62 Matching Annotations
  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    HSV-1 employs UL56 to antagonize expression and function of cGAMP channels
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    sciencedirect.com/science/article/pii/S2211124724004509
  3. Apr 2024
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    Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties
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    sciencedirect.com/science/article/pii/S0092867424003155
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    Oncostatin M signaling drives cancer-associated skeletal muscle wasting
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    sciencedirect.com/science/article/pii/S2666379124001666
  6. Feb 2024
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    IL-37d enhances COP1-mediated C/EBPβ degradation to suppress spontaneous neutrophil migration and tumor progression
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    sciencedirect.com/science/article/pii/S2211124724001153
  8. Dec 2023
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    Loss of α-1,2-mannosidase MAN1C1 promotes tumorigenesis of intrahepatic cholangiocarcinoma through enhancing CD133-FIP200 interaction
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    1. scibot 20 Dec 2023
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    sciencedirect.com/science/article/pii/S2211124723016005
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin alleviates hepatic iron overload and ferroptosis through AMPK-ferroportin pathway in HFD-induced NAFLD
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    1. scibot 13 Dec 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC10711470/
  11. Nov 2023
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    The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency
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    sciencedirect.com/science/article/abs/pii/S1550413123003856
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    PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer
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    sciencedirect.com/science/article/pii/S2451945623003847
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    ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress
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    1. scibot 17 Nov 2023
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    sciencedirect.com/science/article/pii/S2211124723014146
  15. Oct 2023
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    Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer
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    1. scibot 28 Oct 2023
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  17. Sep 2023
  18. www.nature.com www.nature.com
    E2 enzyme Bruce negatively regulates Hippo signaling through POSH-mediated expanded degradation
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      DOI: 10.1038/s41419-023-06130-2

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  19. Jul 2023
  20. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2023 - Cheng - Pharmacological targeting of Axin2 suppresses cell growth and metastasis in-html.html
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    1. scibot 21 Jul 2023
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      DOI: 10.1111/bph.16193

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    52.53.155.43/51180316abfac9593501c4c683749a3ad6cad477/British J Pharmacology - 2023 - Cheng - Pharmacological targeting of Axin2 suppresses cell growth and metastasis in-html.html
  21. Jun 2023
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    Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal
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    1. scibot 23 Jun 2023
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    sciencedirect.com/science/article/pii/S2589004223011124
  23. www.embopress.org www.embopress.org
    Human Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV
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    1. scibot 06 Jun 2023
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      DOI: 10.15252/embr.202256430

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    embopress.org/doi/10.15252/embr.202256430
  24. May 2023
  25. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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      DOI: 10.1111/febs.16780

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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.16780
  26. Apr 2023
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    Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners
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    sciencedirect.com/science/article/pii/S1550413123000955
  28. Jan 2023
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance
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      DOI: 10.1158/2159-8290.CD-21-1463

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    ncbi.nlm.nih.gov/pmc/articles/PMC9357203/
  30. Dec 2022
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-cancer activity of ST101, a novel antagonist of CCAAT/enhancer binding protein β
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    ncbi.nlm.nih.gov/pmc/articles/PMC9630826/
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    USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction
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    sciencedirect.com/science/article/pii/S2211124722015248
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Implications of differential transcription start site selection on chronic myeloid leukemia and prostate cancer cell protein expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC9678739/
  34. Nov 2022
  35. www.sciencedirect.com www.sciencedirect.com
    Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy
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    sciencedirect.com/science/article/pii/S2352396422005357
  36. Aug 2022
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    Ubiquitination of phosphatidylethanolamine in organellar membranes
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    sciencedirect.com/science/article/pii/S1097276522007614
  38. Jun 2022
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    pSNAP: Proteome-wide analysis of elongating nascent polypeptide chains
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    sciencedirect.com/science/article/pii/S2589004222007878
  40. Mar 2022
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prevention and Regression of Megamitochondria and Steatosis by Blocking Mitochondrial Fusion in the Liver
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      DOI: 10.1016/j.isci.2022.103996

