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ACSS2-Mediated Metabolic-Epigenetic Crosstalk Drives Fulvestrant Resistance and Represents a Novel Therapeutic Target

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1. scibot 14 Oct 2025
  
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  DOI: 10.1101/2025.09.23.678089
  
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biorxiv.org/content/10.1101/2025.09.23.678089v1
Sep 2025
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Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells

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1. scibot 12 Sep 2025
  
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  DOI: 10.1101/2025.08.20.671247
  
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biorxiv.org/content/10.1101/2025.08.20.671247v1
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Mitochondrial ACSS1 Links Acetate Metabolism to Pyrimidine Biosynthesis in Nutrient-Stressed B-Cell Lymphomas

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1. scibot 09 Sep 2025
  
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  RRID:AB_2222710
  
  DOI: 10.1101/2025.08.29.673065
  
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biorxiv.org/content/10.1101/2025.08.29.673065v1
Jul 2025
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High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA

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1. scibot 08 Jul 2025
  
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  RRID:AB_2222710
  
  DOI: 10.1016/j.celrep.2025.115947
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00718-1
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115444
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12091147/
Feb 2025
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Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis

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1. scibot 11 Feb 2025
  
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  RRID:AB_2222710
  
  DOI: 10.1016/j.celrep.2025.115284
  
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sciencedirect.com/science/article/pii/S2211124725000555
Jan 2025
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A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells

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1. scibot 28 Jan 2025
  
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  RRID:AB_2222710
  
  DOI: 10.1016/j.chembiol.2025.01.002
  
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sciencedirect.com/science/article/pii/S2451945625000029
Dec 2024
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Nucleo-cytosolic acetyl-CoA drives tumor immune evasion by regulating PD-L1 in melanoma

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1. scibot 02 Dec 2024
  
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  RRID:AB_2222710
  
  DOI: 10.1016/j.celrep.2024.115015
  
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sciencedirect.com/science/article/pii/S2211124724013664
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ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.114988
  
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sciencedirect.com/science/article/pii/S2211124724013391
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma

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1. scibot 18 Jul 2024
  
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  AB_2222710
  
  DOI: 10.1016/j.celrep.2024.114406
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11290356/
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ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart

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1. scibot 04 Jul 2024
  
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  RRID:AB_2222710
  
  DOI: 10.1101/2024.06.21.600099
  
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biorxiv.org/content/10.1101/2024.06.21.600099v1
Mar 2024
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Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs)

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1. scibot 30 Mar 2024
  
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  RRID:AB_2222710
  
  DOI: 10.1186/s11658-024-00563-z
  
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link.springer.com/article/10.1186/s11658-024-00563-z
Jan 2024
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Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression

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1. scibot 11 Jan 2024
  
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  RRID:AB_2222710
  
  DOI: 10.1016/j.celrep.2023.113575
  
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sciencedirect.com/science/article/pii/S2211124723015875
Jul 2023
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Caffeine supplementation and FOXM1 inhibition enhance the antitumor effect of statins in neuroblastoma

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1. scibot 08 Jul 2023
  
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  RRID:AB_2222710
  
  DOI: 10.1158/0008-5472.CAN-22-3450
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10320471/
Jun 2023
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Acetate controls endothelial-to-mesenchymal transition

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1. scibot 21 Jun 2023
  
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  RRID:AB_2222710
  
  DOI: 10.1016/j.cmet.2023.05.010
  
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sciencedirect.com/science/article/pii/S1550413123002036
52.53.155.43 52.53.155.43

can-22-3450-html.html

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1. scibot 01 Jun 2023
  
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  RRID:AB_2222710
  
  DOI: 10.1158/0008-5472.can-22-3450
  
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52.53.155.43/d74c78a2e62f04f8ffa00018470c131fb0d65945/can-22-3450-html.html
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The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming

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1. scibot 01 Jun 2023
  
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  RRID:AB_2222710
  
  DOI: 10.1016/j.celrep.2023.112590
  
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sciencedirect.com/science/article/pii/S2211124723006010
Nov 2022
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Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis

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1. scibot 18 Nov 2022
  
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  RRID:AB_2222710
  
  DOI: 10.1016/j.molcel.2022.10.027
  
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sciencedirect.com/science/article/pii/S1097276522010553
Aug 2022
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Cardiac ultrastructure inspired matrix induces advanced metabolic and functional maturation of differentiated human cardiomyocytes

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1. scibot 02 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111146
  
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sciencedirect.com/science/article/pii/S221112472200955X
Jun 2022
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Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia

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1. scibot 08 Jun 2022
  
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  RRID:AB_2222710
  
  DOI: 10.1016/j.cmet.2022.05.004
  
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sciencedirect.com/science/article/pii/S1550413122001863
May 2022
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Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy

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1. scibot 11 May 2022
  
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  RRID:AB_2222710
  
  DOI: 10.1016/j.celrep.2022.110796
  
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sciencedirect.com/science/article/pii/S2211124722005630
Dec 2021
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Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells

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1. scibot 01 Dec 2021
  
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  RRID:AB_2222710
  
  DOI: 10.1016/j.celrep.2021.110063
  
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reader.elsevier.com/reader/sd/pii/S2211124721015497
May 2021
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Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells

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1. scibot 09 May 2021
  
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  RRID:AB_2222710
  
  DOI: 10.1016/j.stem.2020.12.009
  
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sciencedirect.com/science/article/pii/S1934590920305932
Feb 2021
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Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma

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1. scibot 28 Feb 2021
  
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  DOI: 10.1016/j.cmet.2020.12.011
  
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sciencedirect.com/science/article/pii/S1550413120306665
Nov 2018
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Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals

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1. scibot 05 Nov 2018
  
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  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S0092867418311012
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Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1550413117306204
Nov 2017
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Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging

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1. scibot 08 Nov 2017
  
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  Curator: @patriciaelyse_
  
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sciencedirect.com/science/article/pii/S0092867417308784