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Oct 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Pathogenic mutations in ATAD3A cause dysregulation of RagC/D-TFEB axis and disrupt lysosomal homeostasis

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  DOI: 10.64898/2026.09.23.753918
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13622220/
Sep 2026
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Nuclear body assembly by a viral repeat RNA promotes Kaposi’s sarcoma-associated herpesvirus gene expression

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  DOI: 10.1016/j.molcel.2026.08.022
  
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sciencedirect.com/science/article/pii/S1097276526005915
Aug 2026
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41467_2026_75542_MOESM1_ESM.pdf

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  DOI: 10.1038/s41467-026-75542-3
  
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media.springernature.com/original/springer-static/esm/art:10.1038/s41467-026-75542-3/MediaObjects/41467_2026_75542_MOESM1_ESM.pdf
Jun 2026
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Therapeutic Targeting of Epithelial Mesenchymal Cellular Plasticity in Pancreatic Cancer

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1. scibot 19 Jun 2026
  
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  DOI: 10.1158/1078-0432.CCR-25-2052
  
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aacrjournals.org/clincancerres/article/32/5/869/774723/Therapeutic-Targeting-of-Epithelial-Mesenchymal
May 2026
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Ki-67 promotes circulating tumor cell intravasation and metastasis in breast cancer

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  DOI: 10.1016/j.celrep.2026.117354
  
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sciencedirect.com/science/article/pii/S2211124726004328
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CRL2FEM1B uses heme to recruit BACH1 for degradation and regulate ferroptosis in lung cancer

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Mar 2026
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ROME, an Ancient Gene with a Novel Function in Vertebrates, Is a Key Modulator of Embryonal Development and Cancer Metastasis

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1. scibot 26 Mar 2026
  
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  DOI: 10.1158/2767-9764.CRC-26-0068
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13012068/
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BAF60C links nucleolar stress to β cell dysfunction in type 2 diabetes through controlling Reg3b mRNA decay

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  DOI: 10.1016/j.devcel.2026.02.006
  
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sciencedirect.com/science/article/pii/S1534580726000717
Dec 2025
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Anti-Cancer Effects of the Ethyl Acetate Fraction From Opuntia humifusa on Human Triple-Negative Breast Cancer Cells

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1. scibot 18 Dec 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12705953/
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1-s2.0-S2589004225025647-main-html.html

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  DOI: 10.1016/j.isci.2025.114303
  
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54.241.53.176/6616620d4f1dc598cdc85a941c81195110b67c2e/1-s2.0-S2589004225025647-main-html.html
Oct 2025
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CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma

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1. scibot 02 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116362
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12588357/
Aug 2025
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PALB2 and 53BP1 govern post-resection homologous recombination DNA repair

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  DOI: 10.1016/j.molcel.2025.07.003
  
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sciencedirect.com/science/article/pii/S1097276525006045
Jul 2025
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Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling

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1. scibot 31 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116090
  
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Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell homeostasis in idiopathic pulmonary fibrosis and reverses pulmonary fibrosis in mice

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1. scibot 10 Jul 2025
  
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  DOI: 10.1101/2025.06.30.662456
  
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biorxiv.org/content/10.1101/2025.06.30.662456v1
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Modulation of glucocorticoid receptor function under iron overload

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  DOI: 10.3389/fimmu.2025.1605420
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12213461/
Jun 2025
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RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis

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1. scibot 11 Jun 2025
  
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  DOI: 10.1158/2159-8290.CD-24-0093
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11611684/
May 2025
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KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115444
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12091147/
Mar 2025
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Unveiling IRF4-steered regulation of context-dependent effector programs in CD4+ T cells under Th17- and Treg-skewing conditions

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115407
  
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sciencedirect.com/science/article/pii/S2211124725001780
Jan 2025
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Cytoplasmic mRNA decay controlling inflammatory gene expression is determined by pre-mRNA fate decision

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1. scibot 28 Jan 2025
  
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  DOI: 10.1016/j.molcel.2025.01.001
  
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sciencedirect.com/science/article/pii/S1097276525000012
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Targeting the mevalonate pathway potentiates NUAK1 inhibition-induced immunogenic cell death and antitumor immunity

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  DOI: 10.1016/j.xcrm.2024.101913
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866496/
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Nuclear adenine activates hnRNPA2B1 to enhance antibacterial innate immunity

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  DOI: 10.1016/j.cmet.2024.11.014
  
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sciencedirect.com/science/article/pii/S1550413124004820
Oct 2024
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Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer

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  DOI: 10.1016/j.cell.2024.09.024
  
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sciencedirect.com/science/article/pii/S0092867424010729
Aug 2024
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Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence

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  DOI: 10.1016/j.molcel.2024.08.006
  
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sciencedirect.com/science/article/pii/S1097276524006609
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Protocol for the isolation and purification of endoplasmic reticulum-plasma membrane junctions from the mouse brain

