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Jul 2026
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Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion

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1. scibot 03 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.004
  
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sciencedirect.com/science/article/pii/S1074761326002554
Jun 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Sigma-1 receptor promotes glycolysis in neuronal systems by suppressing GRIM19

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  DOI: 10.1016/j.isci.2026.116092
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13233774/
Apr 2026
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Bacteroides acidifaciens exacerbates cardiac ischemia/reperfusion injury via the microbial-host isozyme DPP4

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  DOI: 10.1016/j.chom.2026.03.012
  
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sciencedirect.com/science/article/pii/S1931312826001204
Feb 2026
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Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylation

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  DOI: 10.1016/j.chembiol.2026.01.003
  
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sciencedirect.com/science/article/pii/S2451945626000231
Dec 2025
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circATF6 triggers calcium overload to synergize with EGFR-TKI in non-small cell lung cancer via modulation of proteostasis

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sciencedirect.com:5037/science/article/pii/S2211124725014317
Nov 2025
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Lactylation of mTOR enhances autophagy in skeletal muscle during exercise

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sciencedirect.com/science/article/pii/S2451945625003447
Mar 2025
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sPLA2-IB and PLA2R Mediate Aberrant Glucose Metabolism in Podocytes via Hyperactivation of the mTOR/HIF-1α Pathway

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1. scibot 14 Mar 2025
  
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  DOI: 10.1007/s12013-025-01714-5
  
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link.springer.com/article/10.1007/s12013-025-01714-5
Aug 2024
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Tumor Vessel Normalization via PFKFB3 Inhibition Alleviates Hypoxia and Increases Tumor Necrosis in Rectal Cancer upon Radiotherapy

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1. scibot 21 Aug 2024
  
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  DOI: 10.1158/2767-9764.CRC-24-0077
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11310748/
Jul 2024
www.cell.com www.cell.com

Altered neuronal lactate dehydrogenase A expression affects cognition in a sex- and age-dependent manner

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1. scibot 23 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110342
  
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cell.com/iscience/abstract/S2589-0042(24)01567-0
Jun 2024
aacrjournals.org aacrjournals.org

Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer

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1. scibot 07 Jun 2024
  
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  DOI: 10.1158/0008-5472.CAN-23-0519
  
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aacrjournals.org/cancerres/article/84/11/1834/745520/Obesogenic-High-Fat-Diet-and-MYC-Cooperate-to
Apr 2024
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JNEUROSCI.1563-23.2024.full (1)-html.html

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1. scibot 26 Apr 2024
  
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  DOI: 10.1523/jneurosci.1563-23.2024
  
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52.53.155.43/3d13c66ed91f2e0714f85e7c6a7de97c0df74a89/JNEUROSCI.1563-23.2024.full (1)-html.html
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Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia

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1. scibot 23 Apr 2024
  
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  DOI: 10.1038/s44318-024-00065-w
  
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  DOI: 10.1038/s44318-024-00065-w
  
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embopress.org/doi/10.1038/s44318-024-00065-w
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CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa

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1. scibot 23 Apr 2024
  
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  DOI: 10.1016/j.xcrm.2024.101459
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11031380/
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Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia

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1. scibot 19 Apr 2024
  
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  DOI: 10.1038/s44318-024-00065-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11021510/
Jan 2024
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Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity

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1. scibot 19 Jan 2024
  
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  DOI: 10.1016/j.cmet.2023.12.016
  
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sciencedirect.com/science/article/pii/S1550413123004679
Dec 2023
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Metabolic regulation of homologous recombination repair by MRE11 lactylation

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1. scibot 22 Dec 2023
  
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  RRID:AB_2137173
  
  DOI: 10.1016/j.cell.2023.11.022
  
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sciencedirect.com/science/article/pii/S009286742301276X
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Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines

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1. scibot 02 Dec 2023
  
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  RRID:AB_2137173
  
  DOI: 10.1158/0008-5472.CAN-22-2316
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10658995/
Aug 2023
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Genetic activation of glycolysis in osteoblasts preserves bone mass in type I diabetes

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1. scibot 10 Aug 2023
  
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  DOI: 10.1016/j.chembiol.2023.07.003
  
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sciencedirect.com/science/article/abs/pii/S2451945623002313
Jul 2023
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Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism

1
1. scibot 15 Jul 2023
  
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  DOI: 10.1016/j.isci.2023.107199
  
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sciencedirect.com/science/article/pii/S2589004223012762
Feb 2023
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Correction: Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis

1
1. scibot 15 Feb 2023
  
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  DOI: 10.7554/eLife.86471
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9910825/
Nov 2022
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A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice

