105 Matching Annotations
  1. Last 7 days
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    RNA sensing induced by chromosome missegregation augments anti-tumor immunity
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    1. scibot 21 Dec 2024
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    sciencedirect.com/science/article/pii/S109727652400950X
  3. Dec 2024
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    Regulation of human interferon signaling by transposon exonization
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    1. scibot 14 Dec 2024
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    sciencedirect.com/science/article/pii/S0092867424013333
  5. Nov 2024
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    Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging
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    sciencedirect.com/science/article/pii/S0092867424012017
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy
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    1. scibot 07 Nov 2024
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    pmc.ncbi.nlm.nih.gov/articles/PMC11513249/
  8. Oct 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon
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    1. scibot 04 Oct 2024
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    sciencedirect.com/science/article/pii/S1550413124003668
  10. Sep 2024
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    Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages
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    sciencedirect.com/science/article/pii/S1550413124003620
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    DDI2 protease controls embryonic development and inflammation via TCF11/NRF1
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    sciencedirect.com/science/article/pii/S2589004224021187
  13. Aug 2024
  14. jbiomedsci.biomedcentral.com jbiomedsci.biomedcentral.com
    Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells
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      9172

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    jbiomedsci.biomedcentral.com/articles/10.1186/s12929-021-00769-9
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    TCF19 Impacts a Network of Inflammatory and DNA Damage Response Genes in the Pancreatic β-Cell
    1
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    mdpi.com/2218-1989/11/8/513/htm
  16. Jul 2024
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    Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity
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    1. scibot 24 Jul 2024
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    sciencedirect.com/science/article/pii/S1074761324002796
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    pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism
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    1. scibot 23 Jul 2024
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    sciencedirect.com/science/article/pii/S1097276524004775
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication
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    1. scibot 14 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11233922/
  20. Jun 2024
  21. www.sciencedirect.com www.sciencedirect.com
    The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies
    1
    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.immuni.2024.05.017

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  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity
    1
    1. scibot 04 Jun 2024
      RRID:AB_2198300

      DOI: 10.1016/j.celrep.2024.114289

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    ncbi.nlm.nih.gov/pmc/articles/PMC11315447/
  23. May 2024
  24. aacrjournals.org aacrjournals.org
    TREX1 inactivation unleashes cancer cell STING-interferon signaling and promotes anti-tumor immunity
    2
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      DOI: 10.1158/2159-8290.CD-23-0700

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    aacrjournals.org/cancerdiscovery/article/14/5/752/745044/TREX1-Inactivation-Unleashes-Cancer-Cell-STING
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    ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity
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    1. scibot 21 May 2024
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    sciencedirect.com/science/article/pii/S0092867424004513
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    Trophoblastic signals facilitate endometrial interferon response and lipid metabolism, ensuring normal decidualization
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      DOI: 10.1016/j.celrep.2024.114246

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    sciencedirect.com/science/article/pii/S2211124724005746
  27. www.biorxiv.org www.biorxiv.org
    Viral mimicry and memory deficits upon microglial deletion of ATRX
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      DOI: 10.1101/2024.05.07.592875

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    biorxiv.org/content/10.1101/2024.05.07.592875v1
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Atherosis-associated lnc_000048 activates PKR to enhance STAT1-mediated polarization of THP-1 macrophages to M1 phenotype
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    ncbi.nlm.nih.gov/pmc/articles/PMC11090429/
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    PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages
    2
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      Cell Signaling TechnologyCat# 9172; RRID: AB_2198300

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    ncbi.nlm.nih.gov/pmc/articles/PMC11022165/
  30. Apr 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C
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    ncbi.nlm.nih.gov/pmc/articles/PMC11046299/
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    Inhibition of Pim kinases triggers a broad antiviral activity by affecting innate immunity and via the PI3K-Akt-mTOR axis the endolysosomal system
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      Cell Signaling, 9172S

