39 Matching Annotations
  1. Last 7 days
  2. www.nature.com www.nature.com
    Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing
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    1. scibot 21 Dec 2024
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      DOI: 10.1038/s41586-024-08348-2

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    nature.com/articles/s41586-024-08348-2
  3. www.sciencedirect.com www.sciencedirect.com
    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
    1
    1. scibot 21 Dec 2024
      RRID:AB_2134736

      DOI: 10.1016/j.celrep.2024.115101

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    sciencedirect.com/science/article/pii/S2211124724014529
  4. www.sciencedirect.com www.sciencedirect.com
    The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance
    1
    1. scibot 17 Dec 2024
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      DOI: 10.1016/j.immuni.2024.11.017

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    sciencedirect.com/science/article/pii/S1074761324005326
  5. Oct 2024
  6. link.springer.com link.springer.com
    High-confidence and high-throughput quantification of synapse engulfment by oligodendrocyte precursor cells
    1
    1. scibot 08 Oct 2024
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      DOI: 10.1038/s41596-024-01048-1

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    link.springer.com/article/10.1038/s41596-024-01048-1
  7. Sep 2024
  8. www.sciencedirect.com www.sciencedirect.com
    Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK
    1
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      RRID:AB_369111

      DOI: 10.1016/j.cmet.2019.05.018

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    sciencedirect.com/science/article/pii/S155041311930258X
  9. Aug 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nephron specific ATP6AP2 knockout increases urinary excretion of fatty acids and decreases renal cortical megalin expression
    1
    1. scibot 22 Aug 2024
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      DOI: 10.1038/s41598-024-69749-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11319469/
  11. Jul 2024
  12. www.biorxiv.org www.biorxiv.org
    Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits
    1
    1. scibot 23 Jul 2024
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      DOI: 10.1101/2024.07.09.602700

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    biorxiv.org/content/10.1101/2024.07.09.602700v1
  13. May 2024
  14. www.biorxiv.org www.biorxiv.org
    Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
    2
    1. scibot 10 May 2024
      ab13524; Abcam

      DOI: 10.1101/2024.01.25.577280

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      DOI: 10.1101/2024.01.25.577280

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    biorxiv.org/content/10.1101/2024.01.25.577280v1
  15. Oct 2023
  16. www.science.org www.science.org
    Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
    1
    1. scibot 17 Oct 2023
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      DOI: 10.1126/sciadv.abo3610

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    science.org/doi/10.1126/sciadv.abo3610
  17. Aug 2023
  18. 52.53.155.43 52.53.155.43
    PIIS2211124723009543-html.html
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    1. scibot 12 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112943

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  19. Sep 2022
  20. www.sciencedirect.com www.sciencedirect.com
    Ral GTPases are critical regulators of spinal cord myelination and homeostasis
    1
    1. scibot 29 Sep 2022
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      DOI: 10.1016/j.celrep.2022.111413

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    sciencedirect.com/science/article/pii/S2211124722012542
  21. Aug 2022
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
    2
    1. scibot 13 Aug 2022
      AB_2134736

      DOI: 10.1126/sciadv.abo3610

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      AB_2134736

      DOI: 10.1126/sciadv.abo3610

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    ncbi.nlm.nih.gov/pmc/articles/PMC9299535/
  23. Apr 2022
  24. www.sciencedirect.com www.sciencedirect.com
    KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion
    1
    1. scibot 07 Apr 2022
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      DOI: 10.1016/j.ebiom.2022.103980

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    sciencedirect.com/science/article/pii/S2352396422001645
  25. Feb 2022
  26. www.embopress.org www.embopress.org
    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
    1
    1. scibot 12 Feb 2022
      RRID:AB_2134736

      DOI: 10.15252/embj.2021108119

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    embopress.org/doi/abs/10.15252/embj.2021108119
  27. Nov 2021
  28. www.sciencedirect.com www.sciencedirect.com
    Structural mechanism for regulation of Rab7 by site-specific monoubiquitination
    1
    1. scibot 19 Nov 2021
      ab13524

      DOI: 10.1016/j.ijbiomac.2021.11.074

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    sciencedirect.com/science/article/pii/S0141813021024715
  29. Aug 2021
  30. www.sciencedirect.com www.sciencedirect.com
    Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic
    1
    1. scibot 27 Aug 2021
      RRID:AB_2134736

      DOI: 10.1016/j.cell.2021.08.002

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    sciencedirect.com/science/article/pii/S0092867421009442
  31. academic.oup.com academic.oup.com
    NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland
    1
    1. scibot 05 Aug 2021
      RRID:AB_2134736

      DOI: 10.1210/en.2019-00230

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    academic.oup.com/endo/article/160/8/1797/5488072
  32. www.sciencedirect.com www.sciencedirect.com
    Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis
    1
    1. scibot 01 Aug 2021
      RRID:AB_2134736

