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Aug 2025
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Aging-induced semaphorin 7a promotes TGF-β1-mediated cell plasticity and breast tumor metastases

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sciencedirect.com/science/article/pii/S2211124725008137
May 2025
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Fibrogenesis-driven tumor progression in clear cell renal cell carcinoma: prognostic, therapeutic implications and the dual role of neuropilin-1

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pmc.ncbi.nlm.nih.gov/articles/PMC12082889/
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Microbial metabolite ammonia disrupts TGF-β signaling to promote colon cancer

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sciencedirect.com/science/article/pii/S0021925825004089
Apr 2025
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A Novel Mechanism of the p53 Isoform Δ40p53α in Regulating Collagen III Expression in TGFβ1-Induced LX-2 Human Hepatic Stellate Cells

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1. scibot 17 Apr 2025
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202403146RR
Mar 2025
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ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma

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sciencedirect.com/science/article/pii/S2666379125001119
Feb 2025
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LRRC75A-AS1 drives the epithelial-mesenchymal transition in cervical cancer by binding IGF2BP1 and inhibiting SYVN1-mediated NLRP3 ubiquitination

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aacrjournals.org/mcr/article/22/12/1075/750095/LRRC75A-AS1-Drives-the-Epithelial-Mesenchymal
Jan 2025
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Negative regulation of lymphangiogenesis by Tenascin-C delays the resolution of inflammation

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ERBB4 selectively amplifies TGF-β pro-metastatic responses

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sciencedirect.com/science/article/pii/S2211124724015614
Dec 2024
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Kinome-wide CRISPR-Cas9 screens revealed EXOSC10 as a positive regulator of TGF-β signaling

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pmc.ncbi.nlm.nih.gov/articles/PMC11605321/
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Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence

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pmc.ncbi.nlm.nih.gov/articles/PMC11617384/
Nov 2024
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p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb

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1. scibot 21 Nov 2024
  
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  DOI: 10.1038/s44318-024-00246-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11574164/
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Vitamin D alleviates HFD-induced hepatic fibrosis by inhibiting DNMT1 to affect the TGFβ1/Smad3 pathway

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Integrated multiomic analysis identifies TRIP13 as a mediator of alveolar epithelial type II cell dysfunction in idiopathic pulmonary fibrosis

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  DOI: 10.1016/j.bbadis.2024.167572
  
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sciencedirect.com/science/article/pii/S0925443924005660
Sep 2024
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Global isonicotinylome analysis identified SMAD3 isonicotinylation promotes liver cancer cell epithelial–mesenchymal transition and invasion

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1. scibot 25 Sep 2024
  
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Aldehydes alter TGF-β signaling and induce obesity and cancer

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sciencedirect.com/science/article/pii/S2211124724010271
Jul 2024
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Cenicriviroc Suppresses and Reverses Steatohepatitis by Regulating Macrophage Infiltration and M2 Polarization in Mice

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1. scibot 18 Jul 2024
  
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  DOI: 10.1210/endocr/bqae069
  
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RNF185 control of COL3A1 expression limits prostate cancer migration and metastatic potential

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1. scibot 07 Jul 2024
  
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  DOI: 10.1158/1541-7786.MCR-23-0512
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10841372/
Jun 2024
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Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and Tgfβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritis

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1. scibot 02 Jun 2024
  
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  DOI: 10.7554/eLife.95640
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11132684/
May 2024
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mcr-23-0478-html.html

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52.53.155.43/a4d1b1195ce648b46cbdc2b7d1e41b22ba16f57e/mcr-23-0478-html.html
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Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging

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ncbi.nlm.nih.gov/pmc/articles/PMC11066433/
Apr 2024
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Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner

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  DOI: 10.1016/j.celrep.2024.114149
  
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HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

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1. scibot 24 Apr 2024
  
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mcr-23-0478-html.html

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52.53.155.43/a4d1b1195ce648b46cbdc2b7d1e41b22ba16f57e/mcr-23-0478-html.html
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Endometrial BMP2 Deficiency Impairs ITGB3-Mediated Trophoblast Invasion in Women with Repeated Implantation Failure

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academic.oup.com/endo/article-abstract/165/3/bqae002/7513513
Feb 2024
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Integrative modelling and analysis of signalling crosstalk reveal molecular switches coordinating YAP transcriptional activities

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Stromal-derived MAOB promotes prostate cancer growth and progression

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ncbi.nlm.nih.gov/pmc/articles/PMC10857382/
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Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and TGFβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritis

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1. scibot 11 Feb 2024
  
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  DOI: 10.1101/2024.01.15.575763
  
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biorxiv.org/content/10.1101/2024.01.15.575763v1
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EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis

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HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

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  DOI: 10.1101/2023.12.05.570182
  
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  DOI: 10.1101/2023.12.05.570182
  
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  DOI: 10.1101/2023.12.05.570182
  
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biorxiv.org/content/10.1101/2023.12.05.570182v1
Jan 2024
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Transforming growth factor-β1 protects against white matter injury and reactive astrogliosis via the p38 MAPK pathway in rodent demyelinating model

