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  1. Last 7 days
  2. www.science.org www.science.org
    Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells
    1
    1. scibot 20 Dec 2024
      AB_2179963

      DOI: 10.1126/scisignal.adi8753

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    science.org/doi/10.1126/scisignal.adi8753
  3. Oct 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
    1
    1. scibot 05 Oct 2024
      AB_2179963

      DOI: 10.1101/2024.09.09.612106

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    ncbi.nlm.nih.gov/pmc/articles/PMC11419079/
  5. Sep 2024
  6. www.sciencedirect.com www.sciencedirect.com
    Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming
    1
    1. scibot 05 Sep 2024
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      DOI: 10.1016/j.immuni.2024.08.008

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    sciencedirect.com/science/article/pii/S1074761324004072
  7. Aug 2024
  8. journals.physiology.org journals.physiology.org
    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
    1
    1. scibot 02 Aug 2024
      RRID AB_2179963

      DOI: 10.1152/ajpcell.00385.2020

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  9. May 2024
  10. 52.53.155.43 52.53.155.43
    Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
    2
    1. scibot 09 May 2024
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      DOI: 10.1016/j.celrep.2024.114173

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    2. scibot 03 May 2024
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      DOI: 10.1016/j.celrep.2024.114173

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    52.53.155.43/7165d3b920717872e9ecee45ef5f3cb3a7917c57/mmc6-html.html
  11. Mar 2024
  12. www.sciencedirect.com www.sciencedirect.com
    MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors
    2
    1. scibot 07 Mar 2024
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      DOI: 10.1016/j.isci.2024.109188

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    2. scibot 06 Mar 2024
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    sciencedirect.com/science/article/pii/S2589004224004097
  13. Feb 2024
  14. 52.53.155.43 52.53.155.43
    mTOR regulates mineralocorticoid receptor transcriptional activity by ULK1- dependent and independent mechanisms
    1
    1. scibot 15 Feb 2024
      AB_2179963

      DOI: 10.1210/endocr/bqae015

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  15. Jul 2023
  16. www.sciencedirect.com www.sciencedirect.com
    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
    2
    1. scibot 08 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112764

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    2. scibot 08 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112764

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    sciencedirect.com/science/article/pii/S2211124723007751
  17. Dec 2022
  18. www.science.org www.science.org
    Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension
    1
    1. scibot 13 Dec 2022
      RRID: AB_2179963

      DOI: 10.1126/scisignal.abn2743

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  19. Nov 2022
  20. academic.oup.com academic.oup.com
    mTOR inhibition decreases angiotensin II-induced steroidogenesis in HAC15 human adrenocortical carcinoma cells
    1
    1. scibot 19 Nov 2022
      AB_2179963

      DOI: 10.1210/endocr/bqac185

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    academic.oup.com/endo/article/164/1/bqac185/6793711
  21. academic.oup.com academic.oup.com
    Angiotensin II regulates mitochondrial mTOR pathway activity dependent on acyl CoA synthetase 4 in adrenocortical cells
    1
    1. scibot 03 Nov 2022
      RRID:AB_2179963

      DOI: 10.1210/endocr/bqac170

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    academic.oup.com/endo/article-abstract/163/12/bqac170/6763139
  22. Nov 2021
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
    1
    1. scibot 24 Nov 2021
      RRID:AB_2179963

      DOI: 10.7554/eLife.71575

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    ncbi.nlm.nih.gov/pmc/articles/PMC8598234/
  24. 52.53.155.43 52.53.155.43
    ajpcell.00385.2020-html.html
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    1. scibot 24 Nov 2021
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  25. www.sciencedirect.com www.sciencedirect.com
    Efferocytosis induces macrophage proliferation to help resolve tissue injury
    1
    1. scibot 16 Nov 2021
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      DOI: 10.1016/j.cmet.2021.10.015

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    sciencedirect.com/science/article/pii/S1550413121005271
  26. Sep 2021
  27. www.sciencedirect.com www.sciencedirect.com
    KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis
    1
    1. scibot 22 Sep 2021
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      DOI: 10.1016/j.molcel.2021.09.001

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    sciencedirect.com/science/article/pii/S1097276521007358
  28. Jul 2021
  29. jcs.biologists.org jcs.biologists.org
    The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3
    1
    1. scibot 31 Jul 2021
      RICTOR

      DOI: 10.1242/jcs.233221

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    jcs.biologists.org/content/132/20/jcs233221
  30. www.sciencedirect.com www.sciencedirect.com
    Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
    1
    1. scibot 22 Jul 2021
      RRID:AB_2179963

      DOI: 10.1016/j.cell.2021.06.028

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    sciencedirect.com/science/article/pii/S0092867421007960
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    An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
    1
    1. scibot 10 Jul 2021
      RRID:AB_2179963