      DOI: 10.1016/j.cell.2018.05.028

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    sciencedirect.com/science/article/pii/S0092867418306408
  33. Jul 2021
  34. www.sciencedirect.com www.sciencedirect.com
    Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells
    1
    1. scibot 02 Jul 2021
      RRID:AB_2134736

      DOI: 10.1016/j.devcel.2021.06.011

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    sciencedirect.com/science/article/pii/S1534580721005189
  35. May 2021
  36. www.sciencedirect.com www.sciencedirect.com
    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
    1
    1. scibot 07 May 2021
      RRID:AB_2134736

      DOI: 10.1016/j.molcel.2020.10.004

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    sciencedirect.com/science/article/pii/S1097276520306870
  37. www.sciencedirect.com www.sciencedirect.com
    Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation
    1
    1. scibot 07 May 2021
      RRID:AB_2134736

      DOI: 10.1016/j.molcel.2020.05.007

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    sciencedirect.com/science/article/pii/S1097276520303087
  38. Apr 2021
  39. www.sciencedirect.com www.sciencedirect.com
    Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer
    1
    1. scibot 27 Apr 2021
      RRID:AB_2134736

      DOI: 10.1016/j.chembiol.2020.06.011

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    sciencedirect.com/science/article/pii/S2451945620302348
  40. Mar 2021
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer’s disease
    1
    1. scibot 11 Mar 2021
      RRID:AB_2134736

      DOI: 10.1186/s13024-021-00435-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC7941983/
  42. Feb 2021
  43. elifesciences.org elifesciences.org
    Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice
    1
    1. scibot 09 Feb 2021
      RRID:AB_2134736

      DOI: 10.7554/eLife.62174

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    elifesciences.org/articles/62174
  44. Sep 2020
  45. elifesciences.org elifesciences.org
    Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model
    1
    1. scibot 10 Sep 2020
      RRID:AB_2134736

      DOI: 10.7554/eLife.40316

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    elifesciences.org/articles/40316
  46. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    Molecular imaging of extracellular tumor pH to reveal effects of loco-regional therapy on liver cancer microenvironment
    1
    1. scibot 07 Sep 2020
      RRID:AB_2134736

      DOI: 10.1158/1078-0432.CCR-19-1702

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    clincancerres.aacrjournals.org/content/26/2/428
  47. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model
    1
    1. scibot 03 Sep 2020
      RRID:AB_2134736

      DOI: 10.1016/j.devcel.2020.06.039

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    pubmed.ncbi.nlm.nih.gov/32710848/
  48. elifesciences.org elifesciences.org
    UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
    1
    1. scibot 03 Sep 2020
      RRID:AB_2134736

      DOI: 10.7554/eLife.37993

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    elifesciences.org/articles/37993
  49. Aug 2020
  50. www.sciencedirect.com www.sciencedirect.com
    ZIGIR, a Granule-Specific Zn2+ Indicator, Reveals Human Islet α Cell Heterogeneity
    1
    1. scibot 26 Aug 2020
      RRID:AB_213473

      DOI: 10.1016/j.celrep.2020.107904

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    sciencedirect.com/science/article/pii/S2211124720308858
  51. Jan 2020
  52. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Extracellular pH mapping of liver cancer on a clinical 3T MRI scanner
    1
    1. scibot 13 Jan 2020
      RRID:AB_2134736

      DOI: 10.1002/mrm.28035

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    onlinelibrary.wiley.com/doi/10.1002/mrm.28035
  53. www.sciencedirect.com www.sciencedirect.com
    Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking
    1
    1. scibot 13 Jan 2020
      RRID:AB_2134736

      DOI: 10.1016/j.celrep.2019.10.015

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    sciencedirect.com/science/article/pii/S2211124719313154
  54. www.sciencedirect.com www.sciencedirect.com
    Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease
    1
    1. scibot 13 Jan 2020
      RRID:AB_2134736

      DOI: 10.1016/j.immuni.2019.12.004

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    sciencedirect.com/science/article/pii/S1074761319305230
  55. www.sciencedirect.com www.sciencedirect.com
    Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models
    1
    1. scibot 13 Jan 2020
      RRID:AB_2134736

      DOI: 10.1016/j.cmet.2018.10.005

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    sciencedirect.com/science/article/pii/S1550413118306375
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_2134736

      DOI: 10.7554/eLife.40316

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    ncbi.nlm.nih.gov/pmc/articles/PMC6464704/
  57. Nov 2018
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 05 Nov 2018
      RRID:AB_2134736

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    ncbi.nlm.nih.gov/pmc/articles/PMC6063731/
  59. www.sciencedirect.com www.sciencedirect.com
    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
    1
    1. scibot 05 Nov 2018
      RRID:AB_2134736

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    sciencedirect.com/science/article/pii/S0092867418305865
  60. www.sciencedirect.com www.sciencedirect.com
    Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner
    1
    1. scibot 05 Nov 2018
      RRID:AB_2134736

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S107476131830075X