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Jun 2026
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PKCα-mediated nuclear translocation of cGAS stabilizes β-catenin and drives metastasis

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  DOI: 10.1016/j.molcel.2026.05.023
  
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Targeting ATF4 overcomes dual resistance to chemo-immunotherapy in gastric cancer by disrupting the DNA damage response

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  DOI: 10.1136/jitc-2026-015109
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13264953/
May 2026
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Wnt5b/FZD1/LRP6 signaling drives renal fibrosis by triggering cytoplasmic stabilization and nuclear translocation of β-catenin under hypoxia

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Global transcriptional changes across multiple isogenic C9orf72 patient iPSC-derived neurons

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Apr 2026
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Acyltransferase ZDHHC22 promotes N-Myc transcriptional activation to drive neuroblastoma progression and chemoresistance

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Tumor-intrinsic FDFT1 determines coordinated macrophage anti-tumor immunity

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  DOI: 10.1016/j.devcel.2026.04.003
  
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54.241.53.176 54.241.53.176

1-s2.0-S258900422601182X-main-html.html

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The tumor promoter role and molecular mechanism of C8orf76/CALB2 axis in clear cell renal cell carcinoma

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  DOI: 10.1016/j.isci.2026.115533
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13098528/
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HSPA2 modulates antiviral immunity by inhibiting TBK1 activation

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  DOI: 10.1016/j.celrep.2026.117222
  
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Mar 2026
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Deubiquitinating enzyme MINDY2 regulates TNF-α-induced cell death by targeting RIPK1

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Feb 2026
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CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma

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  DOI: 10.1016/j.isci.2026.114840
  
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Compartmentalized branched-chain amino acid metabolism orchestrates colorectal cancer dissemination via an UMP-vimentin axis

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Jan 2026
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Extracellular matrix stiffness drives post-mitotic nuclear pore complex assembly to promote neuroblastoma pathogenesis

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1. scibot 23 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116858
  
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2026.01.01.697161v1.full-html.html

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54.241.53.176/ffadff401656d9d116040b3f55c1d0047a810d2e/2026.01.01.697161v1.full-html.html
54.241.53.176 54.241.53.176

1-s2.0-S2589004225028536-main-html.html

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  AB_2136290
  
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54.241.53.176/240dc6a05105efbe0d3f771207c7fadaa29f2101/1-s2.0-S2589004225028536-main-html.html
Nov 2025
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UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.molcel.2025.10.030
  
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Oct 2025
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Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas

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1. scibot 30 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116487
  
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Sep 2025
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HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer

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1. scibot 24 Sep 2025
  
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  DOI: 10.1016/j.cmet.2025.08.009
  
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p53-mediated regulation of epiblast cell numbers predicts reactivation during mouse embryonic diapause

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1. scibot 19 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116298
  
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NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

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  DOI: 10.7554/eLife.103904
  
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Jul 2025
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Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma

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  DOI: 10.1016/j.chom.2025.06.013
  
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Histone marks enable formation of immiscible phase-separated chromatin compartments

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  DOI: 10.1016/j.celrep.2025.116003
  
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MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction

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1. scibot 03 Jul 2025
  
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  DOI: 10.1016/j.molcel.2025.06.005
  
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Jun 2025
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Cingulin is an RNA-binding protein promoting pancreatic cancer through enhancing importin 7-mediated phospho-ERK nuclear translocation

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  DOI: 10.1016/j.celrep.2025.115925
  
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52.53.155.43 52.53.155.43

1-s2.0-S2589004225011393-main-html.html

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May 2025
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Microbiota-derived urocanic acid triggered bytyrosine kinase inhibitors potentiates cancer immunotherapy efficacy

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  DOI: 10.1016/j.chom.2025.04.022
  
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Apr 2025
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ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition

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  DOI: 10.1016/j.molcel.2025.04.004
  
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ZBP1 senses splicing aberration through Z-RNA to promote cell death

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  DOI: 10.1016/j.molcel.2025.03.023
  