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  DOI: 10.1111/jnc.16037
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16037
Dec 2023
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ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors

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  DOI: 10.1016/j.celrep.2023.113541
  
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Smad4 sequestered in SFPQ condensates prevents TGF-β tumor-suppressive signaling

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  DOI: 10.1016/j.devcel.2023.11.020
  
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sciencedirect.com/science/article/pii/S1534580723006184
Nov 2023
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TGFB1 induces fetal reprogramming and enhances intestinal regeneration

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  DOI: 10.1016/j.stem.2023.09.015
  
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CD4+LAG3+T cells are decreased in SSc-ILD and affects fibroblast mesenchymal transition by TGF-β3

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The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery

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Hepatocyte FoxO1 deficiency protects from liver fibrosis via reducing inflammation and TGF-β1 mediated HSC activation

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CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis

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Photobiomodulation inhibits the expression of chondroitin... : Neural Regeneration Research

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SMYD3 induces sorafenib resistance by activating SMAD2/3-mediated epithelial-mesenchymal transition in hepatocellular carcinoma

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Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer

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Increased fibrosis in white adipose tissue of male and female bGH transgenic mice appears independent of TGF-β action

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5-Azacytidine- and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-β-SMAD4 signaling

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CCN2/CTGF tip the balance of growth factors towards TGF-β2 in primary open-angle glaucoma

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IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma

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Epithelial cells activate fibroblasts to promote esophageal cancer development

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Prolyl isomerase Pin1 promotes extracellular matrix production in hepatic stellate cells through regulating formation of the Smad3-TAZ complex

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Targeting activin receptor-like kinase 7 ameliorates adiposity and associated metabolic disorders

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TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state

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Membrane Estrogen Receptor Beta is Sufficient to Mitigate Cardiac Cell Pathology

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Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer

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STAT3 is activated by CTGF-mediated tumor-stroma cross talk to promote HCC progression.

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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

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MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels

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A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

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Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration

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Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma

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PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II

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Nicotinamide N-methyltransferase ameliorates renal fibrosis by its metabolite 1-methylnicotinamide inhibiting the TGF-β1/Smad3 pathway

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BPS Publications

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LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency

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Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice

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Adrenomedullin ameliorates pulmonary fibrosis by regulating TGF-β-Smads signaling and myofibroblast differentiation

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The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression

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Subcellular trafficking of tubular MDM2 implicates in acute kidney injury to chronic kidney disease transition during multiple low‐dose cisplatin exposure

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Untitled document

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TGF‐β1 activates RSC96 Schwann cells migration and invasion through MMP‐2 and MMP‐9 activities

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TNAP is a novel regulator of cardiac fibrosis after myocardial infarction by mediating TGF-β/Smads and ERK1/2 signaling pathways

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Treatment with a probiotic combination reduces abdominal adhesion in rats by decreasing intestinal inflammation and restoring microbial composition

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  DOI: 10.3892/or.2020.7463
  
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Creatine promotes cancer metastasis through activation of Smad2/3

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Jan 2021
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Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

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1. scibot 30 Jan 2021
  
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  DOI: 10.7554/eLife.63545
  
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TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

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  DOI: 10.1016/j.celrep.2020.108221
  
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BPS Publications

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  DOI: 10.1111/bph.15010
  
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The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer

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1. scibot 10 Sep 2020
  
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  DOI: 10.7554/eLife.57679
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7302877/
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PRMT1-p53 Pathway Controls Epicardial EMT and Invasion

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  DOI: 10.1016/j.celrep.2020.107739
  
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Sel1L-Hrd1 ER-associated degradation maintains β-cell identity via TGFβ signaling

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  pSmad2/3
  
  DOI: 10.1172/JCI134874
  
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Jan 2020
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PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.molcel.2019.09.018
  
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Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathways

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  DOI: 10.1016/j.lfs.2019.117139
  
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DNA Damage Activates TGF-β Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor TβRII

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  DOI: 10.1016/j.celrep.2019.06.045
  
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sciencedirect.com/science/article/pii/S2211124719308186
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Untitled document

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  DOI: 10.1016/j.ccell.2018.12.002
  
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sciencedirect.com/science/article/pii/S1535610818305737
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Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth

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Bone morphogenetic protein 2 promotes human trophoblast cell invasion by inducing activin A production

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academic.oup.com/endo/article/159/7/2815/5003399
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Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming

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Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression

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sciencedirect.com/science/article/pii/S2405471217305380
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ncbi.nlm.nih.gov/pmc/articles/PMC5731821/
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europepmc.org/articles/PMC5731821/
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PPARγ Links BMP2 and TGFβ1 Pathways in Vascular Smooth Muscle Cells, Regulating Cell Proliferation and Glucose Metabolism

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Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity

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ncbi.nlm.nih.gov/pmc/articles/PMC5148611/
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TGFβ Signaling Regulates the Timing of CNS Myelination by Modulating Oligodendrocyte Progenitor Cell Cycle Exit through SMAD3/4/FoxO1/Sp1

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ncbi.nlm.nih.gov/pmc/articles/PMC4044250

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