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    sciencedirect.com/science/article/pii/S0166354224001001
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    Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration
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    sciencedirect.com/science/article/pii/S221112472400442X
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    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
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    sciencedirect.com/science/article/pii/S221112472400439X
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    Oncostatin M signaling drives cancer-associated skeletal muscle wasting
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    sciencedirect.com/science/article/pii/S2666379124001666
  36. Mar 2024
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages
    2
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    ncbi.nlm.nih.gov/pmc/articles/PMC11022165/
  38. Feb 2024
  39. www.sciencedirect.com www.sciencedirect.com
    PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2211124724001591
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription
    1
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      Cell Signaling9172S

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    ncbi.nlm.nih.gov/pmc/articles/PMC11056844/
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    The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation
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    sciencedirect.com/science/article/pii/S2211124724001207
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    Balancing macrophage polarization via stem cell-derived apoptotic bodies for diabetic wound healing
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      DOI: 10.1016/j.medj.2024.01.006

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    sciencedirect.com/science/article/pii/S2666634024000369
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    Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs
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    sciencedirect.com/science/article/pii/S2211124724000792
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alleviation of monocyte exhaustion by BCG derivative mycolic acid
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    ncbi.nlm.nih.gov/pmc/articles/PMC10845070/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Subsets of interferon signaling predict response to immune checkpoint blockade in melanoma patients
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      DOI: 10.1158/1078-0432.CCR-23-0215

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    ncbi.nlm.nih.gov/pmc/articles/PMC10524955/
  46. Jan 2024
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10989277/
  48. Dec 2023
  49. www.sciencedirect.com www.sciencedirect.com
    PIM kinases regulate early human Th17 cell differentiation
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    sciencedirect.com/science/article/pii/S221112472301481X
  50. Nov 2023
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression
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      RRID:AB_2198300

      DOI: 10.1158/2767-9764.CRC-23-0265

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    ncbi.nlm.nih.gov/pmc/articles/PMC10680432/
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    PTIR1 acts as an isoform of DDX58 and promotes tumor immune resistance through activation of UCHL5
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      DOI: 10.1016/j.celrep.2023.113388

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    sciencedirect.com/science/article/pii/S2211124723014006
  53. Sep 2023
  54. www.sciencedirect.com www.sciencedirect.com
    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
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      DOI: 10.1016/j.devcel.2023.08.013

