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Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex

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  DOI: 10.1158/2159-8290.CD-25-0271
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12670082/
Nov 2025
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kato-et-al-2025-effects-of-repetition-duration-on-skeletal-muscle-hypertrophy-in-a-rat-model-of-resistance-exercise-html.html

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54.241.53.176/bfd6684909749a932c0efdd415dc51455e705896/kato-et-al-2025-effects-of-repetition-duration-on-skeletal-muscle-hypertrophy-in-a-rat-model-of-resistance-exercise-html.html
Oct 2025
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USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization

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1. scibot 02 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116372
  
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sciencedirect.com/science/article/pii/S221112472501143X
Sep 2025
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Connexin 43 drives glioblastoma cancer stem cell phenotypes through a WNK lysine-deficient protein kinase 1-c-MYC signaling axis

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sciencedirect.com/science/article/pii/S2211124725010745
Aug 2025
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BPS Publications

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1. scibot 21 Aug 2025
  
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  DOI: 10.1111/bph.70158
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70158
Jun 2025
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PRPS activity tunes redox homeostasis in Myc-driven lymphoma

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.redox.2025.103649
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12166406/
May 2025
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Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity

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1. scibot 31 May 2025
  
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  DOI: 10.1016/j.chom.2025.05.004
  
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sciencedirect.com/science/article/pii/S1931312825001830
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A heterodimer of hemoglobin identifies theranostic targets on brain-metastasizing melanoma cells

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1. scibot 16 May 2025
  
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  DOI: 10.1002/ijc.35458
  
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onlinelibrary.wiley.com/doi/10.1002/ijc.35458
Feb 2025
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Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway

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1. scibot 11 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2025.101941
  
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sciencedirect.com/science/article/pii/S266637912500014X
Jan 2025
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Single-cell analysis of neoplastic plasma cells identifies myeloma pathobiology mediators and potential targets

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1. scibot 24 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2024.101925
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866523/
Dec 2024
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Enhanced antitumor immunity in breast cancer: Synergistic effects of ADAM10/ADAM17 inhibition, metabolic modulation, and camptothecin-loaded selenium nanoparticles

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1. scibot 14 Dec 2024
  
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  DOI: 10.1016/j.ijpharm.2024.125037
  
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sciencedirect.com/science/article/pii/S0378517324012717
Oct 2024
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Pharmacologic inhibition of eIF4A blocks NRF2 synthesis to prevent osteosarcoma metastasis

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1. scibot 04 Oct 2024
  
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  DOI: 10.1158/1078-0432.CCR-24-1317
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11443218/
Aug 2024
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Inhibition of bromodomain and extra-terminal proteins targets constitutively active NFκB and STAT signaling in lymphoma and influences the expression of the antiapoptotic proteins BCL2A1 and c-MYC

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1. scibot 29 Aug 2024
  
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  DOI: 10.1186/s12964-024-01782-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11348570/
Jul 2024
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Spatiotemporal changes in Netrin/Dscam1 signaling dictate axonal projection direction in Drosophila small ventral lateral clock neurons

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1. scibot 27 Jul 2024
  
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  DOI: 10.7554/eLife.96041
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11272162/
May 2024
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Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis

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1. scibot 21 May 2024
  
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  DOI: 10.1016/j.cmet.2024.04.018
  
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sciencedirect.com/science/article/pii/S1550413124001384
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linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability

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1. scibot 16 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114240
  
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sciencedirect.com/science/article/pii/S2211124724005680
Mar 2024
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MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma

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1. scibot 22 Mar 2024
  
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  DOI: 10.1016/j.isci.2024.109417
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10952034/
Feb 2024
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Pim kinase inhibitors increase gilteritinib cytotoxicity in FLT3-ITD acute myeloid leukemia through GSK-3β activation and c-Myc and Mcl-1 proteasomal degradation

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1. scibot 21 Feb 2024
  
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  DOI: 10.1158/2767-9764.CRC-23-0379
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10870818/
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Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice

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  DOI: 10.1016/j.cell.2024.01.004
  
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cell.com/cell/fulltext/S0092-8674(24)00006-0
Jan 2024
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Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors

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  DOI: 10.1016/j.celrep.2023.113629
  
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sciencedirect.com/science/article/pii/S2211124723016406
Dec 2023
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Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives

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1. scibot 29 Dec 2023
  
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  DOI: 10.1016/j.isci.2023.108659
  
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sciencedirect.com/science/article/pii/S2589004223027360
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A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling

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1. scibot 21 Dec 2023
  
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  DOI: 10.1016/j.isci.2023.108568
  
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sciencedirect.com/science/article/pii/S2589004223026457
Nov 2023
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Selective inhibition of CDK9 in triple negative breast cancer

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1. scibot 25 Nov 2023
  
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  DOI: 10.1038/s41388-023-02892-3
  
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nature.com/articles/s41388-023-02892-3
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Aryl Hydrocarbon Receptor is a Tumor Promoter in MYCN-Amplified Neuroblastoma Cells Through Suppression of Differentiation

