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Estrogen deprivation exacerbates Alzheimer’s disease pathology through neuronal CTSS signaling

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Aug 2026
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Cholesterol enhances lysosome-autophagosome fusion for better α-synuclein clearance in GBA L444P-mutated Parkinson disease

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sciencedirect.com/science/article/pii/S2211124726008788
Jul 2026
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huang-et-al-2025-cdk5rap3-mediated-regulation-of-lysosomal-and-er-membrane-proteins-is-pivotal-for-the-survival-and-html.html

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Trans-synaptic signaling through GRID1/glutamate receptor delta-1 and CBLN1/cerebellin-1 facilitates autophagic flux in central amygdala and prevents chronic pain

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LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death

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Jun 2026
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AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth

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pmc.ncbi.nlm.nih.gov/articles/PMC12258181/
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Early-onset neuroinflammation drives neurodegeneration caused by lysosomal PI(3,5)P2 insufficiency

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Chaperone-mediated autophagy is a tumor-suppressive mechanism in hepatocellular carcinoma

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May 2026
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An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging mouse neurons

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pmc.ncbi.nlm.nih.gov/articles/PMC13171111/
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Multiparity exacerbates Aβ accumulation and promotes cellular senescence in a mouse model of amyloidosis

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Ndfip2 in TrkA-expressing sensory neurons regulates noxious mechanosensation through control of TrkA signaling and protein levels

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pmc.ncbi.nlm.nih.gov/articles/PMC13158297/
Apr 2026
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A filopodia-based dendritic mechanosensory compartment in CSF-contacting neurons

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biorxiv.org/content/10.64898/2026.04.09.713694v1
Mar 2026
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Astrocytic AEBP1-NPAS3-LIPA pathway coordinates cholesterol homeostasis to regulate Alzheimer’s pathology

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Progressive changes in synapses and glial cells in AppNL-G-F mice, a model of Alzheimer’s disease

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academic.oup.com/braincomms/article/8/1/fcaf484/8377904
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Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain

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Human neuromuscular organoids mimic cancer-induced muscle cachexia

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pmc.ncbi.nlm.nih.gov/articles/PMC12946742/
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Rapamycin Reduces Amyloid‐β Plaques and Improves Behavioral Performance in a Sex‐Dependent Manner in Mouse Models of Amyloidosis

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pmc.ncbi.nlm.nih.gov/articles/PMC12945924/
Feb 2026
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p53 Drives Lung Cancer Regression through a TSC2/TFEB-dependent Senescence Program

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pmc.ncbi.nlm.nih.gov/articles/PMC12877752/
Jan 2026
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Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder

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Sep 2025
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2025.09.04.674092v1.full-html.html

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52.53.155.43/d4c9c6086efb06675e63a3077fc191784844b6fa/2025.09.04.674092v1.full-html.html
Aug 2025
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Mitochondrial damage triggers the concerted degradation of negative regulators of neuronal autophagy

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pmc.ncbi.nlm.nih.gov/articles/PMC12335601/
Jun 2025
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Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain

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nature.com/articles/s41593-025-01973-8
May 2025
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Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV

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sciencedirect.com/science/article/pii/S1550413125002530
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IRE1α promotes phagosomal calcium flux to enhance macrophage fungicidal activity

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cell.com/cell-reports/fulltext/S2211-1247(25)00465-6
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ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion

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Apr 2025
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Molecular elucidation of brain lipofuscin in aging and Neuronal Ceroid Lipofuscinosis

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  DOI: 10.21203/rs.3.rs-6010379/v1
  
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SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment

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Feb 2025
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Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism

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52.53.155.43/17ba4619add80e0a0ad5b6123d474628a07b56f8/2024.09.22.614256.full-html.html
Aug 2024
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Quantitative proteomics unveils known and previously unrecognized alterations in neuropathic nerves

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  DOI: 10.1111/jnc.16189
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16189
Jul 2024
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Aging Differentially Affects Axonal Autophagosome Formation and Maturation

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  DOI: 10.1080/15548627.2023.2236485
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10621248/
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A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle

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  DOI: 10.1016/j.devcel.2020.07.005
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
Jun 2024
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Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8

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May 2024
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No Evidence of Sensory Neuropathy in a Traditional Mouse Model of Idiopathic Parkinson’s Disease

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1. scibot 30 May 2024
  
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  DOI: 10.3390/cells13100799
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11120514/
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No Evidence Of Sensory Neuropathy In A Traditional Mouse Model Of Idiopathic Parkinson’s Disease

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  DOI: 10.20944/preprints202403.0625.v1
  
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Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner

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Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease

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Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model

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Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy

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Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease

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Deciphering the mechanism of action of VP343, an antileishmanial drug candidate, in Leishmania infantum