      DOI: 10.1016/j.molcel.2021.06.017

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    sciencedirect.com/science/article/pii/S1097276521004974
  32. May 2021
  33. www.sciencedirect.com www.sciencedirect.com
    Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism
    1
    1. scibot 06 May 2021
      RRID:AB_2179963

      DOI: 10.1016/j.immuni.2020.07.002

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    sciencedirect.com/science/article/pii/S107476132030282X
  34. Apr 2021
  35. www.sciencedirect.com www.sciencedirect.com
    Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle
    1
    1. scibot 29 Apr 2021
      RRID:AB_2179963

      DOI: 10.1016/j.cmet.2020.08.011

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    sciencedirect.com/science/article/pii/S1550413120304241
  36. Feb 2021
  37. www.cell.com www.cell.com
    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
    1
    1. scibot 24 Feb 2021
      RRID:AB_2179963

      DOI: 10.1016/j.celrep.2020.01.012

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    cell.com/cell-reports/abstract/S2211-1247(20)30021-8
  38. Jan 2021
  39. www.sciencedirect.com www.sciencedirect.com
    Impact of WIN site inhibitor on the WDR5 interactome
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    1. scibot 20 Jan 2021
      RRID:AB_2179963

      DOI: 10.1016/j.celrep.2020.108636

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    sciencedirect.com/science/article/pii/S2211124720316259
  40. Nov 2020
  41. www.sciencedirect.com www.sciencedirect.com
    Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer
    1
    1. scibot 24 Nov 2020
      RRID:AB_2179963

      DOI: 10.1016/j.xcrm.2020.100131

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    sciencedirect.com/science/article/pii/S2666379120301737
  42. Sep 2020
  43. www.sciencedirect.com www.sciencedirect.com
    Metabolic Control over mTOR-Dependent Diapause-like State
    1
    1. scibot 12 Sep 2020
      RRID:AB_2179963

      DOI: 10.1016/j.devcel.2019.12.018

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    sciencedirect.com/science/article/pii/S1534580719310676
  44. www.sciencedirect.com www.sciencedirect.com
    Ubiquitylation of the ER-Shaping Protein Lunapark via the CRL3KLHL12 Ubiquitin Ligase Complex
    1
    1. scibot 10 Sep 2020
      RRID:AB_2179963

      DOI: 10.1016/j.celrep.2020.107664

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    sciencedirect.com/science/article/pii/S2211124720306173
  45. www.cell.com www.cell.com
    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
    1
    1. scibot 08 Sep 2020
      RRID:AB_2179963

      DOI: 10.1016/j.celrep.2020.01.012

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    cell.com/cell-reports/abstract/S2211-1247(20)30021-8
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
    1
    1. scibot 05 Sep 2020
      RRID:AB_2179963

      DOI: 10.7554/eLife.51440

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    ncbi.nlm.nih.gov/pmc/articles/PMC7080408/
  47. www.embopress.org www.embopress.org
    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
    1
    1. scibot 04 Sep 2020
      Rictor

      DOI: 10.15252/embr.201949898

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    embopress.org/doi/abs/10.15252/embr.201949898
  48. Jan 2020
  49. www.sciencedirect.com www.sciencedirect.com
    NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression
    1
    1. scibot 13 Jan 2020
      RRID:AB_2179963

      DOI: 10.1016/j.celrep.2019.06.085

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    sciencedirect.com/science/article/pii/S2211124719308654
  50. www.sciencedirect.com www.sciencedirect.com
    Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
    1
    1. scibot 13 Jan 2020
      RRID:AB_10694641

      DOI: 10.1016/j.immuni.2019.06.007

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    sciencedirect.com/science/article/pii/S1074761319302778
  51. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_2179963

      DOI: 10.1016/j.celrep.2019.02.052

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    sciencedirect.com/science/article/pii/S2211124719302311
  52. www.sciencedirect.com www.sciencedirect.com
    Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
    1
    1. scibot 12 Jan 2020
      RRID:AB_2179963

      DOI: 10.1016/j.cmet.2019.03.005

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    sciencedirect.com/science/article/pii/S1550413119301330
  53. www.sciencedirect.com www.sciencedirect.com
    Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity
    1
    1. scibot 12 Jan 2020
      RRID:AB_2179963

      DOI: 10.1016/j.celrep.2019.02.096

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    sciencedirect.com/science/article/pii/S2211124719302827
  54. Nov 2018
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
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    1. scibot 05 Nov 2018
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    ncbi.nlm.nih.gov/pmc/articles/PMC5926201/
  56. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 05 Nov 2018
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    sciencedirect.com/science/article/pii/S1074761318300700
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Method for the Acute and Rapid Degradation of Endogenous Proteins
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    1. scibot 05 Nov 2018
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    2. scibot 05 Nov 2018
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    ncbi.nlm.nih.gov/pmc/articles/PMC5733393/