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Aug 2025
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Multi-dimensional metabolomic remodeling under diverse muscle atrophic stimuli in vivo

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  DOI: 10.1016/j.celrep.2025.116097
  
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sciencedirect.com/science/article/pii/S221112472500868X
Mar 2025
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1-s2.0-S2589004225004043-main-html.html

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52.53.155.43/a54d23b2534862197be3e5d5ad98a8cc187610fd/1-s2.0-S2589004225004043-main-html.html
Jan 2025
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A conserved acetylation switch enables pharmacological control of tubby-like protein stability

1
1. scibot 10 Jan 2025
  
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  rabbit antiubiquitin
  
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jbc.org/article/S0021-9258(20)00061-7/fulltext
Dec 2024
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The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity

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sciencedirect.com/science/article/pii/S2211124724013846
Jun 2024
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The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress

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sciencedirect.com/science/article/pii/S2211124724006946
Apr 2024
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HSV-1 employs UL56 to antagonize expression and function of cGAMP channels

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  DOI: 10.1016/j.celrep.2024.114122
  
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Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties

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  DOI: 10.1016/j.cell.2024.03.024
  
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sciencedirect.com/science/article/pii/S0092867424003155
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Oncostatin M signaling drives cancer-associated skeletal muscle wasting

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  DOI: 10.1016/j.xcrm.2024.101498
  
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sciencedirect.com/science/article/pii/S2666379124001666
Feb 2024
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IL-37d enhances COP1-mediated C/EBPβ degradation to suppress spontaneous neutrophil migration and tumor progression

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1. scibot 22 Feb 2024
  
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sciencedirect.com/science/article/pii/S2211124724001153
Dec 2023
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Loss of α-1,2-mannosidase MAN1C1 promotes tumorigenesis of intrahepatic cholangiocarcinoma through enhancing CD133-FIP200 interaction

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Metformin alleviates hepatic iron overload and ferroptosis through AMPK-ferroportin pathway in HFD-induced NAFLD

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1. scibot 13 Dec 2023
  
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  DOI: 10.1016/j.isci.2023.108560
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10711470/
Nov 2023
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The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency

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  DOI: 10.1016/j.cmet.2023.10.016
  
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sciencedirect.com/science/article/abs/pii/S1550413123003856
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PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.chembiol.2023.10.023
  
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sciencedirect.com/science/article/pii/S2451945623003847
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ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress

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1. scibot 17 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113402
  
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sciencedirect.com/science/article/pii/S2211124723014146
Oct 2023
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Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer

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  DOI: 10.1016/j.cmet.2023.10.002
  
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sciencedirect.com/science/article/pii/S1550413123003716
Sep 2023
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E2 enzyme Bruce negatively regulates Hippo signaling through POSH-mediated expanded degradation

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1. scibot 14 Sep 2023
  
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  DOI: 10.1038/s41419-023-06130-2
  
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  DOI: 10.1038/s41419-023-06130-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10497580/
Jul 2023
52.53.155.43 52.53.155.43

British J Pharmacology - 2023 - Cheng - Pharmacological targeting of Axin2 suppresses cell growth and metastasis in-html.html

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1. scibot 21 Jul 2023
  
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  DOI: 10.1111/bph.16193
  
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52.53.155.43/51180316abfac9593501c4c683749a3ad6cad477/British J Pharmacology - 2023 - Cheng - Pharmacological targeting of Axin2 suppresses cell growth and metastasis in-html.html
Jun 2023
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Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal

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1. scibot 23 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.107035
  
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Human Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV

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  DOI: 10.15252/embr.202256430
  
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embopress.org/doi/10.15252/embr.202256430
May 2023
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

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  DOI: 10.1111/febs.16780
  
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febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16780
Apr 2023
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Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners

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Jan 2023
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Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance

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  DOI: 10.1158/2159-8290.CD-21-1463
  
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aacrjournals.org/cancerdiscovery/article/12/8/1942/707227/Enhancing-PD-L1-Degradation-by-ITCH-during-MAPK
Dec 2022
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Anti-cancer activity of ST101, a novel antagonist of CCAAT/enhancer binding protein β

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  DOI: 10.1158/1535-7163.MCT-21-0962
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9630826/
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USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction

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  DOI: 10.1016/j.celrep.2022.111653
  
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Implications of differential transcription start site selection on chronic myeloid leukemia and prostate cancer cell protein expression

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  DOI: 10.1016/j.isci.2022.105519
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9678739/
Nov 2022
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Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy

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  DOI: 10.1016/j.ebiom.2022.104353
  
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Aug 2022
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Ubiquitination of phosphatidylethanolamine in organellar membranes

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  DOI: 10.1016/j.molcel.2022.08.008
  
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Jun 2022
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pSNAP: Proteome-wide analysis of elongating nascent polypeptide chains

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  DOI: 10.1016/j.isci.2022.104516
  
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Mar 2022
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Prevention and Regression of Megamitochondria and Steatosis by Blocking Mitochondrial Fusion in the Liver

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  DOI: 10.1016/j.isci.2022.103996
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8927900/
Jan 2022
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Cytosolic adaptation to mitochondria-induced proteostatic stress causes progressive muscle wasting

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  DOI: 10.1016/j.isci.2021.103715
  
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Dec 2021
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AMP-activated protein kinase alpha1 promotes tumor development via FOXP3 elevation in tumor-infiltrating Treg cells

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  DOI: 10.1016/j.isci.2021.103570
  
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Nov 2021
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HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease

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1. scibot 30 Nov 2021
  
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  DOI: 10.1016/j.molcel.2021.10.028
  
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cancerci.biomedcentral.com cancerci.biomedcentral.com

Starvation induced autophagy promotes the progression of bladder cancer by LDHA mediated metabolic reprogramming

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1. scibot 09 Nov 2021
  
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  DOI: 10.1186/s12935-021-02303-1
  
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cancerci.biomedcentral.com/articles/10.1186/s12935-021-02303-1
Aug 2021
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The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies

1
1. scibot 25 Aug 2021
  
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  DOI: 10.1016/j.celrep.2021.109601
  
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sciencedirect.com/science/article/pii/S2211124721010391
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The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis

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O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity

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ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids

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Necroptotic virotherapy of oncolytic alphavirus M1 cooperated with Doxorubicin displays promising therapeutic efficacy in TNBC

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Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation

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Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1

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SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells

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SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways

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SCF‐Slimb is critical for GSK‐3β‐mediated suppression of TAF15‐induced neurotoxicity in Drosophila

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Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells

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TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

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Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex

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Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

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TDP-43 a protein central to amyotrophic lateral sclerosis is destabilized by Tankyrase-1/2

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Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade

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Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome

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Antisense oligonucleotide therapy rescues aggresome formation in a novel spinocerebellar ataxia type 3 human embryonic stem cell line

1
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Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages

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PPEF2 Opposes PINK1-Mediated Mitochondrial Quality Control by Dephosphorylating Ubiquitin

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Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation

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MicroRNA501‐5p induces p53 proteasome degradation through the activation of the mTOR/MDM2 pathway in ADPKD cells

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KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

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Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance

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GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death

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Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy

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Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP.

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Bortezomib Alone and in Combination With Salinosporamid A Induces Apoptosis and Promotes Pheochromocytoma Cell Death In Vitro and in Female Nude Mice

1
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Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9

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