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  DOI: 10.1016/j.isci.2023.108303
  
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sciencedirect.com/science/article/pii/S2589004223023805
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mTORC1 promotes cell growth via m6A-dependent mRNA degradation

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1. scibot 09 Nov 2023
  
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  DOI: 10.1016/j.molcel.2021.03.010
  
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sciencedirect.com/science/article/pii/S1097276521001787
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Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids

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  DOI: 10.1016/j.celrep.2023.113354
  
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sciencedirect.com/science/article/pii/S2211124723013669
Oct 2023
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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

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1. scibot 17 Oct 2023
  
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  DOI: 10.1016/j.molcel.2021.03.009
  
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sciencedirect.com/science/article/pii/S1097276521001775
Sep 2023
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A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer

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  DOI: 10.1038/s41467-023-40798-6
  
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nature.com/articles/s41467-023-40798-6
Aug 2023
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A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis

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1. scibot 17 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112961
  
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  DOI: 10.1016/j.celrep.2023.112961
  
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52.53.155.43/e4339d2342058d0ba733e06b854674a1d2f752a1/PIIS2211124723009725-html.html
Jul 2023
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Orphan quality control shapes network dynamics and gene expression

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  DOI: 10.1016/j.cell.2023.06.015
  
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sciencedirect.com/science/article/pii/S0092867423006918
May 2023
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Dihydroartemisinin inhibited stem cell-like properties and enhanced oxaliplatin sensitivity of colorectal cancer via AKT/mTOR signaling

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1. scibot 11 May 2023
  
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  DOI: 10.1002/ddr.22067
  
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onlinelibrary.wiley.com/doi/10.1002/ddr.22067
Apr 2023
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Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates

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1. scibot 26 Apr 2023
  
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  DOI: 10.1016/j.devcel.2023.04.004
  
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sciencedirect.com/science/article/pii/S1534580723001570
Jan 2023
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Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non–Small Cell Lung Cancer Cells

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1. scibot 14 Jan 2023
  
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  DOI: 10.1158/1541-7786.MCR-21-1000
  
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aacrjournals.org/mcr/article/20/12/1785/710999/Loss-of-VOPP1-Contributes-to-BET-Inhibitor
Aug 2022
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Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach

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  DOI: 10.1016/j.crmeth.2022.100271
  
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Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells

1
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Functional Interaction Between the Oncogenic Kinase NEK2 and Sam68 Promotes a Splicing Program Involved in Migration and Invasion in Triple-Negative Breast Cancer

1
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Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells

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A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer

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Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist

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The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis

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Kel1 is a phosphorylation-regulated noise suppressor of the pheromone signaling pathway

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Downregulation Of Dihydrotestosterone And Estradiol Levels By Hexim1

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BPS Publications

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A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells

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TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

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Untitled document

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Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers

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Intron 1-Mediated Regulation of EGFR Expression In EGFR-Dependent Malignancies is Mediated by AP-1 and BET Proteins

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  c-Myc
  
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Untitled document

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MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat

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  anti-MYC
  
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Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis

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MYC up-regulation confers resistance to everolimus and establishes vulnerability to cyclin dependent kinase inhibitors in pancreatic neuroendocrine neoplasms cells

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ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis

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Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells

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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

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mTORC1 promotes cell growth via m6A-dependent mRNA degradation

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Constitutive androstane receptor induced-hepatomegaly is partially via yes-associated protein activation

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BPS Publications

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Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

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FEBS Press

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NFAT2 overexpression suppresses the malignancy of hepatocellular carcinoma through inducing Egr2 expression

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Sep 2020
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RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia

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Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity

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Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition

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Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr307 on PP2Ac

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Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

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Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling

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sciencedirect.com/science/article/pii/S2211124719311544
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Expression and clinical value of PD‐L1 which is regulated by BRD4 in tongue squamous cell carcinoma

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  RRID:AB_2151827
  
  DOI: 10.1002/jcb.29420
  
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onlinelibrary.wiley.com/doi/10.1002/jcb.29420
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Expression of the double‐stranded RNA‐dependent kinase PKR influences osteosarcoma attachment independent growth, migration, and invasion

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  RRID:AB_2151827
  
  DOI: 10.1002/jcp.29024
  
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Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

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1. scibot 13 Jan 2020
  
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  RRID:AB_2151827
  
  DOI: 10.1016/j.cmet.2019.10.015
  
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TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

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1. scibot 13 Jan 2020
  
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  RRID:AB_2151827
  
  DOI: 10.1016/j.molcel.2019.03.025
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6671628/
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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2018.12.071
  
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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.7554/eLife.44161
  
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Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.ebiom.2019.01.012
  
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sciencedirect.com/science/article/pii/S235239641930012X
Nov 2018
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Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1550413118305667
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Sam68 Allows Selective Targeting of Human Cancer Stem Cells

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1. scibot 08 Nov 2017
  
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  Curator: @chewbeccax
  
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Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments

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1. scibot 08 Nov 2017
  
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De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones

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1. scibot 08 Nov 2017
  
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  Curator: @chewbeccax
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5319840/

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