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Anticancer activity of RAS-GTP inhibition in cholangiocarcinoma

1
1. scibot 24 Apr 2026
  
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  RRID:AB_2174959
  
  DOI: 10.1016/j.ccell.2026.03.020
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
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sciencedirect.com/science/article/pii/S1535610826001741
Apr 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A hotspot phosphorylation site on SHP2 drives oncoprotein activation and drug resistance

1
1. scibot 15 Apr 2026
  
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  RRID:AB_2174959
  
  DOI: 10.1038/s41467-026-70060-8
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13066003/
Mar 2026
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Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation

1
1. scibot 06 Mar 2026
  
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  RRID:AB_2174959
  
  DOI: 10.1016/j.celrep.2026.117046
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
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sciencedirect.com/science/article/pii/S2211124726001245
Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SHP2 regulates VEGFR2 Y1175/ PLCγ signaling to impair tumor endothelial barrier stability

1
1. scibot 20 Feb 2026
  
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  RRID:AB_2174959
  
  DOI: 10.1016/j.isci.2026.114784
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12915272/
Jan 2026
54.241.53.176 54.241.53.176

1-s2.0-S2589004226001598-main-html.html

1
1. scibot 29 Jan 2026
  
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  RRID:AB_2174959
  
  DOI: 10.1038/s44161-022-00172-z
  
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  Curator: @areedewitt04
  
  SciCrunch record: RRID:AB_2174959
  
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  RRID:AB_2174959 RRIDCUR:Unresolved
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54.241.53.176/c9c076bed7a8fde5420672e62ca2e6fd745c85b4/1-s2.0-S2589004226001598-main-html.html
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance

1
1. scibot 07 Sep 2025
  
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  RRID:AB_2174959
  
  DOI: 10.21203/rs.3.rs-7032881/v1
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12340909/
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance

1
1. scibot 11 Aug 2025
  
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  RRID:AB_2174959
  
  DOI: 10.1101/2025.06.11.659120
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12262427/
Dec 2024
www.sciencedirect.com www.sciencedirect.com

Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy

1
1. scibot 06 Dec 2024
  
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  RRID:AB_2174959
  
  DOI: 10.1016/j.xcrm.2024.101838
  
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sciencedirect.com/science/article/pii/S2666379124006098
Sep 2024
www.sciencedirect.com www.sciencedirect.com

m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1

1
1. scibot 10 Sep 2024
  
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  RRID:AB_2174959
  
  DOI: 10.1016/j.cmet.2024.08.006
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
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sciencedirect.com/science/article/pii/S1550413124003334
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma

1
1. scibot 10 Jan 2024
  
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  RRID:AB_2174959
  
  DOI: 10.1158/1078-0432.CCR-23-1317
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10767308/
Dec 2023
52.53.155.43 52.53.155.43

ccr-23-1317-html.html

1
1. scibot 01 Dec 2023
  
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  RRID:AB_2174959
  
  DOI: 10.1158/1078-0432.ccr-23-1317
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
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52.53.155.43/eb06d63ced7d6b4d34065d25e0eab223f52bfb41/ccr-23-1317-html.html
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Clonal evolution in tyrosine kinase inhibitor-resistance: lessons from in vitro-models

1
1. scibot 30 Jun 2023
  
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  RRID:AB_2174959
  
  DOI: 10.3389/fonc.2023.1200897
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10294234/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor

1
1. scibot 30 Jun 2023
  
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  AB_2174959
  
  DOI: 10.1530/REP-22-0367
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10304905/
May 2023
www.sciencedirect.com www.sciencedirect.com

DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons

1
1. scibot 31 May 2023
  
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  RRID:AB_2174959
  
  DOI: 10.1016/j.celrep.2023.112575
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
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sciencedirect.com/science/article/pii/S2211124723005867
Jul 2022
www.sciencedirect.com www.sciencedirect.com

High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition

1
1. scibot 30 Jul 2022
  
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  RRID:AB_2174959
  
  DOI: 10.1016/j.celrep.2022.111095
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
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sciencedirect.com/science/article/pii/S221112472200897X
Dec 2021
cancerimmunolres.aacrjournals.org cancerimmunolres.aacrjournals.org

The Fibronectin–ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells

1
1. scibot 22 Dec 2021
  
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  RRID:AB_2174959
  
  DOI: 10.1158/2326-6066.CIR-21-0240
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
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cancerimmunolres.aacrjournals.org/content/9/11/1283
www.nature.com www.nature.com

A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis

1
1. scibot 21 Dec 2021
  
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  RRID:AB_2174959
  
  DOI: 10.1038/s41467-021-27452-9
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
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nature.com/articles/s41467-021-27452-9
Aug 2021
cancerres.aacrjournals.org cancerres.aacrjournals.org

SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer

1
1. scibot 16 Aug 2021
  
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  RRID:AB_2174959
  
  DOI: 10.1158/0008-5472.CAN-20-3738
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
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cancerres.aacrjournals.org/content/81/12/3215
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

1
1. scibot 13 Apr 2021
  
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  RRID:AB_2174959
  
  DOI: 10.1016/j.cell.2021.03.031
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2174959
  
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  RRIDCUR:Validated RRID:AB_2174959
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sciencedirect.com/science/article/pii/S0092867421003627
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling

1
1. scibot 09 Apr 2021
  
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  RRID:AB_2174959
  
  DOI: 10.7554/eLife.64251
  
  Resource: (Cell Signaling Technology Cat# 3397, RRID:AB_2174959)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2174959
  
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  RRIDCUR:Validated RRID:AB_2174959
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ncbi.nlm.nih.gov/pmc/articles/PMC8024022/
Oct 2020
www.cell.com www.cell.com

Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

1
1. scibot 01 Oct 2020
  
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  RRID:AB_2174959
  
  DOI: 10.1016/j.cell.2020.09.002
  
  Resource: AB_2174959
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2174959
  
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  RRIDCUR:Validated RRID:AB_2174959
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cell.com/cell/fulltext/S0092-8674(20)31143-0