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Oct 2026
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DND1-NANOS3 shapes the PGC transcriptome via a heptanucleotide sequence in mRNA 3′ UTRs

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sciencedirect.com/science/article/pii/S1097276526006532
Sep 2026
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Metabolic regulation of calcium homeostasis via SERCA succination

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  DOI: 10.1126/sciadv.aeh2771
  
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science.org/doi/10.1126/sciadv.aeh2771
Aug 2026
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Reassessment of the roles of coronin proteins as actin effectors and in signaling

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1. scibot 22 Aug 2026
  
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  DOI: 10.1371/journal.pbio.3003904
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13485075/
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The Odf2 status contributes to asymmetric inheritance of CD133-positive recycling endosomes during cytokinesis in SK-N-DZ human neuroblastoma cells

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sciencedirect.com/science/article/pii/S2589004226024405
Jul 2026
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Localized mRNAs and protein synthesis in cortical layer 1

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sciencedirect.com/science/article/pii/S2211124726007655
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Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC13343314/
May 2026
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Regulation of cAMP levels in osteocytes by mechano-sensitive focal adhesion kinase and phosphodiesterase 8A

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pmc.ncbi.nlm.nih.gov/articles/PMC13224023/
Apr 2026
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TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network

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  DOI: 10.1038/s41467-026-72077-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13102947/
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1-s2.0-S2589004226010990-main-html.html

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Genetically encoded manipulation of ATP/ADP ratio in human cells uncovers proteomic and physiological signatures of energy stress

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pmc.ncbi.nlm.nih.gov/articles/PMC13159532/
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A stress-induced PI3P complex controls autophagy in erythroid precursors

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1. scibot 10 Apr 2026
  
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Feb 2026
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2026.01.31.703051.full-html.html

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54.241.53.176/817d1ae27212347f382894a7416c0a21d3d8e9f2/2026.01.31.703051.full-html.html
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Impact of Tau overexpression on DNA replication dynamics in centromeres of human neural progenitor cells

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1. scibot 12 Feb 2026
  
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  DOI: 10.1016/j.isci.2026.114707
  
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Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer’s disease risk factors

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sciencedirect.com/science/article/pii/S1074761326000361
Dec 2025
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Interleukin-1/Toll-like receptor signaling potentiates macrophage olfactory receptor 2-driven atherosclerosis

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  DOI: 10.1016/j.celrep.2025.116639
  
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sciencedirect.com:5037/science/article/pii/S2211124725014111
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PROFILING THE TRPV4 ANKYRIN REPEAT DOMAIN INTERACTOME AND ITS DISRUPTION BY NEUROMUSCULAR DISEASE-CAUSING MUTATIONS

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sciencedirect.com:5037/science/article/pii/S0021925825028431
Nov 2025
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A triple-action PROTAC for wild-type p53 cancer therapy

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.xcrm.2025.102467
  
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Prolyl endopeptidase is a multifunctional host factor required for FMDV infection

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1. scibot 25 Nov 2025
  
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  DOI: 10.1007/s00018-025-05941-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12630515/
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A Hybrid compound H93 treats prostate cancer by directly binding UHRF1 and promoting protein dimerization

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pmc.ncbi.nlm.nih.gov/articles/PMC12627547/
Oct 2025
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Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer

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science.org/doi/10.1126/scisignal.adu7145
Sep 2025
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Control of Inflammatory Response by Tissue Microenvironment

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pmc.ncbi.nlm.nih.gov/articles/PMC11118380/
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Protection against ferroptosis through maintaining homeostasis of docosahexaenoate-containing phospholipids

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Aug 2025
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The yeast Mkt1/Pbp1 complex promotes adaptive responses to respiratory growth

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pmc.ncbi.nlm.nih.gov/articles/PMC12345631/
Jul 2025
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Structural determinants of DANGEROUS MIX 3, an alpha/beta hydrolase that triggers NLR-mediated genetic incompatibility in plants

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cell.com/molecular-cell/abstract/S1097-2765(25)00549-0
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TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling

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sciencedirect.com/science/article/pii/S109727652500509X
Jun 2025
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Hyperacute response proteins synthesized on γ-tubulin-FTO-MARK4 translation microdomains regulate cancer’s acute stress response

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Mitochondrial fumarate inhibits Parkin-mediated mitophagy

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The effect of G-quadruplexes on TDP43 condensation, distribution, and toxicity

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cell.com/structure/fulltext/S0969-2126(25)00184-4
May 2025
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Genomic context influences translesion synthesis DNA polymerase-dependent mechanisms of micronuclei induction by G-quadruplexes

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Apr 2025
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Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction

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Downregulation of PD-L1 expression by Wnt pathway inhibition to enhance PD-1 blockade efficacy in hepatocellular carcinoma

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  DOI: 10.1186/s13062-025-00645-8
  
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link.springer.com/article/10.1186/s13062-025-00645-8
Mar 2025
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TMEM63B functions as a mammalian hyperosmolar sensor for thirst

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  DOI: 10.1016/j.neuron.2025.02.012
  
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sciencedirect.com/science/article/pii/S0896627325001308
Feb 2025
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ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation

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1. scibot 13 Feb 2025
  
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  DOI: 10.1016/j.cell.2025.01.027
  
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sciencedirect.com/science/article/pii/S0092867425000960
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Tubular ER structures shaped by ER-phagy receptors engage in stress-induced Golgi bypass

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  DOI: 10.1016/j.devcel.2025.01.011
  
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sciencedirect.com/science/article/pii/S1534580725000310
Dec 2024
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TBP bookmarks and preserves neural stem cell fate memory by orchestrating local chromatin architecture

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Reactive oxygen species control protein degradation at the mitochondrial import gate

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Degradome analysis to identify direct protein substrates of small-molecule degraders

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RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery

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The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C

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Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity

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PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection

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H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2

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POT1 recruits and regulates CST-Polα/primase at human telomeres

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2024.02.25.581951v1.full-html.html

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A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism

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PABPC1 mediates degradation of C9orf72-FTLD/ALS GGGGCC repeat RNA

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Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production

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METTL17 is an Fe-S cluster checkpoint for mitochondrial translation

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p57Kip2 acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation

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Virus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape

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Reprogramming of Iron Metabolism Confers Ferroptosis Resistance in ECM-Detached Cells

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INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

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Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase

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Hepatitis B Virus Utilizes a Retrograde Trafficking Route via the Trans-Golgi Network to Avoid Lysosomal Degradation

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Pan-Cancer Analysis Reveals Recurrent BCAR4 Gene Fusions across Solid Tumors

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Meiotic nuclear pore complex remodeling provides key insights into nuclear basket organization

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Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis

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GPI-Anchored Ligand-BioID2-Tagging System Identifies Galectin-1 Mediating Zika Virus Entry

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Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance

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Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells

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TMEM106A inhibits enveloped virus release from cell surface

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Single-cell mapping of DNA G-quadruplex structures in human cancer cells

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TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states

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Tyrosine Phosphorylation of DEPTOR Functions as a Molecular Switch to Activate mTOR Signaling

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A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development

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Structural basis and regulation of the reductive stress response

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NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

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Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding

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Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2

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Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection

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Untitled document

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Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice

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  2368
  
  DOI: 10.1016/j.jgg.2021.07.006
  
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Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

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BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association

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Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

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Rickettsia Sca4 Reduces Vinculin-Mediated Intercellular Tension to Promote Spread

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Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells

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Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation

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Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms

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LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP

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H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2

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Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation

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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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  Rabbit monoclonal anti-DYKDDDK Tag
  
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Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion

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FGF Pyramus Has a Transmembrane Domain and Cell-Autonomous Function in Polarity

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Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I

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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

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A Cellular Mechanism to Detect and Alleviate Reductive Stress

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MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism

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Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors

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Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

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Reducing acetylated tau is neuroprotective in brain injury

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NOX1/NADPH oxidase promotes synaptic facilitation induced by repeated D2 receptor stimulation; involvement in behavioral repetition

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  rabbit anti-DYKDDDDK tag
  
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SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation

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  FLAG
  
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Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling

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TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41

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TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

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AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

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Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling

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A Conserved Kinase-Based Body-Temperature Sensor Globally Controls Alternative Splicing and Gene Expression

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JNK signalling regulates antioxidant responses in neurons

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STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition

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DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells

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Mitotic Implantation of the Transcription Factor Prospero via Phase Separation Drives Terminal Neuronal Differentiation

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Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder

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Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation

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A Structure-Informed Atlas of Human-Virus Interactions

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Proximity RNA Labeling by APEX-Seq Reveals the Organization of Translation Initiation Complexes and Repressive RNA Granules

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SLC19A1 Is an Importer of the Immunotransmitter cGAMP

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Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production

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Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex

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Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions

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TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

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Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia

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Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

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Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence

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SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation

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Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer

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Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

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RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health

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  FLAGCell Signaling2368
  
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Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals

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  Rabbit polyclonal anti-DYKDDDK Tag Antibody (FLAG)
  
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Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development

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Regulation of Alcohol Extinction and Cue-Induced Reinstatement by Specific Projections among Medial Prefrontal Cortex, Nucleus Accumbens, and Basolateral Amygdala

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Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

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The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C

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