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  DOI: 10.1016/j.xpro.2024.103253
  
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sciencedirect.com/science/article/pii/S2666166724004180
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The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response

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  DOI: 10.1016/j.celrep.2024.114608
  
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sciencedirect.com/science/article/pii/S2211124724009586
Jul 2024
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Targeting Parkin-regulated metabolomic change in cartilage in the treatment of osteoarthritis

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1. scibot 30 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110597
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11363567/
Jun 2024
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FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity

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  Cell Signaling TechnologyCat# 2032
  
  DOI: 10.1016/j.celrep.2024.114297
  
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sciencedirect.com/science/article/pii/S2211124724006259
Apr 2024
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Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model

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  DOI: 10.1016/j.celrep.2024.114117
  
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sciencedirect.com/science/article/pii/S2211124724004455
Mar 2024
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NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP

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  DOI: 10.1016/j.celrep.2024.113860
  
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sciencedirect.com/science/article/pii/S2211124724001888
Dec 2023
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The ER stress sensor IRE1 interacts with STIM1 to promote store-operated calcium entry, T cell activation, and muscular differentiation

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  DOI: 10.1016/j.celrep.2023.113540
  
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Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity

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  DOI: 10.1016/j.celrep.2023.113515
  
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Exploiting the endogenous yeast nuclear proteome to identify short linear motifs in vivo

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1. scibot 02 Dec 2023
  
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  DOI: 10.1016/j.crmeth.2023.100637
  
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sciencedirect.com/science/article/pii/S2667237523003089
Nov 2023
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PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113414
  
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sciencedirect.com/science/article/pii/S2211124723014262
Oct 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

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1. scibot 17 Oct 2023
  
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  RRID:AB_10694918
  
  DOI: 10.1186/s12967-023-04542-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10577912/
Sep 2023
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Essential role of the amino-terminal region of Drosha for the Microprocessor function

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1. scibot 30 Sep 2023
  
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RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression

1
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Identification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function

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Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer

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Targeting fatty acid reprogramming suppresses CARM1-expressing ovarian cancer

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Targeting CHAF1B enhances Interferon activity against Myeloproliferative Neoplasm cells

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PAC1 deficiency protects obese male mice from immobilization-induced muscle atrophy by suppressing FoxO-atrogene axis

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Histone malonylation is regulated by SIRT5 and KAT2A

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AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance

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Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence

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Sox13 is a novel flow-sensitive transcription factor that prevents inflammation by repressing chemokine expression in endothelial cells

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Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D

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Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance

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Target protein localization and its impact on PROTAC-mediated degradation

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LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response

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FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity

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A mouse model of inherited choline kinase β-deficiency presents with specific cardiac abnormalities and a predisposition to arrhythmia

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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

1
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IRF3-binding lncRNA-ISIR strengthens interferon production in viral infection and autoinflammation

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CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase

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  2032
  
  DOI: 10.1093/nar/gkab805
  
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A Brucella effector modulates the Arf6-Rab8a GTPase cascade to promote intravacuolar replication

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  DOI: 10.15252/embj.2021107664
  
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Nascent RNA scaffolds contribute to chromosome territory architecture and counter chromatin compaction

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Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency in Humanized GH1 Mouse Models

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Jul 2021
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CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer

1
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  Lamin A/C
  
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A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication

2
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Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis

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Jun 2021
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A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing

1
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Jan 2021
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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

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ncbi.nlm.nih.gov/pmc/articles/PMC7868890/
Nov 2020
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ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription

1
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Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

1
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SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is increased by a naturally occurring elongation variant

1
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Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2

1
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Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

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DEAD Box Protein Family Member DDX28 Is a Negative Regulator of Hypoxia-Inducible Factor 2α- and Eukaryotic Initiation Factor 4E2-Directed Hypoxic Translation

1
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  anti-lamin A/C
  
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Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition

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  DOI: 10.7554/eLife.44161
  
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Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium

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  DOI: 10.1016/j.celrep.2019.06.043
  
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FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export

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  DOI: 10.1016/j.celrep.2019.06.072
  
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Untitled document

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Untitled document

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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

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  DOI: 10.1016/j.ccell.2019.01.020
  
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Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals

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β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

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Small-Molecule TLR8 Antagonists via Structure-Based Rational Design

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Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps

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The HDAC6 Inhibitor Tubacin Induces Release of CD133+ Extracellular Vesicles from Cancer Cells

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Glucose Sensing by Skeletal Myocytes Couples Nutrient Signaling to Systemic Homeostasis

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Mesenchyme Homeobox 2 Enhances Migration of Endothelial Colony Forming Cells Exposed to Intrauterine Diabetes Mellitus

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NF-κB regulates neuronal ankyrin-G via a negative feedback loop

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