirect.com/science/article/pii/S2211124723008793
  36. Jun 2023
  37. www.sciencedirect.com www.sciencedirect.com
    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
    1
    1. scibot 08 Jun 2023
      RRID:AB_2128522

      DOI: 10.1016/j.chembiol.2023.05.007

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    sciencedirect.com/science/article/pii/S2451945623001502
  38. May 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma
    1
    1. scibot 20 May 2023
      RRID: AB_2128522

      DOI: 10.1016/j.bcp.2023.115612

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    sciencedirect.com/science/article/pii/S0006295223002034
  40. www.sciencedirect.com www.sciencedirect.com
    Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation
    1
    1. scibot 10 May 2023
      RRID:AB_2128522

      DOI: 10.1016/j.celrep.2023.112490

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    sciencedirect.com/science/article/pii/S2211124723005016
  41. www.sciencedirect.com www.sciencedirect.com
    DUSP4 promotes esophageal squamous cell carcinoma progression by dephosphorylating HSP90β
    1
    1. scibot 05 May 2023
      RRID:AB_2128522

      DOI: 10.1016/j.celrep.2023.112445

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    sciencedirect.com/science/article/pii/S2211124723004564
  42. www.sciencedirect.com www.sciencedirect.com
    Exercise-derived peptide protects against pathological cardiac remodeling
    1
    1. scibot 05 May 2023
      RRID:AB_2128522

      DOI: 10.1016/j.ebiom.2022.104164

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    sciencedirect.com/science/article/pii/S2352396422003450
  43. Apr 2023
  44. www.sciencedirect.com www.sciencedirect.com
    MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer
    1
    1. scibot 12 Apr 2023
      RRID:AB_2128522

      DOI: 10.1016/j.xcrm.2023.101006

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    sciencedirect.com/science/article/pii/S2666379123001167
  45. Mar 2023
  46. 52.53.155.43 52.53.155.43
    943-html.html
    1
    1. scibot 16 Mar 2023
      AB_2128522

      DOI: 10.1158/1078-0432.CCR-22-1763

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    52.53.155.43/c8f103b982e67ed0e9f7f2acbda462e2c6f6fa27/943-html.html
  47. Jan 2023
  48. www.nature.com www.nature.com
    Pacritinib inhibits glucose consumption in squamous cell lung cancer cells by targeting FLT3
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    1. scibot 28 Jan 2023
      RRID:AB_2128522

      DOI: 10.1038/s41598-023-28576-2

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    nature.com/articles/s41598-023-28576-2
  49. Dec 2022
  50. link.springer.com link.springer.com
    RAGE deficiency ameliorates autoimmune hepatitis involving inhibition of IL-6 production via suppressing protein Arid5a in mice
    1
    1. scibot 02 Dec 2022
      RRID:AB_2128522

      DOI: 10.1007/s10238-022-00960-8

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    link.springer.com/article/10.1007/s10238-022-00960-8
  51. Nov 2022
  52. www.sciencedirect.com www.sciencedirect.com
    The target antigen determines the mechanism of acquired resistance to T cell-based therapies
    1
    1. scibot 04 Nov 2022
      RRID:AB_2128522

      DOI: 10.1016/j.celrep.2022.111430

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    sciencedirect.com/science/article/pii/S2211124722012712
  53. Jun 2022
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Circulating Protein Disulfide Isomerase is associated with increased risk of Thrombosis in JAK2-mutated Myeloproliferative Neoplasms
    1
    1. scibot 15 Jun 2022
      RRID:AB_2128522

      DOI: 10.1158/1078-0432.CCR-21-1140

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    ncbi.nlm.nih.gov/pmc/articles/PMC9170286/
  55. May 2022
  56. pubs.acs.org pubs.acs.org
    Simultaneous Delivery of Doxorubicin and Protease Inhibitor Derivative to Solid Tumors via Star-Shaped Polymer Nanomedicines Overcomes P-gp- and STAT3-Mediated Chemoresistance
    1
    1. scibot 24 May 2022
      RRID:AB_2128522

      DOI: 10.1021/acs.biomac.2c00256

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    pubs.acs.org/doi/full/10.1021/acs.biomac.2c00256
  57. Apr 2022
  58. academic.oup.com academic.oup.com
    GH action in prostate cancer cells promotes proliferation limits apoptosis and regulates cancer-related gene expression
    1
    1. scibot 29 Apr 2022
      RRID:AB_2128522

      DOI: 10.1210/endocr/bqac031

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    academic.oup.com/endo/article/163/5/bqac031/6564019
  59. www.nature.com www.nature.com
    Identifying a confused cell identity for esophageal squamous cell carcinoma
    1
    1. scibot 23 Apr 2022
      RRID:AB_2128522

      DOI: 10.1038/s41392-022-00946-8

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    nature.com/articles/s41392-022-00946-8
  60. Mar 2022
  61. www.sciencedirect.com www.sciencedirect.com
    Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells
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    1. scibot 26 Mar 2022
      RRID:AB_2128522

      DOI: 10.1016/j.molcel.2022.02.033

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    sciencedirect.com/science/article/pii/S1097276522002076
  62. journals.lww.com journals.lww.com
    Ruxolitinib attenuates secondary injury after traumatic spinal cord injury
    1
    1. scibot 10 Mar 2022
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      DOI: 10.4103/1673-5374.335165

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  63. academic.oup.com academic.oup.com
    Interleukin-6 trans-signaling promotes progesterone production in human granulosa-lutein cells
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  64. Feb 2022
  65. www.nature.com www.nature.com
    Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo
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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification
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  67. Jan 2022
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    Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses
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  69. Nov 2021
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    Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring
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  71. Oct 2021
  72. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  73. Aug 2021
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    ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis
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    IL6/sIL-6Rα trans-signaling increases PGE2 production in human granulosa cells
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    Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
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  77. Jul 2021
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    ATM Is Required for the Prolactin-Induced HSP90-Mediated Increase in Cellular Viability and Clonogenic Growth After DNA Damage
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  79. europepmc.org europepmc.org
    Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth.
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  80. Jun 2021
  81. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment.
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    Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition
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    Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma
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  84. May 2021
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    An active marine halophenol derivative attenuates lipopolysaccharide-induced acute liver injury in mice by improving M2 macrophage-mediated therapy
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    RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes
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    Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells
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    Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus
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    HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
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  90. Mar 2021
  91. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  92. Feb 2021
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    Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
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  94. Jan 2021
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    Critical role of Syk-dependent STAT1 activation in innate antiviral immunity
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  96. Sep 2020
  97. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A chalcone derivative, 1m‐6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation‐induced endothelial dysfunction
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    The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis
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    PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala
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    Adipocyte Fatty Acid Transfer Supports Megakaryocyte Maturation
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    The Human Cytomegalovirus pUL145 Isoforms Act as Viral DDB1-Cullin-Associated Factors to Instruct Host Protein Degradation to Impede Innate Immunity
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  102. academic.oup.com academic.oup.com
    Prolactin enhances the proliferation of proliferative endometrial glandular cells and endometrial cancer cells
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  103. Jan 2020
  104. www.sciencedirect.com www.sciencedirect.com
    Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
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  106. Nov 2018
  107. www.sciencedirect.com www.sciencedirect.com
    Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response
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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
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    Systematic Functional Annotation of Somatic Mutations in Cancer
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    Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses
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    A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader
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