30 Matching Annotations
  1. Last 7 days
  2. aacrjournals.org aacrjournals.org
    Targeting PLK1 Reduces MMP10 to Enhance Radiosensitivity in HPV- Head and Neck Cancer
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    aacrjournals.org/clincancerres/article/32/2/405/771743/Targeting-PLK1-Reduces-MMP10-to-Enhance
  3. Apr 2026
  4. www.sciencedirect.com www.sciencedirect.com
    An interactome-based framework for DDB1- and CUL4-associated factor prioritization in targeted protein degradation
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    sciencedirect.com/science/article/pii/S1097276526001607
  5. Mar 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NN-01-195, a novel conjugate of HSP90 and AURKA inhibitors, effectively targets solid tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12977774/
  7. Nov 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrative proteogenomics and forward genetics reveals a novel mitotic vulnerability in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12641601/
  9. May 2025
  10. www.sciencedirect.com www.sciencedirect.com
    Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors
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    sciencedirect.com/science/article/pii/S0092867425004143
  11. Apr 2025
  12. www.sciencedirect.com www.sciencedirect.com
    PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124725003122
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The FBXO45–GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962402/
  14. Feb 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MYC and HSF1 Cooperate to Drive Sensitivity to Polo-like Kinase 1 Inhibitor Volasertib in High-grade Serous Ovarian Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11799878/
  16. Dec 2024
  17. www.sciencedirect.com www.sciencedirect.com
    Mapping functional elements of the DNA damage response through base editor screens
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    sciencedirect.com/science/article/pii/S2211124724013986
  18. Nov 2024
  19. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence-Associated Pathologies
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    onlinelibrary.wiley.com/doi/full/10.1002/advs.202404109
  20. Sep 2024
  21. www.sciencedirect.com www.sciencedirect.com
    The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance
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    sciencedirect.com/science/article/pii/S2211124720310913
  22. Jul 2024
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11293342/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11199525/
  25. May 2024
  26. www.sciencedirect.com www.sciencedirect.com
    Molecular subtypes of neuroendocrine carcinomas: A cross-tissue classification framework based on five transcriptional regulators
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    sciencedirect.com/science/article/pii/S1535610824001636
  27. www.biorxiv.org www.biorxiv.org
    Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells
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    biorxiv.org/content/10.1101/2024.05.13.593567v1
  28. Jul 2023
  29. www.sciencedirect.com www.sciencedirect.com
    Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice
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    sciencedirect.com/science/article/pii/S2211124723008239
  30. www.nature.com www.nature.com
    Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma
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    nature.com/articles/s41420-023-01526-7
  31. Apr 2023
  32. www.mdpi.com www.mdpi.com
    TEAD Inhibitors Sensitize KRASG12C Inhibitors via Dual Cell Cycle Arrest in KRASG12C-Mutant NSCLC
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    mdpi.com/1424-8247/16/4/553
  33. Feb 2023
  34. aacrjournals.org aacrjournals.org
    Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
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    aacrjournals.org/cancerres/article/83/2/219/715076/Plk1-Inhibitors-and-Abiraterone-Synergistically
  35. Nov 2022
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pericentriolar matrix (PCM) integrity relies on cenexin and polo-like kinase (PLK)1
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    pmc.ncbi.nlm.nih.gov/articles/PMC9582643/
  37. www.sciencedirect.com www.sciencedirect.com
    Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death
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    sciencedirect.com/science/article/pii/S2451945622003592
  38. May 2022
  39. www.sciencedirect.com www.sciencedirect.com
    AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma
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    sciencedirect.com/science/article/pii/S2589004222006691
  40. Dec 2021
  41. www.sciencedirect.com www.sciencedirect.com
    Low-intensity pulsed ultrasound-generated singlet oxygen induces telomere damage leading to glioma stem cell awakening from quiescence
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    sciencedirect.com/science/article/pii/S2589004221015285
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC8641947/
  43. Jul 2021
  44. www.sciencedirect.com www.sciencedirect.com
    Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation
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    sciencedirect.com/science/article/pii/S2211124721007191
  45. May 2021
  46. www.sciencedirect.com www.sciencedirect.com
    Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability
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    sciencedirect.com/science/article/pii/S1534580720308881
  47. Sep 2020
  48. www.sciencedirect.com www.sciencedirect.com
    PLK1- and PLK4-Mediated Asymmetric Mitotic Centrosome Size and Positioning in the Early Zebrafish Embryo
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    sciencedirect.com/science/article/pii/S0960982220312641
  49. Jan 2020
  50. royalsocietypublishing.org royalsocietypublishing.org
    Oncogenic MYC amplifies mitotic perturbations
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    royalsocietypublishing.org/doi/full/10.1098/rsob.190136
  51. Nov 2018
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC5926201/
  53. Nov 2017
  54. www.sciencedirect.com www.sciencedirect.com
    Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma
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    sciencedirect.com/science/article/pii/S1934590917301376