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  DOI: 10.1158/2767-9764.crc-22-0256
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9648418/
Aug 2022
onlinelibrary.wiley.com onlinelibrary.wiley.com

Differential role of neuronal glucose and PFKFB3 in memory formation during development

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1. scibot 03 Aug 2022
  
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  DOI: 10.1002/glia.24248
  
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onlinelibrary.wiley.com/doi/10.1002/glia.24248
Mar 2022
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Mitochondrial Function Differences between Tumor Tissue of Human Metastatic and Premetastatic CRC

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1. scibot 04 Mar 2022
  
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  DOI: 10.3390/biology11020293
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8869310/
Feb 2022
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Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

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  DOI: 10.1016/j.ccell.2022.01.001
  
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sciencedirect.com/science/article/pii/S1535610822000034
Dec 2021
www.nature.com www.nature.com

GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure

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1. scibot 21 Dec 2021
  
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  DOI: 10.1038/s41419-021-04394-0
  
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nature.com/articles/s41419-021-04394-0
Nov 2021
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Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium

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1. scibot 05 Nov 2021
  
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  DOI: 10.1016/j.isci.2021.103300
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8555494/
Sep 2021
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming

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1. scibot 24 Sep 2021
  
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  DOI: 10.1016/j.cmet.2021.09.002
  
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sciencedirect.com:5037/science/article/pii/S1550413121004216
Aug 2021
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Delivery of membrane impermeable molecules to primary mouse T lymphocytes

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1. scibot 18 Aug 2021
  
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  DOI: 10.1016/j.xpro.2021.100757
  
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sciencedirect.com/science/article/pii/S2666166721004639
Jun 2021
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MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages

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1. scibot 16 Jun 2021
  
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  DOI: 10.1016/j.celrep.2021.109264
  
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sciencedirect.com/science/article/pii/S2211124721006318
May 2021
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Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

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1. scibot 12 May 2021
  
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  DOI: 10.1016/j.immuni.2021.04.008
  
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sciencedirect.com/science/article/pii/S1074761321001709
Apr 2021
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Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy

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1. scibot 24 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.06.014
  
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sciencedirect.com/science/article/pii/S0092867420307455
Feb 2021
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R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis

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1. scibot 28 Feb 2021
  
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  DOI: 10.1016/j.molcel.2020.12.026
  
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sciencedirect.com/science/article/pii/S1097276520309473
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Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis

1
1. scibot 26 Feb 2021
  
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  DOI: 10.7554/eLife.59686
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7529464/
Sep 2020
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Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress

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1. scibot 16 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.108087
  
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sciencedirect.com/science/article/pii/S2211124720310767
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Dynamic Regulation of Mitochondrial Import by the Ubiquitin System

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1. scibot 15 Sep 2020
  
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  DOI: 10.1016/j.molcel.2020.02.012
  
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Alpha-lipoic acid protects against pressure overload-induced heart failure via ALDH2-dependent Nrf1-FUNDC1 signaling

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  RRID:AB_2137173
  
  DOI: 10.1038/s41419-020-02805-2
  
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Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

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1. scibot 13 Jan 2020
  
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  RRID:AB_2137173
  
  DOI: 10.1016/j.celrep.2019.08.068
  
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Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes

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  RRID:AB_2137173
  
  DOI: 10.1007/s00125-019-05030-5
  
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Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

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  DOI: 10.1016/j.cell.2019.05.003
  
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UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses

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1. scibot 13 Jan 2020
  
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  RRID:AB_2137173
  
  DOI: 10.1016/j.celrep.2019.07.097
  
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Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate

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  RRID:AB_2137173
  
  DOI: 10.1016/j.devcel.2019.04.029
  
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Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism

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  RRID:AB_2137173
  
  DOI: 10.1016/j.ebiom.2018.12.019
  
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Untitled document

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  RRID:AB_2137173
  
  DOI: 10.1016/j.immuni.2019.01.021
  
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Nov 2018
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Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

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  RRID:AB_2137173
  
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Selective Anti-tumor Activity of wogonin targeting the Warburg Effect through stablizing p53

1
1. scibot 05 Nov 2018
  
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  LDHA Antibody
  
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Distinct Activities of Glycolytic Enzymes Identify Chronic Lymphocytic Leukemia Patients with a more Aggressive Course and Resistance to Chemo-Immunotherapy

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1. scibot 05 Nov 2018
  
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Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

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Nov 2017
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Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake

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1. scibot 08 Nov 2017
  
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  AB_2137173
  
  Curator: @chewbeccax
  
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