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    sciencedirect.com/science/article/pii/S1534580723004094
  55. Aug 2023
  56. www.sciencedirect.com www.sciencedirect.com
    Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response
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    NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages
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  58. 52.53.155.43 52.53.155.43
    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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  59. 52.53.155.43 52.53.155.43
    Journal of Neurochemistry - 2023 - Kamte-html.html
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  60. Jun 2023
  61. www.sciencedirect.com www.sciencedirect.com
    Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
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    Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine
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    Interferon hyperactivity impairs cardiogenesis in Down syndrome via downregulation of canonical Wnt signaling
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  64. May 2023
  65. www.sciencedirect.com www.sciencedirect.com
    Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway
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  66. Apr 2023
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    Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis
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  68. Jan 2023
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    Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy
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    Differential roles of type I interferon signaling in tumor versus host cells in experimental glioma models
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  71. Dec 2022
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    Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling
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    Mitochondrial cristae architecture protects against mtDNA release and inflammation
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    Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response
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  75. Nov 2022
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    The target antigen determines the mechanism of acquired resistance to T cell-based therapies
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  77. Sep 2022
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    MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer
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    Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
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  80. Aug 2022
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    STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization
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    The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging
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  83. Jun 2022
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    Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction
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  85. May 2022
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    A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling
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    Intracellular infection and immune system cues rewire adipocytes to acquire immune function
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  88. Mar 2022
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    PTPN2 elicits cell autonomous and non–cell autonomous effects on antitumor immunity in triple-negative breast cancer
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    Generation of CRISPR–Cas9-mediated genetic knockout human intestinal tissue–derived enteroid lines by lentivirus transduction and single-cell cloning
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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-dependent Manner
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    Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
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  93. Feb 2022
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    IL-27/IL-27RA signaling may modulate inflammation and progression of benign prostatic hyperplasia via suppressing the LPS/TLR4 pathway
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    Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo
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  96. Jan 2022
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    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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    Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses
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  99. Dec 2021
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  101. Nov 2021
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    Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium
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    IRF3-binding lncRNA-ISIR strengthens interferon production in viral infection and autoinflammation
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  104. Aug 2021
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    CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions
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    Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis
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    Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response
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  108. Jul 2021
  109. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Interleukin 35 ameliorates myocardial ischemia‐reperfusion injury by activating the gp130‐STAT3 axis
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    Necroptotic virotherapy of oncolytic alphavirus M1 cooperated with Doxorubicin displays promising therapeutic efficacy in TNBC
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  111. Jun 2021
  112. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment.
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  113. www.sciencedirect.com www.sciencedirect.com
    Translation stress and collided ribosomes are co-activators of cGAS
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  114. May 2021
  115. www.sciencedirect.com www.sciencedirect.com
    PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR
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  116. www.sciencedirect.com www.sciencedirect.com
    Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses
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  117. www.sciencedirect.com www.sciencedirect.com
    Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities
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  118. academic.oup.com academic.oup.com
    A case of Luscan-Lumish syndrome: Possible involvement of enhanced GH signaling
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  119. www.jimmunol.org www.jimmunol.org
    Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2′3′-Cyclic GMP–AMP and Cisplatin under Steady State and Inflammation
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    Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus
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    sciencedirect.com/science/article/pii/S1097276520303166
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    An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
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    Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates
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    sciencedirect.com/science/article/pii/S1534580720305803
  123. Apr 2021
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    The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design
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  125. Mar 2021
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    Endogenous retrovirus expression activates type-I interferon signaling in an experimental mouse model of mesothelioma development
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  127. Feb 2021
  128. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  129. www.mdpi.com www.mdpi.com
    Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes
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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching
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    ncbi.nlm.nih.gov/pmc/articles/PMC7362873/
  131. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Downregulation of uPAR promotes urokinase translocation into the nucleus and epithelial to mesenchymal transition in neuroblastoma
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    onlinelibrary.wiley.com/doi/10.1002/jcp.29555
  132. Sep 2020
  133. www.sciencedirect.com www.sciencedirect.com
    Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity
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    sciencedirect.com/science/article/pii/S1074761320301291
  134. www.sciencedirect.com www.sciencedirect.com
    Decoding the Transcriptional Response to Ischemic Stroke in Young and Aged Mouse Brain
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    sciencedirect.com/science/article/pii/S2211124720307579
  135. Jan 2020
  136. www.sciencedirect.com www.sciencedirect.com
    Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
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      RRID:AB_2198289

      DOI: 10.1016/j.immuni.2019.06.007

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    sciencedirect.com/science/article/pii/S1074761319302778
  137. elifesciences.org elifesciences.org
    CCN1 interlinks integrin and Hippo pathway to autoregulate tip cell activity
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      DOI: 10.7554/eLife.46012

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  138. www.sciencedirect.com www.sciencedirect.com
    RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer
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      DOI: 10.1016/j.ccell.2018.10.006

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    sciencedirect.com/science/article/pii/S1535610818304720
  139. www.sciencedirect.com www.sciencedirect.com
    IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties
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      DOI: 10.1016/j.cmet.2019.01.006

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    sciencedirect.com/science/article/pii/S1550413119300063
  140. www.sciencedirect.com www.sciencedirect.com
    Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING
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      DOI: 10.1016/j.molcel.2019.02.038

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    sciencedirect.com/science/article/pii/S1097276519301492
  141. Nov 2018
  142. www.sciencedirect.com www.sciencedirect.com
    Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress
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    sciencedirect.com/science/article/pii/S1535610818301223
  143. www.sciencedirect.com www.sciencedirect.com
    The control of oligodendrocyte bioenergetics by interferon-gamma (IFN-γ) and Src homology region 2 domain-containing phosphatase-1 (SHP-1)
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    sciencedirect.com/science/article/pii/S0165572817303703