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    ncbi.nlm.nih.gov/pmc/articles/PMC8927900/
  42. Jan 2022
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    Cytosolic adaptation to mitochondria-induced proteostatic stress causes progressive muscle wasting
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    sciencedirect.com/science/article/pii/S2589004221016850
  44. Dec 2021
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    AMP-activated protein kinase alpha1 promotes tumor development via FOXP3 elevation in tumor-infiltrating Treg cells
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    sciencedirect.com/science/article/pii/S2589004221015406
  46. Nov 2021
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    HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease
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      DOI: 10.1016/j.molcel.2021.10.028

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    sciencedirect.com/science/article/pii/S1097276521009485
  48. link.springer.com link.springer.com
    Starvation induced autophagy promotes the progression of bladder cancer by LDHA mediated metabolic reprogramming
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      DOI: 10.1186/s12935-021-02303-1

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    link.springer.com/article/10.1186/s12935-021-02303-1
  49. Aug 2021
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    The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies
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    sciencedirect.com/science/article/pii/S2211124721010391
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    The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis
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      DOI: 10.1016/j.immuni.2021.06.008

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    sciencedirect.com/science/article/pii/S1074761321002521
  52. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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      DOI: 10.1016/j.molcel.2018.11.015

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    sciencedirect.com/science/article/pii/S1097276518309857
  53. academic.oup.com academic.oup.com
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    academic.oup.com/endo/article/158/10/3097/4082468
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    O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity
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      DOI: 10.1016/j.chom.2018.11.001

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    sciencedirect.com/science/article/pii/S1931312818305584
  55. Jul 2021
  56. www.sciencedirect.com www.sciencedirect.com
    ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids
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      DOI: 10.1016/j.cell.2021.07.003

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    sciencedirect.com/science/article/pii/S0092867421008291
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC5659682/
  58. www.nature.com www.nature.com
    Necroptotic virotherapy of oncolytic alphavirus M1 cooperated with Doxorubicin displays promising therapeutic efficacy in TNBC
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      3933s

      DOI: 10.1038/s41388-021-01869-4

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    nature.com/articles/s41388-021-01869-4
  59. Jun 2021
  60. www.sciencedirect.com www.sciencedirect.com
    Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation
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      DOI: 10.1016/j.celrep.2021.109272

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    sciencedirect.com/science/article/pii/S2211124721006392
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    Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1
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      DOI: 10.1016/j.cmet.2021.05.019

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    sciencedirect.com/science/article/pii/S1550413121002709
  62. May 2021
  63. www.sciencedirect.com www.sciencedirect.com
    SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells
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      DOI: 10.1016/j.molcel.2021.04.002

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  64. Apr 2021
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    SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways
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  66. Feb 2021
  67. onlinelibrary.wiley.com onlinelibrary.wiley.com
    SCF‐Slimb is critical for GSK‐3β‐mediated suppression of TAF15‐induced neurotoxicity in Drosophila
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  68. Sep 2020
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    Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells
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    TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
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  71. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex
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    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
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  73. jcs.biologists.org jcs.biologists.org
    TDP-43 a protein central to amyotrophic lateral sclerosis is destabilized by Tankyrase-1/2
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    Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade
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    Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome
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  76. Jan 2020
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    Antisense oligonucleotide therapy rescues aggresome formation in a novel spinocerebellar ataxia type 3 human embryonic stem cell line
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    Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages
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    PPEF2 Opposes PINK1-Mediated Mitochondrial Quality Control by Dephosphorylating Ubiquitin
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    Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation
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  81. onlinelibrary.wiley.com onlinelibrary.wiley.com
    MicroRNA501‐5p induces p53 proteasome degradation through the activation of the mTOR/MDM2 pathway in ADPKD cells
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    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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      DOI: 10.1016/j.chom.2019.02.015

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    Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance
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  85. Nov 2018
  86. www.sciencedirect.com www.sciencedirect.com
    GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death
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    Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy
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  88. europepmc.org europepmc.org
    Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP.
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  89. Nov 2017
  90. academic.oup.com academic.oup.com
    Bortezomib Alone and in Combination With Salinosporamid A Induces Apoptosis and Promotes Pheochromocytoma Cell Death In Vitro and in Female Nude Mice
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    Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9
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