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Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived Neurotrophic Factor

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Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice

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Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion

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DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons

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Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity

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Immune landscape of a genetically engineered murine model of glioma compared to human glioma by single-cell sequencing

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INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

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Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

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Cystatin B deficiency results in sustained histone H3 tail cleavage in postnatal mouse brain mediated by increased chromatin-associated cathepsin L activity

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Spatiotemporal analysis of axonal autophagosome-lysosome dynamics reveals limited fusion events and slow maturation

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TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4

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p57Kip2 imposes the reserve stem cell state of gastric chief cells

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Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes

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Cytosolic adaptation to mitochondria-induced proteostatic stress causes progressive muscle wasting

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Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion

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Stabilin receptors clear LPS and control systemic inflammation

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A Brucella effector modulates the Arf6-Rab8a GTPase cascade to promote intravacuolar replication

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Degradation of dendritic cargos requires Rab7-dependent transport to somatic lysosomes

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Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus

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A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication

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Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology

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CREG1 promotes lysosomal biogenesis and function

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tandfonline.com/doi/abs/10.1080/15548627.2021.1909997
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Microglia Do Not Take Up Soluble Amyloid-beta Peptides, But Partially Degrade Them by Secreting Insulin-degrading Enzyme

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Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion

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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle

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ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
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Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons

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Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

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Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C

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Lysosome Fusion Maintains Phagosome Integrity during Fungal Infection

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cell.com/cell-host-microbe/fulltext/S1931-3128(20)30505-9
Oct 2020
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14,15-epoxyeicosatrienoic acid alleviates pathology in a mouse model of Alzheimer’s disease

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jneurosci.org/content/40/42/8188
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The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

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Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation

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The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons

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Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons

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Hemozoin produced by mammals confers heme tolerance

1
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  DOI: 10.7554/eLife.49503
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6773446/
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Astrocytic Epoxyeicosatrienoic Acid Signaling in the Medial Prefrontal Cortex Modulates Depressive-like Behaviors

1
1. scibot 13 Jan 2020
  
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jneurosci.org/content/39/23/4606
elifesciences.org elifesciences.org

A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVβ subunits

1
1. scibot 13 Jan 2020
  
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  RRID:AB_528127
  
  DOI: 10.7554/eLife.49253
  
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ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97

1
1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.molcel.2019.03.027
  
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1
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  DOI: 10.7554/eLife.40856
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6292694/
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The Late Endosomal Pathway Regulates the Ciliary Targeting of Tetraspanin Protein Peripherin 2

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1. scibot 13 Jan 2020
  
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  RRID:AB_2134500
  
  DOI: 10.1523/JNEUROSCI.2811-18.2019
  
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jneurosci.org/content/39/18/3376
Nov 2018
www.nature.com www.nature.com

Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation

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nature.com/articles/ncb3631
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sciencedirect.com/science/article/pii/S2211124718315250
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Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1

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sciencedirect.com/science/article/pii/S1550413118303309
onlinelibrary.wiley.com onlinelibrary.wiley.com

Phagocytosis of antibody‐opsonized tumor cells leads to the formation of a discrete vacuolar compartment in macrophages

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onlinelibrary.wiley.com/doi/full/10.1111/tra.12552
academic.oup.com academic.oup.com

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academic.oup.com/hmg/article/26/22/4352/4082708
Nov 2017
academic.oup.com academic.oup.com

Impaired axonal retrograde trafficking of the retromer complex augments lysosomal deficits in Alzheimer’s disease neurons

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1. scibot 08 Nov 2017
  
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academic.oup.com/hmg/article/doi/10.1093/hmg/ddx321/4082708/Impaired-axonal-retrograde-trafficking-of-the
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TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

1
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Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1

1
1. scibot 08 Nov 2017
  
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  anti-LAMP1
  
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Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons

1
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  AB_2134500
  
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α-Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2

1
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ncbi.nlm.nih.gov/pmc/articles/PMC4388928/
Dec 2015
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Untitled document

1
1. judell 21 Dec 2015
  
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  AB_2134500
  
  Antibody ID: AB_2134500
  Target Antigen: Lamp1 See NCBI gene
  Vendor: DSHB
  Cat Num: 1D4B
  Proper Citation: (DSHB Cat# 1D4B, RRID:AB_2134500)
  Reference: PMID:21344404
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jneurosci.org/content/35/14/5724.long
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Untitled document

1
1. judell 17 Dec 2015
  
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  AB_2134500
  
  Antibody ID: AB_2134500
  Target Antigen: Lamp1 See NCBI gene
  Vendor: DSHB
  Cat Num: 1D4B
  Proper Citation: (DSHB Cat# 1D4B, RRID:AB_2134500)
  Reference: PMID:21344404
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jneurosci.org/content/35/14/5724.full

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