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The binding of OTULIN restrains LUBAC activity to prevent TNF-driven immunopathology

1
1. scibot 17 Oct 2026
  
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  RRID:AB_2187734
  
  DOI: 10.1016/j.molcel.2026.09.039
  
  Resource: (Proteintech Cat# 14626-1-AP, RRID:AB_2187734)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1097276526007045
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

LUBAC modulates CBM complex functions downstream of TRAF6 in T cells

1
1. scibot 24 Nov 2025
  
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  RRID:AB_2187734
  
  DOI: 10.1038/s41467-025-65879-6
  
  Resource: (Proteintech Cat# 14626-1-AP, RRID:AB_2187734)
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12602705/
May 2024
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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

1
1. scibot 24 May 2024
  
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  RRID:AB_2187734
  
  DOI: 10.1016/j.immuni.2024.04.025
  
  Resource: (Proteintech Cat# 14626-1-AP, RRID:AB_2187734)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1074761324002309
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis

1
1. scibot 10 Apr 2024
  
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  RRID:AB_2187734
  
  DOI: 10.1038/s41467-024-47289-2
  
  Resource: (Proteintech Cat# 14626-1-AP, RRID:AB_2187734)
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10998861/
Jan 2023
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SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD

1
1. scibot 19 Jan 2023
  
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  RRID:AB_2187734
  
  DOI: 10.1016/j.celrep.2022.111961
  
  Resource: (Proteintech Cat# 14626-1-AP, RRID:AB_2187734)
  
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sciencedirect.com/science/article/pii/S2211124722018654
Oct 2022
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The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling

1
1. scibot 08 Oct 2022
  
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  RRID:AB_2187734
  
  DOI: 10.1016/j.isci.2022.105066
  
  Resource: (Proteintech Cat# 14626-1-AP, RRID:AB_2187734)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2589004222013384
Aug 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

1
1. scibot 13 Aug 2022
  
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  RRID:AB_2187734
  
  DOI: 10.1016/j.cell.2016.07.019
  
  Resource: (Proteintech Cat# 14626-1-AP, RRID:AB_2187734)
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5002269/
Oct 2021
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Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains

1
1. scibot 06 Oct 2021
  
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  RRID:AB_2187734
  
  DOI: 10.1016/j.celrep.2021.109777
  
  Resource: (Proteintech Cat# 14626-1-AP, RRID:AB_2187734)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2187734
  
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sciencedirect.com/science/article/pii/S2211124721012316
Aug 2021
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Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death

1
1. scibot 15 Aug 2021
  
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  RRID:AB_2187734
  
  DOI: 10.1016/j.cell.2021.07.026
  
  Resource: (Proteintech Cat# 14626-1-AP, RRID:AB_2187734)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S0092867421008850
Jul 2021
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Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death

1
1. scibot 31 Jul 2021
  
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  Rabbit polyclonal anti-Sharpin
  
  DOI: 10.1016/j.celrep.2019.11.014
  
  Resource: (Proteintech Cat# 14626-1-AP, RRID:AB_2187734)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2187734
  
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  RRID:AB_2187734 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S2211124719314858
Jun 2021
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OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin

1
1. scibot 22 Jun 2021
  
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  RRID:AB_2187734
  
  DOI: 10.1016/j.molcel.2021.05.031
  
  Resource: (Proteintech Cat# 14626-1-AP, RRID:AB_2187734)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2187734
  
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sciencedirect.com/science/article/pii/S1097276521004445
Sep 2020
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OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis

1
1. scibot 08 Sep 2020
  
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  RRID:AB_2187734
  
  DOI: 10.1016/j.celrep.2020.01.028
  
  Resource: (Proteintech Cat# 14626-1-AP, RRID:AB_2187734)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2187734
  
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  RRID:AB_2187734 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720300371
Jan 2020
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MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2187734
  
  DOI: 10.1016/j.molcel.2019.01.022
  
  Resource: (Proteintech Cat# 14626-1-AP, RRID:AB_2187734)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2187734
  
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  RRID:AB_2187734 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276519300425
Nov 2017
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A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN

1
1. scibot 08 Nov 2017
  
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  RRID:AB_2187734
  
  Curator: @Jmenke
  
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  (Proteintech Group Cat# 14626-1-AP, RRID:AB_2187734)
  
  SciCrunch record: RRID:AB_2187734
  
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  RRID:AB_2187734 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2451945617302805
www.sciencedirect.com www.sciencedirect.com

A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development

1
1. scibot 08 Nov 2017
  
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  RRID:AB_2187734
  
  Curator: @Jmenke
  
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  (Proteintech Group Cat# 14626-1-AP, RRID:AB_2187734)
  
  SciCrunch record: RRID:AB_2187734
  
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  RRID:AB_2187734 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610817303549
europepmc.org europepmc.org

Untitled document

1
1. scibot 08 Nov 2017
  
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  AB_2187734
  
  Resource used:
  
  (Proteintech Group Cat# 14626-1-AP, RRID:AB_2187734)
  
  SciCrunch record: RRID:AB_2187734
  
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europepmc.org/articles/PMC5002269/table/undtbl1/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 08 Nov 2017
  
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  AB_2187734
  
  Resource used:
  
  (Proteintech Group Cat# 14626-1-AP, RRID:AB_2187734)
  
  SciCrunch record: RRID:AB_2187734
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5002269/table/undtbl1/
www.cell.com www.cell.com

Untitled document

1
1. scibot 08 Nov 2017
  
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  AB_2187734
  
  Resource used:
  
  (Proteintech Group Cat# 14626-1-AP, RRID:AB_2187734)
  
  SciCrunch record: RRID:AB_2187734
  
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  RRID:AB_2187734
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cell.com/action/showMethods
www.sciencedirect.com www.sciencedirect.com

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_2187734
  
  Curator: @gabimpine
  
  Resource used:
  
  (Proteintech Group Cat# 14626-1-AP, RRID:AB_2187734)
  
  SciCrunch record: RRID:AB_2187734
  
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  RRID:AB_2187734 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0092867416309266
www.sciencedirect.com www.sciencedirect.com

An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis

1
1. scibot 08 Nov 2017
  
  in Public
  
  SHARPIN antibody (14626-1-AP; Proteintech
  
  Curator: @bandrow
  
  Curator note: Proteintech Group Cat# 14626-1-AP, RRID:AB_2187734
  
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  (Proteintech Group Cat# 14626-1-AP, RRID:AB_2187734)
  
  SciCrunch record: RRID:AB_2187734
  
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sciencedirect.com/science/article/pii/S0002944016000985