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Mar 2025
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PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth

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Feb 2025
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Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance

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  DOI: 10.1084/jem.20231486
  
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Inhibition of SCFKDM2A/USP22-dependent nuclear β-catenin ubiquitylation mediates cerebral ischemic tolerance

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  DOI: 10.1038/s42003-025-07644-5
  
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Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3

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  DOI: 10.1016/j.celrep.2025.115250
  
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Jan 2025
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Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint

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1. scibot 18 Jan 2025
  
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  DOI: 10.1038/s41556-024-01565-x
  
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Claudin-4 stabilizes the genome via nuclear and cell cycle remodeling to support ovarian cancer cell survival

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1. scibot 15 Jan 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0558
  
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The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway

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1. scibot 14 Jan 2025
  
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  DOI: 10.7554/eLife.96600
  
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PDIA3 orchestrates effector T cell program by serving as a chaperone to facilitate the non-canonical nuclear import of STAT1 and PKM2

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A TBK1-independent primordial function of STING in lysosomal biogenesis

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Lamin chromatin binding is modulated by interactions of different LAP2α domains with lamins and chromatin

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PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders

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Claudin-4 remodeling of nucleus-cell cycle crosstalk maintains ovarian tumor genome stability and drives resistance to genomic instability-inducing agents

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Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver

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Excess endocrine growth hormone in acromegaly promotes the aggressiveness and metastasis of triple-negative breast cancer

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Obg-like ATPase 1 exacerbated gemcitabine drug resistance of pancreatic cancer

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Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target

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Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients

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p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

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Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging

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p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

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25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages

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The activation of LBH-CRYAB signaling promotes cardiac protection against ischemia-reperfusion injury by inhibiting apoptosis and ferroptosis

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The deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis

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Class I HDAC inhibitors enhance antitumor efficacy and persistence of CAR-T cells by activation of the Wnt pathway

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An integrated multi-omics analysis reveals osteokines involved in global regulation

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Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation

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Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway

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Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization

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ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression.

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Securin acetylation prevents precocious separase activation and premature sister chromatid separation

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AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments

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A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells

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A GAPDH serotonylation system couples CD8+ T cell glycolytic metabolism to antitumor immunity

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OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB

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Profibrotic role of transcription factor SP1 in cross-talk between fibroblasts and M2 macrophages

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Heterogeneity of perivascular astrocyte endfeet depending on vascular regions in the mouse brain

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Sep 2023
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British J Pharmacology - 2023 - Su-html.html

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British J Pharmacology - 2023 - Dai-html.html

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52.53.155.43/8d076c70ed36377d24eb7bc3686db861bc15751d/British J Pharmacology - 2023 - Dai-html.html
Aug 2023
52.53.155.43 52.53.155.43

PIIS221112472300952X-html.html

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Jul 2023
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STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages

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GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner

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Jun 2023
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Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression

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BPS Publications

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52.53.155.43/a7694b32aeeb75586321cd0d6d28b4685219f279/British J Pharmacology - 2023 - Chen - Emodin promotes hepatic stellate cell senescence and alleviates liver fibrosis via-html.html
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Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges.

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Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity

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Apr 2023
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Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice

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Mar 2023
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Hepatic ZBTB22-mediated Detoxification Ameliorates Acetaminophen-induced Liver Injury by Inhibiting Pregnane X Receptor Signaling

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Feb 2023
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Stabilization of nuclear β-catenin by inhibiting KDM2A mediates cerebral ischemic tolerance

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  DOI: 10.1096/fj.202201657
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202201657
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Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways

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Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation

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sciencedirect.com/science/article/pii/S2211124722016199
Jul 2022
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Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity

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nature.com/articles/s41419-022-05063-6
Jun 2022
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Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis

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Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex

1
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Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis

1
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  DOI: 10.1016/j.molcel.2022.03.016
  
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Feb 2022
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Matrix remodeling controls a nuclear lamin A/C-emerin network that directs Wnt-regulated stem cell fate

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  DOI: 10.1016/j.devcel.2022.01.015
  
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sciencedirect.com/science/article/pii/S1534580722000405
Aug 2021
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Establishment of a GFP::LMNB1 knockin cell line (CSUi002-A-1) from a dystonia patient-specific iPSC by CRISPR/Cas9 editing

1
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www.immunohorizons.org www.immunohorizons.org

3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice

1
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  DOI: 10.4049/immunohorizons.2100028
  
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Untitled document

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Untitled document

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  DOI: 10.1016/j.cell.2018.11.004
  
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sciencedirect.com/science/article/pii/S0092867418314636
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WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids

2
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  DOI: 10.7554/eLife.38279
  
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2. scibot 27 Jul 2021
  
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  RRID:AB_2136290
  
  DOI: 10.7554/eLife.38279
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6234031/
Apr 2021
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RNA Demethylase Alkbh5 is Widely Expressed in Neurons and Decreased during Brain Development

1
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  DOI: 10.1016/j.brainresbull.2020.07.018
  
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sciencedirect.com/science/article/pii/S036192302030575X
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LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

1
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  DOI: 10.7554/eLife.63476
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7939549/
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence

1
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  DOI: 10.1096/fj.202001855RR
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001855RR
Feb 2021
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Chicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d‐galactosamine induced acute liver injury

1
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  DOI: 10.1111/jcmm.14935
  
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onlinelibrary.wiley.com/doi/10.1111/jcmm.14935
Dec 2020
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Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs

1
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  DOI: 10.1016/j.celrep.2020.108475
  
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sciencedirect.com/science/article/pii/S2211124720314649
Sep 2020
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Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function

1
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  DOI: 10.1016/j.ebiom.2020.102797
  
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Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival

1
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  DOI: 10.1016/j.celrep.2019.12.069
  
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Differential effects of integrase strand transfer inhibitors, elvitegravir and raltegravir, on oligodendrocyte maturation: A role for the integrated stress response

1
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  RRID:AB_213690
  
  DOI: 10.1002/glia.23902
  
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onlinelibrary.wiley.com/doi/10.1002/glia.23902
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Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity

1
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  DOI: 10.1016/j.neuron.2020.01.020
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7272217/
Jan 2020
onlinelibrary.wiley.com onlinelibrary.wiley.com

Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury

1
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  DOI: 10.1111/jnc.14827
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.14827
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Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia

1
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  RRID:AB_2136290
  
  DOI: 10.1074/jbc.RA118.006425
  
  Resource: (Proteintech Cat# 12987-1-AP, RRID:AB_2136290)
  
  Curator: @Naa003
  
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  RRID:AB_2136290 RRIDCUR:Validated
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jbc.org/content/294/35/12921.full
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 13 Jan 2020
  
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  RRID:AB_2136290
  
  DOI: 10.1111/bph.14691
  
  Resource: (Proteintech Cat# 12987-1-AP, RRID:AB_2136290)
  
  Curator: @ethanbadger
  
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  RRID:AB_2136290 RRIDCUR:Validated
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14691
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Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2136290
  
  DOI: 10.1016/j.immuni.2019.11.015
  
  Resource: (Proteintech Cat# 12987-1-AP, RRID:AB_2136290)
  
  Curator: @ethanbadger
  
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  RRID:AB_2136290 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1074761319304960
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Untitled document

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1. scibot 12 Jan 2020
  
  in Public
  
  RRID:AB_2136290
  
  DOI: 10.1016/j.celrep.2019.03.028
  
  Resource: (Proteintech Cat# 12987-1-AP, RRID:AB_2136290)
  
  Curator: @ethanbadger
  
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  RRID:AB_2136290 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124719303444
Nov 2017
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Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport

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1. scibot 08 Nov 2017
  
  in Public
  
  AB_2136290
  
  Curator: @Zeljana_Babic
  
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  (Proteintech Group Cat# 12987-1-AP, RRID:AB_2136290)
  
  SciCrunch record: RRID:AB_2136290
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_2136290 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0896627317302398

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